Artificial metalloenzymes and metalloDNAzymes in catalysis: from design to applications
Gespeichert in:
| Weitere Verfasser: | , , |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
[2018]
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34178-8/ Inhaltsverzeichnis |
| Beschreibung: | xiv, 413 Seiten Illustrationen, Diagramme |
| ISBN: | 9783527341788 3527341781 |
Internformat
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| 245 | 1 | 0 | |a Artificial metalloenzymes and metalloDNAzymes in catalysis |b from design to applications |c edited by Montserrat Diéguez, Jan-E. Bäckvall, Oscar Pàmies |
| 264 | 1 | |a Weinheim |b Wiley-VCH |c [2018] | |
| 264 | 4 | |c © 2018 | |
| 300 | |a xiv, 413 Seiten |b Illustrationen, Diagramme | ||
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| 653 | |a Bioanorganische Chemie | ||
| 653 | |a Biochemie | ||
| 653 | |a Biochemistry | ||
| 653 | |a Bioinorganic Chemistry | ||
| 653 | |a Biowissenschaften | ||
| 653 | |a Catalysis | ||
| 653 | |a Catalysis & Chemical Reaction Engineering | ||
| 653 | |a Chemical Engineering | ||
| 653 | |a Chemie | ||
| 653 | |a Chemische Verfahrenstechnik | ||
| 653 | |a Chemistry | ||
| 653 | |a Katalyse | ||
| 653 | |a Katalyse u. Chemische Reaktionstechnik | ||
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| 700 | 1 | |a Pàmies, Oscar |0 (DE-588)1158534019 |4 edt | |
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Datensatz im Suchindex
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| adam_text | CONTENTS
PREFACE XIII
1 PREPARATION OF ARTIFICIAL METALLOENZYMES 1
JARED
C
LEWIS AND KEN ELLIS-GUARDIOLA
1.1 INTRODUCTION 1
1.2 ARM FORMATION VIA METAL BINDING 2
1.2.1 REPURPOSING NATURAL METALLOENZYMES 2
1.2.1.1 CARBOXYPEPTIDASE A 3
1.2.1.2 CARBONIC ANHYDRASE 3
1.2.1.3 METALLO-SS-LACTAMASE 4
1.2.1.4 FERRITIN 5
1.2.2 EXPLOITING SERENDIPITOUS METAL BINDING BY PROTEINS 6
1.2.3 DESIGNING METAL-BINDING SITES IN SCAFFOLD PROTEINS 8
1.2.4 INTRODUCING METAL-BINDING SITES USING UNNATURAL AMINO ACIDS 11
1.3 ARM FORMATION VIA SUPRAMOLECULAR INTERACTIONS 13
1.3.1 COFACTOR BINDING 14
1.3.1.1 HEME PROTEINS 14
1.3.1.2 XYLANASES 16
1.3.1.3 SERUM ALBUMINS 17
1.3.1.4 LACTOCOCCAL MULTIDRUG RESISTANCE REGULATOR 18
1.3.1.5 NIKA 18
1.3.1.6 ANTIBODIES 19
1.3.2 COFACTOR ANCHORING 20
1.3.2.1 (STREPT)AVIDIN 20
1.3.2.2 OTHER ANCHORING SCAFFOLDS 22
1.3.2.3 CARBOXYANHYDRASE 22
1.4 ARM FORMATION VIA COVALENT LINKAGE 23
1.4.1 ACTIVATED SERINE AND CYSTEINE RESIDUES 23
1.4.2 LYSINE RESIDUES 27
1.4.3 CYSTEINE RESIDUES 27
1.4.4 AZIDO PHENYLALANINE 30
1.5 CONCLUSION 31
ACKNOWLEDGMENTS 32
REFERENCES 32
2 PREPARATION OF METALLODNAZYMES 41
CLAIRE E. MCGHEE, RYAN J. LAKE, AND YI LU
2.1 INTRODUCTION 41
2.2 IN VITRO SELECTION OF METALLODNAZYMES IN THE PRESENCE OF
METAL IONS 44
2.2.1 DESIGNING A DNAZYME POOL 45
2.2.1.1 SEQUENCE SPACE 45
2.2.1.2 CHOOSING THE LENGTH OF A RANDOM REGION 46
2.2.2 PERFORMING
IN VITRO SELECTION 46
