Synthetic biology: parts, devices and applications
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Weinheim
Wiley-VCH
[2018]
|
| Schriftenreihe: | Advanced biotechnology
volume 8 |
| Schlagworte: | |
| Online-Zugang: | http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-33075-1/ Inhaltsverzeichnis |
| Beschreibung: | xvi, 409 Seiten Illustrationen, Diagramme |
| ISBN: | 9783527330751 |
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| 084 | |a BIO 120f |2 stub | ||
| 245 | 1 | 0 | |a Synthetic biology |b parts, devices and applications |c edited by Christina Smolke |
| 264 | 1 | |a Weinheim |b Wiley-VCH |c [2018] | |
| 264 | 4 | |c © 2018 | |
| 264 | 4 | |c 2018 | |
| 300 | |a xvi, 409 Seiten |b Illustrationen, Diagramme | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Advanced biotechnology |v volume 8 | |
| 650 | 0 | 7 | |a Synthetische Biologie |0 (DE-588)7684405-5 |2 gnd |9 rswk-swf |
| 653 | |a Biomedical Engineering | ||
| 653 | |a Biomedical Engineering Special Topics | ||
| 653 | |a Biomedizintechnik | ||
| 653 | |a Biotechnologie | ||
| 653 | |a Biotechnologie i. d. Biowissenschaften | ||
| 653 | |a Biotechnologie i. d. Chemie | ||
| 653 | |a Biotechnology | ||
| 653 | |a Biowissenschaften | ||
| 653 | |a Cell & Molecular Biology | ||
| 653 | |a Chemie | ||
| 653 | |a Chemistry | ||
| 653 | |a Life Sciences | ||
| 653 | |a Molecular Bioengineering | ||
| 653 | |a Molekulares Bioengineering | ||
| 653 | |a Spezialthemen Biomedizintechnik | ||
| 653 | |a Synthetische Biologie | ||
| 653 | |a Zell- u. Molekularbiologie | ||
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Synthetische Biologie |0 (DE-588)7684405-5 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Smolke, Christina |0 (DE-588)1160958718 |4 edt | |
| 710 | 2 | |a Wiley-VCH |0 (DE-588)16179388-5 |4 pbl | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, EPDF |z 978-3-527-68808-1 |
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| 830 | 0 | |a Advanced biotechnology |v volume 8 |w (DE-604)BV043302234 |9 8 | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-030298422 | ||
Datensatz im Suchindex
| _version_ | 1804178462467948544 |
|---|---|
| adam_text | V
CONTENTS
ABOUT
THE
SERIES
EDITORS
XV
PART
I
DNA
SYNTHESIS
AND
GENOME
ENGINEERING
1
1
COMPETITION
AND
THE
FUTURE
OF
READING
AND
WRITING
DNA
3
ROBERT
CARLSON
1.1
PRODUCTIVITY
IMPROVEMENTS
IN
BIOLOGICAL
TECHNOLOGIES
3
1.2
THE
ORIGIN
OF
MOORES
LAW
AND
ITS
IMPLICATIONS
FOR
BIOLOGICAL
TECHNOLOGIES
5
1.3
LESSONS
FROM
OTHER
TECHNOLOGIES
6
1.4
PRICING
IMPROVEMENTS
IN
BIOLOGICAL
TECHNOLOGIES
7
1.5
PROSPECTS
FOR
NEW
ASSEMBLY
TECHNOLOGIES
8
1.6
BEYOND
PROGRAMMING
GENETIC
INSTRUCTION
SETS
10
1.7
FUTURE
PROSPECTS
10
REFERENCES
11
2
TRACKABLE
MULTIPLEX
RECOMBINEERING
(TRMR)
AND
NEXT-GENERATION
GENOME
DESIGN
TECHNOLOGIES:
MODIFYING
GENE
EXPRESSION
IN
E.
COLI
BY
INSERTING
SYNTHETIC
DNA
CASSETTES
AND
MOLECULAR
BARCODES
15
EMILY
F.
FREED,
GUR
PINES,
CARRIE
A.
ECKERT,
AND
RYAN
T.
