Frankie starlight:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Weitere Verfasser: | , , , , , |
| Format: | Video Software |
| Sprache: | German English |
| Veröffentlicht: |
[Habichtswald]
ASTRO Distribution GmbH
[2006]
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Original: Frankreich/Großbritannien/Irland/USA, 1995 |
| Beschreibung: | 1 DVD-Video (ca. 96 Min.) 12 cm |
| Zielpublikum: | FSK 12 |
Internformat
MARC
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| 245 | 1 | 0 | |a Frankie starlight |c Regie: Michael Lindsay-Hogg ; Kamera: Paul Laufer ; Drehbuch: Chet Raymo und Ronan O'Leary ; mit Matt Dillon, Anne Parillaud, Gabriel Byrne ; Musik: Elmer Bernstein ; nach dem Roman von Chet Raymo |
| 264 | 1 | |a [Habichtswald] |b ASTRO Distribution GmbH |c [2006] | |
| 264 | 4 | |c © 2006 | |
| 300 | |a 1 DVD-Video (ca. 96 Min.) |c 12 cm | ||
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| 337 | |b v |2 rdamedia | ||
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| 500 | |a Original: Frankreich/Großbritannien/Irland/USA, 1995 | ||
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| 546 | |a Sprache: Deutsch, Englisch | ||
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| 700 | 1 | |a Lindsay-Hogg, Michael |d 1940- |0 (DE-588)13751963X |4 fmd | |
| 700 | 1 | |a Laufer, Paul |0 (DE-588)140324623 |4 cng | |
| 700 | 1 | |a Raymo, Chet |d 1936- |0 (DE-588)121138992 |4 aus |4 aut | |
| 700 | 1 | |a O'Leary, Ronan |4 aus | |
| 700 | 1 | |a Byrne, Gabriel |d 1950- |0 (DE-588)120459205 |4 act | |
| 700 | 1 | |a Parillaud, Anne |d 1960- |0 (DE-588)142198811 |4 act | |
| 700 | 1 | |a Dillon, Matt |d 1964- |0 (DE-588)136025293 |4 act | |
| 700 | 1 | |a Farrell, Colin |d 1976- |0 (DE-588)130525669 |4 act | |
| 700 | 1 | |a Bernstein, Elmer |d 1922-2004 |0 (DE-588)12925021X |4 cmp | |
| 787 | 0 | 8 | |i Filmdrehbuch basiert auf |a Raymo, Chet |t The Dork of Cork |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-030501716 | ||
| 344 | |a digital |h Dolby digital 5.1 | ||
| 346 | |a Laser optical |b PAL | ||
| 347 | |a Videodatei |b DVD-Video |e Region 2 | ||
Datensatz im Suchindex
| _version_ | 1804178752757825536 |
|---|---|
| adam_text | TABLE OF CONTENTS
CHAPTER I -
GENERAL INTRODUCTION 1
1.1 MICROJBIAL COMMUNITIES AND THE
HUMAN MICROBIOME 1
1.2 CYSTIC FIBROSIS AND PATHOGENESIS 3
1.2.1 GENETIC BACKGROUND 4
