Subversive urban planning: alternative forms of urban action in the knowledge society
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English German |
| Veröffentlicht: |
[Kaiserslautern]
Bernd Streich
2018
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | XIX, 214 Seiten 23 cm |
| ISBN: | 9781986756617 |
Internformat
MARC
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|---|---|---|---|
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| 003 | DE-604 | ||
| 005 | 20190820 | ||
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| 245 | 1 | 0 | |a Subversive urban planning |b alternative forms of urban action in the knowledge society |c Bernd Streich |
| 264 | 1 | |a [Kaiserslautern] |b Bernd Streich |c 2018 | |
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Datensatz im Suchindex
| _version_ | 1804178542880096256 |
|---|---|
| adam_text | TABLE OF CONTENTS
TABLE OF CONTENTS
ABBREVIATIONS 4
TABLE OF CONTENTS 7
I. INTRODUCTION 10
A. CIRCULATION AND CARDIOVASCULAR
SYSTEM 10
1. OVERVIEW
OF THE
CARDIOVASCULAR
SYSTEM 10
2. STRUCTURE AND
FUNCTION OF BLOOD VESSELS 12
3. BLOOD FLOW
AND
SHEAR
STRESS 16
4. ATHEROSCLEROSIS 19
B. KLF2 AND
THE
CARDIOVASCULAR
SYSTEM 22
1. THE KLF TRANSCRIPTION FACTOR FAMILY 22
2. KLF2 IN THE
CARDIOVASCULAR
SYSTEM 24
C. MIRNAS IN VASCULAR BIOLOGY 27
1. POSTTRANSCRIPTIONAL REGULATION BY MIRNAS 27
2. MIRNAS IN THE
CARDIOVASCULAR
SYSTEM 30
3. MIRNAS IN CARDIOVASCULAR DISEASE 33
4. MIRNAS AND
SHEAR
STRESS 34
5. MIRNAS IN INTERCELLULAR COMMUNICATION 35
D. INTERCELLULAR COMMUNICATION 38
1. SMALL VESICLES MEDIATED INTERCELLULAR COMMUNICATION 38
2. VESICLE RELEASE 39
3. VESICLE UPTAKE 41
4. SMALL VESICLES IN THE
CARDIOVASCULAR
SYSTEM 42
II. AIM OF THE
STUDY 44
III. MATERIAL AND METHODS 45
A. MATERIALS 45
PAGE | 7
HTTP://D-NB.INFO/1036370771
TABLE OF CONTENTS
1. CONSUMABLES 45
2. EQUIPMENT 45
3. CHEMICALS AND
REAGENTS 46
4. KITS 48
5. ENZYMES 48
6. BACTERIA 49
7. BACTERIAL GROWTH MEDIA
AND
AGAR PLATES 49
8. PLASMIDS 49
9. CELL CULTURE
SOLUTIONS AND
SUPPLEMENTS 49
10. PRIMARY
CELLS AND
CELL LINES 50
11. ANIMALS 50
B. METHODS 51
1. CELL CULTURE 51
2. MOLECULAR
BIOLOGY 59
3. BIOINFORMATICS 64
4. IN VIVO EXPERIMENTS 64
5. STATISTICAL DATA ANALYSIS 64
IV. RESULTS 66
A. KLF2 AND
SHEAR
STRESS REGULATE
THE
EXPRESSION OF SEVERAL MICRORNAS 66
B. KLF2 AND
SHEAR
STRESS INDUCE
THE
EXPRESSION OF MIR-143/-145 70
C. KLF2 DIRECTLY REGULATES MIR-143/-145 EXPRESSION THROUGH BINDING IN
THE
PROMOTER
REGION 76
D. MIR-143/-145 REDUCE
PROLIFERATION OF HUVECS 80
E. ENDOTHELIAL-DERIVED MICROVESICLES COMPOSITION IS REGULATED BY KLF2
AND
SHEAR
STRESS 83
F. EXTRACELLULAR MIR-143/145 ARE PROTECTED BY PHOSPHOLIPID MEMBRANE
BASED
VESICLES 92
PAGE | 8
TABLE OF CONTENTS
G. ENDOTHELIAL-DERIVED MICROVESICLES TRANSMIT RNAS AND OTHER CELLULAR
COMPONENTS
TO SMOOTH MUSCLE
CELLS 95
H. ENDOTHELIAL-DERIVED MIR-143/145 REGULATE GENE EXPRESSION IN SMOOTH
MUSCLE CELLS 100
I. IN VIVO APPLICATION OF MVS FROM KLF2-TRANSDUCED ECS REDUCES LESION-
FORMATION IN APOE -/- MICE
ON HIGH FAT
DIET 103
V. DISCUSSION 106
A. KLF2 REGULATES
