Genetic analyses of sensory and motoneuron physiology in Drosophila melanogaster: = Genetische Analyse sensorischer und motoneuronaler Physiologie in Drosophila melanogaster
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Würzburg
2015
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Volltext Inhaltsverzeichnis |
| Beschreibung: | veröffentlicht 2017 |
| Beschreibung: | 192 Blätter Illustrationen, Diagramme 30 cm |
Internformat
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| 100 | 1 | |a Scholz, Nicole |d 1984- |e Verfasser |0 (DE-588)1148797750 |4 aut | |
| 245 | 1 | 0 | |a Genetic analyses of sensory and motoneuron physiology in Drosophila melanogaster |b = Genetische Analyse sensorischer und motoneuronaler Physiologie in Drosophila melanogaster |c vorgelegt von Nicole Scholz aus Mühlhausen (Thür.) |
| 246 | 1 | 1 | |a Genetische Analyse sensorischer und motoneuronaler Physiologie in Drosophila melanogaster |
| 264 | 1 | |a Würzburg |c 2015 | |
| 300 | |a 192 Blätter |b Illustrationen, Diagramme |c 30 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a veröffentlicht 2017 | ||
| 502 | |b Dissertation |c Julius-Maximilians-Universität Würzburg |d 2015 | ||
| 546 | |a Zusammenfassung in deutscher und englischer Sprache | ||
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| 650 | 0 | 7 | |a Synapse |0 (DE-588)4184224-8 |2 gnd |9 rswk-swf |
| 653 | |a synaptic vesicle tethering | ||
| 653 | |a active zone | ||
| 653 | |a Complexin | ||
| 653 | |a Bruchpilot | ||
| 653 | |a Adhesion-GPCR | ||
| 653 | |a Latrophilin | ||
| 653 | |a mechanosensing | ||
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| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |o urn:nbn:de:bvb:20-opus-123249 |a Scholz, Nicole, 1984- |t Genetic analyses of sensory and motoneuron physiology in Drosophila melanogaster |d Würzburg : Universität Würzburg, 2017 |h Online-Ressource |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-030277827 | ||
Datensatz im Suchindex
| _version_ | 1804178423861477376 |
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| adam_text | CONTENTS
1.
SUMMARY........................................................................................................................
2
1.1. PART I BRUCHPILOT AND COMPLEXIN INTERACT TO REGULATE SYNAPTIC
VESICLE TETHERING TO
THE ACTIVE ZONE
CYTOMATRIX..........................................................................
2
1.2. PART II THE ADHESION-GPCR LATROPHILIN/CIRL SHAPES MECHANOSENSATION
.........
3
2.
ZUSAMMENFASSUNG.........................................................................................................
4
2.1. TEIL I DIE INTERAKTION VON BRUCHPILOT UND COMPLEXIN VERMITTELT DIE
ANBINDUNG
VON SYNAPTISCHEN VESIKELN AN DIE ZYTOMATRIX DER AKTIVEN ZONE
...............
4
2.2. TEIL II ADHAESIONS-GPCR LATROPHILIN/CIRL MODULIERT DIE WAHRNEHMUNG
MECHANISCHER
REIZE....................................................................................
5
3.
BACKGROUND....................................................................................................................
6
P A R TI
4.
INTRODUCTION...................................................................................................................
9
4.1. THE CONCEPT OF NEUROTRANSMISSION AT CHEMICAL SYNAPSES
........................................
9
4.2. SYNAPTIC
VESICLES..............................................................
10
4.2.1. SV
POOLS............................................................................................................
12
4.2.2. SV
TRANSPORT......................................................................................................
14
4.2.3. THE SV MARKER SYNAPTOTAGMIN
........................................................................
15
4.3. THE PRESYNAPTIC ACTIVE ZONE
....................................................................................
16
4.3.1.
ULTRASTRUCTURE....................................................................................................
16
4.3.2. MOLECULAR
LAYOUT...............................................................................................
18
4.3.3.
BRUCHPILOT.........................................................................................................21
4.3.4.
COMPLEXIN.........................................................................................................26
4.4. SCOPE OF THIS
STUDY...........................................................................................
.
....
31
5. RESULTS
..........................................................................................................................33
5.1. EXPRESSION PATTERN OF MEMBRANE-ATTACHED GFP AT THE NM J
..................................
33
5.2. MBRPC TIP CO-LOCALIZES WITH 8V S
.............
................................................................
34
5.3. EXPRESSION OF MOBILE BRPC TIP IN MOTONEURONS IMPAIRS SYNAPTIC
FUNCTION
.............
