Posttranslational Modifications of Proteins: Tools for Functional Proteomics
The majority of all proteins undergo posttranslational modifications that significantly alter their physical and chemical properties, including their folding and conformation distribution, their stability, and, consequently, their activity and function. In Posttranslational Modifications of Proteins...
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2002
|
| Schriftenreihe: | Methods in Molecular Biology™
194 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 Volltext |
| Zusammenfassung: | The majority of all proteins undergo posttranslational modifications that significantly alter their physical and chemical properties, including their folding and conformation distribution, their stability, and, consequently, their activity and function. In Posttranslational Modifications of Proteins: Tools for Functional Proteomics, Christoph Kannicht and a panel of highly experienced researchers describe readily reproducible methods for detecting and analyzing the most important of these modifications, particularly with regard to protein function, proteome research, and the characterization of pharmaceutical proteins. Among the methods presented are those for analyzing the assignment of disulfide bond sites in proteins, protein N-glycosylation and protein O-glycosylation, and oligosaccharides present at specific single glycosylation sites in a protein. Additional powerful techniques facilitate the analysis of glycosylphosphatidylinositols, lipid modifications, protein phosphorylation and sulfation, protein methylation and acetylation, a-amidation, g-glutamate, isoaspartate, and lysine hydroxylation. Comprehensive and state-of-the-art, Posttranslational Modifications of Proteins: Tools for Functional Proteomics serves as a highly practical guide for all investigators of protein structure-function relationships not only in chemical and pharmaceutical research, but also throughout the rapidly growing field of functional proteomics |
| Beschreibung: | 1 Online-Ressource (XI, 322 p. 19 illus) |
| ISBN: | 9781592591817 |
| DOI: | 10.1385/1592591817 |
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| spelling | Posttranslational Modifications of Proteins Tools for Functional Proteomics edited by Christoph Kannicht Totowa, NJ Humana Press 2002 1 Online-Ressource (XI, 322 p. 19 illus) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology™ 194 The majority of all proteins undergo posttranslational modifications that significantly alter their physical and chemical properties, including their folding and conformation distribution, their stability, and, consequently, their activity and function. In Posttranslational Modifications of Proteins: Tools for Functional Proteomics, Christoph Kannicht and a panel of highly experienced researchers describe readily reproducible methods for detecting and analyzing the most important of these modifications, particularly with regard to protein function, proteome research, and the characterization of pharmaceutical proteins. Among the methods presented are those for analyzing the assignment of disulfide bond sites in proteins, protein N-glycosylation and protein O-glycosylation, and oligosaccharides present at specific single glycosylation sites in a protein. Additional powerful techniques facilitate the analysis of glycosylphosphatidylinositols, lipid modifications, protein phosphorylation and sulfation, protein methylation and acetylation, a-amidation, g-glutamate, isoaspartate, and lysine hydroxylation. Comprehensive and state-of-the-art, Posttranslational Modifications of Proteins: Tools for Functional Proteomics serves as a highly practical guide for all investigators of protein structure-function relationships not only in chemical and pharmaceutical research, but also throughout the rapidly growing field of functional proteomics Life Sciences Cell Biology Life sciences Cell biology Proteine (DE-588)4076388-2 gnd rswk-swf Proteomanalyse (DE-588)4596545-6 gnd rswk-swf Labortechnik (DE-588)4123602-6 gnd rswk-swf Posttranslationale Änderung (DE-588)4204069-3 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Proteomanalyse (DE-588)4596545-6 s Posttranslationale Änderung (DE-588)4204069-3 s DE-604 Proteine (DE-588)4076388-2 s Labortechnik (DE-588)4123602-6 s 2\p DE-604 Kannicht, Christoph edt Erscheint auch als Druck-Ausgabe 9780896036789 https://doi.org/10.1385/1592591817 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Posttranslational Modifications of Proteins Tools for Functional Proteomics Life Sciences Cell Biology Life sciences Cell biology Proteine (DE-588)4076388-2 gnd Proteomanalyse (DE-588)4596545-6 gnd Labortechnik (DE-588)4123602-6 gnd Posttranslationale Änderung (DE-588)4204069-3 gnd |
| subject_GND | (DE-588)4076388-2 (DE-588)4596545-6 (DE-588)4123602-6 (DE-588)4204069-3 (DE-588)4143413-4 |
| title | Posttranslational Modifications of Proteins Tools for Functional Proteomics |
| title_auth | Posttranslational Modifications of Proteins Tools for Functional Proteomics |
| title_exact_search | Posttranslational Modifications of Proteins Tools for Functional Proteomics |
| title_full | Posttranslational Modifications of Proteins Tools for Functional Proteomics edited by Christoph Kannicht |
| title_fullStr | Posttranslational Modifications of Proteins Tools for Functional Proteomics edited by Christoph Kannicht |
| title_full_unstemmed | Posttranslational Modifications of Proteins Tools for Functional Proteomics edited by Christoph Kannicht |
| title_short | Posttranslational Modifications of Proteins |
| title_sort | posttranslational modifications of proteins tools for functional proteomics |
| title_sub | Tools for Functional Proteomics |
| topic | Life Sciences Cell Biology Life sciences Cell biology Proteine (DE-588)4076388-2 gnd Proteomanalyse (DE-588)4596545-6 gnd Labortechnik (DE-588)4123602-6 gnd Posttranslationale Änderung (DE-588)4204069-3 gnd |
| topic_facet | Life Sciences Cell Biology Life sciences Cell biology Proteine Proteomanalyse Labortechnik Posttranslationale Änderung Aufsatzsammlung |
| url | https://doi.org/10.1385/1592591817 |
| work_keys_str_mv | AT kannichtchristoph posttranslationalmodificationsofproteinstoolsforfunctionalproteomics |