Design of biomedical devices and systems:
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Boca Raton
CRC Press
[2019]
|
| Ausgabe: | 4th edition |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | "A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc.". - Includes bibliographical references and index |
| Beschreibung: | xxxiv, 508 Seiten Diagramme |
| ISBN: | 9781138723061 |
Internformat
MARC
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| 245 | 1 | 0 | |a Design of biomedical devices and systems |c Paul H. King, Richard C. Fries, Arthur T. Johnson |
| 250 | |a 4th edition | ||
| 264 | 1 | |a Boca Raton |b CRC Press |c [2019] | |
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Datensatz im Suchindex
| _version_ | 1804178947683909632 |
|---|---|
| adam_text | TABLE OF CONTENTS
TABLE OF CONTENTS 0
LIST OF FIGURES 5
LIST OF ABBREVIATIONS 8
1. INTRODUCTION 10
1.1 PULMONARY HYPERTENSION 10
1.1.1 PATHOGENESIS
OF PAH 12
1.2 CARDIAC REMODELING 14
1.2.1
CARDIAC HYPERTROPHY 14
1.2.2 CARDIAC FIBROBLASTS AND MYOCARDIAL FIBROSIS 17
1.3 MECHANICAL
STRESS AND SIGNALING
IN HYPERTROPHIC RESPONSE 19
1.3.1
INTEGRINS 19
1.3.2 RENIN-ANGIOTENSIN SYSTEM 20
1.3.3 ENDOTHELIN-1 20
1.3.4 CALCINEURIN
AND NFAT SIGNALING 21
1.4 GENE
EXPRESSION CHANGES IN CARDIAC HYPERTROPHY 21
1.5 CURRENT
STRATEGIES IN TREATMENT OF PAH AND RIGHT HEART FAILURE 24
1.6 WNT SIGNALING PATHWAY 25
1.6.1
WNT CANONICAL SIGNALING 26
1.6.2 WNT NON-CANONICAL PATHWAYS 29
1.7 WNT
SIGNALING IN CARDIAC HYPERTROPHY 29
1.7.1
THE ROLE OF GSK3P 30
1.7.2 THE ROLE
OF F3-CATENIN 31
2. AIMS
OF THE STUDY 32
3. MATERIALS
AND METHODS 33
3.1 MATERIALS 33
3.1.1 EQUIPMENT 33
3.1.2 PLASTICWARE AND OTHER MATERIALS 34
3.1.3 ANIMAL EXPERIMENTS
EQUIPMENT AND REAGENTS 35
3.1.4 KITS 35
HTTP://D-NB.INFO/1044697717
TABLE OF CONTENTS
3.1.5 CHEMICALS 36
3.1.6 OLIGONUCLEOTIDES
38
3.1.7 ANTIBODIES
AND CELLULAR DYES
38
3.2 METHODS 39
3.2.1
ANIMAL EXPERIMENTS 39
3.2.2 CARDIAC
FIBROBLAST ISOLATION 40
3.2.3 CELL CULTURE 41
3.2.4 SIRNA-MEDIATED IS-CATENIN KNOCKDOWN 41
3.2.5 RNA ISOLATION AND CDNA SYNTHESIS 42
3.2.6 QUANTITATIVE REAL TIME-PCR (QRT-PCR) 43
3.2.7 AGAROSE GEL ELECTROPHORESIS
OF PCR
PRODUCTS 44
3.2.8 PROTEIN ISOLATION 44
3.2.9 PROTEIN FRACTIONATION 45
3.2.10 WESTERN BLOTTING 46
3.2.11
SIRCOL COLLAGEN ASSAY 48
3.2.12 BRDU INCORPORATION ASSAY 48
3.2.13 IMMUNOFLUORESCENCE
STAINING 49
3.2.13 STATISTICAL ANALYSIS 50
4. RESULTS 51
4.1
CARDIAC HYPERTROPHY AND FIBROSIS
IN PAB AND MCT MODELS OF RIGHT VENTRICULAR REMODELING 51
4.2 WNT/P-CATENIN SIGNALING MOLECULES
EXPRESSION IN PAB AND MCT MODELS 57
4.3 ISOLATION AND
CHARACTERIZATION OF CARDIAC FIBROBLASTS 58
4.4 EFFECTS OF WNT3A STIMULATION ON PRIMARY RAT
CARDIAC FIBROBLASTS 61
4.5 SIRNA-MEDIATED P-CATENIN KNOCKDOWN 63
4.6 THE
IMPACT OF WNT/P-CATENIN SIGNALING ON COLLAGEN PRODUCTION 64
4.7 THE
IMPACT OF WNT/P-CATENIN SIGNALING ON RCFS PROLIFERATION 65
4.8 ACTIVATION OF WNT SIGNALING PATHWAY
IN VIVO 67
5. DISCUSSION 69
5.1
CARDIAC HYPERTROPHY IN PAB AND MCT MODELS OF RIGHT VENTRICULAR
REMODELING 69
5.2 WNT/P-CATENIN SIGNALING MOLECULES EXPRESSION IN PAB AND MCT MODELS
71
5.3 CARDIAC
FIBROBLASTS CHARACTERIZATION AND WNT3A STIMULATION 72
5.4
THE IMPACT OF WNT/P-CATENIN SIGNALING ON COLLAGEN PRODUCTION 74
5.5 THE
IMPACT OF WNT/P-CATENIN SIGNALING ON RCFS PROLIFERATION 75
5.6 ACTIVATION OF WNT
SIGNALING PATHWAY IN VIVO 77
5.7 CONCLUSIONS 77
6. SUMMARY 79
7. ZUSAMMENFASSUNG 83
8. APPENDIX 85
9. REFERENCES 88
10. DECLARATION 94
11. ACKNOWLEDGMENTS 95
|
