Verfügbarkeit: Harrison's principles of internal medicine

Harrison's principles of internal medicine: Volume 1 Chapters 1-230

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Bibliographische Detailangaben
Hauptverfasser:	Jameson, J. Larry 1952- (VerfasserIn, HerausgeberIn), Longo, Dan L. 1949- (VerfasserIn, HerausgeberIn)
Weitere Verfasser:	Kasper, Dennis L. 1943- (HerausgeberIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	New York ; Chicago ; San Francisco McGraw Hill Education [2018]
Schlagworte:	Einführung
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	xli, 1647, 214 Seiten Illustrationen
ISBN:	9781259643996 1259643999

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245	1	0	\|a Harrison's principles of internal medicine \|n Volume 1 \|p Chapters 1-230 \|c editors: J. Larry Jameson, MD, PhD (Robert G. Dunlop Professor of Medicine; Dean, Raymond and Ruth Perelman School of Medicine; Executive Vice President, University of Pennsylvania for the Health System, Philadelphia, Pennsylvania), Dennis L. Kasper, MD, Dan L. Longo, MD, Anthony S. Fauci, MD, Stephan L. Hauser, MD, Joseph Loscalzo, MD, PhD
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Datensatz im Suchindex

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adam_text	Contributors Preface..... The Profession of Medicine 1 The Practice of Medicine................. The Editors 2 Promoting Good Health.................... Donald M. Lloyd-Jones, Kathleen M. McKibbin 3 Decision-Making in Clinical Medicine..... Daniel B. Mark, John B. Wong 4 Screening and Prevention of Disease...... Katrina A. Armstrong, Gary }. Martin 5 Health Care Systems in Developed Countries. Richard B. Saltman 6 The Safety and Quali ty of Health Care... David W Bates 7 Racial and Ethnic Disparities in Health Care. Joseph R. Betancourt, Alexander R. Green 8 Ethical Issues in Clinical Medicine...... Bernard Lo, Christine Grady 9 Palliative and End-of-Life Care.......... EzekielJ. Emanuel Cardinal Manifestations and Presentation of Diseases 10 Pain: Pathophysiology and Management..... James P. Rathmell, Howard L. Fields 11 Chest Discomfort......................... David A. Morrow 12 Abdominal Pain.............................. Danny O. Jacobs 13 Headache................................. Peter J. Goadsby 14 Back and Neck Pain....................... John W. Engstrom Alterations in Body Temperature 15 Fever.................................... Charles A. Dinarello, Reuven Porat 16 Fever and Rash........................... Elaine T. Kaye, Kenneth M. Kaye 17 Fever of Unknown Origin.................. Chantal P. Bleeker-Rovers, Jos W. M. van der Meer * 18 19 20 Nervous System Dysfunction 18 Syncope.......................... Roy Freeman 19 Dizziness and Vertigo............ Mark F. Walker, Robert B. Darojf 20 Fatigue.......................... Jeffrey M. Gelfand, Vanja C. Douglas xix ..xl ..1 ..8 13 22 ,27 .33 .37 .44 .47 65 73 .81 .85 .89 102 105 114 21 Neurologic Causes of Weakness and Paralysis.........135 MichaelJ. Aminoff 22 Numbness, Tingling, and Sensory Loss................139 Michael J. Aminoff 23 Gait Disorders, Imbalance, and Falls...............143 Jessica M. Baker, Lewis R. Sudarsky 24 Confusion and Delirium.............................147 S. Andrew Josephson, Bruce L. Miller 25 Dementia...........................................152 William W. Seeley, Bruce L. Miller 26 Aphasia, Memory Loss, Hemispatial Neglect, Frontal Syndromes, and Other Cerebral Disorders.....157 M.-Marsel Mesulam 27 Sleep Disorders...................................166 Thomas E. Scammell, Clifford B. Saper, Charles A. Czeisler slUi and Throat Disorders of Eyes, Ears, Nose, 28 Disorders of the Eye................................177 Jonathan C. Horton 29 Disorders of Smell andTaste.........................194 Richard L. Doty, Steven M. Bromley 30 Disorders of Hearing................................200 Anil K Lalwani 31 Sore Throat, Earache, and Upper Respiratory Symptoms.............................................208 Michael A. Rubin, Larry C. Ford, Ralph Gonzales 32 Oral Manifestations of Disease.....................219 Samuel C. Durso Alterations in Circulatory and Respiratory Functions 33 Dyspnea...........................................226 Rebecca M. Baron 34 Cough.............................................230 Christopher H. Fanta 35 Hemoptysis........................................232 Anna K. Brady, Patricia A. Kritek 36 Hypoxia and Cyanosis..............................234 Joseph Loscalzo 37 Edema.............................................237 Eugene Braunwald, Joseph Loscalzo 38 Approach to the Patient with a Heart Murmur.......240 Patrick T. O’Gara, Joseph Loscalzo 39 Palpitations......................................249 Joseph Loscalzo Alterations in Gastrointestinal Function 40 Dysphagia.............................. .......249 122 Ikuo Hiram, Peter J. Kahrilas 41 Nausea, Vomiting, and Indigestion.......................... .......253 129 William L. Hasler 132 42 Diarrhea and Constipation.......... ........259 Michael Camilleri, Joseph A. Murray 43 Unintentional Weight Loss...........................270 J. Larry Jameson 44 Gastrointestinal Bleeding...........................272 Loren Lairte 45 Jaundice............................................276 Savio John, Daniel S. Pratt 46 Abdominal Swelling and Ascites......................281 Kathleen E. Corey, Lawrence S. Friedman A . V , Alterations in Renal and Urinary- Tract Function 47 Dysuria, Bladder Pain, and the Interstitial Cystitis/ Bladder Pain Syndrome......................285 John W. Warren 48 Azotemia and Urinary Abnormalities..................288 David B. Mount 49 Fluid and Electrolyte Disturbances..................295 David B. Mount 50 Hypercalcemia and Hypocalcemia......................312 Sundeep Khosla 51 Acidosis and Alkalosis..............................315 Thomas D. DuBose, Jr. Alterations in the Skin 52 Approach to the Patient with a Skin Disorder.......324 Kim B. Yancey, Thomas J. Lawley 53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders......................329 Leslie P. Lawley, Calvin O. McCall, Thomas J. Lawley 54 Skin Manifestations of Internal Disease.............339 Jean L. Bolognia, Irwin M. Braverman 55 Immunologically Mediated Skin Diseases..............355 Kim B. Yancey, Thomas J. Lawley 56 Cutaneous Drug Reactions............................362 Robert G. Micheletti, Misha Rosenbach, Bruce U. Wintroub, Kanade Shinkai 57 