Genistein-induced stress signaling selectively derepresses major satellite repeat transcription in mouse heterochromatin:
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| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Freiburg im Breisgau
2018
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | 95 Blätter Illustrationen, Diagramme 30 cm |
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| 245 | 1 | 0 | |a Genistein-induced stress signaling selectively derepresses major satellite repeat transcription in mouse heterochromatin |c vorgelegt von Thomas Fuhrmann |
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Datensatz im Suchindex
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|---|---|
| adam_text | GENISTEIN-INDUCED STRESS SIGNALING SELECTIVELY DEREPRESSES MAJOR
SATELLITE
REPEAT TRANSCRIPTION IN MOUSE HETEROCHROMATIN
1. ABSTRACT 4
2. INTRODUCTION 7
2.1 MOLECULAR DEFINITION OF MOUSE HETEROCHROMATIN 7
2.2 SIGNALING PATHWAYS TO HETEROCHROMATIN 10
2.3 MAJOR STRESS SIGNALING PATHWAYS AND STRESS RESPONSE TRANSCRIPTION
FACTORS 12
2.4 CELL CYCLE AND REPLICATIVE STRESS 16
3. RESULTS 20
3.1 A NEW SU(VAR) SCREEN IN DROSOPHILA IDENTIFIES COMPONENTS OF
HORMONE SIGNALING 20
3.2 THE PHYTOHORMONE GENISTEIN MASSIVELY DEREPRESSES MSR SILENCING 21
3.3 SELECTIVE DEREPRESSION OF MSR REPEATS BY GENISTEIN 23
3.4 STRESS SIGNALING AND CELL CYCLE RESPONSE OF MSR DEREGULATION 28
3.5 TOPOISOMERASE INHIBITION PHENOCOPIES THE MASSIVE DEREPRESSION
OFMSRS 32
3.6 ANALYSIS OF STRESS RESPONSE TRANSCRIPTION FACTORS AND JNK-SIGNALING
IN GENISTEIN-MEDIATED MSR DESILENCING 37
3.7 THE CDKL INHIBITOR RO-3306 ATTENUATES MSR DESILENCING UPON
GENISTEIN EXPOSURE 42
3.8 ANALYSIS OF EXOSOME COMPONENTS FOR MSR REPEAT STABILITY 43
3.9 HISTONE MODIFICATIONS AT MSR REPEATS APPEAR LARGELY UNALTERED
AFTER GENISTEIN TREATMENT 46
3.10 THE RNA POLYMERASE II INHIBITORS DRB AND TRIPTOLIDE, AND THE
BET-INHIBITOR JQ1 ATTENUATE MSR DEREPRESSION 49
3.11 ANALYSIS OF CHANGES IN CHROMATIN ACCESSIBILITY AFTER GENISTEIN
TREATM ENT 54
3.12 48 HOUR GENISTEIN TREATMENT REDUCES H3K9ME3 FOCI IN
SUV39HL-EGFP RESCUED IMEFS 5 7
3.13 GENISTEIN TREATMENT DEREPRESSES (GAATG)N SATELLITES IN HUMAN
MCD34+ CELLS 39
3,14- GENISTEIN INDUCES A SU(VAR) PHENOTYPE IN DROSOPHILA WM4H 60
4- HISCUSSIOIR 62-
4RL. GENISTEIN IS:A:STRONGNNDUCEROF MSR DESILENCING: 62-
4
T
2. DNA-DAMAGEDNDUCES:DESIIENCING:OF MSR REPEATS 63
4R3: GENISTEINSTRESS REQUIRES ACTIVE PROGRESSION THROUGH THEGA/M
CHECKPOINTING) EARLY STAGESOF MITOSIS. 65
4.4- GENISTEINUPREGULATESM SESWITHOUTMAJORCHANGESINCHROMATIN
STATE OR RNA POLYMERASEDI OCCUPANCY 6B
4 5 MODEL FOR THEGENISTEIN-MEDIATEDINDUCTRONOF MSR-REPEATS: 71-
55 MAETERIAII SARADCMATHLODIIS 733
5511 CELL CULTUREOF IMEFS ANDCDRUGTREATMENTS: 73:
5.2 P53, JNKL/2 AND JUN/FOS MUTANT CELL LINES 74
5.3 DETECTION OF MSR REPEAT TRANSCRIPTS BY RT-QPCR 74
5.4 FACS SORTING OF CELLS AND ANALYSIS OF THE APOPTOTIC INDEX 75
5.5 HISEQ RNA-SEQUENCING 76
5.6 INGENUITY PATHWAY ANALYSIS (IPA) 77
5.7 CELL CULTURE OF C
2
C
12
MYOBLASTS AND C
2
C
12
MYOTUBES 77
5.8 IMMUNOFLUORESCENCE 77
5.9 SIRNA KNOCKDOWNS 78
5.10 CELL LYSIS AND WESTERN BLOTTING 79
5.11 CHROMATIN IMMUNOPRECIPITATION 79
5.12 SOUTHERN- AND NORTHERN BLOTTING 80