GILL
2.1
INTRODUCTION
15
2.2
CURRENT
RECOMBINEERING
TECHNIQUES
16
2.2.1
RECOMBINEERING
SYSTEMS
17
2.2.2
CURRENT
MODEL
OF
RECOMBINATION
17
2.3
TRACKABLE
MULTIPLEX
RECOMBINEERING
19
2.3.1
TRMR
AND
T
2
RMR
LIBRARY
DESIGN
AND
CONSTRUCTION
19
2.3.2
EXPERIMENTAL
PROCEDURE
23
2.3.3
ANALYSIS
OF
RESULTS
24
2.4
CURRENT
CHALLENGES
25
2.4.1
TRMR
AND
T
2
RMR
ARE
CURRENTLY
NOT
RECURSIVE
26
2.4.2
NEED
FOR
MORE
PREDICTABLE
MODELS
26
2.5
COMPLEMENTING
TECHNOLOGIES
27
2.5.1
MAGE
27
2.5.2
CREATE
27
VI
CONTENTS
2.6
CONCLUSIONS
28
DEFINITIONS
28
REFERENCES
29
3
SITE-DIRECTED
GENOME
MODIFICATION
WITH
ENGINEERED
ZINC
FINGER
PROTEINS
33
LAUREN
E.
WOODARD,
DANIEL
L.
GALVAN,
AND
MATTHEW
H.
WILSON
3.1
INTRODUCTION
TO
ZINC
FINGER
DNA-BINDING
DOMAINS
AND
CELLULAR
REPAIR
MECHANISMS
33
3.1.1
3.1.2
3.1.3
3.2
ZINC
FINGER
PROTEINS
33
HOMOLOGOUS
RECOMBINATION
34
^SON-HOMOLOGOUS
END
JOINING
35
APPROACHES
FOR
ENGINEERING
OR
ACQUIRING
ZINC
FINGER
PROTEINS
36
3.2.1
3.2.2
3.2.3
3.3
3.4
MODULAR
ASSEMBLY
37
OPEN
AND
CODA
SELECTION
SYSTEMS
37
PURCHASE
VIA
COMMERCIAL
AVENUES
38
GENOME
MODIFICATION
WITH
ZINC
FINGER
NUCLEASES
38
VALIDATING
ZINC
FINGER
NUCLEASE-INDUCED
GENOME
ALTERATION
AND
SPECIFICITY
40
3.5
METHODS
FOR
DELIVERING
ENGINEERED
ZINC
FINGER
NUCLEASES
INTO
CELLS
41
3.6
3.7
ZINC
FINGER
FUSIONS
TO
TRANSPOSASES
AND
RECOMBINASES
41
CONCLUSIONS
42
REFERENCES
43
4
RATIONAL
EFFORTS
TO
STREAMLINE
THE
ESCHERICHIA
COLI
GENOME
49
GABRIELLA
BALIKO,
VIKTOR
VERNYIK,
LLDIKO
KARCAGI,
ZSUZSANNA
GYORFY,
GABOR
DRASKOVITS,
TAMAS
FEHER,
AND
GYORGY
POSFAI
4.1
4.2
4.3
4.4
4.5
4.5.1
4.5.1.1
4.5.1.2
4.5.1.3
4.5.1.4
4.5.1.5
4.5.2
4.5.2.1
4.5.2.2
4.5.2.3
INTRODUCTION
49
THE
CONCEPT OF
A
STREAMLINED
CHASSIS
50
THE
E.
COLI
GENOME
51
RANDOM
VERSUS
TARGETED
STREAMLINING
54
SELECTING
DELETION
TARGETS
55
GENERAL
CONSIDERATIONS
55
NATURALLY
EVOLVED
MINIMAL
GENOMES
55
GENE
ESSENTIALITY
STUDIES
55
COMPARATIVE
GENOMICS
56
IN
SILICO
MODELS
56
ARCHITECTURAL
STUDIES
56
PRIMARY
DELETION
TARGETS
57
PROPHAGES
57
INSERTION
SEQUENCES
(ISS)
57
DEFENSE
SYSTEMS
57
CONTENTS
VII
4.5.2.4
4.5.2.5
4.5.2.6
4.5.2.?