2.2.2.1 ISOLATION OF REACTIVE DNA SEQUENCES 47
2.2.2.2 NEGATIVE SELECTION 49
2.2.23 POOL REGENERATION 49
2.2.2A MONITORING SELECTION PROGRESS 51
2.2.2.5 SEQUENCING 51
2.2.2.6 SEQUENCE ANALYSIS 52
2.2.3 OPTIMIZATION OF DNAZYMES VIA TRUNCATION AND CIS-TO-TRANS
TRANSFORMATION 52
2.2.4 RESELECTION OF DNAZYMES 53
2.3 FROM
IN VITRO SELECTION TO DESIGN OF METALLODNAZYMES IN THE
PRESENCE OF METALLOCOFACTORS 53
2.4 DESIGN AND PREPARATION OF DNA-BASED HYBRID CATALYSTS 54
2.4.1 SUPRAMOLECULARLY ANCHORED DNA-BASED HYBRID CATALYSTS 54
2.4.2 COVALENTLY ANCHORED DNA-BASED HYBRID CATALYSTS 57
2.5 SUMMARY AND FUTURE DIRECTIONS 58
ACKNOWLEDGMENTS 59
REFERENCES 59
3 EXPERIMENTAL CHARACTERIZATION TECHNIQUES OF HYBRID
CATALYSTS 69
JUAN MANGAS-SANCHEZ AND EDUARDO BUSTO
3.1 INTRODUCTION 69
3.2 CHARACTERIZATION OF MODIFIED NATURALLY OCCURRING
METALLOPROTEINS 69
3.3 CHARACTERIZATION OF NEW METALLOENZYMES CREATED FROM METAL-FREE
PROTEINS 73
3.3.1 CHARACTERIZATION OF METALLOENZYMES OBTAINED THROUGH DIRECT METAL
SALT C OM PILATION 73
3.3.2 CHARACTERIZATION OF METALLOENZYMES OBTAINED VIA COVALENT
ANCHORAGE 77
3.3.3 CHARACTERIZATION OF ARTIFICIAL METALLOENZYMES VIA NON-COVALENT
SUPRAMOLECULAR ANCHORING 84
3.3.4 EXPERIMENTAL CHARACTERIZATION OF ARTIFICIAL METALLOENZYMES WITH
DUAL
ACTIVITIES 87
3.4 CHARACTERIZATION OF DNAZYMES 88
3.5 CONCLUSIONS 92
ACKNOWLEDGMENTS 92
REFERENCES 92
4 COMPUTATIONAL STUDIES OF ARTIFICIAL METALLOENZYMES: FROM
METHODS AND MODELS TO DESIGN AND OPTIMIZATION 99
JAIME RODRIGUEZ-GUERRA, LUR ALONSO-COTCHICO, GIUSEPPE SCIORTINO,
AGUSTI LLEDOES, AND JEAN-DIDIER MARECHAL
4.1 INTRODUCTION 99
4.2 FROM COMPUTATIONAL TRANSITION METAL CATALYSIS TO ARTIFICIAL
METALLOENZYMES DESIGN 100
4.3 THE TOOLBOX OF THE ARTIFICIAL ENZYME MODELER 105
4.3.1 FEW GENERALITIES ON MOLECULAR MODELING 105
4.3.2 ACCURATE PHYSICAL MODELS 106
4.3.3 SIMPLIFIED PHYSICAL MODELS 209
4.3.4 ADVANTAGES OF MM-LIKE METHODS 109
4.3.5 HYBRID AND MULTISCALE MODELS 112
4.4 APPLICATION OF COMPUTATIONAL METHODS TO THE OPTIMIZATION AND
DESIGN OF ARTIFICIAL METALLOENZYMES 113
4.4.1 MODIFYING NATURALLY OCCURRING METALLOENZYMES 113
4.4.1.1 OPTIMIZING BIOMOLECULE-COFACTOR AND BIOHYBRID-SUBSTRATE
BINDING 113
4.4.1.2 ACCOUNTING FOR CHANGES IN THE FIRST COORDINATION SPHERE 115
4.4.1.3 COMPUTATIONAL REDESIGN OF NATIVE METALLOENZYME ACTIVITY AND
SELECTIVITY 116
4.4.1.4 MECHANISTIC ELUCIDATION OF REDESIGNED METALLOENZYMES 117
4.4.2 GENERATION OF ARTIFICIAL METALLOENZYMES FROM METAL-FREE
ENZYMES 119
4.4.2.1 DE NOVO ARTIFICIAL METALLOENZYMES: A GENERAL OVERVIEW 119
4.4.2.2 THE PARTICULARITIES OF DE NOVO METALLOENZYMES 121
4.4.2.3 PROTEIN INTERACTIONS WITH ARTIFICIAL COFACTORS 122
4A2.4 SUBSTRATE BINDING AND COMPLETE MECHANISM 125
4.5 OUTLOOK 127
4.6 CONCLUSION 128
ACKNOWLEDGMENTS 128
REFERENCES 129
5 DIRECTED EVOLUTION OF ARTIFICIAL METALLOENZYMES: BRIDGING
SYNTHETIC CHEMISTRY AND BIOLOGY 137
RUIJIE K. ZHANG, DAVID K. ROMNEY,
5.
