Tumor Suppressor Genes: Volume 2 Regulation, Function, and Medicinal Applications
Powerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. In Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications, leading physician scientists a...
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2003
|
| Schriftenreihe: | Methods in Molecular Biology™
223 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 Volltext |
| Zusammenfassung: | Powerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. In Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications, leading physician scientists and researchers explore the cell biology and biochemical function of the tumor suppressor genes, as well as their physiological role in vivo. The authors detail the physical methods-NMR, microarray approaches, posttranslational structure analysis, analysis of regulation at the gene expression and protein signaling levels-used to understand the function of tumor suppressor genes. In vivo approaches discussed include studies in yeast, Drosophila, mice, and human tumors. The authors also discuss how one ultimately derives a "tumor progression model," the drug discovery process, and the weaknesses of cancers that allow drugs to selectively kill them. Other aspects reviewed include screening strategies, targeting the blood supply of tumors, and the replacement of defective cancer genes to achieve a therapeutic effect. The companion volume of this set, Tumor Suppressor Genes, Volume 1: Pathways and Isolation Strategies, covers all known tumor suppressor genes, describing their cellular signaling pathways, how they were discovered, how they can be analyzed, and how they can be optimally used in cancer therapeutics Comprehensive and authoritative, the two volumes of Tumor Suppressor Genes provide an unparalleled compilation of key data on all known tumor suppressor pathways and a treasury of techniques for their discovery, analysis, and uses in cancer therapeutics |
| Beschreibung: | 1 Online-Ressource (XIX, 657 p) |
| ISBN: | 9781592593293 |
| DOI: | 10.1385/1592593291 |
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| 520 | |a Powerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. In Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications, leading physician scientists and researchers explore the cell biology and biochemical function of the tumor suppressor genes, as well as their physiological role in vivo. The authors detail the physical methods-NMR, microarray approaches, posttranslational structure analysis, analysis of regulation at the gene expression and protein signaling levels-used to understand the function of tumor suppressor genes. In vivo approaches discussed include studies in yeast, Drosophila, mice, and human tumors. The authors also discuss how one ultimately derives a "tumor progression model," the drug discovery process, and the weaknesses of cancers that allow drugs to selectively kill them. Other aspects reviewed include screening strategies, targeting the blood supply of tumors, and the replacement of defective cancer genes to achieve a therapeutic effect. The companion volume of this set, Tumor Suppressor Genes, Volume 1: Pathways and Isolation Strategies, covers all known tumor suppressor genes, describing their cellular signaling pathways, how they were discovered, how they can be analyzed, and how they can be optimally used in cancer therapeutics Comprehensive and authoritative, the two volumes of Tumor Suppressor Genes provide an unparalleled compilation of key data on all known tumor suppressor pathways and a treasury of techniques for their discovery, analysis, and uses in cancer therapeutics | ||
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| spelling | Tumor Suppressor Genes Volume 2 Regulation, Function, and Medicinal Applications edited by Wafik S. El-Deiry Totowa, NJ Humana Press 2003 1 Online-Ressource (XIX, 657 p) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology™ 223 Powerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. In Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications, leading physician scientists and researchers explore the cell biology and biochemical function of the tumor suppressor genes, as well as their physiological role in vivo. The authors detail the physical methods-NMR, microarray approaches, posttranslational structure analysis, analysis of regulation at the gene expression and protein signaling levels-used to understand the function of tumor suppressor genes. In vivo approaches discussed include studies in yeast, Drosophila, mice, and human tumors. The authors also discuss how one ultimately derives a "tumor progression model," the drug discovery process, and the weaknesses of cancers that allow drugs to selectively kill them. Other aspects reviewed include screening strategies, targeting the blood supply of tumors, and the replacement of defective cancer genes to achieve a therapeutic effect. The companion volume of this set, Tumor Suppressor Genes, Volume 1: Pathways and Isolation Strategies, covers all known tumor suppressor genes, describing their cellular signaling pathways, how they were discovered, how they can be analyzed, and how they can be optimally used in cancer therapeutics Comprehensive and authoritative, the two volumes of Tumor Suppressor Genes provide an unparalleled compilation of key data on all known tumor suppressor pathways and a treasury of techniques for their discovery, analysis, and uses in cancer therapeutics Medicine & Public Health Oncology Medicine Tumorsuppressor-Gen (DE-588)4326903-5 gnd rswk-swf Labortechnik (DE-588)4123602-6 gnd rswk-swf Tumorsuppressor-Gen (DE-588)4326903-5 s Labortechnik (DE-588)4123602-6 s DE-604 El-Deiry, Wafik S. edt Erscheint auch als Druck-Ausgabe 9780896039872 https://doi.org/10.1385/1592593291 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Tumor Suppressor Genes Volume 2 Regulation, Function, and Medicinal Applications Medicine & Public Health Oncology Medicine Tumorsuppressor-Gen (DE-588)4326903-5 gnd Labortechnik (DE-588)4123602-6 gnd |
| subject_GND | (DE-588)4326903-5 (DE-588)4123602-6 |
| title | Tumor Suppressor Genes Volume 2 Regulation, Function, and Medicinal Applications |
| title_auth | Tumor Suppressor Genes Volume 2 Regulation, Function, and Medicinal Applications |
| title_exact_search | Tumor Suppressor Genes Volume 2 Regulation, Function, and Medicinal Applications |
| title_full | Tumor Suppressor Genes Volume 2 Regulation, Function, and Medicinal Applications edited by Wafik S. El-Deiry |
| title_fullStr | Tumor Suppressor Genes Volume 2 Regulation, Function, and Medicinal Applications edited by Wafik S. El-Deiry |
| title_full_unstemmed | Tumor Suppressor Genes Volume 2 Regulation, Function, and Medicinal Applications edited by Wafik S. El-Deiry |
| title_short | Tumor Suppressor Genes |
| title_sort | tumor suppressor genes volume 2 regulation function and medicinal applications |
| title_sub | Volume 2 Regulation, Function, and Medicinal Applications |
| topic | Medicine & Public Health Oncology Medicine Tumorsuppressor-Gen (DE-588)4326903-5 gnd Labortechnik (DE-588)4123602-6 gnd |
| topic_facet | Medicine & Public Health Oncology Medicine Tumorsuppressor-Gen Labortechnik |
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