4.S.2.8
4.6
4.6.1
4.6.2
4.6.2.1
4.6.2.2
4.6.2.S
4.6.2.4
4.7
4.7.1
GENES
OF
UNKNOWN
AND
EXOTIC
FUNCTIONS
58
REPEAT
SEQUENCES
58
VIRULENCE
FACTORS
AND
SURFACE
STRUCTURES
58
GENETIC
DIVERSITY-GENERATING
FACTORS
59
REDUNDANT
AND
OVERLAPPING FUNCTIONS
59
TARGETED
DELETION
TECHNIQUES
59
GENERAL
CONSIDERATIONS
59
BASIC
METHODS
AND
STRATEGIES
60
CIRCULAR
DNA-BASED
METHOD
60
LINEAR
DNA-BASED
METHOD
62
STRATEGY
FOR
PILING
DELETIONS
62
NEW
VARIATIONS
ON
DELETION
CONSTRUCTION
63
GENOME-REDUCING
EFFORTS
AND THE
IMPACT OF
STREAMLINING
64
COMPARATIVE
GENOMICS-BASED GENOME
STABILIZATION
AND
IMPROVEMENT
64
4.7.2
4.7.3
4.7.4
4.8
4.8.1
4.8.2
4.8.3
4.8.4
4.8.5
4.9
GENOME
REDUCTION
BASED
ON
GENE
ESSENTIALITY
66
COMPLEX
STREAMLINING
EFFORTS
BASED
ON
GROWTH
PROPERTIES
67
ADDITIONAL
GENOME
REDUCTION
STUDIES
68
SELECTED
RESEARCH APPLICATIONS
OF
STREAMLINED-GENOME
E,
COLI
68
TESTING
GENOME
STREAMLINING
HYPOTHESES
68
MOBILE
GENETIC
ELEMENTS,
MUTATIONS,
AND
EVOLUTION
69
GENE
FUNCTION
AND
NETWORK
REGULATION
69
CODON
REASSIGNMENT
70
GENOME
ARCHITECTURE
70
CONCLUDING
REMARKS,
CHALLENGES,
AND
FUTURE
DIRECTIONS
71
REFERENCES
73
5
FUNCTIONAL
REQUIREMENTS
IN
THE
PROGRAM
AND
THE
CELL
CHASSIS
FOR
NEXT-GENERATION
SYNTHETIC
BIOLOGY
81
ANTOINE
DANCHIN,
AGNIESZKA
SEKOWSKA,
AND
STANISLAS
NORIA
5.1
A
PREREQUISITE
TO
SYNTHETIC
BIOLOGY:
AN
ENGINEERING
DEFINITION
OF
WHAT
LIFE
IS
81
5.2
5.3
5.4
5.4.1
FUNCTIONAL
ANALYSIS:
MASTER
FUNCTION
AND
HELPER
FUNCTIONS
83
A
LIFE-SPECIFIC
MASTER
FUNCTION:
BUILDING
UP
A
PROGENY
85
HELPER
FUNCTIONS
86
MATTER:
BUILDING
BLOCKS
AND
STRUCTURES
(WITH
EMPHASIS
ON
DNA)
87
5.4.2
5.4.3
5.4.4
5.4.5
5.5
ENERGY
91
MANAGING
SPACE
92
TIME
95
INFORMATION
96
CONCLUSION
97
ACKNOWLEDGMENTS
98
REFERENCES
98
VIII
CONTENTS
PART
II
PARTS
AND
DEVICES
SUPPORTING
CONTROL
OF
PROTEIN
EXPRESSION
AND
ACTIVITY
107
6
CONSTITUTIVE
AND
REGULATED
PROMOTERS
IN
YEAST:
HOW
TO
DESIGN
AND
MAKE
USE
OF
PROMOTERS
IN
S.
CEREVISIAE
109
DIANA
5.
M.
OTTOZ
AND
FABIAN
RUDOLF
6.1
6.2
6.3
6.3.1
6.3.2
6.4
6.4.1
6.4.2
6.5
INTRODUCTION
109
YEAST
PROMOTERS
110
NATURAL
YEAST
PROMOTERS
113
REGULATED
PROMOTERS
113
CONSTITUTIVE
PROMOTERS
115
SYNTHETIC
YEAST
PROMOTERS
116
MODIFIED
NATURAL
PROMOTERS
116
SYNTHETIC
HYBRID
PROMOTERS
117
CONCLUSIONS
121
DEFINITIONS
122
REFERENCES
122
7
SPLICING
AND
ALTERNATIVE
SPLICING
IMPACT
ON
GENE
DESIGN
131
BEATRIX
SUESS,
KATRIN
KEMMERER,
AND
JULIA
E.
