Tandem Repeats in Genes, Proteins, and Disease: Methods and Protocols
The genomes of humans, as well as many other species, are interspersed with hundreds of thousands of tandem repeats of DNA sequences. Those tandem repeats located as codons within open reading frames encode amino acid runs, such as polyglutamine and polyalanine. Tandem repeats have not only been i...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2013
|
| Schriftenreihe: | Methods in Molecular Biology, Methods and Protocols
1017 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 Volltext |
| Zusammenfassung: | The genomes of humans, as well as many other species, are interspersed with hundreds of thousands of tandem repeats of DNA sequences. Those tandem repeats located as codons within open reading frames encode amino acid runs, such as polyglutamine and polyalanine. Tandem repeats have not only been implicated in biological evolution, development and function but also in a large collection of human disorders. In Tandem Repeats in Genes, Proteins, and Disease: Methods and Protocols, expert researchers in the field detail many methods covering the analysis of tandem repeats in DNA, RNA and protein, in healthy and diseased states. This will include molecular genetics, molecular biology, biochemistry, proteomics, biophysics, cell biology, and molecular and cellular approaches to animal models of tandem repeat disorders. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoratative and Practical, Tandem Repeats in Genes, Proteins, and Disease: Methods and Protocols aids scientists in continuing to study the unique methodological challenges that come from repetitive DNA and poly-amino acid sequences |
| Beschreibung: | 1 Online-Ressource (XI, 258 p. 55 illus., 23 illus. in color) |
| ISBN: | 9781627034388 |
| DOI: | 10.1007/978-1-62703-438-8 |
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| spelling | Tandem Repeats in Genes, Proteins, and Disease Methods and Protocols edited by Danny M. Hatters, Anthony J. Hannan Totowa, NJ Humana Press 2013 1 Online-Ressource (XI, 258 p. 55 illus., 23 illus. in color) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology, Methods and Protocols 1017 The genomes of humans, as well as many other species, are interspersed with hundreds of thousands of tandem repeats of DNA sequences. Those tandem repeats located as codons within open reading frames encode amino acid runs, such as polyglutamine and polyalanine. Tandem repeats have not only been implicated in biological evolution, development and function but also in a large collection of human disorders. In Tandem Repeats in Genes, Proteins, and Disease: Methods and Protocols, expert researchers in the field detail many methods covering the analysis of tandem repeats in DNA, RNA and protein, in healthy and diseased states. This will include molecular genetics, molecular biology, biochemistry, proteomics, biophysics, cell biology, and molecular and cellular approaches to animal models of tandem repeat disorders. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoratative and Practical, Tandem Repeats in Genes, Proteins, and Disease: Methods and Protocols aids scientists in continuing to study the unique methodological challenges that come from repetitive DNA and poly-amino acid sequences Biomedicine Human Genetics Gene Function Medicine Human genetics Medical genetics Hatters, Danny M. edt Hannan, Anthony J. edt Erscheint auch als Druck-Ausgabe 9781627034371 https://doi.org/10.1007/978-1-62703-438-8 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Tandem Repeats in Genes, Proteins, and Disease Methods and Protocols Biomedicine Human Genetics Gene Function Medicine Human genetics Medical genetics |
| title | Tandem Repeats in Genes, Proteins, and Disease Methods and Protocols |
| title_auth | Tandem Repeats in Genes, Proteins, and Disease Methods and Protocols |
| title_exact_search | Tandem Repeats in Genes, Proteins, and Disease Methods and Protocols |
| title_full | Tandem Repeats in Genes, Proteins, and Disease Methods and Protocols edited by Danny M. Hatters, Anthony J. Hannan |
| title_fullStr | Tandem Repeats in Genes, Proteins, and Disease Methods and Protocols edited by Danny M. Hatters, Anthony J. Hannan |
| title_full_unstemmed | Tandem Repeats in Genes, Proteins, and Disease Methods and Protocols edited by Danny M. Hatters, Anthony J. Hannan |
| title_short | Tandem Repeats in Genes, Proteins, and Disease |
| title_sort | tandem repeats in genes proteins and disease methods and protocols |
| title_sub | Methods and Protocols |
| topic | Biomedicine Human Genetics Gene Function Medicine Human genetics Medical genetics |
| topic_facet | Biomedicine Human Genetics Gene Function Medicine Human genetics Medical genetics |
| url | https://doi.org/10.1007/978-1-62703-438-8 |
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