SELDI-TOF Mass Spectrometry: Methods and Protocols
SELDI is distinct from other TOF-MS technologies in that it couples features of chromatography and mass spectrometry, facilitating analyte enrichment and sample cleanup on an array surface. In the growing field of proteomics, SELDI technology has been widely used for biomarker discovery and characte...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer New York
2012
|
| Schriftenreihe: | Methods in Molecular Biology, Methods and Protocols
818 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 Volltext |
| Zusammenfassung: | SELDI is distinct from other TOF-MS technologies in that it couples features of chromatography and mass spectrometry, facilitating analyte enrichment and sample cleanup on an array surface. In the growing field of proteomics, SELDI technology has been widely used for biomarker discovery and characterization in diverse applications including diagnostics, drug development, and basic research. SELDI-based biomarker studies can typically be divided into four phases: discovery, validation, purification and identification, and assay development. SELDI-TOF Mass Spectrometry: Methods and Protocols provides an overview of the current applications of SELDI-TOF MS (surface enhanced laser desorption/ionization time-of-flight mass spectrometry), with an emphasis on study and experimental design, data analysis and interpretation, and assay development. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, SELDI-TOF Mass Spectrometry: Methods and Protocols will provide information on optimizing study design, experimental protocols, and data analysis and interpretation to yield robust biomarkers and biomarker assays, using examples from different disease areas |
| Beschreibung: | 1 Online-Ressource (X, 239 p. 54 illus., 4 illus. in color) |
| ISBN: | 9781617794186 |
| DOI: | 10.1007/978-1-61779-418-6 |
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| id | DE-604.BV044950584 |
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| indexdate | 2024-07-10T08:05:34Z |
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| isbn | 9781617794186 |
| language | English |
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| spelling | SELDI-TOF Mass Spectrometry Methods and Protocols edited by Charlotte H. Clarke, Diane L. Bankert McCarthy New York, NY Springer New York 2012 1 Online-Ressource (X, 239 p. 54 illus., 4 illus. in color) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology, Methods and Protocols 818 SELDI is distinct from other TOF-MS technologies in that it couples features of chromatography and mass spectrometry, facilitating analyte enrichment and sample cleanup on an array surface. In the growing field of proteomics, SELDI technology has been widely used for biomarker discovery and characterization in diverse applications including diagnostics, drug development, and basic research. SELDI-based biomarker studies can typically be divided into four phases: discovery, validation, purification and identification, and assay development. SELDI-TOF Mass Spectrometry: Methods and Protocols provides an overview of the current applications of SELDI-TOF MS (surface enhanced laser desorption/ionization time-of-flight mass spectrometry), with an emphasis on study and experimental design, data analysis and interpretation, and assay development. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, SELDI-TOF Mass Spectrometry: Methods and Protocols will provide information on optimizing study design, experimental protocols, and data analysis and interpretation to yield robust biomarkers and biomarker assays, using examples from different disease areas Life Sciences Protein Science Spectroscopy/Spectrometry Life sciences Spectroscopy Proteins Clarke, Charlotte H. edt McCarthy, Diane L. Bankert edt Erscheint auch als Druck-Ausgabe 9781617794179 https://doi.org/10.1007/978-1-61779-418-6 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | SELDI-TOF Mass Spectrometry Methods and Protocols Life Sciences Protein Science Spectroscopy/Spectrometry Life sciences Spectroscopy Proteins |
| title | SELDI-TOF Mass Spectrometry Methods and Protocols |
| title_auth | SELDI-TOF Mass Spectrometry Methods and Protocols |
| title_exact_search | SELDI-TOF Mass Spectrometry Methods and Protocols |
| title_full | SELDI-TOF Mass Spectrometry Methods and Protocols edited by Charlotte H. Clarke, Diane L. Bankert McCarthy |
| title_fullStr | SELDI-TOF Mass Spectrometry Methods and Protocols edited by Charlotte H. Clarke, Diane L. Bankert McCarthy |
| title_full_unstemmed | SELDI-TOF Mass Spectrometry Methods and Protocols edited by Charlotte H. Clarke, Diane L. Bankert McCarthy |
| title_short | SELDI-TOF Mass Spectrometry |
| title_sort | seldi tof mass spectrometry methods and protocols |
| title_sub | Methods and Protocols |
| topic | Life Sciences Protein Science Spectroscopy/Spectrometry Life sciences Spectroscopy Proteins |
| topic_facet | Life Sciences Protein Science Spectroscopy/Spectrometry Life sciences Spectroscopy Proteins |
| url | https://doi.org/10.1007/978-1-61779-418-6 |
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