WEIGAND
7.1
7.2
7.2.1
7.2.2
7.2.3
THE
DISCOVERY
OF
SPLIT
GENES
*
131
NUCLEAR
PRE-MRNA
SPLICING
IN
MAMMALS
132
INTRONS
AND
EXONS:
A
DEFINITION
132
THE
CATALYTIC
MECHANISM
OF
SPLICING
132
A
COMPLEX
MACHINERY
TO
REMOVE
NUCLEAR INTRONS:
THE
SPLICEOSOME
132
7.2.4
7.3
7.3.1
7.4
7.4.1
7.4.2
7.5
7.5.1
7.5.2
7.5.3
7.5.4
7.5.5
7.5.6
7.6
7.6.1
7.6.2
7.6.3
7.7
7.7.1
7.7.2
EXON
DEFINITION
134
SPLICING
IN
YEAST
135
ORGANIZATION
AND DISTRIBUTION OF
YEAST
INTRONS
135
SPLICING
WITHOUT
THE
SPLICEOSOME
136
GROUP
I
AND
GROUP
II
SELF-SPLICING
INTRONS
136
TRNA
SPLICING
137
ALTERNATIVE
SPLICING
IN
MAMMALS
137
DIFFERENT
MECHANISMS
OF
ALTERNATIVE
SPLICING
137
AUXILIARY
REGULATORY
ELEMENTS
139
MECHANISMS
OF
SPLICING
REGULATION
140
TRANSCRIPTION-COUPLED
ALTERNATIVE
SPLICING
142
ALTERNATIVE
SPLICING
AND
NONSENSE-MEDIATED
DECAY
143
ALTERNATIVE
SPLICING
AND
DISEASE
144
CONTROLLED
SPLICING
IN
S.
CEREVISIAE
145
ALTERNATIVE
SPLICING
145
REGULATED
SPLICING
146
FUNCTION
OF
SPLICING
IN
S.
CEREVISIAE
147
SPLICING
REGULATION
BY
RIBOSWITCHES
147
REGULATION
OF
GROUP
I
INTRON
SPLICING
IN
BACTERIA
148
REGULATION
OF
ALTERNATIVE
SPLICING
BY
RIBOSWITCHES
IN
EUKARYOTES
148
CONTENTS
IX
7.8
7.8.1
7.8.2
7.9
SPLICING
AND
SYNTHETIC
BIOLOGY
150
IMPACT
OF
INTRONS
ON
GENE
EXPRESSION
150
CONTROL
OF
SPLICING
BY
ENGINEERED
RNA-BASED
DEVICES
151
CONCLUSION
153
ACKNOWLEDGMENTS
153
DEFINITIONS
153
REFERENCES
153
8
DESIGN
OF
LIGAND-CONTROLLED
GENETIC
SWITCHES
BASED
ON
RNA
INTERFERENCE
169
SHUNNICHI
KASHIDA
AND
HIROHIDE
SAITO
8.1
UTILITY
OF
THE
RNAI
PATHWAY
FOR
APPLICATION
IN
MAMMALIAN
CELLS
169
8.2
DEVELOPMENT
OF
RNAI
SWITCHES
THAT
RESPOND
TO
TRIGGER
MOLECULES
170
8.2.1
8.2.2
8.2.3
8.3
8.4
8.5
SMALL
MOLECULE-TRIGGERED
RNAI
SWITCHES
171
OLIGONUCLEOTIDE-TRIGGERED
RNAI
SWITCHES
173
PROTEIN-TRIGGERED
RNAI
SWITCHES
174
RATIONAL
DESIGN
OF
FUNCTIONAL
RNAI
SWITCHES
174
APPLICATION
OF
THE
RNAI
SWITCHES
175
FUTURE
PERSPECTIVES
177
DEFINITIONS
178
REFERENCES
178
9
SMALL
MOLECULE-RESPONSIVE
RNA
SWITCHES
(BACTERIA):
IMPORTANT
ELEMENT
OF
PROGRAMMING
GENE
EXPRESSION
IN
RESPONSE
TO
ENVIRONMENTAL
SIGNALS
IN
BACTERIA
181
YOHEI
YOKOBAYASHI
9.1
9.2
9.2.1
9.2.2
9.2.3
9.3
9.3.1
9.3.2
9.4
9.5
INTRODUCTION
181
DESIGN
STRATEGIES
181
APTAMERS
181
SCREENING
AND
GENETIC
SELECTION
182
RATIONAL
DESIGN
183
MECHANISMS
183
TRANSLATIONAL
REGULATION
183
TRANSCRIPTIONAL
REGULATION
184
COMPLEX
RIBOSWITCHES
185
CONCLUSIONS
185
KEYWORDS
WITH
DEFINITIONS
185
REFERENCES
186
10
PROGRAMMING
GENE
EXPRESSION
BY
ENGINEERING
TRANSCRIPT
STABILITY
CONTROL
AND
PROCESSING
IN
BACTERIA
189
JASON
T.
STEVENS
AND
JAMES
M.
CAROTHERS
10.1
10.1.1
10.1.2
AN
INTRODUCTION
TO
TRANSCRIPT
CONTROL
189
WHY
CONSIDER
TRANSCRIPT
CONTROL?
