Genomics of pathogenic and commensal Escherichia coli: = Genomik pathogener und kommensaler Escherichia coli
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Würzburg
2017
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Volltext Inhaltsverzeichnis |
| Beschreibung: | Kumulative Arbeit mit Sonderabdrucke aus verschiedenen Zeitschriften |
| Beschreibung: | xxiii, 275 Seiten Illustrationen, Diagramme 30 cm |
Internformat
MARC
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| 100 | 1 | |a Leimbach, Andreas |d 1980- |e Verfasser |0 (DE-588)1154514870 |4 aut | |
| 245 | 1 | 0 | |a Genomics of pathogenic and commensal Escherichia coli |b = Genomik pathogener und kommensaler Escherichia coli |c submitted by Andreas Leimbach from Schweinfurt |
| 246 | 1 | 1 | |a Genomik pathogener und kommensaler Escherichia coli |
| 264 | 1 | |a Würzburg |c 2017 | |
| 300 | |a xxiii, 275 Seiten |b Illustrationen, Diagramme |c 30 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Kumulative Arbeit mit Sonderabdrucke aus verschiedenen Zeitschriften | ||
| 502 | |b Dissertation |c Julius-Maximilians-University of Würzburg |d 2017 | ||
| 546 | |a Zusammenfassung in deutscher und englischer Sprache | ||
| 650 | 0 | 7 | |a Pathogenität |0 (DE-588)4205990-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Genomik |0 (DE-588)4776397-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Escherichia coli |0 (DE-588)4070959-0 |2 gnd |9 rswk-swf |
| 653 | |a high-throughput sequencing | ||
| 653 | |a virulence factors | ||
| 653 | |a pathotypes | ||
| 653 | |a phylogeny | ||
| 653 | |a ecoli_VF_collection | ||
| 653 | |a bac-genomics-scripts | ||
| 653 | |a autotransporter | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Escherichia coli |0 (DE-588)4070959-0 |D s |
| 689 | 0 | 1 | |a Pathogenität |0 (DE-588)4205990-2 |D s |
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| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |o urn:nbn:de:bvb:20-opus-154539 |a Leimbach, Andreas |t Genomics of pathogenic and commensal Escherichia coli |d Würzburg : Universität Würzburg, 2017 |h Online-Ressource |
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| 856 | 4 | 1 | |u https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-154539 |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030261765&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 912 | |a ebook | ||
