Metabolic engineering of microbial hosts for the biosynthesis of high molecular weight hyaluronan:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Aachen
Apprimus
2018
|
| Ausgabe: | 1. Auflage |
| Schriftenreihe: | Applied microbiology
Volume 6 |
| Schlagworte: | |
| Online-Zugang: | Volltext Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | IX, 124 Seiten Illustrationen, Diagramme 21 cm |
| ISBN: | 9783863596293 |
| DOI: | 10.18154/RWTH-2018-224575 |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | CONTENT
SUMMARY.........................................................................................................................................I
ZUSAMMENFASSUNG..........................................................................................................................
ILL
LIST OF
FIGURES....................................................................................................................................V
LIST OF
TABLES..................................................................................................................................
VII
LIST OF
ABBREVIATIONS.......................................................................................................................
IX
1. GENERAL
INTRODUCTION.................................................................................................................
3
1.1
BIOECONOMY........................................................................................................................3
1.2
POLYSACCHARIDES..................................................................................................................
4
1.3
GLYCOSAMINOGLYCANS............................................................................................................
5
1.4
HYALURONAN..........................................................................................................................6
1.4.1
BIOSYNTHESIS................................................................................................................
6
1.4.2 FUNCTIONS AND
APPLICATIONS.........................................................................................
8
1.4.3 PRODUCTION
METHODS..................................................................................................
9
1.5 SCOPE AND OUTLINE OF THE
THESIS.........................................................................................
11
1.6
REFERENCES.........................................................................................................................13
2. SACCHAROMYCES CEREVISIAE AS CHASSIS FOR HYALURONAN PRECURSOR
PRODUCTION....................................19
2.1 CHARACTERISTICS OF S.
CEREVISIAE............................................................................................
19
2.2 GENETIC MANIPULATION OF S.
CEREVISIAE.................................................................................20
2.3 HOW TO MAKE S. CEREVISIAE AN EFFICIENT HA PRECURSOR PRODUCER
........................................
21
MATERIAL AND
METHODS..............................................................................................................
24
RESULTS......................................................................................................................................
34
DISCUSSION................................................................................................................................41
2.4 EVALUATION OF ESCHERICHIA COLI AS ALTERNATIVE CHASSIS FOR SYNTHETIC
PRECURSOR PATHWAYS
......
43
2.5
REFERENCES........................................................................................................................
46
3. IMPLEMENTATION OF THE HYALURONAN SYNTHASE IN S. CEREVISIAE
.....................................................
53
3.1 GLYCOSYLTRANS
FERASES.........................................................................................................53
3.2 THE HA SYNTHASE IS A VERSATILE
ENZYME...........................................................................
53
3.2.1 VERTEBRATE VERSUS BACTERIAL HAS - SIMILARITIES AND
DIFFERENCES................................55
3.3 PROMISING HAS CANDIDATES FOR RECOMBINANT HIGH MW HA
PRODUCTION..........................57
MATERIAL AND
METHODS..............................................................................................................
58
RESULTS.......................................................................................................................................63
DISCUSSION................................................................................................................................
68
3.4
REFERENCES..........................................................................................................................70
4. DIVERSITY OF STREPTOCOCCAL HYALURONAN
SYNTHASES.....................................................................
77
4.1 FACTORS INFLUENCING THE MOLECULAR WEIGHT OF HYALURONAN
...............................................
77
4.2 LMCTOCOCCUS LACTIS AS EXPRESSION HOST
...................................................................................
78
MATERIAL AND
METHODS...............................................................................................................79
RESULTS.......................................................................................................................................86
DISCUSSION................................................................................................................................
92
4.3
REFERENCES.........................................................................................................................95
5. GENERAL DISCUSSION AND
OUTLOOK.............................................................................................
101
5.1
REFERENCES.......................................................................................................................
105
6.
APPENDIX................................................................................................................................
109
6.1 TO CHAPTER 2
...................................................................................................................
109
6.2 TO CHAPTER 3
...................................................................................................................
110
6.2.1 AMINO ACID SEQUENCES USED FOR CONSTRUCTION OF FIG. 3.2
......................................
110
6.2.2 CODON-OPTIMIZED SYNTHASE GENE
SEQUENCES........................................................... 114
6.2.3 FLUORESCENCE MICROSCOPY PICTURES AND CTAB
.......................................................
116
6.3 TO CHAPTER 4
...................................................................................................................
118
6.3.1 AMINO ACID SEQUENCES OF THE DIFFERENT
HASS.........................................................118
CURRICULUM
VITAE...........................................................................................................................
