Contrast Agents I: Magnetic Resonance Imaging
Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
2002
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| Schriftenreihe: | Topics in Current Chemistry
221 |
| Schlagworte: | |
| Online-Zugang: | UBT01 Volltext |
| Zusammenfassung: | Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1–2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases [1] |
| Beschreibung: | 1 Online-Ressource (X, 249 p. 21 illus., 2 illus. in color) |
| ISBN: | 9783540457336 |
| DOI: | 10.1007/3-540-45733-X |
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| 520 | |a Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1–2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases [1] | ||
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| id | DE-604.BV045152012 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:10:07Z |
| institution | BVB |
| isbn | 9783540457336 |
| language | English |
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| physical | 1 Online-Ressource (X, 249 p. 21 illus., 2 illus. in color) |
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| publisher | Springer Berlin Heidelberg |
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| series2 | Topics in Current Chemistry |
| spelling | Contrast Agents I Magnetic Resonance Imaging edited by Werner Krause Berlin, Heidelberg Springer Berlin Heidelberg 2002 1 Online-Ressource (X, 249 p. 21 illus., 2 illus. in color) txt rdacontent c rdamedia cr rdacarrier Topics in Current Chemistry 221 Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1–2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases [1] Chemistry Analytical Chemistry Physical Chemistry Organic Chemistry Characterization and Evaluation of Materials Biochemistry, general Laboratory Medicine Laboratory medicine Analytical chemistry Organic chemistry Physical chemistry Biochemistry Materials science Krause, Werner edt Erscheint auch als Druck-Ausgabe 9783540422471 https://doi.org/10.1007/3-540-45733-X Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Contrast Agents I Magnetic Resonance Imaging Chemistry Analytical Chemistry Physical Chemistry Organic Chemistry Characterization and Evaluation of Materials Biochemistry, general Laboratory Medicine Laboratory medicine Analytical chemistry Organic chemistry Physical chemistry Biochemistry Materials science |
| title | Contrast Agents I Magnetic Resonance Imaging |
| title_auth | Contrast Agents I Magnetic Resonance Imaging |
| title_exact_search | Contrast Agents I Magnetic Resonance Imaging |
| title_full | Contrast Agents I Magnetic Resonance Imaging edited by Werner Krause |
| title_fullStr | Contrast Agents I Magnetic Resonance Imaging edited by Werner Krause |
| title_full_unstemmed | Contrast Agents I Magnetic Resonance Imaging edited by Werner Krause |
| title_short | Contrast Agents I |
| title_sort | contrast agents i magnetic resonance imaging |
| title_sub | Magnetic Resonance Imaging |
| topic | Chemistry Analytical Chemistry Physical Chemistry Organic Chemistry Characterization and Evaluation of Materials Biochemistry, general Laboratory Medicine Laboratory medicine Analytical chemistry Organic chemistry Physical chemistry Biochemistry Materials science |
| topic_facet | Chemistry Analytical Chemistry Physical Chemistry Organic Chemistry Characterization and Evaluation of Materials Biochemistry, general Laboratory Medicine Laboratory medicine Analytical chemistry Organic chemistry Physical chemistry Biochemistry Materials science |
| url | https://doi.org/10.1007/3-540-45733-X |
| work_keys_str_mv | AT krausewerner contrastagentsimagneticresonanceimaging |