B. JENNIFER KAN, AND FRANCES H. ARNOLD
5.1 EVOLUTION ENABLES CHEMICAL INNOVATION 137
5.1.1 STRATEGIES FOR DIRECTED EVOLUTION 138
5.1.2 DIRECTED EVOLUTION AS AN UPHILL WALK IN THE PROTEIN FITNESS
LANDSCAPE 139
5.2 DIRECTED EVOLUTION APPLIED TO NATURAL METALLOENZYMES 140
5.2.1 ENHANCING THE STABILITY OF A CARBONIC ANHYDRASE 140
5.2.2 EXPANDING THE SCOPE OF P450-CATALYZED OXIDATION REACTIONS 142
5.3 DIRECTED EVOLUTION OF HEMOPROTEINS FOR ABIOLOGICAL CATALYSIS 144
5.3.1 NONNATURAL CARBENE TRANSFER REACTIONS WITH ENGINEERED P450BM3
VARIANTS 145
5.3.2 NONNATURAL NITRENE TRANSFER REACTIONS WITH ENGINEERED P450BM3
VARIANTS 146
5.3.3 ENGINEERING CYTOCHROME C FOR NONNATURAL CATALYSIS 151
5.3.4 ENGINEERING MYOGLOBIN FOR NONNATURAL CATALYSIS 151
5.3.5 DIRECTED EVOLUTION OF MYOGLOBIN-DERIVED CATALYSTS CREATED THROUGH
METAL-ION REPLACEMENT 154
5.4 METALLOENZYMES WITH ARTIFICIAL COFACTORS OR METAL-BINDING SITES 155
5.4.1 ARTIFICIAL HYDROLASE WITH BIOTIC METAL IONS IN DE NOVO
BINDING
SITES 155
5.4.2 ARTIFICIAL HYDROGENASES DERIVED FROM STREPTAVIDIN 157
5.4.3 CROSS-COUPLING WITH A PD-STREPTAVIDIN CONJUGATE 160
5.4.4 ALKENE METATHESIS CATALYZED BY AN RU-STREPTAVIDIN CONJUGATE 160
5.4.5 CARBENE TRANSFER WITH CONJUGATE OF RHODIUM AND PROLINE
OLIGOPEPTIDASE 162
5.5 CONCLUSION 164
ACKNOWLEDGMENTS 166
REFERENCES 166
6 ARTIFICIAL METALLOENZYMES FOR HYDROGENATION AND TRANSFER
HYDROGENATION REACTIONS 171
MANUEL BASAURI-MOLINA AND ROBERTUSJ. M. KLEIN GEBBINK
6.1 IMPACT OF METALLOHYDROGENASES IN THE FIELD OF ARTIFICIAL
METALLOENZYMES 171
6.2 BIOTINYLATED METAL COMPLEXES IN AVIDIN AND STREPTAVIDIN 173
6.2.1 HYDROGENATION OF TV-PROTECTED AMINO ACIDS 173
6.2.2 TRANSFER HYDROGENATION OF KETONES 178
6.2.3 TRANSFER HYDROGENATION OF IMINES 180
6.2.4 ATHASES IN CASCADE REACTIONS 182
6.3 ARTIFICIAL ENZYMES WITH COVALENT METALLOPROTEIN CONSTITUTION 184
6.3.1 PAPAIN AND PHOTOACTIVE YELLOW PROTEIN 184
6.3.2 SERINE PROTEASES 188
6.3.3 HUMAN CARBONIC ANHYDRASE 191
6.4 CHEMOCATALYSTS EMBEDDED IN PROTEIN MOTIFS 191
6.5 CONCLUSIONS 193
REFERENCES 194
