Verfügbarkeit: Novel insights into germinal center B cell and T follicular helper cell biology

Novel insights into germinal center B cell and T follicular helper cell biology: learning from human primary immunodeficencies

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Bibliographische Detailangaben
1. Verfasser:	Unger, Susanne (VerfasserIn)
Format:	Abschlussarbeit Buch
Sprache:	English
Veröffentlicht:	Freiburg im Breisgau 2017
Schlagworte:	Hochschulschrift
Online-Zugang:	Inhaltsverzeichnis Inhaltsverzeichnis
Beschreibung:	vi, 120 Blätter Illustrationen, Diagramme 30 cm

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MARC


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Datensatz im Suchindex

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adam_text	CONTENT CONTENT............................................................................................................. II ABBREVIATIONS................................................................................................... IV 1 SUMMARY................................................................................................... 1 2 INTRODUCTION.............................................................................................. 2 2.1 THE GERMINAL CENTER REACTION.................................................................2 2.1.1 INITIATION OF THE GC REACTION: B CELL/T CELL INTERACTION .................... 3 2.1.2 CLASS-SWITCH RECOMBINATION, SOMATIC HYPERMUTATION AND SELECTION........................................................................................3 2.1.3 DIFFERENTIATION OF CLASS-SWITCHED MEMORY B CELLS AND LONG- LIVED PLASMA CELLS..........................................................................5 2.2 DIFFERENTIATION AND FUNCTION OF T FOLLICULAR HELPER CELLS .......................... 5 2.3 COMMON VARIABLE IMMUNODEFICIENCY DISORDERS (CVID) ........................ 8 3 AIMS OF THE THESIS..................................................................................11 4 RESULTS.................................................................................................... 12 5 DISCUSSION.............................................................................................. 19 5.1 CVID PATIENTS WITH LYMPHADENOPATHY SUFFER FROM A DEFECT IN GC OUTPUT DEFECT RATHER THAN GC FORMATION .............................................. 19 5.2 EFFECT OF MONOGENETIC DEFECTS ON TFH DIFFERENTIATION ......................... 24 5.3 RETENTION OF PLASMABLASTS IN GC OF CVID PATIENTS WITH LYMPHADENOPATHY................................................................................29 5.4 IMPACT OF TH1 SHIFT ON GC MORPHOLOGY .............................................. 30 5.5 CONTRIBUTION OF CHRONIC IMMUNE ACTIVATION TO IMMUNODEFICIENCY ....... 33 5.6 ROLE OF TFHZTH1/TH17 IN AUTOIMMUNITY ............................................ 37 5.7 CD21LOW B CELLS AND TH1/TH17 MICROENVIRONMENT ............................. 39 5.8 OUTLOOK................................................................................................41 6 REFERENCES..............................................................................................43 7 LIST OF PUBLICATIONS................................................................................54 8 DANKSAGUNG 57 CONTENT________________________________________________ IN 9 ORIGINAL PUBLICATIONS.............................................................................58 9.1 ILL-DEFINED GERMINAL CENTERS AND SEVERELY REDUCED PLASMA CELLS ARE HISTOLOGICAL HALLMARKS OF LYMPHADENOPATHY IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY .................................................. 58 9.2 TH1 PHENOTYPE OF T FOLLICULAR HELPER CELLS INDICATES AN IFNY- ASSOCIATED IMMUNE DEREGULATION IN CD21LOW CVID PATIENTS ............ 71 9.3 EXTENDING THE CLINICAL AND IMMUNOLOGICAL PHENOTYPE OF HUMAN INTERLEUKIN-21 RECEPTOR DEFICIENCY ....................................................... 92 9.4 ENTEROVIRAL INFECTION IN A PATIENT WITH BLNK ADAPTOR PROTEIN DEFICIENCY............................................................................................ 98 9.5 EARLY ONSET COMBINED IMMUNODEFICIENCY AND AUTOIMMUNITY IN PATIENTS WITH LOSS-OF-FUNCTION MUTATION IN LAT .................................. 104 9.6 AUTOSOMAL GAIN OF FUNCTION STAT1 MUTATION AND SEVERE BRONCHIECTASIS .............................................. 120
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discipline	Biologie Medizin
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spelling	Unger, Susanne Verfasser (DE-588)1140058339 aut Novel insights into germinal center B cell and T follicular helper cell biology learning from human primary immunodeficencies vorgelegt von Susanne Unger Freiburg im Breisgau 2017 vi, 120 Blätter Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Albert-Ludwigs-Universität Freiburg im Breisgau 2017 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1142149641/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030472422&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Unger, Susanne Novel insights into germinal center B cell and T follicular helper cell biology learning from human primary immunodeficencies
subject_GND	(DE-588)4113937-9
title	Novel insights into germinal center B cell and T follicular helper cell biology learning from human primary immunodeficencies
title_auth	Novel insights into germinal center B cell and T follicular helper cell biology learning from human primary immunodeficencies
title_exact_search	Novel insights into germinal center B cell and T follicular helper cell biology learning from human primary immunodeficencies
title_full	Novel insights into germinal center B cell and T follicular helper cell biology learning from human primary immunodeficencies vorgelegt von Susanne Unger
title_fullStr	Novel insights into germinal center B cell and T follicular helper cell biology learning from human primary immunodeficencies vorgelegt von Susanne Unger
title_full_unstemmed	Novel insights into germinal center B cell and T follicular helper cell biology learning from human primary immunodeficencies vorgelegt von Susanne Unger
title_short	Novel insights into germinal center B cell and T follicular helper cell biology
title_sort	novel insights into germinal center b cell and t follicular helper cell biology learning from human primary immunodeficencies
title_sub	learning from human primary immunodeficencies
topic_facet	Hochschulschrift
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work_keys_str_mv	AT ungersusanne novelinsightsintogerminalcenterbcellandtfollicularhelpercellbiologylearningfromhumanprimaryimmunodeficencies

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