Photosensitivity and Other Reactions to Light......372 Alexander G. Marneros, David R. Bickers i ■ Hematologic Alterations 58 Interpreting Peripheral Blood Smears...........379 Dan L. Longo 59 Anemia and Polycythemia........................385 John W. Adamson, Dan L. Longo 60 Disorders of Granulocytes and Monocytes........394 Steven M. Holland, John I. Gallin 61 Bleeding and Thrombosis........................404 Barbara A. Konkle 62 Enlargement of Lymph Nodes and Spleen...........411 Dan L. Longo i Pharmacology 63 Principles of Clinical Pharmacology............419 Dan M. Roden 64 Pharmacogenomics...............................429 Dan M. Roden Oncology and Hematology Neoplastic Disorders 65 Approach to the Patient with Cancer................435 Dan L. Longo 66 Prevention and Early Detection of Cancer...........443 Jennifer M. Croswell, Otis W. Brawley, Barnett S. Kramer 67 Cancer Genetics....................................452 Fred Bunz, Bert Vogelstein 68 Cancer Cell Biology................................461 Jeffrey W. Clark, Dan L. Longo 69 Principles of Cancer Treatment.......................480 Edward A. Sausville, Dan L. Longo 70 Infections in Patients with Cancer.................502 Robert W. Finberg 71 Oncologic Emergencies..............................511 Rasim Gucalp, Janice P. Dutcher 72 Cancer of the Skin.................................522 Brendan D. Curti, Sancy Leachman, Walter J. Urba 73 Head and Neck Cancer...............................532 Everett E. Yokes 74 Neoplasms of the Lung..............................537 Leora Horn, Christine M. Lovly 75 Breast Cancer......................................555 Daniel F. Hayes, Marc E. Lippman 76 Upper Gastrointestinal Tract Cancers...............566 Robert J. Mayer 77 Lower Gastrointestinal Cancers.....................572 Robert J. Mayer 78 Tumors of the Liver and Biliary Tree.................578 Josep M. Llovet 79 Pancreatic Cancer..................................591 Daniel D. Von Hoff 80 Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas...................................596 Robert T. Jensen 81 Renal Cell Carcinoma...............................616 Robert J. Motzer 82 Cancer of the Bladder and Urinary Tract..............619 Noah M. Hahn 83 Benign and Malignant Diseases of the Prostate......623 Howard I. Scher, James A. Eastham 84 Testicular Cancer..................................632 DavidJ. Vaughn 85 Gynecologic Malignancies...........................637 David Spriggs 86 Primary and Metastatic Tumors of the Nervous System.......................................643 LisaM. DeAngelis, Patrick Y. Wen 87 Soft Tissue and Bone Sarcomas and Bone Metastases......................................653 Shreyaskumar R. Patel 88 Carcinoma of Unknown Primary.......................657 Gauri R. Varadhachary, James L. Abbruzzese 89 Paraneoplastic Syndromes: Endocrinologic/ Hematologic..........................................662 J. Larry Jameson, Dan L. Longo 90 Paraneoplastic Neurologie Syndromes and Autoimmune Encephalitis..............................668 Josep Dalmau, Myrna R. Rosenfeld 91 Late Consequences of Cancer and Its Treatment.......674 Carl E. Fréter, Dan L. Longo 92 Hematopoietic Stem Cells.........................679 David T. Scadden, Dan L. Longo 93 Iron Deficiency and Other Hypoproliferative Anemias... 683 John W. Adamson 94 Disorders of Hemoglobin..........................690 EdwardJ. Benz, Jr. 95 Megaloblastic Anemias............................698 A. Victor HoJJbrand 96 Hemolytic Anemias................................708 Lucio Luzzatto ; V ; Infectious Diseases .. [hiF^ïïiT lîfi Basic Considerations in Infectious Diseases 115 Approach to the Patient with an Infectious Disease...859 Neeraj K Surana, Dennis L. Kasper 116 Molecular Mechanisms of Microbial Pathogenesis........866 Gerald B. Pier 117 Approach to the Acutely 111 Infected Febrile Patient.877 Tamar F. Barlam, Dennis L. Kasper 118 Immunization Principles and Vaccine Use..............884 Nancy Messonnier, Anne Schuchat, Lisa A. Jackson 119 Health Recommendations for International Travel......892 Jay S. Keystone, Phyllis E. Kozarsky 120 Climate Change and Infectious Disease................900 Aaron S. Bernstein 97 Anemia Due to Acute Blood Loss......723 -------------------- Dan L. Longo ! Mil Clinical Syndromes: 98 Bone MarrowFailure Syndromes Including Community-Acquired Infections Aplastic Anemia and Myelodysplasia..................723 Neal S. Young 99 Polycythemia Vera and Other Myeloproliferative Neoplasms...........................................733 Jerry L. Spivak 100 Acute Myeloid Leukemia.............................739 William Blum, Clara D. Bloomfield 101 Chronic Myeloid Leukemia...........................748 Hagop Kantarjian, Jorge Cortes 102 Acute Lymphoid Leukemia............................757 Dieter Hoelzer 103 Chronic Lymphocytic Leukemia.......................763 Jennifer A. Woyach, John C. Byrd 104 Non-Hodgkin’s Lymphoma.............................769 Caron A. Jacobson, Dan L. Longo 105 Hodgkin’s Lymphoma.................................780 Caron A. Jacobson, Dan L. Longo 106 Less Common Hematologic Malignancies...............783 Ayalew Tejferi, Dan L. Longo 107 Plasma Cell Disorders..............................793 Nikhil C. Munshi, Dan L. Longo, Kenneth C. Anderson 108 Amyloidosis........................................803 John L. Berk, Vaishali Sanchorawala 109 Transfusion Biology and Therapy....................809 Jeffery S. Dzieczkowski, Pierre Tiberghien, Kenneth C. Anderson 110 Hematopoietic Cell Transplantation.................816 Frederick R. Appelbaum 111 Disorders of Platelets and Vessel Wall...............822 Barbara A. Konkle 112 Coagulation Disorders.................................830 Voider R. Arruda, Katherine A. High 113 Arterial and Venous Thrombosis........................839 Jane E. Freedman, Joseph Loscalzo 114 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs.843 Jeffrey I. Weitz 121 Pneumonia..........................................908 Lionel A. Mandell, Richard Wunderink 122 Lung Abscess........................................919 Rebecca M. Baron, Miriam Baron Barshak 123 Infective Endocarditis..............................921 Adolf W. Karchmer 124 Infections of the Skin, Muscles, and SoftTissues.....933 Dennis L. Stevens 125 Infectious Arthritis................................939 Lawrence C. Madoff 126 Osteomyelitis.......................................944 Werner Zimmerli 127 Intraabdominal