1 HYBRID CATALYSTS FOR OXIDATION REACTIONS 199
CHRISTINE CAVAZZA, CAROLINE MARCHI-DELAPIERRE, AND STEPHANE MENAGE
7.1 METAL SWITCH 201
7.2 STRUCTURAL MODULATION OF NATURAL ENZYMES 201
7.3 COFACTOR REPLACEMENT: RECONSTITUTION STRATEGY 206
7.4 RATIONAL DESIGN OF ENZYMES 209
7.5 DE NOVO
SYNTHETIC ACTIVE SITE 211
7.6 DE NOVO
PROTEIN SCAFFOLD 216
171 CONCLUDING REMARKS 219
REFERENCES 220
8 HYBRID CATALYSTS AS LEWIS ACID 225
GERARD ROELFES, IVANA DRIENOVSKA, AND LARA VILLARINO
8.1 INTRODUCTION 225
8.2 C -C BOND-FORMING REACTIONS 225
8.2.1 DIELS-ALDER REACTIONS 225
8.2.1.1 DNA-BASED HYBRID CATALYSTS 226
8.2.1.2 METALLOPEPTIDE-BASED HYBRID CATALYST 231
8.2.1.3 PROTEIN-BASED HYBRID CATALYSTS 231
8.2.2 CONJUGATE ADDITION REACTIONS 236
8.2.2.1 MICHAEL ADDITION 236
8.2.2.2 FRIEDEL-CRAFTS ALKYLATION 238
8.3 C-X BOND-FORMING REACTIONS 240
8.3.1 OXA-MICHAEL ADDITIONS 240
8.3.1.1 DNA-BASED HYBRID CATALYST 242
8.3.1.2 PROTEIN-BASED HYBRID CATALYSTS 242
8.3.2 FLUORINATIONS 243
8.4 HYDROLYTIC REACTIONS 244
8.4.1 DNA-BASED HYBRID CATALYST 244
8.4.2 PROTEIN-BASED HYBRID CATALYST 244
8.5 CONCLUSIONS AND OUTLOOK 246
REFERENCES 246
9 HYBRID CATALYSTS FOR C-H ACTIVATION AND OTHER X-H INSERTION
REACTIONS 253
THOMAS R. WARD AND MICHELA M. PELLIZZONI
9.1 GENERAL INTRODUCTION 253
9.2 ARTIFICIAL METALLOENZYMES FOR C-H INSERTION 253
9.2.1 INTRODUCTION 253
9.2.2 ARTIFICIAL METALLOENZYMES BASED ON THE BIOTIN-STREPTAVIDIN
TECHNOLOGY 254
9.2.3 ARTIFICIAL METALLOENZYMES BASED ON THE MYOGLOBIN SCAFFOLD 257
9.2.4 ARTIFICIAL METALLOENZYMES BASED ON POP SCAFFOLD 260
9.2.4.1 SI-H INSERTION 260
9.2.4.2 CYCLOPROPANATION 261
9.3 REPURPOSING HEMOPROTEINS FOR C-H INSERTION REACTIONS 262
9.3.1 INTRODUCTION 262
9.3.2 CYCLOPROPANATION 262
9.3.3 AZIRIDINATION 265
9.3.4 C-H AMINATION 266
9.3.5 N -H INSERTION 269
9.3.6 S-H INSERTION 271
9.3.7 SULFIMIDATION 274
9.3.8 SIGMATROPIC REARRANGEMENT 275
9.3.9 HALOGENATION 276
9.4 CONCLUSION 279
REFERENCES 279
10 HYBRID CATALYSTS FOR OTHER C-C AND C-X BOND FORMATION
REACTIONS 285
PETER J. DEUSS, MEGAN V. DOBLE; AMANDA
G.