A NUMBER
OF MIRNAS IN ECS 106
B. FUNCTION OF MIR-143/-145 IN ECS 107
C. INTERCELLULAR COMMUNICATION BETWEEN
ECS AND
SMCS THROUGH MVS 108
D. MVS RELEASED BY KLF2-TRANSDUCED ECS ARE
ATHEROPROTECTIVE 109
E. POSSIBLE APPLICATIONS ILL
VI. SUMMARY 113
VII. ZUSAMMENFASSUNG 118
VIII. REFERENCES 124
IX. EIDESSTATTLICHE ERKLARUNG 137
X. LEBENSLAUF 138
XI. DANKSAGUNG 140
PAGE | 9
|
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| id | DE-604.BV044952760 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:05:38Z |
| institution | BVB |
| isbn | 9781986756617 |
| language | English German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-030345508 |
| oclc_num | 1036370771 |
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| physical | XIX, 214 Seiten 23 cm |
| publishDate | 2018 |
| publishDateSearch | 2018 |
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| publisher | Bernd Streich |
| record_format | marc |
| spelling | Streich, Bernd Verfasser (DE-588)171650689 aut Subversive Stadtplanung Subversive urban planning alternative forms of urban action in the knowledge society Bernd Streich [Kaiserslautern] Bernd Streich 2018 XIX, 214 Seiten 23 cm txt rdacontent n rdamedia nc rdacarrier Subversion (DE-588)4213485-7 gnd rswk-swf Divergentes Denken (DE-588)4150308-9 gnd rswk-swf Stadtplanung (DE-588)4056754-0 gnd rswk-swf Stadtplanung (DE-588)4056754-0 s Divergentes Denken (DE-588)4150308-9 s Subversion (DE-588)4213485-7 s DE-604 B:DE-101 application/pdf http://d-nb.info/1156206855/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030345508&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Streich, Bernd Subversive urban planning alternative forms of urban action in the knowledge society Subversion (DE-588)4213485-7 gnd Divergentes Denken (DE-588)4150308-9 gnd Stadtplanung (DE-588)4056754-0 gnd |
| subject_GND | (DE-588)4213485-7 (DE-588)4150308-9 (DE-588)4056754-0 |
| title | Subversive urban planning alternative forms of urban action in the knowledge society |
| title_alt | Subversive Stadtplanung |
| title_auth | Subversive urban planning alternative forms of urban action in the knowledge society |
| title_exact_search | Subversive urban planning alternative forms of urban action in the knowledge society |
| title_full | Subversive urban planning alternative forms of urban action in the knowledge society Bernd Streich |
| title_fullStr | Subversive urban planning alternative forms of urban action in the knowledge society Bernd Streich |
| title_full_unstemmed | Subversive urban planning alternative forms of urban action in the knowledge society Bernd Streich |
| title_short | Subversive urban planning |
| title_sort | subversive urban planning alternative forms of urban action in the knowledge society |
| title_sub | alternative forms of urban action in the knowledge society |
| topic | Subversion (DE-588)4213485-7 gnd Divergentes Denken (DE-588)4150308-9 gnd Stadtplanung (DE-588)4056754-0 gnd |
| topic_facet | Subversion Divergentes Denken Stadtplanung |
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