Infections and Abscesses.............952 Miriam Baron Barshak, Dennis L. Kasper 128 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning.............................959 Richelle C. Charles, Stephen B. Calderwood, Regina C. LaRocque 129 Clostridium difficile Infection, Including Pseudomembranous Colitis.............................964 Dale N. Gerding, Stuart Johnson 130 Urinary Tract Infections, Pyelonephritis, and Prostatitis.....................................968 Kalpana Gupta, Barbara W. Trautner 131 Sexually Transmitted Infections: Overview and Clinical Approach................................976 Jeanne M. Marrazzo, King K. Holmes 132 Encephalitis......................................991 Karen L. Roos, Kenneth L. Tyler 133 Acute Meningitis..................................998 Karen L. Roos, Kenneth L. Tyler 134 Chronic and Recurrent Meningitis.................1007 Walter J. Koroshetz, Michael R. Wilson, Avindra Nath 135 Brain Abscess and Empyema........................1013 Karen L. Roos, Kenneth L. Tyler 136 Infectious Complications of Bites..................1019 Sandeep S. Jubbal, Florencia Pereyra, Lawrence C. Madoff Clinical Syndromes: Health Care-Associated Infections 137 Infections Acquired in Health Care Facilities..1022 Robert A. Weinstein 138 Infections in Transplant Recipients............1030 Robert W. Finberg, Joyce D. Fingeroth .. • Therapy for Bacterial Diseases 139 Treatment and Prophylaxis of Bacterial Infections.1042 David C. Hooper, Erica S. Shenoy, Christy A. Varughese 140 Bacterial Resistance to Antimicrobial Agents......1057 David C. Hooper 1 s Diseases Caused by Gram-Positive Bacteria 141 Pneumococcal Infections...........................1062 David Goldblatt, Katherine L. O Brien 142 Staphylococcal Infections.........................1071 Franklin D. Lowy 143 Streptococcal Infections..........................1081 Michael R. Wessels 144 Enterococcal Infections...........................1089 Cesar A. Arias, Barbara E. Murray 145 Diphtheria and Other Corynebacterial Infections...1095 William R. Bishai, John R. Murphy 146 Listeria monocytogenes Infections.................1100 Elizabeth L. Hohmann, Daniel A. Portnoy 147 Tetanus...........................................1102 C. Louise Thwaites, Lam Minh Yen 148 Botulism..........................................1105 Agam K. Rao, Susan Maslanka 149 Gas Gangrene and Other Clostridial Infections.....1109 Amy E. Bryant, Dennis L. Stevens Diseases Caused by Gram-Negative Bacteria 150 Meningococcal Infections..........................1114 Andrew J. Pollard 151 Gonococcal Infections.............................1122 Sanjay Ram, Peter A. Rice 152 Haemophilus and Moraxella Infections...........1129 Timothy F. Murphy 153 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria.............1134 Tamar F Barlam, Dennis L. Kasper 154 Legionella Infections........................ 1137 Victor L. Yu, M. Luisa Pedro-Botet, Yusen E. Lin 155 Pertussis and Other Bordetella Infections......1142 Karina A. Top, Scott A. Halperin 156 Diseases Caused by Gram-Negative Enteric Bacilli.1146 Thomas A. Russo, James R. Johnson 157 Acinetobacter Infections.......................1158 Rossana Rosa, L. Silvia Munoz-Price 158 Helicobacter pylori Infections.................1162 John C. Atherton, Martin J. Blaser 159 Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species.....................1167 Reuben Ramphal 160 Salmonellosis.....................................1173 David A. Pegues, Samuel I. Miller 161 Shigellosis.......................................1180 Philippe J. Sansonetti,Jean Bergounioux 162 Infections Due to Campylobacter and Related Organisms..................................1184 Beth D. Kirkpatrick, Martin J. Blaser 163 Cholera and Other Vibrioses.......................1186 Matthew K. Waldor, Edward T. Ryan 164 Brucellosis.......................................1192 Nicholas J. Beeching 165 Tularemia.........................................1196 Jeannine M. Petersen, Paul S. Mead 166 Plague and Other Yersinia Infections..............1200 Michael B. Prentice 167 Bartonella Infections, Including Cat-Scratch Disease............................................1209 Michael Giladi, Moshe Ephros 168 Donovanosis.......................................1214 Nigel O’Farrell u Miscellaneous Bacterial Infections 169 Nocardiosis..................................... 1215 Gregory A. Filice 170 Actinomycosis.....................................1220 Thomas A. Russo 171 Whipple’s Disease.................................1223 Thomas A. Russo 172 Infections Due to Mixed Anaerobic Organisms......1227 Neeraj K. Surana, Dennis L. Kasper i »i • Mycobacterial Diseases 173 Tuberculosis......................................1236 Mario C. Raviglione 174 Leprosy...........................................1259 Robert H. Gelber 175 Nontuberculous Mycobacterial Infections...........1266 Steven M. Holland 176 Antimycobacterial Agents..........................1270 Divya Reddy, Max R. O’Donnell » - Spirochetal Diseases 177 Syphilis..........................................1279 Sheila A. Lukehart 178 Endemic Treponematoses............................1286 Sheila A. Lukehart 179 Leptospirosis.....................................1290 Jin F. P. Wagenaar, Marga G. A. Goris 180 Relapsing Fever...................................1295 Alan G. Barbour 181 Lyme Borreliosis................................ 1298 Allen C. Steere I dKLnüêif Vq\| Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae 182 Rickettsial Diseases............................1303 David H. Walker, J. Stephen Dumler, Lucas S. Blanton, Thomas Marrie 183 Infections Due to Mycoplasmas................1313 R. Doug Hardy 184 Chlamydial Infections........................1316 Charlotte A. Gaydos, Thomas C. Quinn Viral Diseases: General Considerations 185 Medical Virology.....................................1325 Fred Wang, Elliott Kieff 186 Antiviral Chemotherapy, Excluding Antiretroviral Drugs................................................1334 Lindsey R. Baden Infections Due to DNAViruses 187 Herpes Simplex Virus Infections............... Lawrence Corey 188 Varicella-Zoster Virus Infections............. RichardJ. Whitley 189 Epstein-Barr Virus Infections, Including Infectious Mononucleosis................................... Jeffrey I. Cohen 190 Cytomegalovirus and Human Herpesvirus Types 6,7, and 8................................ Camille Nelson Kotton, Martin S. Hirsch 191 Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections............................... Fred Wang 192 Parvovirus Infections......................... Kevin E. Brown 193 Human Papillomavirus Infections Damn R. Brown, Aaron Ermel 1345 1354 1358 1361 1366 1367 1370 Infections Due to DNA and RNA Respiratory Viruses 194 Common Viral Respiratory Infections........ James E. Crowe, Jr. 195 Influenza.................................. Peter F. Wright V; Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses 1375 1382 196 The Human Retroviruses...........................1388 Dan L. Longo, Anthony S. Fauci 197 Human Immunodeficiency Virus Disease: AIDS and Related Disorders........................1393 Anthony S. Fauci, Gregory K. Folkers, H. Clifford Lane Infections Due to RNA Viruses 198 Viral Gastroenteritis......................... Umesh D. Parashar, Roger I. Glass 199 Enterovirus, Parechovirus, and Reovirus Infections Jeffrey I. Cohen 200 Measles (Rubeola)............................ Kaitlin Rainwater-Lovett, William J. Moss 201 Rubella (German Measles)..................... Laura A. Zimmerman, Susan E. Reef 202 Mumps........................................ Steven A. Rubin 1463 1468 1474 1478 1481 203 Rabies and Other Rhabdovirus Infections..........1484 Alan C. Jackson 204 Arthropod-Borne and Rodent-Borne Virus Infections...................................1489 Jens H. Kuhn, Rémi N. Charrel 205 Ebolavirus and Marburgvirus Infections...........1509 Jens H. Kuhn illflillli - Fungal Infections 206 Diagnosis and Treatment of Fungal Infections John E. Edwards, Jr. 207 Histoplasmosis.......................... Chadi A. Hage, L. Joseph Wheat 208 Coccidioidomycosis...................... Neil M. Ampel 209 Blastomycosis........................... S. Travis King, Rathel L. Nolan, III 210 Cryptococcosis.......................... Arturo Casadevall 211 Candidiasis............................. John E. Edwards, Jr. 212 Aspergillosis........................... David W. Denning 213 Mucormycosis............................ Brad Spellberg, Ashraf S. Ibrahim 214 Superficial Mycoses and Less Common Systemic Mycoses........................... Carol A. Kauffman 215 Pneumocystis Infections................. Alison Morris, Henry Masur lilUHJ Protozoal and Helminthic Infections: General Considerations 216 Introduction to Parasitic Infections............1551 Sharon L. Reed, Charles E. Davis 217 Agents Used to Treat Parasitic Infections.......1556 Thomas A. Moore 1515 1518 1521 1524 1526 1529 1532 1537 1541 1547 ¡fjiftPProtozoal Infections 218 Amebiasis and Infection with Free-Living Amebae.....1568 Rosa M. Andrade, Sharon L. Reed 219 Malaria........................................1575 Nicholas J. White, Elizabeth A. Ashley 220 Babesiosis.....................................1590 Edouard Vannier, Peter J. Krause 221 Leishmaniasis..................................1594 Shyam Sundar 222 Chagas Disease and African Trypanosomiasis.....1601 François Chappuis, Yves Jackson 223 Toxoplasma Infections........................ 1609 Kami Kim 224 Protozoal Intestinal Infections and Trichomoniasis.1615 Peter F. Weller Helminthic Infections 225 Introduction to Helminthic Infections........1620 Peter F. Weller 226 Trichinellosis and OtherTissue Nematode Infections... 1621 Peter F. Weller 227 Intestinal Nematode Infections.........................1625 Peter F. Weller; Thomas B. Nutman 228 Filarial and Related Infections........................1629 Thomas B. Nutman, Peter F. Weller 229 Schistosomiasis and OtherTrematode Infections..........1635 Birgitte Jyding Vennervald 230 Cestode Infections.....................................1641 A. Clinton White, Jr., Peter F. Weller nr»ii ^5i ; ; Disorders of the Cardiovascular \| ¡System Introduction to Cardiovascular Disorders 231 Approach to the Patient with Possible Cardiovascular Disease.............................1649 Joseph Loscalzo 232 Basic Biology of the Cardiovascular System........1651 Joseph Loscalzo, Peter Libby, CalumA. MacRae 233 Epidemiology of Cardiovascular Disease............1662 Thomas A. Gaziano,J. Michael Gaziano 14:,. ■ r?,s Diagnosis of Cardiovascular Disorders 234 Physical Examination of the Cardiovascular System 1666 Patrick T. O’Gara, Joseph Loscalzo 235 Electrocardiography................................1675 Ary L. Goldberger 236 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/ Computed Tomography Imaging..........................1683 Marcelo F. Di Carli, RaymondY. Kwong, Scott D. Solomon 237 Diagnostic Cardiac Catheterization and Coronary Angiography.................................1709 Jane A. Leopold, David P. Faxon BB Disorders of Rhythm 238 Principles of Electrophysiology....................1716 David D. Spragg, Gordon F. Tomaselli 239 The Bradyarrhythmias: Disorders of the Sinoatrial Node......................................1722 David D. Spragg, Gordon F. Tomaselli 240 The Bradyarrhythmias: Disorders of the Atrioventricular Node................................1727 David D. Spragg, Gordon F. Tomaselli 241 Approach to Supraventricular Tachyarrhythmias......1733 Gregory F. Michaud, William G. Stevenson 242 Physiologic and Nonphysiologic Sinus Tachycardia..1735 Gregory F. Michaud, William G. Stevenson 243 Focal Atrial Tachycardia...........................1736 Gregory F. Michaud, William G. Stevenson 244 Paroxysmal Supraventricular Tachycardias...........1739 Gregory F. Michaud, William G. Stevenson 245 Common Atrial Flutter, Macroreentrant, and Multifocal Atrial Tachycardias...................1743 Gregory F. Michaud, William G. Stevenson 246 Atrial Fibrillation.....................................1746 Gregory F. Michaud, William G. Stevenson 247 Approach to Ventricular Arrhythmias.....................1750 Roy M. John, William G. Stevenson 248 Premature Ventricular Beats, Non-Sustained Ventricular Tachycardia, and Idioventricular Rhythm ... 1755 Roy M. John, William G. Stevenson 249 Sustained Ventricular Tachycardia.....................1757 Roy M. John, William G. Stevenson 250 Polymorphic Ventricular Tachycardia and Ventricular Fibrillation................................1759 Roy M. John, William G. Stevenson 251 Electrical Storm and Incessant VT.....................1762 Roy M. John, William G. Stevenson Disorders of the Heart 252 Heart Failure: Pathophysiology and Diagnosis......................................... 