JARVIS, AND PAUL CJ. KARNER
10.1 INTRODUCTION 285
10.2 ALLYLIC SUBSTITUTION 286
10.2.1 CHIRAL PHOSPHANE LIGANDS BASED ON CHIRAL BUILDING BLOCKS FROM
NATURE 286
10.2.2 PHOSPHANE-MODIFIED SYNTHETIC POLYPEPTIDES 287
10.2.3 PHOSPHANE-MODIFIED PROTEINS 289
10.2.4 OLIGONUCLEOTIDES-BASED HYBRID CATALYSTS 291
10.3 PALLADIUM-CATALYZED CROSS-COUPLING REACTIONS 296
10.4 HYDROFORMYLATION 302
10.5 PHENYLACETYLENE POLYMERIZATION 304
10.6 OLEFIN METATHESIS 307
10.7 SUMMARY AND FUTURE TRENDS 312
ACKNOWLEDGMENTS 314
REFERENCES 314
11 METAL-ENZYME HYBRID CATALYSTS IN CASCADE AND
MULTICOMPONENT PROCESSES 321
BOI HOA SAN, JESS GUSTHART, SEUNG SEO LEE, AND KYEONG KYU KIM
11.1 INTRODUCTION 321
11.2 METAL-BASED CATALYST HYBRIDS WITH ENZYMES FOR CASCADE AND
MULTICOMPONENT PROCESSES 322
11.2.1 GOLD NANOPARTICLE-BASED ENZYME HYBRID 324
11.2.2 PALLADIUM AND PLATINUM NANOPARTICLE-BASED ENZYME HYBRIDS 326
11.2.3 OTHER METALS USED FOR METAL-ENZYME HYBRID CATALYSTS 330
11.2.4 ORGANOMETALLIC MATERIAL HYBRID WITH PROTEIN/ENZYME 333
11.3 DESIGN STRATEGY FOR METAL-ENZYME HYBRID CATALYSTS IN
MULTICOMPONENT CASCADE REACTIONS 334
11.3.1 DESIGN STRATEGIES FOR DEVELOPING MULTISTEP REACTIONS IN
METAL-ENZYME HYBRID CATALYSTS 335
11.4 REACTION MECHANISMS OF METAL-ENZYME HYBRID CATALYSTS IN
MULTICOMPONENT CASCADE REACTIONS 339
11.4.1 EXAMPLES OF CASCADE REACTIONS 340
11.4.2 MECHANISMS OF COMMONLY USED ENZYMES 341
11.5 CONCLUSION AND FUTURE PERSPECTIVES 343
ACKNOWLEDGMENTS 343
REFERENCES 343
12 METALLOENZYME-LNSPIRED SYSTEMS FOR ALTERNATIVE ENERGY
HARVEST 353
MARKUS D. KAERKAES, OSCAR VERHO, AND BJOERN AEKERMARK
12.1 INTRODUCTION: ARTIFICIAL PHOTOSYNTHESIS 353
12.2 HYDROGEN EVOLUTION 355
12.2.1 HYDROGENASES: IRON-BASED METALLOENZYMES FOR HYDROGEN
EVOLUTION 355
12.2.2 OTHER METAL-BASED BIOHYBRID SYSTEMS FOR HYDROGEN PRODUCTION 363
12.3 HYBRID SYSTEMS FOR OVERALL WATER SPLITTING 364
12.4 BIOINSPIRED SYSTEMS FOR 0 2 REDUCTION 364
12.4.1 SIMPLE BIOELECTRODES FOR APPLICATIONS IN BIOSENSING 366
12.4.2 MULTICATALYTIC HYBRID SYSTEMS FOR MORE EFFICIENT BIOELECTRODES
367
12.4.3 FUTURE DIRECTIONS IN BIOELECTROCATALYSIS RESEARCH 370
12.5 CONCLUSIONS AND OUTLOOK 372
ACKNOWLEDGMENTS 373
REFERENCES 373
13 SYNTHESIS AND APPLICATION OF HYBRID CATALYSTS WITH
METALLOENZYME-LIKE PROPERTIES 383
JOSE M. POLOMO
13.1 INTRODUCTION 383
13.2 SYNTHESIS OF PD NANOBIOHYBRIDS (PD(O)NPS-ENZYME HYBRIDS) 384
13.3 SYNTHESIS OF AU NANOBIOHYBRIDS 387
13.4 SYNTHESIS OF AG NANOBIOHYBRIDS 391
13.5 SYNTHESIS OF CU NANOBIOHYBRIDS 392
13.6 SYNTHESIS OF PT NANOBIOHYBRIDS 394
13.7 CHEMICAL APPLICATIONS OF NANOBIOHYBRIDS 395
13.7.1 SYNERGISTIC EFFECT 396
13.7.2 DUAL ACTIVITY IN CASCADE PROCESSES 396
13.8 CONCLUSIONS 399
ACKNOWLEDGMENTS 400
REFERENCES 400
INDEX 405
|
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV045238809 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T08:12:27Z |
| institution | BVB |
| institution_GND | (DE-588)16179388-5 |
| isbn | 9783527341788 3527341781 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-030627040 |
| oclc_num | 1037983535 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-83 DE-11 |
| owner_facet | DE-19 DE-BY-UBM DE-83 DE-11 |
| physical | xiv, 413 Seiten Illustrationen, Diagramme |