189
THE
RNA
DEGRADATION
PROCESS
IN
E.
COLI
190
X
I
CONTENTS
10.1.3
THE
EFFECTS
OF
TRANSLATION
ON
TRANSCRIPT
STABILITY
192
10.1.4
STRUCTURAL
AND
NONCODING
RNA-MEDIATED
TRANSCRIPT
CONTROL
193
10.1.5
POLYADENYLATION
AND
TRANSCRIPT
STABILITY
195
10.2
SYNTHETIC
CONTROL
OF
TRANSCRIPT
STABILITY
195
10.2.1
TRANSCRIPT
STABILITY
CONTROL
AS
A
*
TUNING
KNOB
*
195
10.2.2
SECONDARY
STRUCTURE
AT
THE
5
AND
3
ENDS
196
10.2.3
NONCODING
RNA-MEDIATED
197
10.2.4
MODEL-DRIVEN
TRANSCRIPT
STABILITY
CONTROL
FOR
METABOLIC
PATHWAY
ENGINEERING
198
10.3
MANAGING
TRANSCRIPT
STABILITY
201
10.3.1
TRANSCRIPT
STABILITY
AS
A
CONFOUNDING
FACTOR
201
10.3.2
ANTICIPATING
TRANSCRIPT
STABILITY
ISSUES
201
10.3.3
UNIFORMITY
OF
5
AND
3
ENDS
202
10.3.4
RBS
SEQUESTRATION
BY
RIBOREGULATORS
AND
RIBOSWITCHES
203
10.3.5
EXPERIMENTALLY
PROBING
TRANSCRIPT
STABILITY
204
10.4
POTENTIAL
MECHANISMS
FOR
TRANSCRIPT
CONTROL
205
10.4.1
LEVERAGING
NEW
TOOLS
205
10.4.2
UNUSED
MECHANISMS
FOUND
IN
NATURE
206
10.5
CONCLUSIONS
AND
DISCUSSION
207
ACKNOWLEDGMENTS
208
DEFINITIONS
208
REFERENCES
209
11
SMALL
FUNCTIONAL
PEPTIDES
AND
THEIR
APPLICATION
IN
SUPERFUNCTIONALIZING
PROTEINS
217
SONJA
BILLERBECK
11.1
INTRODUCTION
217
11.2
PERMISSIVE
SITES
AND
THEIR
IDENTIFICATION
IN
A
PROTEIN
218
11.3
FUNCTIONAL
PEPTIDES
220
11.3.1
FUNCTIONAL
PEPTIDES
THAT
ACT
AS
BINDERS
220
11.3.2
PEPTIDE
MOTIFS
THAT
ARE
RECOGNIZED
BY
LABELING
ENZYMES
221
11.3.3
PEPTIDES
AS
PROTEASE
CLEAVAGE
SITES
222
11.3.4
REACTIVE
PEPTIDES
223
11.3.5
PHARMACEUTICALLY
RELEVANT
PEPTIDES:
PEPTIDE
EPITOPES,
SUGAR
EPITOPE
MIMICS,
AND
ANTIMICROBIAL
PEPTIDES
223
11.3.5.1
PEPTIDE
EPITOPES
224
11.3.5.2
PEPTIDE
MIMOTOPES
224
11.3.5.3
ANTIMICROBIAL
PEPTIDES
225
11.4
CONCLUSIONS
227
DEFINITIONS
228
ABBREVIATIONS
228
ACKNOWLEDGMENT
229
REFERENCES
229
CONTENTS
XI
PART
III
PARTS
AND
DEVICES
SUPPORTING
SPATIAL
ENGINEERING
237
12
METABOLIC
CHANNELING
USING
DNA
AS
A
SCAFFOLD
239
MOJCA
BENCINA,
JERNEJA
MORI
,
ROK
GABER,
AND
ROMAN
JERALA
12.1
INTRODUCTION
239
12.2
BIOSYNTHETIC
APPLICATIONS
OF
DNA
SCAFFOLD
242
12.2.1
L-THREONINE
242
12.2.2
TRANS-
RESVERATROL
245
12.2.3
1,2-PROPANEDIOL
246
12.2.4
MEVALONATE
246
12.3
DESIGN
OF
DNA-BINDING
PROTEINS
AND
TARGET
SITES
247
12.3.1
ZINC
FINGER
DOMAINS
248
12.3.2
TAL-DNA
BINDING
DOMAINS
249
12.3.3
OTHER
DNA-BINDING
PROTEINS
250
12.4
DNA
PROGRAM
250
12.4.1
SPACERS
BETWEEN
DNA-TARGET
SITES
250
12.4.2
NUMBER OF
DNA
SCAFFOLD
REPEATS
252
12.4.3
DNA-TARGET
SITE
ARRANGEMENT
253
12.5
APPLICATIONS
OF
DNA-GUIDED
PROGRAMMING
254
DEFINITIONS
255
REFERENCES
256
13
SYNTHETIC
RNA
SCAFFOLDS
FOR
SPATIAL
ENGINEERING
IN
CELLS
261
GAIRIK
SACHDEVA,
CAMERON
MYHRVOLD,
PENG
YIN,
AND
PAMELA
A.
