Verfügbarkeit: Role of acetylation and conserved amino acids of the influenza A virus nucleoprotein

Role of acetylation and conserved amino acids of the influenza A virus nucleoprotein:

Gespeichert in:

Bibliographische Detailangaben
1. Verfasser:	Giese, Sebastian (VerfasserIn)
Format:	Abschlussarbeit Buch
Sprache:	English
Veröffentlicht:	Freiburg im Breisgau 2017
Schlagworte:	Hochschulschrift
Online-Zugang:	Inhaltsverzeichnis Inhaltsverzeichnis
Beschreibung:	Enthält Zeitschriftenaufsätze
Beschreibung:	145 Seiten Illustrationen, Diagramme 30 cm

Internformat

MARC


LEADER	00000nam a2200000 c 4500
001	BV045085422
003	DE-604
005	00000000000000.0
007	t
008	180712s2017 gw a\|\|\| m\|\|\| 00\|\|\| eng d
015			\|a 18,H06 \|2 dnb
016	7		\|a 1156627230 \|2 DE-101
020			\|c Broschur
035			\|a (OCoLC)1136277189
035			\|a (DE-599)DNB1156627230
040			\|a DE-604 \|b ger \|e rda
041	0		\|a eng
044			\|a gw \|c XA-DE
049			\|a DE-355
084			\|a 570 \|2 sdnb
100	1		\|a Giese, Sebastian \|e Verfasser \|0 (DE-588)1127649639 \|4 aut
245	1	0	\|a Role of acetylation and conserved amino acids of the influenza A virus nucleoprotein \|c vorgelegt von Sebastian Giese
264		1	\|a Freiburg im Breisgau \|c 2017
300			\|a 145 Seiten \|b Illustrationen, Diagramme \|c 30 cm
336			\|b txt \|2 rdacontent
337			\|b n \|2 rdamedia
338			\|b nc \|2 rdacarrier
500			\|a Enthält Zeitschriftenaufsätze
502			\|b Dissertation \|c Albert-Ludwigs-Universität Freiburg im Breisgau \|d 2017
655		7	\|0 (DE-588)4113937-9 \|a Hochschulschrift \|2 gnd-content
856	4	2	\|m B:DE-101 \|q application/pdf \|u http://d-nb.info/1156627230/04 \|3 Inhaltsverzeichnis
856	4	2	\|m DNB Datenaustausch \|q application/pdf \|u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030476317&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA \|3 Inhaltsverzeichnis
999			\|a oai:aleph.bib-bvb.de:BVB01-030476317