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| author | King, Paul H. 1941- Fries, Richard C. Johnson, Arthur T. |
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| dewey-full | 610.28 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
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| dewey-sort | 3610.28 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 4th edition |
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| id | DE-604.BV045225178 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:12:04Z |
| institution | BVB |
| isbn | 9781138723061 |
| language | English |
| lccn | 018025828 |
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| owner_facet | DE-92 DE-898 DE-BY-UBR |
| physical | xxxiv, 508 Seiten Diagramme |
| publishDate | 2019 |
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| publisher | CRC Press |
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| spelling | King, Paul H. 1941- Verfasser (DE-588)1017707111 aut Design of biomedical devices and systems Paul H. King, Richard C. Fries, Arthur T. Johnson 4th edition Boca Raton CRC Press [2019] xxxiv, 508 Seiten Diagramme txt rdacontent n rdamedia nc rdacarrier "A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc.". - Includes bibliographical references and index Biomedical engineering Biomaterial (DE-588)4267769-5 gnd rswk-swf Produktentwicklung (DE-588)4139402-1 gnd rswk-swf Biomedizinische Technik (DE-588)4006882-1 gnd rswk-swf Produktgestaltung (DE-588)4047340-5 gnd rswk-swf Medizinisches Gerät (DE-588)4038281-3 gnd rswk-swf Medizinisches Gerät (DE-588)4038281-3 s Biomaterial (DE-588)4267769-5 s Biomedizinische Technik (DE-588)4006882-1 s Produktgestaltung (DE-588)4047340-5 s Produktentwicklung (DE-588)4139402-1 s b DE-604 Fries, Richard C. Verfasser aut Johnson, Arthur T. Verfasser (DE-588)17119702X aut DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030613701&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | King, Paul H. 1941- Fries, Richard C. Johnson, Arthur T. Design of biomedical devices and systems Biomedical engineering Biomaterial (DE-588)4267769-5 gnd Produktentwicklung (DE-588)4139402-1 gnd Biomedizinische Technik (DE-588)4006882-1 gnd Produktgestaltung (DE-588)4047340-5 gnd Medizinisches Gerät (DE-588)4038281-3 gnd |
| subject_GND | (DE-588)4267769-5 (DE-588)4139402-1 (DE-588)4006882-1 (DE-588)4047340-5 (DE-588)4038281-3 |
| title | Design of biomedical devices and systems |
| title_auth | Design of biomedical devices and systems |
| title_exact_search | Design of biomedical devices and systems |
| title_full | Design of biomedical devices and systems Paul H. King, Richard C. Fries, Arthur T. Johnson |
| title_fullStr | Design of biomedical devices and systems Paul H. King, Richard C. Fries, Arthur T. Johnson |
| title_full_unstemmed | Design of biomedical devices and systems Paul H. King, Richard C. Fries, Arthur T. Johnson |
| title_short | Design of biomedical devices and systems |
| title_sort | design of biomedical devices and systems |
| topic | Biomedical engineering Biomaterial (DE-588)4267769-5 gnd Produktentwicklung (DE-588)4139402-1 gnd Biomedizinische Technik (DE-588)4006882-1 gnd Produktgestaltung (DE-588)4047340-5 gnd Medizinisches Gerät (DE-588)4038281-3 gnd |
| topic_facet | Biomedical engineering Biomaterial Produktentwicklung Biomedizinische Technik Produktgestaltung Medizinisches Gerät |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030613701&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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