SILVER
13.1
INTRODUCTION
261
13.2
STRUCTURAL
ROLES
OF
NATURAL
RNA
261
13.2.1
RNA
AS
A
NATURAL
CATALYST
262
13.2.2
RNA
SCAFFOLDS
IN
NATURE
263
13.3
DESIGN
PRINCIPLES
FOR
RNA
ARE
WELL
UNDERSTOOD
263
13.3.1
RNA
SECONDARY
STRUCTURE
IS
PREDICTABLE
264
13.3.2
RNA
CAN
SELF-ASSEMBLE
INTO
STRUCTURES
265
13.3.3
DYNAMIC
RNAS
CAN
BE
RATIONALLY
DESIGNED
265
13.3.4
RNA
CAN
BE
SELECTED
IN
VITRO
TO
ENHANCE
ITS
FUNCTION
266
13.4
APPLICATIONS
OF
DESIGNED
RNA
SCAFFOLDS
266
13.4.1
TOOLS
FOR
RNA
RESEARCH
266
13.4.2
LOCALIZING
METABOLIC
ENZYMES
ON
RNA
267
13.4.3
PACKAGING
THERAPEUTICS
ON
RNA
SCAFFOLDS
269
13.4.4
RECOMBINANT
RNA
TECHNOLOGY
269
13.5
CONCLUSION
270
13.5.1
NEW
APPLICATIONS
270
13.5.2
TECHNOLOGICAL
ADVANCES
270
DEFINITIONS
271
REFERENCES
271
XII
CONTENTS
14
SEQUESTERED:
DESIGN
AND
CONSTRUCTION
OF
SYNTHETIC
ORGANELLES
279
THAWATCHAI
CHAIJARASPHONG
AND
DAVID
F.
SAVAGE
14.1
INTRODUCTION
279
14.2
ON
ORGANELLES
281
14.3
PROTEIN-BASED
ORGANELLES
283
14.3.1
BACTERIAL
MICROCOMPARTMENTS
283
14.3.1.1
TARGETING
285
14.3.1.2
PERMEABILITY
287
14.3.1.3
CHEMICAL
ENVIRONMENT
288
14.3.1.4
BIOGENESIS
289
14.3.2
ALTERNATIVE
PROTEIN
ORGANELLES:
A
MINIMAL
SYSTEM
290
14.4
LIPID-BASED
ORGANELLES
292
14.4.1
REPURPOSING
EXISTING
ORGANELLES
293
14.4.1.1
THE
MITOCHONDRION
293
14.4.1.2
THE
VACUOLE
294
14.5
DE
NOVO
ORGANELLE
CONSTRUCTION
AND
FUTURE
DIRECTIONS
295
ACKNOWLEDGMENTS
297
REFERENCES
297
PART
IV
EARLY
APPLICATIONS
OF
SYNTHETIC
BIOLOGY:
PATHWAYS,
THERAPIES,
AND
CELL-FREE
SYNTHESIS
307
15
CELL-FREE
PROTEIN
SYNTHESIS:
AN
EMERGING
TECHNOLOGY
FOR
UNDERSTANDING,
HARNESSING,
AND
EXPANDING
THE
CAPABILITIES
OF
BIOLOGICAL
SYSTEMS
309
JENNIFER
A.
SCHOBORG
AND
MICHAEL
C.