1763 Douglas L. Mann, Murali Chakinala 253 Heart Failure: Management.........................1769 Mandeep R. Mehra 254 Cardiomyopathy and Myocarditis....................1779 Neal K. Lakdawala, Lynne Warner Stevenson, Joseph Loscalzo 255 Cardiac Transplantation and Prolonged Assisted Circulation................................1797 Mandeep R. Mehra 256 Aortic Valve Disease..............................1802 Patrick T. O’Gara, Joseph Loscalzo 257 Aortic Regurgitation..............................1809 Patrick T. O’Gara, Joseph Loscalzo 258 Mitral Stenosis...................................1813 Patrick T. O’Gara, Joseph Loscalzo 259 Mitral Regurgitation..............................1818 Patrick T. O’Gara, Joseph Loscalzo 260 Mitral Valve Prolapse.............................1821 Patrick T. O Gara, Joseph Loscalzo 261 Tricuspid Valve Disease...........................1823 Patrick T. O’Gara, Joseph Loscalzo 262 Pulmonic Valve Disease............................1826 Patrick T. O’Gara, Joseph Loscalzo 263 Multiple and Mixed Valvular Heart Disease.........1827 Patrick T. O’Gara, Joseph Loscalzo 264 Congenital Heart Disease in the Adult.............1829 Anne Marie Valente, Michael J. Landzberg 265 Pericardial Disease...............................1841 Eugene Braunwald 266 Atrial Myxoma and Other Cardiac Tumors............1847 Eric H. Awtry SESIIilll Coronary and Peripheral Vascular Disease 267 Ischemic Heart Disease........................1850 Elliott M. Antman, Joseph Loscalzo 268 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina).1866 Robert P. Giugliano, Christopher P. Cannon, Eugene Braunwald 269 ST-Segment Elevation Myocardial Infarction.......1872 Elliott M. Antman, Joseph Loscalzo 270 Percutaneous Coronary Interventions and Other Interventional Procedures.........................1885 David P. Faxon, Deepak L. Bhatt 271 Hypertensive Vascular Disease....................1890 Theodore A. Kotchen 272 Renovascular Disease.............................1906 Stephen C. Textor 273 Deep Venous Thrombosis and Pulmonary Thromboembolism................................. 1910 Samuel Z. Goldhaber 274 Diseases of the Aorta............................1917 Mark A. Creager, Joseph Loscalzo ITS Arterial Diseases of the Extremities...............1923 Mark A. Creager, Joseph Loscalzo 276 Chronic Venous Disease and Lymphedema............1930 Mark A. Creager, Joseph Loscalzo 277 Pulmonary Hypertension...........................1935 Aaron B. Waxman, Joseph Loscalzo Disorders of the Respiratory System Diagnosis of Respiratory Disorders 278 Approach to the Patient with Disease of the Respiratory System...................................1943 Patricia A. Kritek, Bruce D. Levy 279 Disturbances of Respiratory Function................1945 Edward T. Naureckas, Julian Solway 280 Diagnostic Procedures in Respiratory Disease........1951 Anne L. Fuhlbrigge, Augustine M. K. Choi iHÜ Diseases of the Respiratory System 281 Asthma..............................................1957 Peter J Barnes 282 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia......................1970 Praveen Akuthota, Michael E. Wechsler 283 Occupational and Environmental Lung Disease........1976 John R. Balmes 284 Bronchiectasis.....................................1983 Rebecca M. Baron, Miriam Baron Barshak 285 Cystic Fibrosis....................................1986 Eric J. Sorscher 286 Chronic Obstructive Pulmonary Disease..............1990 Edwin K Silverman, James D. Crapo, Barry J. Make 287 Interstitial Lung Disease..........................1999 Gary M. Hunninghake, Ivan O. Rosas 288 Disorders of the Pleura............................2006 Richard W. Light 289 Disorders of the Mediastinum..................... 2009 Richard W. Light 290 Disorders of Ventilation...........................2010 John F. McConville, Julian Solway, Babak Mokhlesi 291 Sleep Apnea........................................2013 Andrew Wellman, Susan Redline 292 Lung Transplantation...............................2018 Elbert P. Trulock, III Critical Care Medicine 293 Approach to the Patient with Critical Illness......2023 John P Kress, Jesse B. Hall 294 Acute Respiratory Distress Syndrome................2030 Rebecca M. Baron, Bruce D. Levy 295 Mechanical Ventilatory Support....................2035 Bartolomé R. Gelli Shock and Cardiac Arrest 296 Approach to the Patient with Shock...............2039 Anthony F. Massaro 297 Sepsis and Septic Shock...........................2044 Christopher W. Seymour, Derek C. Angus 298 Cardiogenic Shock and Pulmonary Edema.............2052 David H. Ingbar, Holger Thiele 299 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death.......................................2059 Christine M. Albert, William G. Stevenson 300 Coma.................................................2068 S. Andrew Josephson, Allan H. Ropper, Stephen L. Hauser 301 Severe Acute Encephalopathies and Critical Care Weakness.................................2074 J. Claude Hemphill, III, Wade S. Smith, S. Andrew Josephson, Daryl R. Gress 302 Subarachnoid Hemorrhage..............................2084 J. Claude Hemphill, III, Wade S. Smith, Daryl R. Gress Disorders of the Kidney and ; j Urinary Tract 303 Cellular and Molecular Biology of the Kidney.......2089 Alfred L. George, Jr., Eric G. Neilson 304 Acute Kidney Injury................................2099 Sushrut S. Waikar, Joseph V. Bonventre 305 Chronic Kidney Disease.............................2111 Joanne M. Bargman, Karl L. Skorecki 306 Dialysis in the Treatment of Renal Failure.......2121 Kathleen D. Liu, Glenn M. Chertow 307 Transplantation in the Treatment of Renal Failure..2126 JamilAzzi, Edgar L. Milford, Mohamed H Sayegh, Anil Chandraker 308 Glomerular Diseases...............................2132 Julia B. Lewis, Eric G. Neilson 309 Polycystic Kidney Disease and Other Inherited Disorders ofTubule Growth and Development...........2150 Jing Zhou, Martin R. Poliak 310 Tubulointerstitial Diseases of the Kidney.........2157 Laurence H. Beck, Jr., David J. Salant 311 Vascular Injury to the Kidney.....................2164 Ronald S. Go, Nelson Leung 312 Nephrolithiasis...................................2168 Gary C. Curhan 313 Urinary Tract Obstruction.........................2173 Julian L. Seifter 1 Disorders of the Gastrointestinal System [ - - h Disorders of the Alimentary Tract 314 Approach to the Patient with Gastrointestinal Disease.. 