35
5.4. BRPCTERM IS SUFFICIENT TO TETHER SVS TO ECTOPIC SITES OF THE
MOTONEURON
................
37
5.5. SCREEN FOR BRP
INTERACTORS.....................................................................................44
5.6. CPX MEDIATES SV TETHERING TO
BRP.......................................................................45
5.6.1. CPX AND BRP INTERACT
GENETICALLY........................................................................
47
5.6.2. BRP AND CPX TETHER SVS TO THE AZ
SCAFFOLD................................................... 49
5.6.3. BRP AND CPX FUNCTION TO PREVENT SYNAPTIC DEPRESSION
...................................
51
6.
DISCUSSION.....................................................................................................................
53
6.1. ACCUMULATION OF BRP BAIT
VARIANTS.......................................................................
53
6.2. A BRP PEPTIDE INDUCES SYNAPTIC SHORT-TERM DEPRESSION AND ALTERS
LARVAL
LOCOMOTION..............................................................................................................
55
6.3. ASSOCIATION OF SVS WITH BRP BAIT VARIANTS
...........................................................
56
6.4. ABSENCE OF CPX FROM SVS ABOLISHED ASSOCIATION OF SVS WITH BRPC LONG
.............
57
6.5. SV DETACHED CPX FORMS AGGLOMERATIONS DISTANT FROM AZS
..................................
58
6.6. CPX AND BRP EXERT THEIR FUNCTIONS IN A COMMON SIGNALING CASCADE
.....................
58
6.7. BRP AND CPX PREVENT SYNAPTIC SHORT-TERM DEPRESSION
..........................................
60
PART II
7.
INTRODUCTION.................................................................................................................
65
7.1. ADHESION-CLASS G-PROTEINE COUPLED RECEPTORS
.......................................................
65
7.2. LATROPHILIN/COR/ A PROTOTYPIC ADHESION-GPCR MEMBER
.....................................
68
7.3. STRUCTURAL FEATURES OF
LATROPHILIN............................................................................
68
7.4. FUNCTIONAL FEATURES OF
LATROPHILIN.........................................................................
72
7.5. LATROPHILINS IN MAMMALS, C. ELEGANS AND
DROSOPHILA
...........................................
74
7.6. THE ONEROUS SEARCH FOR ENDOGENOUS LIGANDS OF LATROPHILIN
...................................
77
7.7.
MECHANOSENSATION...................................................................................................
78
7.8. SCOPE OF THIS
STUDY.................................................................................................
83
8.
RESULTS..........................................................................................................................
84
8.1. GENERATION OF DCIRL NULL ALLELE -
DCIRLKO................................................................
84
8.2. GENOMIC ENGINEERING OF DCIRL
TOOLKIT.....................................................................
85
8.3. NEURONAL EXPRESSION PATTERN OF DCIRL IN LARVAL AND ADULT STAGES
.........................
87
8.4. DCIRLK0 LARVAE DISPLAY CURTAILED CRAWLING DISTANCES
...............................................
89
8.5. DCIRL PROMOTES ELEVATION OF POSTSYNAPTIC DISCS-LARGE
............................................
91
8.6. DCIRL HAS NO IMPACT ON PRESYNAPTIC COMPONENTS OF THE LARVAL NMJ
...............
.
......93
8.7. DCIRL FUNCTIONS IN PERIPHERAL SENSORY CHORDOTONAL NEURONS
....................................
97
8.8. DCIRL IS EXPENDABLE FOR PROTEIN DECOR AND STRUCTURAL INTEGRITY OF
CHORDOTONAL
ORGANS..................................................................................................
99
8.9. DCIRL REGULATES RESPONSIVENESS OF CHORDOTONAL NEURONS TO MECHANICAL
STRAIN
.....
101
8.10. DCIRL GENETICALLY INTERACTS WITH CONSTITUENTS OF THE
MECHANOTRANSDUCTION
COMPLEX................................................................................................................103
8.11. CZS-REGULATORY ELEMENTS NECESSARY FOR SPECIALIZATION OF
CHORDOTONAL CILIA
ARE PRESENT IN THE DCIRL PROMOTOR.................. 105
9.
DISCUSSION...................................................................................................................
108
9.1. INVESTIGATION OF DCIRL *S IN VIVO FUNCTION
...............................................................
108
9.1.1. DCIRLKO ANIMALS DEVELOP NORMALLY AND STRUCTURAL INTEGRITY OF THE
NERVOUS
SYSTEM IS
PRESERVED..........................................................................................108
9.1.2. EXPRESSION PROFILE OF DCIRL IN LARVAL AND ADULT STAGE
...................................