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Datensatz im Suchindex
| _version_ | 1804178395436679168 |
|---|---|
| adam_text | CON TENTS
I GENERAL INTRODUCTION
1
1
INTRODUCTION Z
1.1 BACTERIAL GENOMICS 3
1.1.1 CURRENT SEQUENCING TECHNOLOGIES (IN MICROBIOL
OGY) 5
1.1.2 HIGH-THROUGHPUT DATA DELUGE AND RESULTING CHAL
LENGES 9
1.1.3 BACTERIAL (WHOLE-GENOME SHOTGUN) SEQUENCING 11
1.2 E. COLI PHYLOGENY AND POPULATION GENOMICS 13
1.2.1 E. COLI AS AN ALL-ROUNDER: THE THIN LINE BETWEEN
COMMENSALISM AND PATHOGENICITY 13
1.3 AUTOTRANSPORTER PROTEINS 46
1.4 GERMAN 2011 OI04:H4 STEC OUTBREAK 48
1.5 BOVINE MASTITIS 49
1.5.1 BOVINE MASTITIS PATHOGENS AND DISEASE PATHO
GENESIS 50
1.5.2 THE COW IMMUNE SYSTEM IN THE UDDER 53
1.5.3 E. COLI BOVINE MASTITIS 55
2
THESIS AIMS
61
II E. COLI VIRULENCE FACTOR COLLECTION AND BACTE
RIAL GENOMICS SCRIPTS 63
3
E. COLI VIRULENCE FACTOR COLLECTION
65
3.1 INTRODUCTION 65
3.2 CONSTRUCTION OF THE E. COLI VIRULENCE FACTOR COLLECTION 67
4
BACTERIAL GENOMICS SCRIPTS 73
III PUBLICATIONS 77
5 PUBLICATIONS 79
5.1 AUTOTRANSPORTER PREVALENCE IN E. COLI 79
5.1.1 PREVALENCE OF AUTOTRANSPORTERS IN ESCHERICHIA COLI:
WHAT IS THE IMPACT OF PHYLOGENY AND PATHOTYPE? 79
5.2 GENOMIC ANALYSES OF TWO STEC ISOLATES FROM THE GER
MAN 2011 EPIDEMIC 104
5.2.1 GENOME SEQUENCE ANALYSES OF TWO ISOLATES FROM
THE RECENT ESCHERICHIA COLI OUTBREAK IN GERMANY
REVEAL THE EMERGENCE OF A NEW PATHOTYPE: ENTERO-
AGGREGATIVE-HAEMORRHAGIC ESCHERICHIA COLI (EA-
HEC) 104
5.3 ANALYSES OF BOVINE MASTITIS AND COMMENSAL E. COLI ISO
LATE GENOMES 119
XVIII CONTENTS
5.3.1 THE LIPOPOLYSACCHARIDE OF THE MASTITIS ISOLATE
ES
CHERICHIA COLI STRAIN 1303 COMPRISES A NOVEL O-
ANTIGEN AND THE RARE K-12 CORE TYPE 119
5.3.2 COMPLETE GENOME SEQUENCES OF ESCHERICHIA COLI
STRAINS 1303 AND ECC-1470 ISOLATED FROM BOVINE
MASTITIS 134
5.3.3 WHOLE-GENOME DRAFT SEQUENCES OF SIX COMMEN
SAL FECAL AND SIX MASTITIS-ASSOCIATED ESCHERICHIA
COLI STRAINS OF BOVINE ORIGIN 137
5.3.4 NO EVIDENCE FOR A BOVINE MASTITIS ESCHERICHIA COLI
PATHOTYPE 140
IV GENERAL DISCUSSION 193
6
DISCUSSION
195
6.1 THE ELUSIVE E. COLI 1303 O70 SEROTYPE 195
6.2 FURTHER CONSEQUENCES OF THE GERMAN 2011 STEC EPI
DEMIC 196
6.2.1 CLINICAL EFFECT OF THE HYBRID
ST E C /E A E C
PATHO
TYPE 196
6.2.2 REAL-TIME ANALYSIS OF THE OUTBREAK E. COLI GENOME 197
6 .2 .3
FUTURE VIGILANCE FOR O IOQTIQ
STEC 2 0 0
6.3 FLEXIBILITY OF E. COLI GENOMES AND PATHOTYPES 202
6.3.1 AMBIGUOUS AND EMERGING (HYBRID) E. COLI PATHO
TYPES 203
6.3.2 IMPACT OF PHYLOGENETIC GENEALOGY ON GENE CON
TENT 204
6.4 IMPLICATIONS AND OUTLOOK ON BOVINE E. COLI MASTITIS 205
6.4.1 CURRENT SHORTCOMINGS OF MASTITIS-ASSOCIATED E.
COLI GENOMICS 205
6.4.2 PREVENTION AND TREATMENT STRATEGIES FOR E. COLI
MASTITIS 207
6.4.3 OUTLOOK ON E. COLI MASTITIS RESEARCH 215
7 THE FUTURE OF DIAGNOSTIC AND PUBLIC HEALTH MI
CROBIOLOGY 219
7.1 WHY DO WE NEED TO MODERNIZE MICROBIAL DIAGNOSTICS
AND EPIDEMIOLOGY? 219
7.2 CURRENT STATE OF CLINICAL MICROBIOLOGY 220
7.3 WHAT CAN WE EXPECT IN THE FUTURE? 222
V APPENDIX
2 2 7
A INDIVIDUAL AUTHOR CONTRIBUTIONS 229
B CURRICULUM VITA; 239
BIBLIOGRAPHY 243
|
| any_adam_object | 1 |
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| ctrlnum | (OCoLC)1135388657 (DE-599)DNB1149193069 |
| discipline | Biologie Medizin |
| format | Thesis Book |
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| spelling | Leimbach, Andreas 1980- Verfasser (DE-588)1154514870 aut Genomics of pathogenic and commensal Escherichia coli = Genomik pathogener und kommensaler Escherichia coli submitted by Andreas Leimbach from Schweinfurt Genomik pathogener und kommensaler Escherichia coli Würzburg 2017 xxiii, 275 Seiten Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Kumulative Arbeit mit Sonderabdrucke aus verschiedenen Zeitschriften Dissertation Julius-Maximilians-University of Würzburg 2017 Zusammenfassung in deutscher und englischer Sprache Pathogenität (DE-588)4205990-2 gnd rswk-swf Genomik (DE-588)4776397-8 gnd rswk-swf Escherichia coli (DE-588)4070959-0 gnd rswk-swf high-throughput sequencing virulence factors pathotypes phylogeny ecoli_VF_collection bac-genomics-scripts autotransporter (DE-588)4113937-9 Hochschulschrift gnd-content Escherichia coli (DE-588)4070959-0 s Pathogenität (DE-588)4205990-2 s Genomik (DE-588)4776397-8 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:20-opus-154539 Leimbach, Andreas Genomics of pathogenic and commensal Escherichia coli Würzburg : Universität Würzburg, 2017 Online-Ressource B:DE-101 application/pdf http://d-nb.info/1149193069/04 Inhaltsverzeichnis https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-154539 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030261765&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Leimbach, Andreas 1980- Genomics of pathogenic and commensal Escherichia coli = Genomik pathogener und kommensaler Escherichia coli Pathogenität (DE-588)4205990-2 gnd Genomik (DE-588)4776397-8 gnd Escherichia coli (DE-588)4070959-0 gnd |
| subject_GND | (DE-588)4205990-2 (DE-588)4776397-8 (DE-588)4070959-0 (DE-588)4113937-9 |
| title | Genomics of pathogenic and commensal Escherichia coli = Genomik pathogener und kommensaler Escherichia coli |
| title_alt | Genomik pathogener und kommensaler Escherichia coli |
| title_auth | Genomics of pathogenic and commensal Escherichia coli = Genomik pathogener und kommensaler Escherichia coli |
| title_exact_search | Genomics of pathogenic and commensal Escherichia coli = Genomik pathogener und kommensaler Escherichia coli |
| title_full | Genomics of pathogenic and commensal Escherichia coli = Genomik pathogener und kommensaler Escherichia coli submitted by Andreas Leimbach from Schweinfurt |
| title_fullStr | Genomics of pathogenic and commensal Escherichia coli = Genomik pathogener und kommensaler Escherichia coli submitted by Andreas Leimbach from Schweinfurt |
| title_full_unstemmed | Genomics of pathogenic and commensal Escherichia coli = Genomik pathogener und kommensaler Escherichia coli submitted by Andreas Leimbach from Schweinfurt |
| title_short | Genomics of pathogenic and commensal Escherichia coli |
| title_sort | genomics of pathogenic and commensal escherichia coli genomik pathogener und kommensaler escherichia coli |
| title_sub | = Genomik pathogener und kommensaler Escherichia coli |
| topic | Pathogenität (DE-588)4205990-2 gnd Genomik (DE-588)4776397-8 gnd Escherichia coli (DE-588)4070959-0 gnd |
| topic_facet | Pathogenität Genomik Escherichia coli Hochschulschrift |
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