Die Bedeutung des Retrosplenialen Cortex in der Alzheimer-Erkrankung:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Köln
2017
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| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | ii, 157 Seiten Illustrationen 21 cm |
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| 245 | 1 | 0 | |a Die Bedeutung des Retrosplenialen Cortex in der Alzheimer-Erkrankung |c vorgelegt von Kim Nguyen-Hong Dillen |
| 264 | 1 | |a Köln |c 2017 | |
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Datensatz im Suchindex
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|---|---|
| adam_text | T
ABLE
OF
C
ONTENTS
GLOSSARY..........................................................................................................................
I
CHAPTER 1:
INTRODUCTION.................................................................................................1
1.1
OVERVIEW...........................................................................................................
1
1.2 THE PATHOGENESIS AND PROGRESSION OF ALZHEIMER*S DISEASE
..............................
2
1.3 THE PATHOLOGY OF ALZHEIMER*S DISEASE AND ASSOCIATED BIOMARKERS
..................
4
1.4 FUNCTIONAL CONNECTIVITY IN THE DM
N.................................................................5
1.5 THE ROLE OF THE
RSC...........................................................................................6
1.6 RESEARCH OBJECTIVE OF THIS THESIS
.......................................................................7
CHAPTER 2: ALE META-ANALYSIS SUGGESTS INTEGRATIVE ROLE OF THE HUMAN
RETROSPLENIAL CORTEX IN SPATIAL COGNITIVE PROCESSES
.................................................
9
2.1 PUBLICATION STATUS
..............................................................................................9
2.2 PERSONAL CONTRIBUTION
........................................................................................9
2.3
ABSTRACT.............................................................................................................9
2.4
INTRODUCTION.....................................................................................................
10
2.5 METHODS AND
MATERIAL......................................................................................
11
2.5.1 SELECTION OF
STUDIES.............................................................................
11
2.5.1.1 DATABASE SEARCH
STRATEGY........................................................11
2.5.1.2 INCLUSION AND EXCLUSION CRITERIA
.............................................12
2.5.1.3 RECORDED EXPERIMENT
DETAILS..................................................13
2.5.2 ALE
ANALYSIS.......................................................................................20
2.5.2.1 INDIVIDUAL ALE
ANALYSES........................................................20
2.5.2.2 DIFFERENCE ALE ANALYSES
.......................................................21
2.5.3 ANATOMICALLY-INFORMED IN-HOUSE RSC M ASK
.....................................
21
2.5.4 CORRELATION ANALYSES USING SPEARMAN*S RANK CORRELATION
...................
22
2.6
RESULTS.............................................................................................................22
2.6.1 STUDY
DEMOGRAPHICS............................................................................22
2.6.2 ALE ANALYSES WITHOUT USE OF THE RSC M ASK
.....................................
23
2.6.2.1 INDIVIDUAL ANALYSES OF ALL CATEGORIES
.....................................
23
2.6.2.2 DIFFERENCE ANALYSES OF ALL CATEGORIES
.....................................
25
2.6.3 ALE ANALYSES USING THE RSC MASK
...................................................
26
2.6.3.1 INDIVIDUAL ANALYSES OF ALL CATEGORIES WITH RSC MASK
APPLIED................................................................................................
26
2.6.3.2 DIFFERENCE ANALYSES OF ALL CATEGORIES WITH RSC MASK
APPLIED................................................................................................
27
2.6.4 CORRELATION OF ACTIVATION CLUSTERS BY MEANS OF SPEARMAN*S P
........
27
2.6.4.1 CATEGORIES WITHOUT RSC MASK
...............................................27
2.6.4.2 CATEGORIES WITH RSC MASK
APPLIED........................................27
2.7
DISCUSSION.......................................................................................................
28
2.7.1 CONNECTIVITY WITH ADJACENT AREAS AND CO-ACTIVATION
...........................28
2.7.1.1 CORTICAL CONNECTIONS OF THE RSC WITH SURROUNDING BRAIN
REGIONS................................................................................................
28
2.7.2 ACTIVATION OF THE RSC AND ITS NETWORK REFLECTS THE MUTUAL
INTERDEPENDENCE OF SPATIAL COGNITION
...........................................................29
2.7.3 THE RSC OPERATES AS UNIFIED FUNCTIONAL SYSTEM NECESSITATING
CONNECTIVITY PATTERNS TO SUPPORT SPECIFIC FUNCTIONS
.....................................30
2.7.4 IMPORTANCE OF USING A RSC MASK
......................................................
31
2.7.5
LIMITATIONS..........................................................................................
32
2.7.6
CONCLUSION..........................................................................................
33
2.8
ACKNOWLEDGEMENTS.........................................................................................
33
CHAPTER 3: ABERRANT FUNCTIONAL CONNECTIVITY DIFFERENTIATES RETROSPLENIAL
CORTEX FROM POSTERIOR CINGULATE CORTEX IN PRODROMAL ALZHEIMER*S DISEASE
.......
