G-Quadruplex DNA: Methods and Protocols
Recent work has revealed that stabilizing G-quadruplexes in telomeric DNA inhibits telomerase activity, providing impetus for the development of G-quartet-interacting drugs, while G-quartet-containing oligonucleotides have been recognized as a potent class of aptamers effective against STAT3 and oth...
Gespeichert in:
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2010
|
| Schriftenreihe: | Methods in Molecular Biology, Methods and Protocols
608 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 Volltext |
| Zusammenfassung: | Recent work has revealed that stabilizing G-quadruplexes in telomeric DNA inhibits telomerase activity, providing impetus for the development of G-quartet-interacting drugs, while G-quartet-containing oligonucleotides have been recognized as a potent class of aptamers effective against STAT3 and other transcription factors implicated in oncogenesis, proving these guanine-quartets to be a vital and rich area for future study. In G-Quadruplex DNA: Methods and Protocols, experts in the field present a collection of detailed techniques for studying G-quartet formation, dynamics, and molecular recognition. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, G-Quadruplex DNA: Methods and Protocols promises to be a useful resource for those familiar with G-quartets as well as an easy entry point for those researchers from diverse fields who are just developing an interest in the exciting implications of G-quadruplex DNA. |
| Beschreibung: | 1 Online-Ressource (XII, 276 p. 65 illus., 2 illus. in color) |
| ISBN: | 9781597453639 |
| DOI: | 10.1007/978-1-59745-363-9 |
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| institution | BVB |
| isbn | 9781597453639 |
| language | English |
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| spelling | G-Quadruplex DNA Methods and Protocols edited by Peter Baumann Totowa, NJ Humana Press 2010 1 Online-Ressource (XII, 276 p. 65 illus., 2 illus. in color) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology, Methods and Protocols 608 Recent work has revealed that stabilizing G-quadruplexes in telomeric DNA inhibits telomerase activity, providing impetus for the development of G-quartet-interacting drugs, while G-quartet-containing oligonucleotides have been recognized as a potent class of aptamers effective against STAT3 and other transcription factors implicated in oncogenesis, proving these guanine-quartets to be a vital and rich area for future study. In G-Quadruplex DNA: Methods and Protocols, experts in the field present a collection of detailed techniques for studying G-quartet formation, dynamics, and molecular recognition. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, G-Quadruplex DNA: Methods and Protocols promises to be a useful resource for those familiar with G-quartets as well as an easy entry point for those researchers from diverse fields who are just developing an interest in the exciting implications of G-quadruplex DNA. Life Sciences Biochemistry, general Cell Biology Human Genetics Life sciences Human genetics Biochemistry Cell biology Baumann, Peter edt Erscheint auch als Druck-Ausgabe 9781588299505 https://doi.org/10.1007/978-1-59745-363-9 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | G-Quadruplex DNA Methods and Protocols Life Sciences Biochemistry, general Cell Biology Human Genetics Life sciences Human genetics Biochemistry Cell biology |
| title | G-Quadruplex DNA Methods and Protocols |
| title_auth | G-Quadruplex DNA Methods and Protocols |
| title_exact_search | G-Quadruplex DNA Methods and Protocols |
| title_full | G-Quadruplex DNA Methods and Protocols edited by Peter Baumann |
| title_fullStr | G-Quadruplex DNA Methods and Protocols edited by Peter Baumann |
| title_full_unstemmed | G-Quadruplex DNA Methods and Protocols edited by Peter Baumann |
| title_short | G-Quadruplex DNA |
| title_sort | g quadruplex dna methods and protocols |
| title_sub | Methods and Protocols |
| topic | Life Sciences Biochemistry, general Cell Biology Human Genetics Life sciences Human genetics Biochemistry Cell biology |
| topic_facet | Life Sciences Biochemistry, general Cell Biology Human Genetics Life sciences Human genetics Biochemistry Cell biology |
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