Patch-Clamp Methods and Protocols:
Since its inception, patch-clamp has continued to be widely considered the gold standard method to record ion channel activity. Patch-Clamp Methods and Protocols, Second Edition, provides a comprehensive collection of new techniques for the development of automated, high-throughput screening systems...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer New York
2014
|
| Ausgabe: | 2nd ed. 2014 |
| Schriftenreihe: | Methods in Molecular Biology, Methods and Protocols
1183 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 Volltext |
| Zusammenfassung: | Since its inception, patch-clamp has continued to be widely considered the gold standard method to record ion channel activity. Patch-Clamp Methods and Protocols, Second Edition, provides a comprehensive collection of new techniques for the development of automated, high-throughput screening systems for pharmacological evaluation, the use of various patch-clamp configurations together with novel molecular biological and imaging methodologies, and enhanced stimulation protocols and perfusion systems. Divided into sections on pharmacology, physiology, and biophysics, the chapters cover methods to generate more physiologically relevant conditions for drug application and screening technologies, recently developed applications such as optogenetic stimulation, advances in whole-cell recordings in freely-moving animals, and novel technologies to create custom microelectrodes designed for reducing the access resistance and improving the rate of molecular diffusion. Patch-clamp is an indispensable technique for conducting pharmacological, physiological and biophysical research aimed at understanding crucial aspects of cellular and network function. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Patch -Clamp Methods and Protocols, Second Edition will provide a useful technical and methodological guide to diverse audiences of electrophysiologists, from students to experienced investigators |
| Beschreibung: | 1 Online-Ressource (XI, 403 p. 105 illus., 41 illus. in color) |
| ISBN: | 9781493910960 |
| DOI: | 10.1007/978-1-4939-1096-0 |
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| spelling | Patch-Clamp Methods and Protocols edited by Marzia Martina, Stefano Taverna 2nd ed. 2014 New York, NY Springer New York 2014 1 Online-Ressource (XI, 403 p. 105 illus., 41 illus. in color) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology, Methods and Protocols 1183 Since its inception, patch-clamp has continued to be widely considered the gold standard method to record ion channel activity. Patch-Clamp Methods and Protocols, Second Edition, provides a comprehensive collection of new techniques for the development of automated, high-throughput screening systems for pharmacological evaluation, the use of various patch-clamp configurations together with novel molecular biological and imaging methodologies, and enhanced stimulation protocols and perfusion systems. Divided into sections on pharmacology, physiology, and biophysics, the chapters cover methods to generate more physiologically relevant conditions for drug application and screening technologies, recently developed applications such as optogenetic stimulation, advances in whole-cell recordings in freely-moving animals, and novel technologies to create custom microelectrodes designed for reducing the access resistance and improving the rate of molecular diffusion. Patch-clamp is an indispensable technique for conducting pharmacological, physiological and biophysical research aimed at understanding crucial aspects of cellular and network function. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Patch -Clamp Methods and Protocols, Second Edition will provide a useful technical and methodological guide to diverse audiences of electrophysiologists, from students to experienced investigators Biomedicine Neurosciences Human Physiology Medicine Human physiology Patch-Clamp-Methode (DE-588)4279564-3 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Patch-Clamp-Methode (DE-588)4279564-3 s 2\p DE-604 Martina, Marzia edt Taverna, Stefano edt Erscheint auch als Druck-Ausgabe 9781493910953 https://doi.org/10.1007/978-1-4939-1096-0 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Patch-Clamp Methods and Protocols Biomedicine Neurosciences Human Physiology Medicine Human physiology Patch-Clamp-Methode (DE-588)4279564-3 gnd |
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| title | Patch-Clamp Methods and Protocols |
| title_auth | Patch-Clamp Methods and Protocols |
| title_exact_search | Patch-Clamp Methods and Protocols |
| title_full | Patch-Clamp Methods and Protocols edited by Marzia Martina, Stefano Taverna |
| title_fullStr | Patch-Clamp Methods and Protocols edited by Marzia Martina, Stefano Taverna |
| title_full_unstemmed | Patch-Clamp Methods and Protocols edited by Marzia Martina, Stefano Taverna |
| title_short | Patch-Clamp Methods and Protocols |
| title_sort | patch clamp methods and protocols |
| topic | Biomedicine Neurosciences Human Physiology Medicine Human physiology Patch-Clamp-Methode (DE-588)4279564-3 gnd |
| topic_facet | Biomedicine Neurosciences Human Physiology Medicine Human physiology Patch-Clamp-Methode Aufsatzsammlung |
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