123
|
| any_adam_object | 1 |
| author | Schulte, Sandra 1989- |
| author_GND | (DE-588)1160550220 |
| author_facet | Schulte, Sandra 1989- |
| author_role | aut |
| author_sort | Schulte, Sandra 1989- |
| author_variant | s s ss |
| building | Verbundindex |
| bvnumber | BV045080919 |
| collection | ebook |
| ctrlnum | (OCoLC)1048242365 (DE-599)DNB1160451710 |
| dewey-full | 660.62 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 660 - Chemical engineering |
| dewey-raw | 660.62 |
| dewey-search | 660.62 |
| dewey-sort | 3660.62 |
| dewey-tens | 660 - Chemical engineering |
| discipline | Chemie / Pharmazie |
| doi_str_mv | 10.18154/RWTH-2018-224575 |
| edition | 1. Auflage |
| format | Thesis Book |
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| genre_facet | Hochschulschrift |
| id | DE-604.BV045080919 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T08:08:04Z |
| institution | BVB |
| isbn | 9783863596293 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-030471891 |
| oclc_num | 1048242365 |
| open_access_boolean | 1 |
| owner | DE-29T DE-83 |
| owner_facet | DE-29T DE-83 |
| physical | IX, 124 Seiten Illustrationen, Diagramme 21 cm |
| psigel | ebook |
| publishDate | 2018 |
| publishDateSearch | 2018 |
| publishDateSort | 2018 |
| publisher | Apprimus |
| record_format | marc |
| series | Applied microbiology |
| series2 | Applied microbiology |
| spelling | Schulte, Sandra 1989- Verfasser (DE-588)1160550220 aut Metabolic engineering of microbial hosts for the biosynthesis of high molecular weight hyaluronan vorgelegt von M. Sc. Sandra Schulte aus Kassel (Hessen), Deutschland 1. Auflage Aachen Apprimus 2018 IX, 124 Seiten Illustrationen, Diagramme 21 cm txt rdacontent n rdamedia nc rdacarrier Applied microbiology Volume 6 Dissertation RWTH Aachen University 2018 Saccharose (DE-588)4178816-3 gnd rswk-swf Biokonversion (DE-588)4145610-5 gnd rswk-swf Lactococcus lactis (DE-588)4183661-3 gnd rswk-swf Synthasen (DE-588)4206693-1 gnd rswk-swf Gentechnisch veränderter Organismus (DE-588)4353579-3 gnd rswk-swf Herstellung (DE-588)4159653-5 gnd rswk-swf Hyaluronsäure (DE-588)4160834-3 gnd rswk-swf Saccharomyces cerevisiae (DE-588)4178812-6 gnd rswk-swf Acetylglucosamin (DE-588)4296470-2 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Hyaluronsäure (DE-588)4160834-3 s Herstellung (DE-588)4159653-5 s Saccharose (DE-588)4178816-3 s Acetylglucosamin (DE-588)4296470-2 s Biokonversion (DE-588)4145610-5 s Synthasen (DE-588)4206693-1 s Saccharomyces cerevisiae (DE-588)4178812-6 s Gentechnisch veränderter Organismus (DE-588)4353579-3 s DE-604 Lactococcus lactis (DE-588)4183661-3 s Erscheint auch als Online-Ausgabe, PDF https://doi.org/10.18154/RWTH-2018-224575 Applied microbiology Volume 6 (DE-604)BV042644516 6 https://doi.org/10.18154/RWTH-2018-224575 Resolving-System kostenfrei Volltext B:DE-101 application/pdf http://d-nb.info/1160451710/04 Resolving-System kostenfrei Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030471891&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schulte, Sandra 1989- Metabolic engineering of microbial hosts for the biosynthesis of high molecular weight hyaluronan Applied microbiology Saccharose (DE-588)4178816-3 gnd Biokonversion (DE-588)4145610-5 gnd Lactococcus lactis (DE-588)4183661-3 gnd Synthasen (DE-588)4206693-1 gnd Gentechnisch veränderter Organismus (DE-588)4353579-3 gnd Herstellung (DE-588)4159653-5 gnd Hyaluronsäure (DE-588)4160834-3 gnd Saccharomyces cerevisiae (DE-588)4178812-6 gnd Acetylglucosamin (DE-588)4296470-2 gnd |
| subject_GND | (DE-588)4178816-3 (DE-588)4145610-5 (DE-588)4183661-3 (DE-588)4206693-1 (DE-588)4353579-3 (DE-588)4159653-5 (DE-588)4160834-3 (DE-588)4178812-6 (DE-588)4296470-2 (DE-588)4113937-9 |
| title | Metabolic engineering of microbial hosts for the biosynthesis of high molecular weight hyaluronan |
| title_auth | Metabolic engineering of microbial hosts for the biosynthesis of high molecular weight hyaluronan |
| title_exact_search | Metabolic engineering of microbial hosts for the biosynthesis of high molecular weight hyaluronan |
| title_full | Metabolic engineering of microbial hosts for the biosynthesis of high molecular weight hyaluronan vorgelegt von M. Sc. Sandra Schulte aus Kassel (Hessen), Deutschland |
| title_fullStr | Metabolic engineering of microbial hosts for the biosynthesis of high molecular weight hyaluronan vorgelegt von M. Sc. Sandra Schulte aus Kassel (Hessen), Deutschland |
| title_full_unstemmed | Metabolic engineering of microbial hosts for the biosynthesis of high molecular weight hyaluronan vorgelegt von M. Sc. Sandra Schulte aus Kassel (Hessen), Deutschland |
| title_short | Metabolic engineering of microbial hosts for the biosynthesis of high molecular weight hyaluronan |
| title_sort | metabolic engineering of microbial hosts for the biosynthesis of high molecular weight hyaluronan |
| topic | Saccharose (DE-588)4178816-3 gnd Biokonversion (DE-588)4145610-5 gnd Lactococcus lactis (DE-588)4183661-3 gnd Synthasen (DE-588)4206693-1 gnd Gentechnisch veränderter Organismus (DE-588)4353579-3 gnd Herstellung (DE-588)4159653-5 gnd Hyaluronsäure (DE-588)4160834-3 gnd Saccharomyces cerevisiae (DE-588)4178812-6 gnd Acetylglucosamin (DE-588)4296470-2 gnd |
| topic_facet | Saccharose Biokonversion Lactococcus lactis Synthasen Gentechnisch veränderter Organismus Herstellung Hyaluronsäure Saccharomyces cerevisiae Acetylglucosamin Hochschulschrift |
| url | https://doi.org/10.18154/RWTH-2018-224575 http://d-nb.info/1160451710/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030471891&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV042644516 |
| work_keys_str_mv | AT schultesandra metabolicengineeringofmicrobialhostsforthebiosynthesisofhighmolecularweighthyaluronan |