| publishDate | 2018 |
| publishDateSearch | 2018 |
| publishDateSort | 2018 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Artificial metalloenzymes and metalloDNAzymes in catalysis from design to applications edited by Montserrat Diéguez, Jan-E. Bäckvall, Oscar Pàmies Weinheim Wiley-VCH [2018] © 2018 xiv, 413 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Enzymkatalyse (DE-588)4152480-9 gnd rswk-swf Metallkomplexe (DE-588)4038898-0 gnd rswk-swf Bioanorganische Chemie Biochemie Biochemistry Bioinorganic Chemistry Biowissenschaften Catalysis Catalysis & Chemical Reaction Engineering Chemical Engineering Chemie Chemische Verfahrenstechnik Chemistry Katalyse Katalyse u. Chemische Reaktionstechnik Life Sciences (DE-588)4143413-4 Aufsatzsammlung gnd-content Metallkomplexe (DE-588)4038898-0 s Enzymkatalyse (DE-588)4152480-9 s DE-604 Diéguez, Montserrat (DE-588)1158533683 edt Bäckvall, Jan-E. 1947- (DE-588)129357588 edt Pàmies, Oscar (DE-588)1158534019 edt Wiley-VCH (DE-588)16179388-5 pbl Erscheint auch als Online-Ausgabe, PDF 978-3-527-80407-8 Erscheint auch als Online-Ausgabe, EPUB 978-3-527-80409-2 Erscheint auch als Online-Ausgabe, MOBI 978-3-527-80406-1 Erscheint auch als Online-Ausgabe, OBOOK 978-3-527-80408-5 B:DE-101 application/pdf http://d-nb.info/1155189426/04 Inhaltsverzeichnis X:MVB http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34178-8/ DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030627040&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Artificial metalloenzymes and metalloDNAzymes in catalysis from design to applications Enzymkatalyse (DE-588)4152480-9 gnd Metallkomplexe (DE-588)4038898-0 gnd |
| subject_GND | (DE-588)4152480-9 (DE-588)4038898-0 (DE-588)4143413-4 |
| title | Artificial metalloenzymes and metalloDNAzymes in catalysis from design to applications |
| title_auth | Artificial metalloenzymes and metalloDNAzymes in catalysis from design to applications |
| title_exact_search | Artificial metalloenzymes and metalloDNAzymes in catalysis from design to applications |
| title_full | Artificial metalloenzymes and metalloDNAzymes in catalysis from design to applications edited by Montserrat Diéguez, Jan-E. Bäckvall, Oscar Pàmies |
| title_fullStr | Artificial metalloenzymes and metalloDNAzymes in catalysis from design to applications edited by Montserrat Diéguez, Jan-E. Bäckvall, Oscar Pàmies |
| title_full_unstemmed | Artificial metalloenzymes and metalloDNAzymes in catalysis from design to applications edited by Montserrat Diéguez, Jan-E. Bäckvall, Oscar Pàmies |
| title_short | Artificial metalloenzymes and metalloDNAzymes in catalysis |
| title_sort | artificial metalloenzymes and metallodnazymes in catalysis from design to applications |
| title_sub | from design to applications |
| topic | Enzymkatalyse (DE-588)4152480-9 gnd Metallkomplexe (DE-588)4038898-0 gnd |
| topic_facet | Enzymkatalyse Metallkomplexe Aufsatzsammlung |
| url | http://d-nb.info/1155189426/04 http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34178-8/ http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030627040&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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