Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects
The paraoxonase or PON family of genes resides on human chromosome 7q2t-22 in the order PONt, PON3 and PON2. PONt was one of the early genes identified as an environmentally relevant gene, in that it is important in determining an individual's sensitivity or resistance to exposure from specific...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
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Boston, MA
Springer US
2002
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| Online-Zugang: | BTU01 Volltext |
| Zusammenfassung: | The paraoxonase or PON family of genes resides on human chromosome 7q2t-22 in the order PONt, PON3 and PON2. PONt was one of the early genes identified as an environmentally relevant gene, in that it is important in determining an individual's sensitivity or resistance to exposure from specific organophosphorus (OP) insecticides. Paraoxonase (PONt) is an A esterase (i. e. , not inhibited by OP compounds) initially identified for its ability to catalytically hydrolyze paraoxon, the toxic metabolite (oxon form) of the insecticide parathion. Evidence accumulated in the past several years has established that this enzyme, which is present at variable levels in liver and serum of different individuals, is an important determinant of sensitivity to toxicity of specific organophosphorus compounds including chlorpyrifos oxon and diazoxon. Recent experiments have pointed out that it is the catalytic efficiency of PONt together with the levels of PONt that are important in determining the degree of resistance. Surprisingly, even though PONt has a higher catalytic efficiency than PONtQ)92 for paraoxon RJ92 hydrolysis, it does not provide significant in vivo protection against an exposure to paraoxon. Interest in this enzyme has also emerged from the finding that it displays genetic polymorphisms in most populations, with a significant number of the individuals in a given population canying a PONt gene that puts them at risk for a specific OP exposure |
| Beschreibung: | 1 Online-Ressource (XVII, 216 p) |
| ISBN: | 9781461510277 |
| DOI: | 10.1007/978-1-4615-1027-7 |
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| 245 | 1 | 0 | |a Paraoxonase (PON1) in Health and Disease |b Basic and Clinical Aspects |c edited by Lucio G. Costa, Clement E. Furlong |
| 264 | 1 | |a Boston, MA |b Springer US |c 2002 | |
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| 520 | |a The paraoxonase or PON family of genes resides on human chromosome 7q2t-22 in the order PONt, PON3 and PON2. PONt was one of the early genes identified as an environmentally relevant gene, in that it is important in determining an individual's sensitivity or resistance to exposure from specific organophosphorus (OP) insecticides. Paraoxonase (PONt) is an A esterase (i. e. , not inhibited by OP compounds) initially identified for its ability to catalytically hydrolyze paraoxon, the toxic metabolite (oxon form) of the insecticide parathion. Evidence accumulated in the past several years has established that this enzyme, which is present at variable levels in liver and serum of different individuals, is an important determinant of sensitivity to toxicity of specific organophosphorus compounds including chlorpyrifos oxon and diazoxon. Recent experiments have pointed out that it is the catalytic efficiency of PONt together with the levels of PONt that are important in determining the degree of resistance. Surprisingly, even though PONt has a higher catalytic efficiency than PONtQ)92 for paraoxon RJ92 hydrolysis, it does not provide significant in vivo protection against an exposure to paraoxon. Interest in this enzyme has also emerged from the finding that it displays genetic polymorphisms in most populations, with a significant number of the individuals in a given population canying a PONt gene that puts them at risk for a specific OP exposure | ||
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Datensatz im Suchindex
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| dewey-tens | 570 - Biology |
| discipline | Biologie |
| doi_str_mv | 10.1007/978-1-4615-1027-7 |
| format | Electronic eBook |
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| id | DE-604.BV045176713 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:10:45Z |
| institution | BVB |
| isbn | 9781461510277 |
| language | English |
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| spelling | Paraoxonase (PON1) in Health and Disease Basic and Clinical Aspects edited by Lucio G. Costa, Clement E. Furlong Boston, MA Springer US 2002 1 Online-Ressource (XVII, 216 p) txt rdacontent c rdamedia cr rdacarrier The paraoxonase or PON family of genes resides on human chromosome 7q2t-22 in the order PONt, PON3 and PON2. PONt was one of the early genes identified as an environmentally relevant gene, in that it is important in determining an individual's sensitivity or resistance to exposure from specific organophosphorus (OP) insecticides. Paraoxonase (PONt) is an A esterase (i. e. , not inhibited by OP compounds) initially identified for its ability to catalytically hydrolyze paraoxon, the toxic metabolite (oxon form) of the insecticide parathion. Evidence accumulated in the past several years has established that this enzyme, which is present at variable levels in liver and serum of different individuals, is an important determinant of sensitivity to toxicity of specific organophosphorus compounds including chlorpyrifos oxon and diazoxon. Recent experiments have pointed out that it is the catalytic efficiency of PONt together with the levels of PONt that are important in determining the degree of resistance. Surprisingly, even though PONt has a higher catalytic efficiency than PONtQ)92 for paraoxon RJ92 hydrolysis, it does not provide significant in vivo protection against an exposure to paraoxon. Interest in this enzyme has also emerged from the finding that it displays genetic polymorphisms in most populations, with a significant number of the individuals in a given population canying a PONt gene that puts them at risk for a specific OP exposure Environment Ecotoxicology Pharmacology/Toxicology Cardiology Public Health Pharmacology Public health Costa, Lucio G. edt Furlong, Clement E. edt Erscheint auch als Druck-Ausgabe 9781461353584 https://doi.org/10.1007/978-1-4615-1027-7 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Paraoxonase (PON1) in Health and Disease Basic and Clinical Aspects Environment Ecotoxicology Pharmacology/Toxicology Cardiology Public Health Pharmacology Public health |
| title | Paraoxonase (PON1) in Health and Disease Basic and Clinical Aspects |
| title_auth | Paraoxonase (PON1) in Health and Disease Basic and Clinical Aspects |
| title_exact_search | Paraoxonase (PON1) in Health and Disease Basic and Clinical Aspects |
| title_full | Paraoxonase (PON1) in Health and Disease Basic and Clinical Aspects edited by Lucio G. Costa, Clement E. Furlong |
| title_fullStr | Paraoxonase (PON1) in Health and Disease Basic and Clinical Aspects edited by Lucio G. Costa, Clement E. Furlong |
| title_full_unstemmed | Paraoxonase (PON1) in Health and Disease Basic and Clinical Aspects edited by Lucio G. Costa, Clement E. Furlong |
| title_short | Paraoxonase (PON1) in Health and Disease |
| title_sort | paraoxonase pon1 in health and disease basic and clinical aspects |
| title_sub | Basic and Clinical Aspects |
| topic | Environment Ecotoxicology Pharmacology/Toxicology Cardiology Public Health Pharmacology Public health |
| topic_facet | Environment Ecotoxicology Pharmacology/Toxicology Cardiology Public Health Pharmacology Public health |
| url | https://doi.org/10.1007/978-1-4615-1027-7 |
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