Holdings: Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models

Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models: = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen

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Bibliographic Details
Main Author:	Becker, Andreas (Author)
Format:	Thesis Book
Language:	English
Published:	Erlangen ; Nürnberg [2017]
Subjects:	Pyroglutaminsäure Amyloid > beta- Glutaminyl-Peptid-Cyclotransferase Hochschulschrift
Online Access:	Inhaltsverzeichnis Inhaltsverzeichnis
Item Description:	Enthält Sonderabdrucke
Physical Description:	X, 164 Seiten Illustrationen, Diagramme 21 cm

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MARC


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245	1	0	\|a Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models \|b = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen \|c vorgelegt von Andreas Becker
246	1	3	\|a Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen
246	1	1	\|a Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen
264		1	\|a Erlangen ; Nürnberg \|c [2017]
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adam_text	TABLE OF CONTENTS TABLE OF CONTENTS.....................................................................................................................VII ABBREVIATIONS.............................................................................................................................. IX 1 SUMMARIES............................................................................................................................ 1 1.1 ZUSAMMENFASSUNG...................................................................................................... 1 1.2 SUMMARY....................................................................................................................... 5 2 INTRODUCTION...........................................................................................................................9 2.1 HISTORY OF ALZHEIMERS DISEASE ............................................................................... 11 2.2 GENETIC FACTORS OF ALZHEIMERS DISEASE..................................................................13 2.3 PATHOLOGICAL MECHANISMS OF ALZHEIMERS DISEASE..............................................15 2.3.1 AMYLOID BETA IN ALZHEIMERS DISEASE.............................................................. 16 2.3.2 TAU IN ALZHEIMERS DISEASE.............................................................................. 18 2.3.3 NEUROINFLAMMATION IN ALZHEIMERS DISEASE...................................................19 2.3.4 THE PATHOLOGICAL CASCADE OF ALZHEIMERS DISEASE.......................................20 2.4 ANIMAL MODELS OF ALZHEIMERS DISEASE ................................................................. 23 3 AIM OF THESIS...................................................................................................................... 25 4 RESULTS (OWN PUBLICATIONS)..............................................................................................29 4.1 AUTHORS CONTRIBUTION...................................................................................................29 4.2 SCHILLING ET A L.,2 0 1 1 ................................................................................................. 31 4.2.1 SCHILLING ET AL., 2011 - SUPPLEMENTAL MATERIAL...........................................43 4.3 ALEXANDRU ET AL., 2011............................................................................................... 49 4.4 BECKER ET AL., 2013.....................................................................................................63 4.4.1 BECKER ET AL., 2013 - SUPPLEMENTAL MATERIAL ................................................ 83 4.5 BECKER ET AL., 2016.....................................................................................................69 4.5.1 BECKER ET AL., 2 0 1 6 - SUPPLEMENTAL MATERIAL .............................................. 103 5 DISCUSSION.........................................................................................................................111 5.1 ROLE OF GLUTAMINYL CYCLASES IN VIVO 112 5.1.1 NEW ANIMAL MODELS WITH ALTERED QC ACTIVITY ............................................ 116 5.1.2 COMPARISON OF QC-KO AND ISOQC-KO.........................................................119 5.2 ROLE OF PE-ASS IN VIVO..............................................................................................122 5.2.1 THE AMYLOIDOGENIC PATHWAY...........................................................................123 5.2.2 GENERATION OF PE-ASS IN VIVO...........................................................................125 5.2.3 NEW ANIMAL MODELS WITH INCREASED PE-ASS FORMATION ............................. 126 5.2.4 COMPARISON OF ETNA AND T B A ....................................................................128 6 CONCLUSION........................................................................................................................133 6.1.1 THE EFFECTS OF PE-ASS........................................................................................134 6.1.2 INFLUENCE OF GLUTAMINYL CYCLASES ON PE-ASS FORMATION..............................136 7 OUTLOOK...............................................................................................................................137 8 APPENDICES.......................................................................................................................139 6.1 FIGURES.......................................................................................................................139 8.2 TABLES......................................................................................................................... 139 6.3 REFERENCES................................................................................................................140
any_adam_object	1
author	Becker, Andreas
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building	Verbundindex
bvnumber	BV044862414
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discipline	Biologie Medizin
format	Thesis Book
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spelling	Becker, Andreas Verfasser aut Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen vorgelegt von Andreas Becker Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen Erlangen ; Nürnberg [2017] X, 164 Seiten Illustrationen, Diagramme 21 cm txt rdacontent n rdamedia nc rdacarrier Enthält Sonderabdrucke Dissertation Friedrich-Alexander-Universität Erlangen-Nürnberg 2017 Pyroglutaminsäure (DE-588)4386088-6 gnd rswk-swf Amyloid beta- (DE-588)4385528-3 gnd rswk-swf Glutaminyl-Peptid-Cyclotransferase (DE-588)4796106-5 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Glutaminyl-Peptid-Cyclotransferase (DE-588)4796106-5 s Amyloid beta- (DE-588)4385528-3 s Pyroglutaminsäure (DE-588)4386088-6 s DE-604 B:DE-101 application/pdf http://d-nb.info/1152044524/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030257064&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Becker, Andreas Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen Pyroglutaminsäure (DE-588)4386088-6 gnd Amyloid beta- (DE-588)4385528-3 gnd Glutaminyl-Peptid-Cyclotransferase (DE-588)4796106-5 gnd
subject_GND	(DE-588)4386088-6 (DE-588)4385528-3 (DE-588)4796106-5 (DE-588)4113937-9
title	Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen
title_alt	Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen
title_auth	Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen
title_exact_search	Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen
title_full	Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen vorgelegt von Andreas Becker
title_fullStr	Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen vorgelegt von Andreas Becker
title_full_unstemmed	Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen vorgelegt von Andreas Becker
title_short	Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models
title_sort	influence of glutaminyl cyclases on pyroglutamate amyloid beta formation in transgenic mouse models einfluss der glutaminylzyklasen auf die bildung von pyroglutamat beta amyloid in transgenen mausmodellen
title_sub	= Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen
topic	Pyroglutaminsäure (DE-588)4386088-6 gnd Amyloid beta- (DE-588)4385528-3 gnd Glutaminyl-Peptid-Cyclotransferase (DE-588)4796106-5 gnd
topic_facet	Pyroglutaminsäure Amyloid beta- Glutaminyl-Peptid-Cyclotransferase Hochschulschrift
url	http://d-nb.info/1152044524/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030257064&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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