MAP Kinase Signaling Protocols:
Mitogen-activated protein kinase (MAPK) signaling cascades initiate highly significant cellular processes and are involved in a large number of diseases, including cancer and diabetes. In MAP Kinase Signaling Protocols, leading researchers with extensive hands-on experience describe in detail both c...
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2004
|
| Schriftenreihe: | Methods in Molecular Biology™
250 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 URL des Erstveröffentlichers |
| Zusammenfassung: | Mitogen-activated protein kinase (MAPK) signaling cascades initiate highly significant cellular processes and are involved in a large number of diseases, including cancer and diabetes. In MAP Kinase Signaling Protocols, leading researchers with extensive hands-on experience describe in detail both classic and cutting-edge techniques for the detection and measurement of the MAPKs and other components in these cascades. The protocols include methods for the determination of the subcellular localization of these components, the structural and biophysical analysis of the components, and identification of novel components of known and unknown signaling cascades. Additional methods examine the upstream mechanisms of activation of MAPK cascades by various receptors, the mechanisms involved in the downregulation of the MAPK cascades, and identification of targets of the MAPK cascades. A number of techniques use inhibitors in research on MAPK and transgenic mice for studies of MAPK signaling. Each readily reproducible protocol is described in step-by-step detail and includes a background introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and versatile, MAP Kinase Signaling Protocols offers biochemists, cell biologists, physicians, and biotechnologists all the essential laboratory techniques needed to conduct productive studies of MAPK signaling in health and disease, in measuring the influence of drugs, and in a broad range of experimental systems |
| Beschreibung: | 1 Online-Ressource (XII, 332 p) |
| ISBN: | 9781592596713 |
| DOI: | 10.1385/1592596711 |
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| 520 | |a Mitogen-activated protein kinase (MAPK) signaling cascades initiate highly significant cellular processes and are involved in a large number of diseases, including cancer and diabetes. In MAP Kinase Signaling Protocols, leading researchers with extensive hands-on experience describe in detail both classic and cutting-edge techniques for the detection and measurement of the MAPKs and other components in these cascades. The protocols include methods for the determination of the subcellular localization of these components, the structural and biophysical analysis of the components, and identification of novel components of known and unknown signaling cascades. Additional methods examine the upstream mechanisms of activation of MAPK cascades by various receptors, the mechanisms involved in the downregulation of the MAPK cascades, and identification of targets of the MAPK cascades. A number of techniques use inhibitors in research on MAPK and transgenic mice for studies of MAPK signaling. Each readily reproducible protocol is described in step-by-step detail and includes a background introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and versatile, MAP Kinase Signaling Protocols offers biochemists, cell biologists, physicians, and biotechnologists all the essential laboratory techniques needed to conduct productive studies of MAPK signaling in health and disease, in measuring the influence of drugs, and in a broad range of experimental systems | ||
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| spelling | MAP Kinase Signaling Protocols edited by Rony Seger Totowa, NJ Humana Press 2004 1 Online-Ressource (XII, 332 p) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology™ 250 Mitogen-activated protein kinase (MAPK) signaling cascades initiate highly significant cellular processes and are involved in a large number of diseases, including cancer and diabetes. In MAP Kinase Signaling Protocols, leading researchers with extensive hands-on experience describe in detail both classic and cutting-edge techniques for the detection and measurement of the MAPKs and other components in these cascades. The protocols include methods for the determination of the subcellular localization of these components, the structural and biophysical analysis of the components, and identification of novel components of known and unknown signaling cascades. Additional methods examine the upstream mechanisms of activation of MAPK cascades by various receptors, the mechanisms involved in the downregulation of the MAPK cascades, and identification of targets of the MAPK cascades. A number of techniques use inhibitors in research on MAPK and transgenic mice for studies of MAPK signaling. Each readily reproducible protocol is described in step-by-step detail and includes a background introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and versatile, MAP Kinase Signaling Protocols offers biochemists, cell biologists, physicians, and biotechnologists all the essential laboratory techniques needed to conduct productive studies of MAPK signaling in health and disease, in measuring the influence of drugs, and in a broad range of experimental systems Life Sciences Biochemistry, general Life sciences Biochemistry MAP-Kinase (DE-588)4576144-9 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content MAP-Kinase (DE-588)4576144-9 s DE-604 Seger, Rony edt Erscheint auch als Druck-Ausgabe 9780896039988 https://doi.org/10.1385/1592596711 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | MAP Kinase Signaling Protocols Life Sciences Biochemistry, general Life sciences Biochemistry MAP-Kinase (DE-588)4576144-9 gnd |
| subject_GND | (DE-588)4576144-9 (DE-588)4143413-4 |
| title | MAP Kinase Signaling Protocols |
| title_auth | MAP Kinase Signaling Protocols |
| title_exact_search | MAP Kinase Signaling Protocols |
| title_full | MAP Kinase Signaling Protocols edited by Rony Seger |
| title_fullStr | MAP Kinase Signaling Protocols edited by Rony Seger |
| title_full_unstemmed | MAP Kinase Signaling Protocols edited by Rony Seger |
| title_short | MAP Kinase Signaling Protocols |
| title_sort | map kinase signaling protocols |
| topic | Life Sciences Biochemistry, general Life sciences Biochemistry MAP-Kinase (DE-588)4576144-9 gnd |
| topic_facet | Life Sciences Biochemistry, general Life sciences Biochemistry MAP-Kinase Aufsatzsammlung |
| url | https://doi.org/10.1385/1592596711 |
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