JEWETT
15.1
INTRODUCTION
309
15.2
BACKGROUND/CURRENT
STATUS
311
15.2.1
PLATFORMS
311
15.2.1.1
PROKARYOTIC
PLATFORMS
311
15.2.1.2
EUKARYOTIC
PLATFORMS
312
15.2.2
TRENDS
314
15.3
PRODUCTS
316
15.3.1
NONCANONICAL
AMINO
ACIDS
316
15.3.2
GLYCOSYLATION
316
15.3.3
ANTIBODIES
318
15.3.4
MEMBRANE
PROTEINS
318
15.4
HIGH-THROUGHPUT
APPLICATIONS
320
15.4.1
PROTEIN
PRODUCTION
AND
SCREENING
320
15.4.2
GENETIC
CIRCUIT OPTIMIZATION
321
15.5
FUTURE
OF
THE
FIELD
321
DEFINITIONS
322
ACKNOWLEDGMENTS
322
REFERENCES
323
CONTENTS
XIII
16
16.1
16.2
16.3
16.3.1
16.3.2
16.3.2.1
16.3.2.2
16.3.2.3
16.4
17
17.1
17.2
17.3
17.3.1
17.3.2
17.3.3
17.4
18
18.1
18.2
18.2.1
18.2.2
18.2.2.1
APPLYING
ADVANCED
DNA
ASSEMBLY
METHODS
TO
GENERATE
PATHWAY
LIBRARIES
331
DAWN
T.
ERIKSEN
,
RAN
CHAO,
AND
HUIMIN
ZHAO
INTRODUCTION
331
ADVANCED
DNA
ASSEMBLY
METHODS
333
GENERATION
OF
PATHWAY
LIBRARIES
334
IN
VITRO
ASSEMBLY
METHODS
335
IN
VIVO
ASSEMBLY
METHODS
339
IN
VIVO
CHROMOSOMAL
INTEGRATION
339
IN
VIVO
PLASMID ASSEMBLY
AND
ONE-STEP
OPTIMIZATION
LIBRARIES
340
IN
VIVO
PLASMID ASSEMBLY
AND
ITERATIVE
MULTI-STEP
OPTIMIZATION
LIBRARIES
341
CONCLUSIONS
AND
PROSPECTS
343
DEFINITIONS
343
REFERENCES
344
SYNTHETIC
BIOLOGY
IN
IMMUNOTHERAPY
AND
STEM
CELL
THERAPY
ENGINEERING
349
PATRICK
HO
AND
YVONNE
Y.
CHEN
THE
NEED
FOR
A
NEW
THERAPEUTIC
PARADIGM
349
RATIONALE
FOR
CELLULAR
THERAPIES
350
SYNTHETIC
BIOLOGY
APPROACHES
TO
CELLULAR
IMMUNOTHERAPY
ENGINEERING
351
CAR
ENGINEERING
FOR
ADOPTIVE
T-CELL
THERAPY
352
GENETIC
ENGINEERING
TO
ENHANCE
T-CELL
THERAPEUTIC
FUNCTION
357
GENERATING
SAFER
T-CELL
THERAPEUTICS
WITH
SYNTHETIC
BIOLOGY
359
CHALLENGES
AND
FUTURE
OUTLOOK
362
ACKNOWLEDGMENT
364
DEFINITIONS
364
REFERENCES
365
PART
V
SOCIETAL
RAMIFICATIONS
OF
SYNTHETIC
BIOLOGY
373
SYNTHETIC
BIOLOGY:
FROM
GENETIC
ENGINEERING
2.0
TO
RESPONSIBLE
RESEARCH
AND
INNOVATION
375
LEI
PEI
AND
MARKUS
SCHMIDT
INTRODUCTION
375
PUBLIC
PERCEPTION
OF
THE
NASCENT
FIELD
OF
SYNTHETIC
BIOLOGY
376
PERCEPTION
OF
SYNTHETIC
BIOLOGY
IN
THE
UNITED
STATES
377
PERCEPTION
OF
SYNTHETIC
BIOLOGY
IN EUROPE
379
EUROPEAN
UNION
379
XIV
CONTENTS
18.2.2.2
AUSTRIA
379
18.2.2.3
GERMANY
381
18.2.2.4
NETHERLANDS
382
18.2.2.5
UNITED
KINGDOM
383
18.2.3
OPINIONS
FROM
CONCERNED
CIVIL
SOCIETY
GROUPS
384
18.3
FRAMES
AND
COMPARATORS
384
18.3.1
GENETIC
ENGINEERING:
TECHNOLOGY
AS
CONFLICT
386
18.3.2
NANOTECHNOLOGY:
TECHNOLOGY
AS
PROGRESS
387
18.3.3
INFORMATION
TECHNOLOGY:
TECHNOLOGY
AS
GADGET
387
18.3.4
SB:
WHICH
DEBATE
TO
COME?