1.2.2 PATHOGENESIS OF LUNG DISEASES 4
1.3 DIAGNOSTIC
METHODS FOR RESPIRATORY INFECTIOUS DISEASES IN CLINIC AND RESEARCH 5
1.3.1 SSCP FINGERPRINTING 7
1.3.2 ILLUMINA-BASED NEXT GENERATION SEQUENCING 8
1.3.3 EXHALED BREATH ANALYSIS BASED ON VOC-BIOMARKER 9
1.4 STUDIES
OF MICROBIAL INFECTIONS IN CF RESPIRATORY TRACTS 11
1.5 STUDIES
OF EXHALED BREATH DIAGNOSTICS FOR LUNG DISEASES 14
1.6 STATISTICAL ANALYSIS 15
1.7 RESEARCH APPROACH 16
1.7.1 OBJECTIVES OF THESIS 17
1.8 REFERENCES 18
CHAPTER II - ASSESSMENT OF DISTINCT
BACTERIAL COMMUNITIES AND THEIR
PATHOGENIC POTENTIAL IN SPUTUM
FROM ADULT CYSTIC FIBROSIS PATIENTS 27
2.1 ABSTRACT 28
2.2 INTRODUCTION 29
2.3 MATERIAL AND METHODS 30
2.3.1 PATIENT COHORT AND SAMPLE COLLECTION 30
2.3.2 SPUTUM PREPARATION AND DNA EXTRACTION 31
2.3.3 FINGERPRINTS BY SSCP ELECTROPHORESIS AND SEQUENCING OF INDIVIDUAL
BANDS 31
2.3.4 PREPARATION OF ILLUMINA HIGH-THROUGHPUT SEQUENCING 32
2.3.5 DATA PROCESSING AND PHYLOGENETIC ANALYSIS 33
2.3.6 STATISTICAL ANALYSIS 34
IX
HTTP://D-NB.INFO/1048214869
2.4 RESULTS 34
2.4.1 COMPARISONS OF METHODS FOR
MICROBIAL COMPOSITION PROFILING 34
2.4.2 COMMUNITY COMPOSITION AND DOMINANT BACTERIAL
SPECIES 41
2.4.3 COMPARISON OF HOST
FACTORS AND THE
BACTERIAL COMMUNITY COMPOSITION 43
2.4.4 COMMUNITY COMPOSITION AND POLYMICROBIAL CONSORTIA 45
2.4.5 COMMUNITY DYNAMICS 49
2.5 DISCUSSION 51
2.5.1 VALIDATION OF METHODS FOR
MICROBIAL COMMUNITY PROFILING 51
2.5.2 SINGLE BACTERIAL SPECIES
VERSUS POLYMICROBIAL CONSORTIA 52
2.5.3 CLINICAL RELEVANCE OF BACTERIAL SPECIES IS DEPENDING ON CONSORTIA
54
2.6 REFERENCES 56
2.7 SUPPLEMENTARY
MATERIAL 60
CHAPTER III - CHARACTERIZATION OF FUNGAL
AND BACTERIAL COMMUNITIES IN
SPUTUM SAMPLES FROM
ADULT PATIENTS WITH
CYSTIC FIBROSIS 68
3.1 ABSTRACT 69
3.2 INTRODUCTION 70
3.3 MATERIAL AND METHODS 72
3.3.1 SAMPLE COLLECTION 72
3.3.2 SPUTUM PREPARATION AND DNA EXTRACTION 72
3.3.3 PCR AMPLIFICATION AND PREPARATION OF SSDNA 73
3.3.4 SSCP FINGERPRINTS AND SEQUENCING OF INDIVIDUAL SSDNA BANDS 73
3.3.5 DATA PROCESSING AND PHYLOGENETIC
ANALYSIS 74
3.4 RESULTS 75
3.4.1 COMPARISON OF FUNGAL AND BACTERIAL SPECIES RICHNESS IN CF COHORT
75
3.4.2 SPECIES DIVERSITY AND OCCURRENCE FREQUENCY OF BACTERIA IN CF
COHORT 78
3.4.3 SPECIES DIVERSITY AND OCCURRENCE FREQUENCY OF FUNGI IN CF COHORT
80
3.4.4 DYNAMICS OF FUNGAL OTUS AND CLINICAL ABNORMALITIES IN INDIVIDUAL
CF PATIENTS ...
