Duchenne muscular dystrophy: methods and protocols
This volume explores experimental approaches used to study Duchenne muscular dystrophy (DMD), an X-linked degenerative skeletal muscle disease caused by mutations in the dystrophin gene. Including the latest progress and scientific achievements, the book covers recent discoveries achieved through in...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer New York
2018
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| Schriftenreihe: | Methods in Molecular Biology
1687 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 Volltext |
| Zusammenfassung: | This volume explores experimental approaches used to study Duchenne muscular dystrophy (DMD), an X-linked degenerative skeletal muscle disease caused by mutations in the dystrophin gene. Including the latest progress and scientific achievements, the book covers recent discoveries achieved through in vivo gene editing which have proven to be promising in restoring dystrophin expression, at least in ameliorating skeletal muscle symptoms, and the contents focus on "Omics" techniques in gene expression, protein expression, miRNAs, and long non-coding RNA analysis, as well as experimental studies of the structural/functional changes affecting the skeletal and cardiac muscles and ongoing preclinical studies and clinical trials. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Duchenne Muscular Dystrophy: Methods and Protocols serves as a guide for researchers exploring the complicated nature of dystrophin in the hope of helping the victims of this disorder |
| Beschreibung: | 1 Online-Ressource (XII, 287 Seiten) Illustrationen |
| ISBN: | 9781493973743 |
| DOI: | 10.1007/978-1-4939-7374-3 |
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| 520 | |a This volume explores experimental approaches used to study Duchenne muscular dystrophy (DMD), an X-linked degenerative skeletal muscle disease caused by mutations in the dystrophin gene. Including the latest progress and scientific achievements, the book covers recent discoveries achieved through in vivo gene editing which have proven to be promising in restoring dystrophin expression, at least in ameliorating skeletal muscle symptoms, and the contents focus on "Omics" techniques in gene expression, protein expression, miRNAs, and long non-coding RNA analysis, as well as experimental studies of the structural/functional changes affecting the skeletal and cardiac muscles and ongoing preclinical studies and clinical trials. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Duchenne Muscular Dystrophy: Methods and Protocols serves as a guide for researchers exploring the complicated nature of dystrophin in the hope of helping the victims of this disorder | ||
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| dewey-full | 611.01816 |
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| isbn | 9781493973743 |
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| spelling | Duchenne muscular dystrophy methods and protocols edited by Camilla Bernardini New York, NY Springer New York 2018 1 Online-Ressource (XII, 287 Seiten) Illustrationen txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology 1687 This volume explores experimental approaches used to study Duchenne muscular dystrophy (DMD), an X-linked degenerative skeletal muscle disease caused by mutations in the dystrophin gene. Including the latest progress and scientific achievements, the book covers recent discoveries achieved through in vivo gene editing which have proven to be promising in restoring dystrophin expression, at least in ameliorating skeletal muscle symptoms, and the contents focus on "Omics" techniques in gene expression, protein expression, miRNAs, and long non-coding RNA analysis, as well as experimental studies of the structural/functional changes affecting the skeletal and cardiac muscles and ongoing preclinical studies and clinical trials. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Duchenne Muscular Dystrophy: Methods and Protocols serves as a guide for researchers exploring the complicated nature of dystrophin in the hope of helping the victims of this disorder Biomedicine Molecular Medicine Medicine Molecular biology Bernardini, Camilla 1970- (DE-588)1246457466 edt Erscheint auch als Druck-Ausgabe 978-1-4939-7373-6 Erscheint auch als Druck-Ausgabe 978-1-4939-7375-0 Erscheint auch als Druck-Ausgabe 978-1-4939-8466-4 https://doi.org/10.1007/978-1-4939-7374-3 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Duchenne muscular dystrophy methods and protocols Biomedicine Molecular Medicine Medicine Molecular biology |
| title | Duchenne muscular dystrophy methods and protocols |
| title_auth | Duchenne muscular dystrophy methods and protocols |
| title_exact_search | Duchenne muscular dystrophy methods and protocols |
| title_full | Duchenne muscular dystrophy methods and protocols edited by Camilla Bernardini |
| title_fullStr | Duchenne muscular dystrophy methods and protocols edited by Camilla Bernardini |
| title_full_unstemmed | Duchenne muscular dystrophy methods and protocols edited by Camilla Bernardini |
| title_short | Duchenne muscular dystrophy |
| title_sort | duchenne muscular dystrophy methods and protocols |
| title_sub | methods and protocols |
| topic | Biomedicine Molecular Medicine Medicine Molecular biology |
| topic_facet | Biomedicine Molecular Medicine Medicine Molecular biology |
| url | https://doi.org/10.1007/978-1-4939-7374-3 |
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