35
3.1 PUBLICATION STATUS
............................................................................................
35
3.2 PERSONAL CONTRIBUTION
......................................................................................
35
3.3 A
BSTRACT...........................................................................................................
35
3.4
INTRODUCTION.....................................................................................................
36
3.5 METHODS AND
MATERIAL......................................................................................
38
3.5.1 PARTICIPANTS
.........................................................................................
38
3.5.2 EXCLUSION
CRITERIA................................................................................
38
3.5.3 INCLUSION
CRITERIA.................................................................................
38
3.5.4 STANDARD PROTOCOL, APPROVAL, AND
CONSENT...........................................40
3.5.5 NEUROPSYCHOLOGICAL TESTING
................................................................40
3.5.6 MR
IMAGING........................................................................................
42
3.5.6.1 DATA
ACQUISITION......................................................................42
3.5.6.2 DATA ANALYSIS AND PREPROCESSING
............................................42
3.5.6.3 REGISTRATION OF FUNCTIONAL D A TA
..............................................
43
3.5.6.4 REMOVAL OF ARTEFACTUAL COMPONENTS
......................................
43
3.5.6.5 DEFINITION OF SEED R O
I...........................................................44
3.5.6.6 FUNCTIONAL SEED-BASED CONNECTIVITY ANALYSIS
........................
45
3.5.7 STATISTICAL ANALYSIS OF DEMOGRAPHIC, NEUROPSYCHOLOGICAL, AND
NEUROIMAGING DATA
.......................................................................................46
3.6
RESULTS.............................................................................................................47
3.6.1 DEMOGRAPHIC
INFORMATION...................................................................47
3.6.2 NEUROPSYCHOLOGICAL TEST PERFORMANCE
................................................47
3.6.3 FC
CHANGES..........................................................................................48
3.6.3.1 RSC-SEED
CONNECTIVITY...........................................................48
3.6.3.2 PCC-SEED
CONNECTIVITY...........................................................48
3.6.4 CORRELATION OF FC WITH COGNITIVE TEST PERFORMANCE ON THE VERBAL
LEARNING MEMORY TEST AND BRIEF TEST OF
ATTENTION..........................................53
3.6.4.1 RSC-SEED
CONNECTIVITY...........................................................53
3.6.4.2 PCC-SEED
CONNECTIVITY...........................................................54
3.7
DISCUSSION.......................................................................................................55
3.7.1 FUNCTIONAL DIFFERENTIATION OF THE RSC FROM THE PCC IN AD
.............
56
3.7.1.1 HIGHER FC FROM THE RSC TO THE LATERAL OCCIPITAL CORTEX
INDICATES COMPENSATORY PROCESSES IN PRODROMAL AD RELATIVE TO HC AND
S C D
....................................................................................................56
3.7.1.2 HIGHER FC FROM THE PCC TO THE LINGUAL GYRUS INDICATES
DYSFUNCTIONAL PROCESSES IN PRODROMAL AD RELATIVE TO HC AND SCD ..57
3.7.2 UNIQUE FC PATTERNS IN AN AT-RISK
GROUP...............................................58
3.7.2.1 HIGHER FC FROM THE RSC TO FRONTAL MEDIAL REGIONS IN SCD
RELATIVE TO HC AND PRODROMAL A D
......................................................58
3.7.3 LIMITATION
.......................................................................
59
3.7.4
CONCLUSION..........................................................................................60
3.8
ACKNOWLEDGEMENTS.........................................................................................60
SUPPLEMENTAL
METHODS..........................................................................................61
CHAPTER 4: FUNCTIONAL DISINTEGRATION OF DEFAULT MODE NETWORK HUBS IN
PRODROMAL ALZHEIMER*S D
ISEASE..................................................................................77
4.1 PUBLICATION STATUS
............................................................................................
77
4.2 PERSONAL CONTRIBUTION
......................................................................................
77
4.3 A
BSTRACT...........................................................................................................
77
4.4
INTRODUCTION.....................................................................................................
78
4.5 METHODS AND
MATERIAL......................................................................................
80
4.5.1 PARTICIPANTS
.........................................................................................
80
4.5.2 NEUROPSYCHOLOGICAL ASSESSMENT
......................................................... 81
4.5.3 MR
PROCEDURE.....................................................................................
84
4.5.3.1 DATA
ACQUISITION......................................................................
84
4.5.3.2 IMAGE PREPROCESSING AND DATA ANALYSIS
..................................84
4.5.3.3 SINGLE-SUBJECT
ANALYSIS........................................................... 85
4.5.3.4 GROUP-LEVEL
ANALYSIS...............................................................
85
4.5.3.5 WITHIN-GROUP COMPARISONS OF FUNCTIONAL DYNAMICS...............87
4.5.4 STATISTICAL
ANALYSES..............................................................................
88
4.6
RESULTS.............................................................................................................
