Adeno-Associated Virus: Methods and Protocols
Today, progress in rAAV-mediated gene transfer is so robust that long-term, efficient, and regulatable transgene expression is reproducibly achieved in large animal models. The complexity of gene transfer agents in the context of their clinical use requires investigators from a wide variety of back...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2011
|
| Schriftenreihe: | Methods in Molecular Biology, Methods and Protocols
807 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 Volltext |
| Zusammenfassung: | Today, progress in rAAV-mediated gene transfer is so robust that long-term, efficient, and regulatable transgene expression is reproducibly achieved in large animal models. The complexity of gene transfer agents in the context of their clinical use requires investigators from a wide variety of backgrounds to have an understanding — or at least an appreciation of — the regulatory environment and constraints that affect vector design, manufacturing, pre-clinical testing, and clinical use, with an emphasis on patient protection. In Adeno-Associated Virus: Methods and Protocols, experts from the United States and Europe have contributed current knowledge of this multi-dimensional field relating to the biology of AAV, rAAV vector design, vector manufacturing and product testing, performance of rAAV vectors in major organs, rAAV-related immunological issues, design of animal and clinical studies, and clinical experience. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Adeno-Associated Virus: Methods and Protocols provides a complete and comprehensive understanding of this multi-disciplinary and rapidly progressing field |
| Beschreibung: | 1 Online-Ressource (XIII, 462 p. 43 illus., 20 illus. in color) |
| ISBN: | 9781617793707 |
| DOI: | 10.1007/978-1-61779-370-7 |
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| dewey-ones | 591 - Specific topics in natural history of animals |
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| discipline | Biologie |
| doi_str_mv | 10.1007/978-1-61779-370-7 |
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| isbn | 9781617793707 |
| language | English |
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| spelling | Adeno-Associated Virus Methods and Protocols edited by Richard O. Snyder, Philippe Moullier Totowa, NJ Humana Press 2011 1 Online-Ressource (XIII, 462 p. 43 illus., 20 illus. in color) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology, Methods and Protocols 807 Today, progress in rAAV-mediated gene transfer is so robust that long-term, efficient, and regulatable transgene expression is reproducibly achieved in large animal models. The complexity of gene transfer agents in the context of their clinical use requires investigators from a wide variety of backgrounds to have an understanding — or at least an appreciation of — the regulatory environment and constraints that affect vector design, manufacturing, pre-clinical testing, and clinical use, with an emphasis on patient protection. In Adeno-Associated Virus: Methods and Protocols, experts from the United States and Europe have contributed current knowledge of this multi-dimensional field relating to the biology of AAV, rAAV vector design, vector manufacturing and product testing, performance of rAAV vectors in major organs, rAAV-related immunological issues, design of animal and clinical studies, and clinical experience. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Adeno-Associated Virus: Methods and Protocols provides a complete and comprehensive understanding of this multi-disciplinary and rapidly progressing field Life Sciences Animal Genetics and Genomics Human Genetics Gene Therapy Life sciences Human genetics Gene therapy Animal genetics Snyder, Richard O. edt Moullier, Philippe edt Erscheint auch als Druck-Ausgabe 9781617793691 https://doi.org/10.1007/978-1-61779-370-7 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Adeno-Associated Virus Methods and Protocols Life Sciences Animal Genetics and Genomics Human Genetics Gene Therapy Life sciences Human genetics Gene therapy Animal genetics |
| title | Adeno-Associated Virus Methods and Protocols |
| title_auth | Adeno-Associated Virus Methods and Protocols |
| title_exact_search | Adeno-Associated Virus Methods and Protocols |
| title_full | Adeno-Associated Virus Methods and Protocols edited by Richard O. Snyder, Philippe Moullier |
| title_fullStr | Adeno-Associated Virus Methods and Protocols edited by Richard O. Snyder, Philippe Moullier |
| title_full_unstemmed | Adeno-Associated Virus Methods and Protocols edited by Richard O. Snyder, Philippe Moullier |
| title_short | Adeno-Associated Virus |
| title_sort | adeno associated virus methods and protocols |
| title_sub | Methods and Protocols |
| topic | Life Sciences Animal Genetics and Genomics Human Genetics Gene Therapy Life sciences Human genetics Gene therapy Animal genetics |
| topic_facet | Life Sciences Animal Genetics and Genomics Human Genetics Gene Therapy Life sciences Human genetics Gene therapy Animal genetics |
| url | https://doi.org/10.1007/978-1-61779-370-7 |
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