Biomedical applications of functionalized nanoparticles: chances & risks
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Ulm
[2018]
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | 87, VIII Blätter Illustrationen, Diagramme 30 cm |
Internformat
MARC
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Datensatz im Suchindex
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|---|---|
| adam_text | TABLE OF CONTENTS
TABLE OF
CONTENTS..............................................................................................................................ILL
LIST OF
ABBREVIATIONS.........................................................................................................................
V
INTRODUCTION.........................................................................................................................................1
AIM OF THE
STUDY...............................................................................................................................13
MATERIALS AND
METHODS...................................................................................................................
14
CELLS AND
REAGENTS.....................................................................................................................
14
EQUIPMENT....................................................................................................................................
15
SYNTHESIS OF POLYSTYRENE
NANOPARTICLES...................................................................................
16
SYNTHESIS AND FUNCTIONALIZATION OF IRON OXIDE (FEO) NANOPARTICLES
....................................
17
SYNTHESIS OF GOLD
NANOPARTICLES................................................................................................18
PHYSICOCHEMICAL CHARACTERIZATION OF
NANOPARTICLES...............................................................18
MEASUREMENT OF ATOMIC GOLD
CONCENTRATIONS.........................................................................18
CELLULAR UPTAKE OF ASS OLIGOMERS AND FEO-ASS
PARTICLES........................................................18
ELECTRON
MICROSCOPY...................................................................................................................
19
CELL
VIABILITY.................................................................................................................................
20
IN VITRO PROGENITOR
ASSAY............................................................................................................20
ANALYSIS OF SURFACE MARKER EXPRESSION BY FLOW
CYTOMETRY...................................................21
ASSESSMENT OF MITOCHONDRIAL NUMBER AND CELLULAR
NADH...................................................21
QUANTIFICATION OF CELLULAR ATP
LEVELS.......................................................................................
22
QUANTIFICATION OF CYTOKINE SECRETION BY ENZYME-LINKED IMMUNOSORBENT
ASSAY
...............
22
APOPTOSIS
ASSAYS.......................................................................................................................
22
ROS
MEASUREMENT.....................................................................................................................23
MITOCHONDRIAL MEMBRANE
POTENTIAL...........................................................................................23
ANALYSIS OF LYSOSOMAL
INTEGRITY.................................................................................................
23
WESTERN IMMUNOBLOT
ANALYSIS...................................................................................................23
MITOCHONDRIAL RESPIRATORY COMPLEX ACTIVITIES
.24
MITOCHONDRIAL RESPIRATION
AML XENOGRAFT
MODEL................................................................................................................
25
CLINICAL CHEMISTRY AND HISTOLOGICAL
ANALYSIS...........................................................................26
STATISTICAL
ANALYSIS......................................................................................................................
26
RESULTS.............................................................................................................................................28
EFFECTS OF AMINO- AND CARBOXY-FUNCTIONALIZED NANOPARTICLES ON MACROPHAGE
POLARIZATION
AND
FUNCTION................................................................................................................................
28
MACROPHAGE TARGETING USING AMYLOID SS OLIGOMERS
...............................................................
32
AMINO-FUNCTIONALIZED GOLD NANOPARTICLES WITH THERAPEUTIC POTENTIAL FOR
THE TREATMENT OF
ACUTE MYELOID
LEUKEMIA.............................................................................................................35
DISCUSSION.......................................................................................................................................
68
EFFECTS OF AMINO- AND CARBOXY-FUNCTIONALIZED NANOPARTICLES ON MACROPHAGE
POLARIZATION
AND
FUNCTION................................................................................................................................
68
MACROPHAGE TARGETING USING ASS
OLIGOMERS............................................................................70
AMINO-FUNCTIONALIZED GOLD NANOPARTICLES WITH THERAPEUTIC POTENTIAL FOR
THE TREATMENT OF
ACUTE MYELOID
LEUKEMIA.............................................................................................................71
CONCLUSION..................................................................................................................................
78
SUMMARY.........................................................................................................................................
80
REFERENCES......................................................................................................................................82
ACKNOWLEDGEMENTS......................................................................................................................
VIII
|
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| author | Gaiser, Ann-Kathrin 1987- |
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| author_facet | Gaiser, Ann-Kathrin 1987- |
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| discipline | Chemie / Pharmazie |
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| spelling | Gaiser, Ann-Kathrin 1987- Verfasser (DE-588)1161431918 aut Biomedical applications of functionalized nanoparticles chances & risks submitted by Ann-Kathrin Gaiser Ulm [2018] 87, VIII Blätter Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Universität Ulm 2018 Nanopartikel (DE-588)4333369-2 gnd rswk-swf Gold (DE-588)4157819-3 gnd rswk-swf Nanoparticles. Metal nanoparticles. Biomedical technology. (DE-588)4113937-9 Hochschulschrift gnd-content Nanopartikel (DE-588)4333369-2 s Gold (DE-588)4157819-3 s DE-604 Universität Ulm (DE-588)30607-1 dgg B:DE-101 application/pdf http://d-nb.info/1162098457/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030593978&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gaiser, Ann-Kathrin 1987- Biomedical applications of functionalized nanoparticles chances & risks Nanopartikel (DE-588)4333369-2 gnd Gold (DE-588)4157819-3 gnd |
| subject_GND | (DE-588)4333369-2 (DE-588)4157819-3 (DE-588)4113937-9 |
| title | Biomedical applications of functionalized nanoparticles chances & risks |
| title_auth | Biomedical applications of functionalized nanoparticles chances & risks |
| title_exact_search | Biomedical applications of functionalized nanoparticles chances & risks |
| title_full | Biomedical applications of functionalized nanoparticles chances & risks submitted by Ann-Kathrin Gaiser |
| title_fullStr | Biomedical applications of functionalized nanoparticles chances & risks submitted by Ann-Kathrin Gaiser |
| title_full_unstemmed | Biomedical applications of functionalized nanoparticles chances & risks submitted by Ann-Kathrin Gaiser |
| title_short | Biomedical applications of functionalized nanoparticles |
| title_sort | biomedical applications of functionalized nanoparticles chances risks |
| title_sub | chances & risks |
| topic | Nanopartikel (DE-588)4333369-2 gnd Gold (DE-588)4157819-3 gnd |
| topic_facet | Nanopartikel Gold Hochschulschrift |
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