89
4.6.1 DEMOGRAPHICAL AND COGNITIVE CHARACTERISTICS
.....................................89
4.6.2 FUNCTIONAL
DYNAMICS...........................................................................
89
4.6.2.1 DMN HUBS HIERARCHY WITHIN-GROUPS
......................................89
4.6.2.2 DMN HUB COUPLING
WITHIN-GROUPS.........................................90
4.6.2.3 DMN HUB COUPLING
BETWEEN-GROUPS......................................94
4.6.2.4 CORRELATIONS WITH COGNITIVE PERFORMANCE ON THE VLMT
.......
95
4.7
DISCUSSION.......................................................................................................
96
4.7.1 NETWORK HIERARCHIES ARE DIFFERENTLY ORGANIZED IN SCD AND PRODROMAL
AD COMPARED TO H C
....................................................................................
97
4.7.2 DISRUPTED FUNCTIONAL DYNAMICS OF PREFRONTAL AND PARIETAL DMN HUBS
IN
PRODROMAL A D
..............................................................................................
98
4.7.3 THE HIPPOCAMPUS SEGREGATES WITH DISEASE
PROGRESSION......................99
4.7.4 CONCLUSION
........................................................................................
100
4.8
ACKNOWLEDGEMENTS.......................................................................................
101
CHAPTER 5:
DISCUSSION.................................................................................................
103
5.1 SUMMARY OF RESULTS
.......................................................................................
103
5.2 THE ROLE OF THE RSC IN A D
............................................................................104
5.2.1 THE COMPLEXITY AND UNIQUENESS OF THE R S C
.....................................104
5.2.2 FC PATTERNS AND DMN CHANGES AS NEW NON-INVASIVE BIOMARKER
.....
107
5.2.3 CLINICAL SIGNIFICANCE
.........................................................................
110
5.3 STRENGTHS, LIMITATIONS, AND FUTURE RESEARCH
PROSPECTS....................................112
5.3.1 METHODOLOGICAL
PERSPECTIVE..............................................................
112
5.3.2 DIAGNOSTIC
PERSPECTIVE......................................................................114
5.3.3 FUTURE
PROSPECTS................................................................................
114
5.4 CONCLUSION AND SIGNIFICANCE
.........................................................................115
SUMMARY.....................................................................................................................
117
ZUSAMMENFASSUNG......................................................................................................
119
REFERENCES....................................................................................................................
123
PRELIMINARY
PUBLICATIONS............................................................................................
149
APPENDIX......................................................................................................................
151
LIST OF
TABLES.......................................................................................................
151
LIST OF
FIGURES.....................................................................................................
152
LEBENSLAUF...................................................................................................................
153
|
| any_adam_object | 1 |
| author | Dillen, Kim Nguyen-Hong 1982- |
| author_GND | (DE-588)1151127574 |
| author_facet | Dillen, Kim Nguyen-Hong 1982- |
| author_role | aut |
| author_sort | Dillen, Kim Nguyen-Hong 1982- |
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| building | Verbundindex |
| bvnumber | BV045115077 |
| ctrlnum | (OCoLC)1136385434 (DE-599)DNB1151663875 |
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| spelling | Dillen, Kim Nguyen-Hong 1982- Verfasser (DE-588)1151127574 aut Die Bedeutung des Retrosplenialen Cortex in der Alzheimer-Erkrankung vorgelegt von Kim Nguyen-Hong Dillen Köln 2017 ii, 157 Seiten Illustrationen 21 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Universität zu Köln 2017 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1151663875/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030505317&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Dillen, Kim Nguyen-Hong 1982- Die Bedeutung des Retrosplenialen Cortex in der Alzheimer-Erkrankung |
| subject_GND | (DE-588)4113937-9 |
| title | Die Bedeutung des Retrosplenialen Cortex in der Alzheimer-Erkrankung |
| title_auth | Die Bedeutung des Retrosplenialen Cortex in der Alzheimer-Erkrankung |
| title_exact_search | Die Bedeutung des Retrosplenialen Cortex in der Alzheimer-Erkrankung |
| title_full | Die Bedeutung des Retrosplenialen Cortex in der Alzheimer-Erkrankung vorgelegt von Kim Nguyen-Hong Dillen |
| title_fullStr | Die Bedeutung des Retrosplenialen Cortex in der Alzheimer-Erkrankung vorgelegt von Kim Nguyen-Hong Dillen |
| title_full_unstemmed | Die Bedeutung des Retrosplenialen Cortex in der Alzheimer-Erkrankung vorgelegt von Kim Nguyen-Hong Dillen |
| title_short | Die Bedeutung des Retrosplenialen Cortex in der Alzheimer-Erkrankung |
| title_sort | die bedeutung des retrosplenialen cortex in der alzheimer erkrankung |
| topic_facet | Hochschulschrift |
| url | http://d-nb.info/1151663875/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030505317&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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