82
3.5 DISCUSSION 85
3.5.1 MICROBIAL SPECIES IDENTIFICATION 85
3.5.2 BACTERIAL SPECIES PRESENT IN CF SPUTUM 86
X
3.5.3 FUNGAL SPECIES PRESENT IN CF SPUTUM 88
3.5.4 CLINICAL RELEVANCE OF FUNGAL SPECIES 90
3.6 CONCLUSION & OUTLOOK 91
3.7 REFERENCES 92
3.8 SUPPLEMENTARY MATERIAL 97
CHAPTER IV -
MONITORING THE
VOCS COMPOSITION
OF MAJOR
MICROBIAL
PATHOGENS FOR
CLINICAL DIAGNOSTIC PURPOSES 103
4.1 ABSTRACT 104
4.2 INTRODUCTION 105
4.3 MATERIAL AND METHODS 107
4.3.1 CELL CULTURE AND MICROBIAL STRAIN PREPARATION 107
4.3.2 MICROBIAL IN VITRO MODELS FOR MEASUREMENTS OF VOC EMISSIONS 107
4.3.3 IMAGING OF HOST-PATHOGEN INTERACTION CULTURES 108
4.3.4 SOLID PHASE
MICRO-EXTRACTION (SPME) 109
4.3.5 GAS
CHROMATOGRAPHY/MASS SPECTROSCOPY (GC/MS) PARAMETERS 109
4.3.6 CF COHORT 110
4.3.7 IN VIVO BREATH SAMPLING 110
4.3.8 DATA PROCESSING AND STATISTICAL ANALYSIS 110
4.4 RESULTS 112
4.4.1 IN VITRO VOCS MONITORING IN BIOFILMS OF CF PATHOGENS 112
4.4.2 IN VITRO VOCS MONITORING IN HOST-PATHOGEN INTERACTION CULTURES
(A549 CELLS) 115
4.4.3 IN VIVO VOCS
MONITORING IN EXHALED BREATH OF CF PATIENTS 121
4.5 DISCUSSION 124
4.5.1 RELEVANCE OF APPROPRIATE STATISTICAL METHODS IN VOC EMISSION
ANALYSIS 124
4.5.2 APPLICATION OF IN VITRO VOC EMISSION MODELS FOR MICROBIAL
DISCRIMINATION 124
4.5.3 FEASIBILITY OF EXHALED VOCS ANALYSIS FOR DIAGNOSTICS OF PULMONARY
INFECTIONS... 126
4.6 CONCLUSION AND PERSPECTIVES 128
4.7 REFERENCES 128
4.8 SUPPLEMENTARY MATERIAL 133
XI
CHAPTER V - GENERAL DISCUSSION 134
5.1 DIAGNOSTIC METHODS FOR
LOWER RESPIRATORY INFECTIONS 134
5.2 MICROBIAL COMMUNITY STRUCTURE
AND COMPOSITION IN CF SPUTUM 135
5.3 IMPACT OF COMMUNITIES
ON MICROBIAL INFECTIONS 137
5.4 OUTLOOK AND CONCLUSION 139
5.5 REFERENCES 140
APPENDIX 143
XII
|
| any_adam_object | 1 |
| author | Raymo, Chet 1936- Bernstein, Elmer 1922-2004 |
| author2 | Laufer, Paul Raymo, Chet 1936- O'Leary, Ronan Byrne, Gabriel 1950- Parillaud, Anne 1960- Dillon, Matt 1964- Farrell, Colin 1976- |
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| author2_variant | p l pl c r cr r o ro g b gb a p ap m d md c f cf |
| author_GND | (DE-588)13751963X (DE-588)140324623 (DE-588)121138992 (DE-588)120459205 (DE-588)142198811 (DE-588)136025293 (DE-588)130525669 (DE-588)12925021X |
| author_facet | Raymo, Chet 1936- Bernstein, Elmer 1922-2004 Laufer, Paul Raymo, Chet 1936- O'Leary, Ronan Byrne, Gabriel 1950- Parillaud, Anne 1960- Dillon, Matt 1964- Farrell, Colin 1976- |
| author_role | aut cmp |
| author_sort | Raymo, Chet 1936- |
| author_variant | c r cr e b eb |
| building | Verbundindex |
| bvnumber | BV045111402 |
| classification_rvk | AP 51400 |
| ctrlnum | (OCoLC)1048214869 (DE-599)BVBBV045111402 |
| discipline | Allgemeines |
| format | Video Software |
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| genre | (DE-588)4017102-4 Film gnd-content (DE-588)4585125-6 DVD-Video gnd-carrier |
| genre_facet | Film DVD-Video |
| id | DE-604.BV045111402 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:08:58Z |