2177 William L. Hasler, Chung Owyang 315 Gastrointestinal Endoscopy.........................2182 Louis Michel Wong Kee Song, Mark Topazian 316 Diseases of the Esophagus...........................2209 Peter J. Kahrilas, Ikuo Hirano 317 Peptic Ulcer Disease and Related Disorders.........2220 John Del Valle 318 Disorders of Absorption.............................2244 Henry J. Binder 319 Inflammatory Bowel Disease..........................2258 Sonia Friedman, Richard S. Blumberg 320 Irritable Bowel Syndrome............................2276 Chung Owyang 321 Diverticular Disease and Common Anorectal Disorders............................................2283 Rizwan Ahmed, Susan L. Gearhart 322 Mesenteric Vascular Insufficiency...................2291 Satinderjit Locham, Mahmoud Malas 323 Acute Intestinal Obstruction........................2294 Danny O. Jacobs 324 Acute Appendicitis and Peritonitis..................2298 Danny 0. Jacobs Nutrition 325 Nutrient Requirements and Dietary Assessment... Johanna Dwyer 326 Vitamin and Trace Mineral Deficiency and Excess Paolo M. Suter, Robert M. Russell 327 Malnutrition and Nutritional Assessment...... Gordon L. Jensen 328 Enteral and Parenteral Nutrition............. L. John HoJJer, Bruce R. Bistrian, David F. Driscoll 2303 2309 2319 2324 1 J F t Liver and Biliary Tract Disease 329 Approach to the Patient with Liver Disease.........2332 Marc G. Ghany, Jay H. Hoofnagle 330 Evaluation of Liver Function.......................2338 Daniel S. Pratt 331 The Hyperbilirubinemias.............................2342 Allan W. WolkoJJ 332 Acute Viral Hepatitis............................. 2347 Jules L. Dienstag 333 Toxic and Drug-Induced Hepatitis....................2366 William M. Lee, Jules L. Dienstag 334 Chronic Hepatitis...................................2375 Jules L. Dienstag 335 Alcoholic Liver Disease.............................2399 Mark E. Mailliard, Michael F. Sorrell 336 Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis......................................2401 Manal F. Abdelmalek, Anna Mae Diehl 337 Cirrhosis and Its Complications....................2405 Bruce R. Bacon 338 Liver Transplantation..............................2414 Raymond T. Chung, Jules L. Dienstag 339 Diseases of the Gallbladder and Bile Ducts..........2422 Norton J. Greenberger, Gustav Baumgartner • IV V1- Disorders of the Pancreas 340 Approach to the Patient with Pancreatic Disease...2433 Darwin L. Conwell, Norton J. Greenberger, Peter A. Banks 341 Acute and Chronic Pancreatitis.....................2437 Darwin L. Conwell, Peter A. Banks, Norton J. Greenberger Immune-Mediated, Inflammatory, and Rheumatologie Disorders The Immune System in Health and Disease 342 Introduction to the Immune System.................2451 Barton F. Haynes, Kelly A. Soderberg, Anthony S. Fauci 343 The Major Histocompatibility Complex...............2480 Gerald T. Nepom 344 Primary Immune Deficiency Diseases................2488 Alain Fischer 345 Urticaria, Angioedema, and Allergic Rhinitis......2498 Katherine N. Cahill, Joshua A. Boyce 346 Anaphylaxis.......................................2506 David Hong, Joshua A. Boyce 347 Mastocytosis......................................2508 Cem Akin, Joshua A. Boyce 348 Autoimmunity and Autoimmune Diseases..............2510 Betty Diamond, Peter E. Lipsky 349 Systemic Lupus Erythematosus......................2515 Bevra Hannahs Hahn 350 Antiphospholipid Syndrome.........................2526 Haralampos M. Moutsopoulos 351 Rheumatoid Arthritis..............................2527 Ankoor Shah, E. William St. Clair 352 Acute Rheumatic Fever.............................2541 Jonathan R. Carapetis 353 Systemic Sclerosis (Scleroderma) and Related Disorders...........................................2546 John Varga 354 Sjogren’s Syndrome................................2560 Haralampos M. Moutsopoulos 355 The Spondyloarthritides...........................2563 Joel D. Taurog 356 The Vasculitis Syndromes..........................2574 Carol A. Langford, Anthony S. Fauci 357 Behfet’s Syndrome.................................2589 Haralampos M. Moutsopoulos 358 Inflammatory Myopathies...........................2590 Steven A. Greenberg, Anthony A. Amato 359 Relapsing Polychondritis..........................2597 Carol A. Langford xiv I 360 Sarcoidosis....................................2600 Robert P. Baughman, Elyse E. Lower 361 IgG4-Related Disease...........................2607 John H. Stone 362 Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases........................2610 Daniel L. Kastner jESSSMI Disorders of the Joints and Adjacent Tissues 363 Approach to Articular and Musculoskeletal Disorders.............................................2614 John J. Cush 364 Osteoarthritis......................................2624 David T. Felson, Tuhina Neogi 365 Gout and Other Crystal-Associated Arthropathies....2631 H Ralph Schumacher, Lan X. Chen 366 Fibromyalgia........................................2636 Leslie J Crofford 367 Arthritis Associated with Systemic Disease, and Other Arthritides.....................................2639 Carol A. Langford Brian E Mandell 368 Periarticular Disorders of the Extremities..........2646 Carol A. Langford WMMM Endocrinology 369 Approach to the Patient with Endocrine Disorders.2649 J. Larry Jameson 370 Mechanisms of Hormone Action.....................2653 J. Larry Jameson 371 Physiology of Anterior Pituitary Hormones........2659 Shlomo Melmed, J. Larry Jameson 372 Hypopituitarism..................................2664 Shlomo Melmed, J. Larry Jameson 373 Pituitary Tumor Syndromes........................2670 Shlomo Melmed J. Larry Jameson 374 Disorders of the Neurohypophysis.................2684 Gary L. Robertson 375 Thyroid Gland Physiology and Testing.............2692 J. Larry Jameson, Susan J. Mandel Anthony P. Weetman 376 Hypothyroidism...................................2698 J. Larry Jameson, Susan J Mandel’ Anthony P. Weetman 377 Hyperthyroidism..................................2703 J. Larry Jameson, Susan J. Mandel, Anthony P. Weetman 378 Thyroid Nodular Disease and Thyroid Cancer.......2710 J. Larry Jameson, Susan J. Mandel, Anthony P Weetman 379 Disorders of the Adrenal Cortex..................2719 Wiebke Arlt 380 Pheochromocytoma.................................2739 Hartmut P. H Neumann 381 Multiple Endocrine Neoplasia.....................2746 R. V. Thakker 382 Autoimmune Polyendocrine Syndromes................2756 Peter A. Gottlieb, Aaron W. Michels Sex- and Gender-Based Medicine 383 Disorders of Sex Development...................2760 John C. AchermannJ. Larry Jameson 384 Disorders of the Testes and Male Reproductive System............................................2769 Shalender Bhasin, J. Larry Jameson 385 Disorders of the Female Reproductive System....2787 Janet E. Hall 386 Menstrual Disorders and Pelvic Pain.............2794 Janet E. Hall 387 Hirsutism.......................................2799 David A. Ehrmann 388 Menopause and Postmenopausal Hormone Therapy.... 