109
9.1.3. REMOVAL OF DCIRL DISRUPTS LARVAL LOCOMOTION
.................................................
114
9.1.4. DCIRL IS REQUIRED FOR THE PERCEPTION OF MECHANICAL STIMULI
THROUGH
CHORDOTONAL SENSORY NEURONS
..........................................................................
116
9.1.5. A NOVEL ROLE FOR ADHESION-GPCR AS METABOTROPIC MECHANOSENSORS
.............
119
10. GENERAL MATERIAL & METHODS
...................................................................................
122
10.1. MOLECULAR
BIOLOGY................................................................................................122
10.1.1.
MATERIALS........................................................................................................122
10.1.2. TRANSGENE ENGINEERING
..................................................................................
122
10.2. DROSOPHILA MELANOGASTER
...................................................................................
124
10.2.1. FLY
CULTIVATION...............................................................................................
124
10.2.2. TRANSGENESIS
..................................................................................................
125
10.2.3. FLY
GENETICS....................................................................................................125
10.2.4. ISOLATION AND PURIFICATION OF GENOMIC DNA
.................................................
127
10.3. CELL
CULTURE......................................................................................
127
10.4. IMMUNOHISTOCHEMISTRY
.......................................................................................
128
10.4.1.
MATERIALS.......................................................................................................
128
10.4.2. PREPARATION OF LARVAL BODY WALL MUSCLES
.......................................................
128
10.4.3. PREPARATION OF WHOLE-MOUNT BRAINS FROM DROSOPHILA LARVAE AND
ADULT
FLIES.......................................................................................................
129
10.4.4. FIXATION AND STAINING PROCEDURES
..................................................................
129
10.4.4.1. LARVAL BODY WALL MUSCLES
...........................................................................
129
10.4.4.2. LARVAL PENTASCOLOPIDIAL ORGAN
....................................................................
130
10.4.4.3. LARVAL AND ADULT BRAIN SPECIMEN
................................................................
130
10.4.5. PREPARATION AND CRYOSECTIONING OF ADULT DROSOPHILA HEADS
..........................
130
10.4.6. FIXATION AND STAINING PROCEDURES OF CRYOSECTIONS
.........................................
131
10.5.
IMAGING................................................................................................................132
10.5.1. CONFOCAL MICROSCOPY
....................................................................................
132
10.5.2. IMAGE PROCESSING AND QUANTIFICATION PROCEDURES
..........................................
132
10.5.3. QUANTIFICATION OF KURZSCHLUSS
..............................................................
132
10.6. ELECTRON
MICROSCOPY............................................................................................133
10.6.1. FIXATION, CONTRASTING AND EMBEDDING PROCEDURE
...........................................
133
10.6.2. ULTRA-THIN SECTIONING AND CONTRASTING
............................................................
133
10.6.3. IMAGE ACQUISITION AND IMAGE
ANALYSIS...........................................................134
10.7. BEHAVIORAL
ASSAYS.................................................................................................134
10.7.1. SOUND-INDUCED STARTLE RESPONSE
PARADIGM.....................................................134
10.7.2. LARVAL LOCOMOTION
PARADIGM..........................................................................135
10.8. ELECTROPHYSIOLOGICAL
ANALYSIS..............................................................................135
10.9. DATA
ANALYSIS........................................................................................................136
11
.
SUPPLEMENTAL
INFORMATION........................................................................................
137
12
.
REFERENCES..................................................................................................................
147
13
.
FIGURES AND
TABLES......................................................................................................
182
14
.
ABBREVIATIONS..............................................................................................................185
15
.
APPENDIX....................................................................................................................
190
15.1.
PUBLICATIONS..........................................................................................................190
15.2. CURRICULUM
VITAE................................................................................................