Datensatz im Suchindex

_version_	1804178704206659584
adam_text	TABLE OF CONTENT ACKNOWLEDGMENT.................................................................................................................................. 5 PUBLICATIONS AND MANUSCRIPTS............................................................................................................. 6 ABSTRACT.................................................................................................................................................. 7 ZUSAMMENFASSUNG IN DEUTSCHER SPRACHE.........................................................................................9 LIST OF ABBREVIATIONS........................................................................................................................... 11 I. INTRODUCTION......................................................................................................................................12 1.1. INFLUENZA A VIRUS....................................................................................................................... 12 1.11. PARTICLE COMPOSITION AND GENOME ORGANIZATION...................................................................13 1.111. REPLICATION CYCLE..................................................................................................................... 14 1.111.1 RECEPTOR MEDIATED ENDOCYTOSIS......................................................................................14 1.111.2 NUCLEAR VRNP IMPORT AND VIRAL GENOME REPLICATION..................................................... 15 1.111.3 NUCLEAR EXPORT AND VRNP TRANSPORT TOWARDS THE APICAL PLASMA MEMBRANE............16 1.111.4 GENOME PACKAGING.......................................................................................................... 16 I.III.5. PARTICLE RELEASE.................................................................................................................17 I.III.6 ANTIVIRAL MECHANISMS........................................................................................................17 I.IV. THE VIRAL RIBONUCLEOPROTEIN COMPLEX....................................................................................19 I V. NUCLEOPROTEIN...........................................................................................................................20 I .VI. PROTEIN MODIFICATIONS............................................................................................................. 21 I.VII. PROTEIN ACETYLATION..:............................................................................................................. 23 I. VIII. OBJECTIVES.......................................................................................................................... 25 II. RESULTS AND DISCUSSION..................................................................................................................26 11.1. IAV NP IS ACETYLATED UPON INFECTION ..................................................................................... 26 11.11. IAV NP ACETYLATION AT K229 IS NECESSARY FOR VIRAL GROWTH ................................................ 27 11.111. IAV NP ACETYLATION AT K229 IS NECESSARY FOR VIRAL PARTICLE RELEASE ............................... 29 II. IV. IAV NP ACETYLATION AT K229 DOES NOT AFFECT GENOME PACKAGING...................................30 II.V. IAV NP ACETYLATION AT K229 DOES NOT AFFECT GENOME BUNDLING IN THE CYTOPLASM ......... 31 II.VI. MIMICKING CONSTANT ACETYLATION AT NP K229 IMPAIRS PARTICLE RELEASE............................32 VII. MIMICKING CONSTANT NP HYPER-ACETYLATION AT TWO LYSINE RESIDUES INHIBITS CRNA BINDING............................................................................................................................................... 36 II.VIII. HIGHLY CONSERVED NP RESIDUES REGULATE VIRAL GENOME PACKAGING.................................39 II.IX. NP MEDIATED MXA RESISTANCE IS ACCOMPANIED BY HAMPERED NUCLEAR VRNP IMPORT.42 III. CONCLUSION......................................................................................................................................45 IV. ORIGINAL PUBLICATIONS AND MANUSCRIPTS....................................................................................... 46 IV. I. ROLE OF INFLUENZA A VIRUS NP ACETYLATION ON VIRAL GROWTH AND REPLICATION.* ................. 46 IV . THE FEAT OF PACKAGING EIGHT UNIQUE GENOME SEGMENTS............................................98 IV.III. A CONSERVED INFLUENZA A VIRUS NUCLEOPROTEIN CODE CONTROLS SPECIFIC VIRAL GENOME PACKAGING...................................................................................................................................... 110 IV.IV. INFLUENZA A VIRUSES ESCAPE FROM MXA RESTRICTION AT THE EXPENSE OF EFFICIENT NUCLEAR VRNP IMPORT.* .................................................................................................................................122 V. BIBLIOGRAPHY...................................................................................................................................138 ERKLAERUNG............................................................................................................................................. 145
any_adam_object	1
author	Giese, Sebastian
author_GND	(DE-588)1127649639
author_facet	Giese, Sebastian
author_role	aut
author_sort	Giese, Sebastian
author_variant	s g sg
building	Verbundindex
bvnumber	BV045085422
ctrlnum	(OCoLC)1136277189 (DE-599)DNB1156627230
discipline	Biologie
format	Thesis Book
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01439nam a2200361 c 4500</leader><controlfield tag="001">BV045085422</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">180712s2017 gw a\|\|\| m\|\|\| 00\|\|\| eng d</controlfield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">18,H06</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">1156627230</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="c">Broschur</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1136277189</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DNB1156627230</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">570</subfield><subfield code="2">sdnb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Giese, Sebastian</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)1127649639</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Role of acetylation and conserved amino acids of the influenza A virus nucleoprotein</subfield><subfield code="c">vorgelegt von Sebastian Giese</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Freiburg im Breisgau</subfield><subfield code="c">2017</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">145 Seiten</subfield><subfield code="b">Illustrationen, Diagramme</subfield><subfield code="c">30 cm</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Enthält Zeitschriftenaufsätze</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="b">Dissertation</subfield><subfield code="c">Albert-Ludwigs-Universität Freiburg im Breisgau</subfield><subfield code="d">2017</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">B:DE-101</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://d-nb.info/1156627230/04</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030476317&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-030476317</subfield></datafield></record></collection>
genre	(DE-588)4113937-9 Hochschulschrift gnd-content
genre_facet	Hochschulschrift
id	DE-604.BV045085422
illustrated	Illustrated
indexdate	2024-07-10T08:08:12Z
institution	BVB
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-030476317
oclc_num	1136277189
open_access_boolean
owner	DE-355 DE-BY-UBR
owner_facet	DE-355 DE-BY-UBR
physical	145 Seiten Illustrationen, Diagramme 30 cm
publishDate	2017
publishDateSearch	2017
publishDateSort	2017
record_format	marc
spelling	Giese, Sebastian Verfasser (DE-588)1127649639 aut Role of acetylation and conserved amino acids of the influenza A virus nucleoprotein vorgelegt von Sebastian Giese Freiburg im Breisgau 2017 145 Seiten Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Enthält Zeitschriftenaufsätze Dissertation Albert-Ludwigs-Universität Freiburg im Breisgau 2017 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1156627230/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030476317&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Giese, Sebastian Role of acetylation and conserved amino acids of the influenza A virus nucleoprotein
subject_GND	(DE-588)4113937-9
title	Role of acetylation and conserved amino acids of the influenza A virus nucleoprotein
title_auth	Role of acetylation and conserved amino acids of the influenza A virus nucleoprotein
title_exact_search	Role of acetylation and conserved amino acids of the influenza A virus nucleoprotein
title_full	Role of acetylation and conserved amino acids of the influenza A virus nucleoprotein vorgelegt von Sebastian Giese
title_fullStr	Role of acetylation and conserved amino acids of the influenza A virus nucleoprotein vorgelegt von Sebastian Giese
title_full_unstemmed	Role of acetylation and conserved amino acids of the influenza A virus nucleoprotein vorgelegt von Sebastian Giese
title_short	Role of acetylation and conserved amino acids of the influenza A virus nucleoprotein
title_sort	role of acetylation and conserved amino acids of the influenza a virus nucleoprotein
topic_facet	Hochschulschrift
url	http://d-nb.info/1156627230/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030476317&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT giesesebastian roleofacetylationandconservedaminoacidsoftheinfluenzaavirusnucleoprotein

Verfügbarkeit

Es ist kein Print-Exemplar vorhanden.

Fernleihe Bestellen Achtung: Nicht im THWS-Bestand! Inhaltsverzeichnis
Inhaltsverzeichnis

MARC

Datensatz im Suchindex

Es ist kein Print-Exemplar vorhanden.

Ähnliche Einträge