Checkpoint Controls and Cancer: Volume 2: Activation and Regulation Protocols
Intracellular checkpoint controls constitute a network of signal transduction pathways that protect cells from external stresses and internal errors by means of cell cycle arrest, DNA repair, or apoptosis. Failure of this machinery can lead to embryonic death, genetic diseases, and cancer. In Checkp...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2004
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| Schriftenreihe: | Methods in Molecular Biology
281 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 Volltext |
| Zusammenfassung: | Intracellular checkpoint controls constitute a network of signal transduction pathways that protect cells from external stresses and internal errors by means of cell cycle arrest, DNA repair, or apoptosis. Failure of this machinery can lead to embryonic death, genetic diseases, and cancer. In Checkpoint Controls and Cancer, Volume 2: Activation and Regulation Protocols, Axel H. Schönthal, PhD, marshals a prestigious panel of researchers working at the cutting edges of their fields to present readily reproducible experimental protocols for the study of the molecular components of checkpoint controls and their regulation. Described in step-by-step detail, these powerful techniques offer such novel approaches as the use of genome databases and siRNA to analyze how cells of the human body can escape proper surveillance to grow into a tumor. Additional experimental methods are provided for the manipulation of checkpoint pathways and the analysis of the resulting consequences for the cellular phenotype. The earlier first volume, Reviews and Model Systems, comprehensively describes the complexities of checkpoint controls and the model systems available to study them. Comprehensive and up-to-date, the two volumes of Checkpoint Controls and Cancer offer novice and experienced researchers alike not only entré into the complexities of this vast field, but also to the full panoply of productive tools needed to deepen understanding of the systems, as well as to develop new and more effective therapies |
| Beschreibung: | 1 Online-Ressource (XVIII, 358 p) |
| ISBN: | 9781592598113 |
| DOI: | 10.1385/1592598110 |
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| id | DE-604.BV044952026 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:05:37Z |
| institution | BVB |
| isbn | 9781592598113 |
| language | English |
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| physical | 1 Online-Ressource (XVIII, 358 p) |
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| spelling | Checkpoint Controls and Cancer Volume 2: Activation and Regulation Protocols edited by Axel H. Schönthal Totowa, NJ Humana Press 2004 1 Online-Ressource (XVIII, 358 p) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology 281 Intracellular checkpoint controls constitute a network of signal transduction pathways that protect cells from external stresses and internal errors by means of cell cycle arrest, DNA repair, or apoptosis. Failure of this machinery can lead to embryonic death, genetic diseases, and cancer. In Checkpoint Controls and Cancer, Volume 2: Activation and Regulation Protocols, Axel H. Schönthal, PhD, marshals a prestigious panel of researchers working at the cutting edges of their fields to present readily reproducible experimental protocols for the study of the molecular components of checkpoint controls and their regulation. Described in step-by-step detail, these powerful techniques offer such novel approaches as the use of genome databases and siRNA to analyze how cells of the human body can escape proper surveillance to grow into a tumor. Additional experimental methods are provided for the manipulation of checkpoint pathways and the analysis of the resulting consequences for the cellular phenotype. The earlier first volume, Reviews and Model Systems, comprehensively describes the complexities of checkpoint controls and the model systems available to study them. Comprehensive and up-to-date, the two volumes of Checkpoint Controls and Cancer offer novice and experienced researchers alike not only entré into the complexities of this vast field, but also to the full panoply of productive tools needed to deepen understanding of the systems, as well as to develop new and more effective therapies Biomedicine Cancer Research Medicine Cancer research Schönthal, Axel H. edt Erscheint auch als Druck-Ausgabe 9781588295002 https://doi.org/10.1385/1592598110 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Checkpoint Controls and Cancer Volume 2: Activation and Regulation Protocols Biomedicine Cancer Research Medicine Cancer research |
| title | Checkpoint Controls and Cancer Volume 2: Activation and Regulation Protocols |
| title_auth | Checkpoint Controls and Cancer Volume 2: Activation and Regulation Protocols |
| title_exact_search | Checkpoint Controls and Cancer Volume 2: Activation and Regulation Protocols |
| title_full | Checkpoint Controls and Cancer Volume 2: Activation and Regulation Protocols edited by Axel H. Schönthal |
| title_fullStr | Checkpoint Controls and Cancer Volume 2: Activation and Regulation Protocols edited by Axel H. Schönthal |
| title_full_unstemmed | Checkpoint Controls and Cancer Volume 2: Activation and Regulation Protocols edited by Axel H. Schönthal |
| title_short | Checkpoint Controls and Cancer |
| title_sort | checkpoint controls and cancer volume 2 activation and regulation protocols |
| title_sub | Volume 2: Activation and Regulation Protocols |
| topic | Biomedicine Cancer Research Medicine Cancer research |
| topic_facet | Biomedicine Cancer Research Medicine Cancer research |
| url | https://doi.org/10.1385/1592598110 |
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