Platelets and Megakaryocytes: Volume 1: Functional Assays
Platelets are an essential element of the body's hemostasis system, and yet, through their involvement in thrombosis, are also a major cause of morbidity and mortality. Platelets have a limited lifespan and must be continually manufactured by their precursor, the megakaryocyte. In Platelets and...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2004
|
| Schriftenreihe: | Methods In Molecular Biology™
272 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 Volltext |
| Zusammenfassung: | Platelets are an essential element of the body's hemostasis system, and yet, through their involvement in thrombosis, are also a major cause of morbidity and mortality. Platelets have a limited lifespan and must be continually manufactured by their precursor, the megakaryocyte. In Platelets and Megakaryocytes, Volume 1: Functional Assays, leading expert researchers-many responsible for seminal discoveries in the field-describe basic and advanced techniques for analyzing platelet and megakaryocyte function in step-by-step detail. The approaches presented for platelet analysis include aggregometry, secretion, arachidonic acid metabolism, procoagulent response, platelet adhesion under static and flow conditions, flow cytometry, and production of microparticles. Techniques presented for megakaryocyte function research include those used to study the development of specialized structures for platelet production, the appearance of platelet-specific surface receptors, and the increase in ploidy. All protocols follow the successful Methods in Molecular Biology™ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. A companion volume, Platelets and Megakaryocytes, Volume 2: Perspectives and Techniques offers a state-of-the-art survey of our understanding of these cells, with emphasis on the role of cell signaling in their regulation and function, as well as the use of molecular and post-genomic techniques for their study. Comprehensive and cutting-edge, the two volumes of Platelets and Megakaryocytes offer novice and experienced cell biologists, hematologists, and clinicians not only a benchmark survey of the field, but also a comprehensive library of proven techniques essential for productive research on platelets and megakaryocytes today |
| Beschreibung: | 1 Online-Ressource (XIX, 385 p) |
| ISBN: | 9781592597826 |
| DOI: | 10.1385/1592597823 |
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| 520 | |a Platelets are an essential element of the body's hemostasis system, and yet, through their involvement in thrombosis, are also a major cause of morbidity and mortality. Platelets have a limited lifespan and must be continually manufactured by their precursor, the megakaryocyte. In Platelets and Megakaryocytes, Volume 1: Functional Assays, leading expert researchers-many responsible for seminal discoveries in the field-describe basic and advanced techniques for analyzing platelet and megakaryocyte function in step-by-step detail. The approaches presented for platelet analysis include aggregometry, secretion, arachidonic acid metabolism, procoagulent response, platelet adhesion under static and flow conditions, flow cytometry, and production of microparticles. Techniques presented for megakaryocyte function research include those used to study the development of specialized structures for platelet production, the appearance of platelet-specific surface receptors, and the increase in ploidy. All protocols follow the successful Methods in Molecular Biology™ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. A companion volume, Platelets and Megakaryocytes, Volume 2: Perspectives and Techniques offers a state-of-the-art survey of our understanding of these cells, with emphasis on the role of cell signaling in their regulation and function, as well as the use of molecular and post-genomic techniques for their study. Comprehensive and cutting-edge, the two volumes of Platelets and Megakaryocytes offer novice and experienced cell biologists, hematologists, and clinicians not only a benchmark survey of the field, but also a comprehensive library of proven techniques essential for productive research on platelets and megakaryocytes today | ||
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| spelling | Platelets and Megakaryocytes Volume 1: Functional Assays edited by Jonathan M. Gibbins, Martyn P. Mahaut-Smith Totowa, NJ Humana Press 2004 1 Online-Ressource (XIX, 385 p) txt rdacontent c rdamedia cr rdacarrier Methods In Molecular Biology™ 272 Platelets are an essential element of the body's hemostasis system, and yet, through their involvement in thrombosis, are also a major cause of morbidity and mortality. Platelets have a limited lifespan and must be continually manufactured by their precursor, the megakaryocyte. In Platelets and Megakaryocytes, Volume 1: Functional Assays, leading expert researchers-many responsible for seminal discoveries in the field-describe basic and advanced techniques for analyzing platelet and megakaryocyte function in step-by-step detail. The approaches presented for platelet analysis include aggregometry, secretion, arachidonic acid metabolism, procoagulent response, platelet adhesion under static and flow conditions, flow cytometry, and production of microparticles. Techniques presented for megakaryocyte function research include those used to study the development of specialized structures for platelet production, the appearance of platelet-specific surface receptors, and the increase in ploidy. All protocols follow the successful Methods in Molecular Biology™ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. A companion volume, Platelets and Megakaryocytes, Volume 2: Perspectives and Techniques offers a state-of-the-art survey of our understanding of these cells, with emphasis on the role of cell signaling in their regulation and function, as well as the use of molecular and post-genomic techniques for their study. Comprehensive and cutting-edge, the two volumes of Platelets and Megakaryocytes offer novice and experienced cell biologists, hematologists, and clinicians not only a benchmark survey of the field, but also a comprehensive library of proven techniques essential for productive research on platelets and megakaryocytes today Medicine & Public Health Hematology Medicine Megakaryozyt (DE-588)4169265-2 gnd rswk-swf Thrombozyt (DE-588)4059964-4 gnd rswk-swf Labortechnik (DE-588)4123602-6 gnd rswk-swf Megakaryozyt (DE-588)4169265-2 s Thrombozyt (DE-588)4059964-4 s Labortechnik (DE-588)4123602-6 s b DE-604 Gibbins, Jonathan M. edt Mahaut-Smith, Martyn P. edt Erscheint auch als Druck-Ausgabe 9781588291011 https://doi.org/10.1385/1592597823 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Platelets and Megakaryocytes Volume 1: Functional Assays Medicine & Public Health Hematology Medicine Megakaryozyt (DE-588)4169265-2 gnd Thrombozyt (DE-588)4059964-4 gnd Labortechnik (DE-588)4123602-6 gnd |
| subject_GND | (DE-588)4169265-2 (DE-588)4059964-4 (DE-588)4123602-6 |
| title | Platelets and Megakaryocytes Volume 1: Functional Assays |
| title_auth | Platelets and Megakaryocytes Volume 1: Functional Assays |
| title_exact_search | Platelets and Megakaryocytes Volume 1: Functional Assays |
| title_full | Platelets and Megakaryocytes Volume 1: Functional Assays edited by Jonathan M. Gibbins, Martyn P. Mahaut-Smith |
| title_fullStr | Platelets and Megakaryocytes Volume 1: Functional Assays edited by Jonathan M. Gibbins, Martyn P. Mahaut-Smith |
| title_full_unstemmed | Platelets and Megakaryocytes Volume 1: Functional Assays edited by Jonathan M. Gibbins, Martyn P. Mahaut-Smith |
| title_short | Platelets and Megakaryocytes |
| title_sort | platelets and megakaryocytes volume 1 functional assays |
| title_sub | Volume 1: Functional Assays |
| topic | Medicine & Public Health Hematology Medicine Megakaryozyt (DE-588)4169265-2 gnd Thrombozyt (DE-588)4059964-4 gnd Labortechnik (DE-588)4123602-6 gnd |
| topic_facet | Medicine & Public Health Hematology Medicine Megakaryozyt Thrombozyt Labortechnik |
| url | https://doi.org/10.1385/1592597823 |
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