| institution | BVB |
| language | German English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-030501716 |
| oclc_num | 1048214869 |
| open_access_boolean | |
| owner | DE-384 |
| owner_facet | DE-384 |
| physical | 1 DVD-Video (ca. 96 Min.) 12 cm |
| publishDate | 2006 |
| publishDateSearch | 2005 |
| publishDateSort | 2005 |
| publisher | ASTRO Distribution GmbH |
| record_format | marc |
| spelling | Frankie starlight Regie: Michael Lindsay-Hogg ; Kamera: Paul Laufer ; Drehbuch: Chet Raymo und Ronan O'Leary ; mit Matt Dillon, Anne Parillaud, Gabriel Byrne ; Musik: Elmer Bernstein ; nach dem Roman von Chet Raymo [Habichtswald] ASTRO Distribution GmbH [2006] © 2006 1 DVD-Video (ca. 96 Min.) 12 cm tdi rdacontent v rdamedia vd rdacarrier Original: Frankreich/Großbritannien/Irland/USA, 1995 FSK 12 Sprache: Deutsch, Englisch (DE-588)4017102-4 Film gnd-content (DE-588)4585125-6 DVD-Video gnd-carrier Lindsay-Hogg, Michael 1940- (DE-588)13751963X fmd Laufer, Paul (DE-588)140324623 cng Raymo, Chet 1936- (DE-588)121138992 aus aut O'Leary, Ronan aus Byrne, Gabriel 1950- (DE-588)120459205 act Parillaud, Anne 1960- (DE-588)142198811 act Dillon, Matt 1964- (DE-588)136025293 act Farrell, Colin 1976- (DE-588)130525669 act Bernstein, Elmer 1922-2004 (DE-588)12925021X cmp Filmdrehbuch basiert auf Raymo, Chet The Dork of Cork DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030501716&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis digital Dolby digital 5.1 Laser optical PAL Videodatei DVD-Video Region 2 |
| spellingShingle | Raymo, Chet 1936- Bernstein, Elmer 1922-2004 Frankie starlight |
| subject_GND | (DE-588)4017102-4 (DE-588)4585125-6 |
| title | Frankie starlight |
| title_auth | Frankie starlight |
| title_exact_search | Frankie starlight |
| title_full | Frankie starlight Regie: Michael Lindsay-Hogg ; Kamera: Paul Laufer ; Drehbuch: Chet Raymo und Ronan O'Leary ; mit Matt Dillon, Anne Parillaud, Gabriel Byrne ; Musik: Elmer Bernstein ; nach dem Roman von Chet Raymo |
| title_fullStr | Frankie starlight Regie: Michael Lindsay-Hogg ; Kamera: Paul Laufer ; Drehbuch: Chet Raymo und Ronan O'Leary ; mit Matt Dillon, Anne Parillaud, Gabriel Byrne ; Musik: Elmer Bernstein ; nach dem Roman von Chet Raymo |
| title_full_unstemmed | Frankie starlight Regie: Michael Lindsay-Hogg ; Kamera: Paul Laufer ; Drehbuch: Chet Raymo und Ronan O'Leary ; mit Matt Dillon, Anne Parillaud, Gabriel Byrne ; Musik: Elmer Bernstein ; nach dem Roman von Chet Raymo |
| title_short | Frankie starlight |
| title_sort | frankie starlight |
| topic_facet | Film DVD-Video |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030501716&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT lindsayhoggmichael frankiestarlight AT lauferpaul frankiestarlight AT raymochet frankiestarlight AT olearyronan frankiestarlight AT byrnegabriel frankiestarlight AT parillaudanne frankiestarlight AT dillonmatt frankiestarlight AT farrellcolin frankiestarlight AT bernsteinelmer frankiestarlight |