191
|
| any_adam_object | 1 |
| author | Scholz, Nicole 1984- |
| author_GND | (DE-588)1148797750 |
| author_facet | Scholz, Nicole 1984- |
| author_role | aut |
| author_sort | Scholz, Nicole 1984- |
| author_variant | n s ns |
| building | Verbundindex |
| bvnumber | BV044883681 |
| collection | ebook |
| ctrlnum | (OCoLC)1104878743 (DE-599)DNB1148797807 |
| discipline | Biologie |
| format | Thesis Book |
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| publishDateSort | 2015 |
| record_format | marc |
| spelling | Scholz, Nicole 1984- Verfasser (DE-588)1148797750 aut Genetic analyses of sensory and motoneuron physiology in Drosophila melanogaster = Genetische Analyse sensorischer und motoneuronaler Physiologie in Drosophila melanogaster vorgelegt von Nicole Scholz aus Mühlhausen (Thür.) Genetische Analyse sensorischer und motoneuronaler Physiologie in Drosophila melanogaster Würzburg 2015 192 Blätter Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier veröffentlicht 2017 Dissertation Julius-Maximilians-Universität Würzburg 2015 Zusammenfassung in deutscher und englischer Sprache Taufliege (DE-588)4078168-9 gnd rswk-swf G-Protein gekoppelter Rezeptor (DE-588)7723480-7 gnd rswk-swf Synapse (DE-588)4184224-8 gnd rswk-swf synaptic vesicle tethering active zone Complexin Bruchpilot Adhesion-GPCR Latrophilin mechanosensing (DE-588)4113937-9 Hochschulschrift gnd-content Taufliege (DE-588)4078168-9 s G-Protein gekoppelter Rezeptor (DE-588)7723480-7 s Synapse (DE-588)4184224-8 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:20-opus-123249 Scholz, Nicole, 1984- Genetic analyses of sensory and motoneuron physiology in Drosophila melanogaster Würzburg : Universität Würzburg, 2017 Online-Ressource B:DE-101 application/pdf http://d-nb.info/1148797807/04 Inhaltsverzeichnis https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-123249 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030277827&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Scholz, Nicole 1984- Genetic analyses of sensory and motoneuron physiology in Drosophila melanogaster = Genetische Analyse sensorischer und motoneuronaler Physiologie in Drosophila melanogaster Taufliege (DE-588)4078168-9 gnd G-Protein gekoppelter Rezeptor (DE-588)7723480-7 gnd Synapse (DE-588)4184224-8 gnd |
| subject_GND | (DE-588)4078168-9 (DE-588)7723480-7 (DE-588)4184224-8 (DE-588)4113937-9 |
| title | Genetic analyses of sensory and motoneuron physiology in Drosophila melanogaster = Genetische Analyse sensorischer und motoneuronaler Physiologie in Drosophila melanogaster |
| title_alt | Genetische Analyse sensorischer und motoneuronaler Physiologie in Drosophila melanogaster |
| title_auth | Genetic analyses of sensory and motoneuron physiology in Drosophila melanogaster = Genetische Analyse sensorischer und motoneuronaler Physiologie in Drosophila melanogaster |
| title_exact_search | Genetic analyses of sensory and motoneuron physiology in Drosophila melanogaster = Genetische Analyse sensorischer und motoneuronaler Physiologie in Drosophila melanogaster |
| title_full | Genetic analyses of sensory and motoneuron physiology in Drosophila melanogaster = Genetische Analyse sensorischer und motoneuronaler Physiologie in Drosophila melanogaster vorgelegt von Nicole Scholz aus Mühlhausen (Thür.) |
| title_fullStr | Genetic analyses of sensory and motoneuron physiology in Drosophila melanogaster = Genetische Analyse sensorischer und motoneuronaler Physiologie in Drosophila melanogaster vorgelegt von Nicole Scholz aus Mühlhausen (Thür.) |
| title_full_unstemmed | Genetic analyses of sensory and motoneuron physiology in Drosophila melanogaster = Genetische Analyse sensorischer und motoneuronaler Physiologie in Drosophila melanogaster vorgelegt von Nicole Scholz aus Mühlhausen (Thür.) |
| title_short | Genetic analyses of sensory and motoneuron physiology in Drosophila melanogaster |
| title_sort | genetic analyses of sensory and motoneuron physiology in drosophila melanogaster genetische analyse sensorischer und motoneuronaler physiologie in drosophila melanogaster |
| title_sub | = Genetische Analyse sensorischer und motoneuronaler Physiologie in Drosophila melanogaster |
| topic | Taufliege (DE-588)4078168-9 gnd G-Protein gekoppelter Rezeptor (DE-588)7723480-7 gnd Synapse (DE-588)4184224-8 gnd |
| topic_facet | Taufliege G-Protein gekoppelter Rezeptor Synapse Hochschulschrift |
| url | http://d-nb.info/1148797807/04 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-123249 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030277827&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT scholznicole geneticanalysesofsensoryandmotoneuronphysiologyindrosophilamelanogastergenetischeanalysesensorischerundmotoneuronalerphysiologieindrosophilamelanogaster AT scholznicole genetischeanalysesensorischerundmotoneuronalerphysiologieindrosophilamelanogaster |
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