388
18.4
TOWARD
RESPONSIBLE
RESEARCH
AND
INNOVATION
(RRI)
IN
SYNTHETIC
BIOLOGY
389
18.4.1
ENGAGEMENT
OF
ALL
SOCIETAL
ACTORS
-
RESEARCHERS,
INDUSTRY,
POLICY
MAKERS,
AND
CIVIL
SOCIETY-
AND
THEIR
JOINT
PARTICIPATION
IN
THE
RESEARCH
AND
INNOVATION
390
18.4.2
GENDER
EQUALITY
391
18.4.3
SCIENCE
EDUCATION
392
18.4.4
OPEN
ACCESS
392
18.4.5
ETHICS
394
18.4.6
GOVERNANCE
395
18.5
CONCLUSION
396
ACKNOWLEDGMENTS
397
REFERENCES
397
INDEX
403
|
| any_adam_object | 1 |
| author2 | Smolke, Christina |
| author2_role | edt |
| author2_variant | c s cs |
| author_GND | (DE-588)1160958718 |
| author_facet | Smolke, Christina |
| building | Verbundindex |
| bvnumber | BV044904719 |
| classification_rvk | WC 5800 WF 9710 WF 9740 WF 9741 |
| classification_tum | BIO 120f |
| ctrlnum | (OCoLC)1036362706 (DE-599)DNB1140659995 |
| discipline | Biologie |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV044904719 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T08:04:21Z |
| institution | BVB |
| institution_GND | (DE-588)16179388-5 |
| isbn | 9783527330751 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-030298422 |
| oclc_num | 1036362706 |
| open_access_boolean | |
| owner | DE-29T DE-703 DE-M49 DE-BY-TUM DE-11 DE-19 DE-BY-UBM DE-83 DE-634 |
| owner_facet | DE-29T DE-703 DE-M49 DE-BY-TUM DE-11 DE-19 DE-BY-UBM DE-83 DE-634 |
| physical | xvi, 409 Seiten Illustrationen, Diagramme |
| publishDate | 2018 |
| publishDateSearch | 2018 |
| publishDateSort | 2018 |
| publisher | Wiley-VCH |
| record_format | marc |
| series | Advanced biotechnology |
| series2 | Advanced biotechnology |
| spelling | Synthetic biology parts, devices and applications edited by Christina Smolke Weinheim Wiley-VCH [2018] © 2018 2018 xvi, 409 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Advanced biotechnology volume 8 Synthetische Biologie (DE-588)7684405-5 gnd rswk-swf Biomedical Engineering Biomedical Engineering Special Topics Biomedizintechnik Biotechnologie Biotechnologie i. d. Biowissenschaften Biotechnologie i. d. Chemie Biotechnology Biowissenschaften Cell & Molecular Biology Chemie Chemistry Life Sciences Molecular Bioengineering Molekulares Bioengineering Spezialthemen Biomedizintechnik Synthetische Biologie Zell- u. Molekularbiologie (DE-588)4143413-4 Aufsatzsammlung gnd-content Synthetische Biologie (DE-588)7684405-5 s DE-604 Smolke, Christina (DE-588)1160958718 edt Wiley-VCH (DE-588)16179388-5 pbl Erscheint auch als Online-Ausgabe, EPDF 978-3-527-68808-1 Erscheint auch als Online-Ausgabe, EPUB 978-3-527-68809-8 Erscheint auch als Online-Ausgabe, MOBI 978-3-527-68807-4 Erscheint auch als Online-Ausgabe, oBook 978-3-527-68810-4 Advanced biotechnology volume 8 (DE-604)BV043302234 8 X:MVB http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-33075-1/ DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030298422&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Synthetic biology parts, devices and applications Advanced biotechnology Synthetische Biologie (DE-588)7684405-5 gnd |
| subject_GND | (DE-588)7684405-5 (DE-588)4143413-4 |
| title | Synthetic biology parts, devices and applications |
| title_auth | Synthetic biology parts, devices and applications |
| title_exact_search | Synthetic biology parts, devices and applications |
| title_full | Synthetic biology parts, devices and applications edited by Christina Smolke |
| title_fullStr | Synthetic biology parts, devices and applications edited by Christina Smolke |
| title_full_unstemmed | Synthetic biology parts, devices and applications edited by Christina Smolke |
| title_short | Synthetic biology |
| title_sort | synthetic biology parts devices and applications |
| title_sub | parts, devices and applications |
| topic | Synthetische Biologie (DE-588)7684405-5 gnd |
| topic_facet | Synthetische Biologie Aufsatzsammlung |
| url | http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-33075-1/ http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030298422&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV043302234 |
| work_keys_str_mv | AT smolkechristina syntheticbiologypartsdevicesandapplications AT wileyvch syntheticbiologypartsdevicesandapplications |