2803 Jo Ann E. Manson, Shari S. Bassuk 389 Infertility and Contraception...................2810 Janet E. Hall 390 Sexual Dysfunction..............................2816 Kevin T. McVary 391 Womens Health...................................2823 Andrea Dunaif 392 Men’s Health....................................2828 Shalender Bhasin, Shehzad Basaria 393 Lesbian, Gay, Bisexual, and Transgender (LGBT) Health............................................2835 Baligh R. Yehia, Harvey J. Makadon ISSSFli Obesity, Diabetes Mellitus, and Metabolic Syndrome 394 Pathobiology of Obesity.........................2837 Jeffrey S. Flier, Eleftheria Maratos-Flier 395 Evaluation and Management of Obesity............2843 Robert R Kushner 396 Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology...................................2850 Alvin C. Powers, Kevin D. Niswender, Carmella Evans-Molina 397 Diabetes Mellitus: Management and Therapies.....2859 Alvin C. Powers, Kevin D. Niswender, Michael R. Rickels 398 Diabetes Mellitus: Complications................2875 Alvin C. Powers, John M. Stafford, Michael R. Rickels 399 Hypoglycemia....................................2883 Philip E.Cryer, Stephen N Davis 400 Disorders of Lipoprotein Metabolism.............2889 Daniel J. Rader, Sekar Kathiresan 401 The Metabolic Syndrome..........................2903 Robert H Eckel i: M 1-lii) it Disorders of Bone and Mineral Metabolism 402 Bone and Mineral Metabolism in Health and Disease......................................2909 E Richard Bringhurst, Marie B. Demay, Henry M. Kronenberg 403 Disorders of the Parathyroid Gland and Calcium Homeostasis......................................2921 John T. Potts, Jr., Harald W. Juppner 404 Osteoporosis....................................2942 Robert Lindsay, Felicia Cosman Endocrinology and Metabolism 405 Paget’s Disease and Other Dysplasias of Bone...........2959 Murray J. Favus, Tamara ] Vokes Disorders of Intermediary Metabolism iS/v.ViitJA. VAvi w 406 Heritable Disorders of Connective Tissue...........2967 Darwin J. Prockop, John F. Bateman 407 Hemochromatosis...................................2977 Lawrie W. Powell 408 Wilsons Disease...................................2982 George J. Brewer 409 The Porphyrias....................................2984 Robert J. Desnick, Manisha Balwani 410 Disorders of Purine and Pyrimidine Metabolism.....2997 John N. Mecchella,, Christopher M. Burns 411 Lysosomal Storage Diseases........................3003 Robert J. Hopkin, Gregory A. Grabowski 412 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism................3009 Priya S. Kishnani, Yuan-Tsong Chen 413 Inherited Disorders of Amino Acid Metabolism in Adults..............................................3015 Nicola Longo 414 Inherited Defects of Membrane Transport...........3020 Nicola Longo i WW U Neurologic Disorders IMEiSiSlHi Sy Diagnosis of Neurologic Disorders 415 Approach to the Patient with Neurologic Disease...3025 Daniel H. Lowenstein, Joseph B. Martin, Stephen L. Hauser 416 Neuroimaging in Neurologic Disorders..............3030 William P. Dillon 417 Pathobiology of Neurologic Diseases...............3039 Stephen L. Hauser; Arnold R. Kriegstein, Stanley B. Prusiner HSiB Diseases of the Central Nervous System 418 Seizures and Epilepsy...............................3050 Daniel H Lowenstein 419 Cerebrovascular Diseases............................3068 Wade S. Smithy S. Claiborne JohnstonyJ. Claude Hemphill, III 420 Ischemic Stroke.....................................3079 Wade S. Smith, S. Claiborne Johnston, J. Claude Hemphill, III 421 Intracranial Hemorrhage.............................3091 Wade S. Smith, J. Claude Hemphill, III, S. Claiborne Johnston 422 Migraine and Other Primary Headache Disorders...... 3096 Peter J. Goadsby 423 Alzheimer’s Disease.................................3108 William W. Seeley, Bruce L. Miller 424 Frontotemporal Dementia.............................3115 William W. Seeley, Bruce L. Miller 425 Vascular Dementia...................................3118 Joel Kramer, William W. Seeley, Bruce L. Miller 426 Dementia with Lewy Bodies...........................3119 William W Seeley, Caroline M. Tanner, Bruce L. Miller 427 Parkinsons Disease..................................3120 C. Warren Olanow, Christine Klein, Anthony H V. Schapira 428 Tremor, Chorea, and Other Movement Disorders........3132 C. Warren Olanow, Christine Klein, Jose A. Obeso 429 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases..................................... Robert H. Brown, Jr. 430 Prion Diseases.................................... Stanley B. Prusiner, Bruce L. Miller 431 Ataxic Disorders.................................. Roger N. Rosenberg 432 Disorders of the Autonomic Nervous System......... Christopher H. Gibbons, John W Engstrom 433 Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders..................................... M. Flint Beal, Stephen L. Hauser 434 Diseases of the Spinal Cord....................... Stephen L. Hauser 435 Concussion and Other Traumatic Brain Injuries..... Geoffrey T. Manley, Stephen L. Hauser, Michael McCrea 436 Multiple Sclerosis................................ Bruce A. C. Cree, Stephen L. Hauser 437 Neuromyelitis Optica.............................. Bruce A. C. Cree, Stephen L. Hauser XV 3141 3166 3172 3183 3188 3202 Nerve and Muscle Disorders 438 Peripheral Neuropathy.........................3204 Anthony A. Amato, Richard J. Barohn 439 Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies...................................3225 Stephen L. Hauser, Anthony A. Amato 440 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction.........................3232 Anthony A. Amato 441 Muscular Dystrophies and Other Muscle Diseases.3239 Anthony A. Amato, Robert H. Brown, Jr. PtoIwcII Chronic Fatigue Syndrome 442 Chronic Fatigue Syndrome.................3254 Gijs Bleijenberg, Jos W. M. van der Meer WMMMM Psychiatric and Addiction Disorders 443 Biology of Psychiatric Disorders..................3256 Robert 0. Messing, Eric J. Nestler, Matthew W. State 444 Psychiatric Disorders................................3262 Victor I. Reus 445 Alcohol and Alcohol Use Disorders.................3277 Marc A. Schuckit 446 Opioid-Related Disorders.............................3284 Thomas R. Kosten, Colin N. Haile 447 Cocaine and Other Commonly Used Drugs................3287 Karr an A. Phillips, Antonello Bond 448 Nicotine Addiction...................................3292 David M. Burns f^PPlj Poisoning, Drug Overdose, and , ,] Envenomation 449 Heavy Metal Poisoning.........................3297 Howard Hu 450 Poisoning and Drug Overdose...................3300 Mark B. Mycyk 451 Disorders Caused by Venomous Snakebites and Marine Animal Exposures............................ Charles Lei, Kirsten B. Hornbeak, Paul S. Auerbach, L. iVirra 452 Ectoparasite Infestations and Arthropod Injuries Richard J Pollack, Scott A. Norton liipll Disorders Associated with I ! Environmental Exposures 453 Altitude Illness.................... Buddha Basnyat, Geoffrey Tabin 454 Hypothermia and Peripheral Cold Injuries Daniel F. Danzl 455 Heat-Related Illnesses.............. Daniel F. Danzl 3313 3324 3333 3338 3343 Wmm Genes, the Environment, and Disease 456 Principles of Human Genetics.........................3347 J. Larry Jameson, Peter Kopp 457 The Practice of Genetics in Clinical Medicine........3369 Susan M. Domchek, / Larry Jameson, Susan Miesfeldt 458 Gene and Cell Based Therapy in Clinical Medicine...3375 Katherine A. High, Malcolm K. Brenner 459 The Human Microbiome.................................3379 Neeraj K Surana, Dennis L. Kasper I IjMÆi Global Medicine 460 Global Issues in Medicine................... Joseph J. Rhatigan, Paul Farmer 461 Worldwide Changes in Patterns of Infectious Disease......................................... George W. Rutherford, Jaime Sepulveda 462 Primary Care and Global Health.............. Tim Evans, Kumanan Rasanathan 3391 3401 3404 463 The Biology of Aging. ............................................3413 Rafael de Cabo, David G, Le Conteur 464 Clinical Problems Associated with the Aging Process.... 3420 Joseph G. Ouslander, Bernardo Reyes Consultative Medicine 465 Approach to Medical Consultation.....................3439 Jack Ende, Jeffrey Bern 466 Medical Disorders During Pregnancy...................3440 Robert L. Barbiéri, John T. Repke 467 Medical Evaluation of the Surgical Patient.............3446 Prashant Vaishnava, Kim A. Eagle Frontiers 468 Behavioral Economics and Health....................3453 Kevin G. Volpp, George Loewenstein, David A. Asch 469 Complementary, Alternative, and Integrative Health Approaches.............................................3462 Josephine P. Briggs 470 Telomere Disease.....................................3466 Rodrigo T. Calado, Neal S. Young 471 The Role of Epigenetics in Disease and Treatment.....3471 Brian C. Capell, Shelley L Berger 472 Mitochondrial DNA and Heritable Traits and Diseases......................................... 3476 KarlL. Skorecki, Bruce H. Cohen 473 Applications of Stem Cell Biology in Clinical Medicine......................................3488 John A. Kessler 474 Microbial Genomics and Infectious Disease............3491 Roby E Bhattacharyya, Yonatan H. Grad, Deborah T. Hung 475 The Role of Circadian Biology in Health and Disease.....................................3504 Jonathan Cedernaes, Kathryn Moynihan Ramsey, Joseph Bass 476 Network Medicine: Systems Biology in Health and Disease...................................3515 Joseph Loscalzo 477 Emerging Neurotherapeutic Technologies.............3522 Jyoti Mishra, Karunesh Ganguly Index......................................................1-1
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spelling	Harrison's principles of internal medicine Volume 1 Chapters 1-230 editors: J. Larry Jameson, MD, PhD (Robert G. Dunlop Professor of Medicine; Dean, Raymond and Ruth Perelman School of Medicine; Executive Vice President, University of Pennsylvania for the Health System, Philadelphia, Pennsylvania), Dennis L. Kasper, MD, Dan L. Longo, MD, Anthony S. Fauci, MD, Stephan L. Hauser, MD, Joseph Loscalzo, MD, PhD New York ; Chicago ; San Francisco McGraw Hill Education [2018] xli, 1647, 214 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier (DE-588)4151278-9 Einführung gnd-content Jameson, J. Larry 1952- (DE-588)141497335 edt wpr aut Kasper, Dennis L. 1943- (DE-588)107676648X edt wpr Longo, Dan L. 1949- (DE-588)141573864 edt wpr aut (DE-604)BV045221196 1 Erscheint auch als Online-Ausgabe, Volume 1 978-1-259-64400-9 Erscheint auch als Online-Ausgabe, Volume 1 1-259-64400-6 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030609814&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Jameson, J. Larry 1952- Longo, Dan L. 1949- Harrison's principles of internal medicine
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title	Harrison's principles of internal medicine
title_auth	Harrison's principles of internal medicine
title_exact_search	Harrison's principles of internal medicine
title_full	Harrison's principles of internal medicine Volume 1 Chapters 1-230 editors: J. Larry Jameson, MD, PhD (Robert G. Dunlop Professor of Medicine; Dean, Raymond and Ruth Perelman School of Medicine; Executive Vice President, University of Pennsylvania for the Health System, Philadelphia, Pennsylvania), Dennis L. Kasper, MD, Dan L. Longo, MD, Anthony S. Fauci, MD, Stephan L. Hauser, MD, Joseph Loscalzo, MD, PhD
title_fullStr	Harrison's principles of internal medicine Volume 1 Chapters 1-230 editors: J. Larry Jameson, MD, PhD (Robert G. Dunlop Professor of Medicine; Dean, Raymond and Ruth Perelman School of Medicine; Executive Vice President, University of Pennsylvania for the Health System, Philadelphia, Pennsylvania), Dennis L. Kasper, MD, Dan L. Longo, MD, Anthony S. Fauci, MD, Stephan L. Hauser, MD, Joseph Loscalzo, MD, PhD
title_full_unstemmed	Harrison's principles of internal medicine Volume 1 Chapters 1-230 editors: J. Larry Jameson, MD, PhD (Robert G. Dunlop Professor of Medicine; Dean, Raymond and Ruth Perelman School of Medicine; Executive Vice President, University of Pennsylvania for the Health System, Philadelphia, Pennsylvania), Dennis L. Kasper, MD, Dan L. Longo, MD, Anthony S. Fauci, MD, Stephan L. Hauser, MD, Joseph Loscalzo, MD, PhD
title_short	Harrison's principles of internal medicine
title_sort	harrison s principles of internal medicine chapters 1 230
topic_facet	Einführung
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