6. TABLES 82
6.1 LIST OF COMPOUNDS 82
6.2 LIST OF OLIGONUCLEOTIDES 82
6.3 LIST OF ANTIBODIES 84
7. REFERENCES 85
8. ABBREVIATIONS 94
9. ACKNOWLEDGEMENTS 95
|
| any_adam_object | 1 |
| author | Fuhrmann, Thomas |
| author_GND | (DE-588)1161765808 |
| author_facet | Fuhrmann, Thomas |
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| author_sort | Fuhrmann, Thomas |
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| building | Verbundindex |
| bvnumber | BV045229901 |
| ctrlnum | (OCoLC)1136407320 (DE-599)BSZ506870448 |
| discipline | Biologie |
| format | Thesis Book |
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| indexdate | 2024-07-10T08:12:12Z |
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| language | English |
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| physical | 95 Blätter Illustrationen, Diagramme 30 cm |
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| spelling | Fuhrmann, Thomas Verfasser (DE-588)1161765808 aut Genistein-induced stress signaling selectively derepresses major satellite repeat transcription in mouse heterochromatin vorgelegt von Thomas Fuhrmann Freiburg im Breisgau 2018 95 Blätter Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Albert-Ludwigs-Universität Freiburg im Breisgau 2018 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1163849626/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030618303&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Fuhrmann, Thomas Genistein-induced stress signaling selectively derepresses major satellite repeat transcription in mouse heterochromatin |
| subject_GND | (DE-588)4113937-9 |
| title | Genistein-induced stress signaling selectively derepresses major satellite repeat transcription in mouse heterochromatin |
| title_auth | Genistein-induced stress signaling selectively derepresses major satellite repeat transcription in mouse heterochromatin |
| title_exact_search | Genistein-induced stress signaling selectively derepresses major satellite repeat transcription in mouse heterochromatin |
| title_full | Genistein-induced stress signaling selectively derepresses major satellite repeat transcription in mouse heterochromatin vorgelegt von Thomas Fuhrmann |
| title_fullStr | Genistein-induced stress signaling selectively derepresses major satellite repeat transcription in mouse heterochromatin vorgelegt von Thomas Fuhrmann |
| title_full_unstemmed | Genistein-induced stress signaling selectively derepresses major satellite repeat transcription in mouse heterochromatin vorgelegt von Thomas Fuhrmann |
| title_short | Genistein-induced stress signaling selectively derepresses major satellite repeat transcription in mouse heterochromatin |
| title_sort | genistein induced stress signaling selectively derepresses major satellite repeat transcription in mouse heterochromatin |
| topic_facet | Hochschulschrift |
| url | http://d-nb.info/1163849626/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030618303&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT fuhrmannthomas genisteininducedstresssignalingselectivelyderepressesmajorsatelliterepeattranscriptioninmouseheterochromatin |
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