Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models: = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen
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| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Erlangen ; Nürnberg
[2017]
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | Enthält Sonderabdrucke |
| Beschreibung: | X, 164 Seiten Illustrationen, Diagramme 21 cm |
Internformat
MARC
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| 100 | 1 | |a Becker, Andreas |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models |b = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen |c vorgelegt von Andreas Becker |
| 246 | 1 | 3 | |a Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen |
| 246 | 1 | 1 | |a Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen |
| 264 | 1 | |a Erlangen ; Nürnberg |c [2017] | |
| 300 | |a X, 164 Seiten |b Illustrationen, Diagramme |c 21 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Enthält Sonderabdrucke | ||
| 502 | |b Dissertation |c Friedrich-Alexander-Universität Erlangen-Nürnberg |d 2017 | ||
| 650 | 0 | 7 | |a Pyroglutaminsäure |0 (DE-588)4386088-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Amyloid |g beta- |0 (DE-588)4385528-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Glutaminyl-Peptid-Cyclotransferase |0 (DE-588)4796106-5 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Glutaminyl-Peptid-Cyclotransferase |0 (DE-588)4796106-5 |D s |
| 689 | 0 | 1 | |a Amyloid |g beta- |0 (DE-588)4385528-3 |D s |
| 689 | 0 | 2 | |a Pyroglutaminsäure |0 (DE-588)4386088-6 |D s |
| 689 | 0 | |5 DE-604 | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-030257064 | ||
Datensatz im Suchindex
| _version_ | 1804178387079528448 |
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| adam_text | TABLE OF CONTENTS
TABLE OF
CONTENTS.....................................................................................................................VII
ABBREVIATIONS..............................................................................................................................
IX
1
SUMMARIES............................................................................................................................
1
1.1
ZUSAMMENFASSUNG......................................................................................................
1
1.2
SUMMARY.......................................................................................................................
5
2
INTRODUCTION...........................................................................................................................9
2.1 HISTORY OF ALZHEIMER*S DISEASE
...............................................................................
11
2.2 GENETIC FACTORS OF ALZHEIMER*S
DISEASE..................................................................13
2.3 PATHOLOGICAL MECHANISMS OF ALZHEIMER*S
DISEASE..............................................15
2.3.1 AMYLOID BETA IN ALZHEIMER*S
DISEASE.............................................................. 16
2.3.2 TAU IN ALZHEIMER*S
DISEASE..............................................................................
18
2.3.3 NEUROINFLAMMATION IN ALZHEIMER*S
DISEASE...................................................19
2.3.4 THE PATHOLOGICAL CASCADE OF ALZHEIMER*S
DISEASE.......................................20
2.4 ANIMAL MODELS OF ALZHEIMER*S DISEASE
.................................................................
23
3 AIM OF
THESIS......................................................................................................................
25
4 RESULTS (OWN
PUBLICATIONS)..............................................................................................29
4.1 AUTHORS
CONTRIBUTION...................................................................................................29
4.2 SCHILLING ET A L.,2 0 1 1
.................................................................................................
31
4.2.1 SCHILLING ET AL., 2011 - SUPPLEMENTAL
MATERIAL...........................................43
4.3 ALEXANDRU ET AL.,
2011...............................................................................................
49
4.4 BECKER ET AL.,
2013.....................................................................................................63
4.4.1 BECKER ET AL., 2013 - SUPPLEMENTAL MATERIAL
................................................
83
4.5 BECKER ET AL.,
2016.....................................................................................................69
4.5.1 BECKER ET AL., 2 0 1 6 - SUPPLEMENTAL MATERIAL
..............................................
103
5
DISCUSSION.........................................................................................................................111
5.1 ROLE OF GLUTAMINYL CYCLASES IN VIVO
112
5.1.1 NEW ANIMAL MODELS WITH ALTERED QC ACTIVITY
............................................
116
5.1.2 COMPARISON OF QC-KO AND
ISOQC-KO.........................................................119
5.2 ROLE OF PE-ASS IN
VIVO..............................................................................................122
5.2.1 THE AMYLOIDOGENIC
PATHWAY...........................................................................123
5.2.2 GENERATION OF PE-ASS IN
VIVO...........................................................................125
5.2.3 NEW ANIMAL MODELS WITH INCREASED PE-ASS FORMATION
.............................
126
5.2.4 COMPARISON OF ETNA AND T B A
....................................................................128
6
CONCLUSION........................................................................................................................133
6.1.1 THE EFFECTS OF
PE-ASS........................................................................................134
6.1.2 INFLUENCE OF GLUTAMINYL CYCLASES ON PE-ASS
FORMATION..............................136
7
OUTLOOK...............................................................................................................................137
8
APPENDICES.......................................................................................................................139
6.1
FIGURES.......................................................................................................................139
8.2
TABLES.........................................................................................................................
139
6.3
REFERENCES................................................................................................................140
|
| any_adam_object | 1 |
| author | Becker, Andreas |
| author_facet | Becker, Andreas |
| author_role | aut |
| author_sort | Becker, Andreas |
| author_variant | a b ab |
| building | Verbundindex |
| bvnumber | BV044862414 |
| ctrlnum | (OCoLC)1044691679 (DE-599)DNB1152044524 |
| discipline | Biologie Medizin |
| format | Thesis Book |
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| language | English |
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| spelling | Becker, Andreas Verfasser aut Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen vorgelegt von Andreas Becker Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen Erlangen ; Nürnberg [2017] X, 164 Seiten Illustrationen, Diagramme 21 cm txt rdacontent n rdamedia nc rdacarrier Enthält Sonderabdrucke Dissertation Friedrich-Alexander-Universität Erlangen-Nürnberg 2017 Pyroglutaminsäure (DE-588)4386088-6 gnd rswk-swf Amyloid beta- (DE-588)4385528-3 gnd rswk-swf Glutaminyl-Peptid-Cyclotransferase (DE-588)4796106-5 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Glutaminyl-Peptid-Cyclotransferase (DE-588)4796106-5 s Amyloid beta- (DE-588)4385528-3 s Pyroglutaminsäure (DE-588)4386088-6 s DE-604 B:DE-101 application/pdf http://d-nb.info/1152044524/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030257064&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Becker, Andreas Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen Pyroglutaminsäure (DE-588)4386088-6 gnd Amyloid beta- (DE-588)4385528-3 gnd Glutaminyl-Peptid-Cyclotransferase (DE-588)4796106-5 gnd |
| subject_GND | (DE-588)4386088-6 (DE-588)4385528-3 (DE-588)4796106-5 (DE-588)4113937-9 |
| title | Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen |
| title_alt | Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen |
| title_auth | Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen |
| title_exact_search | Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen |
| title_full | Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen vorgelegt von Andreas Becker |
| title_fullStr | Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen vorgelegt von Andreas Becker |
| title_full_unstemmed | Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen vorgelegt von Andreas Becker |
| title_short | Influence of glutaminyl cyclases on pyroglutamate-amyloid beta formation in transgenic mouse models |
| title_sort | influence of glutaminyl cyclases on pyroglutamate amyloid beta formation in transgenic mouse models einfluss der glutaminylzyklasen auf die bildung von pyroglutamat beta amyloid in transgenen mausmodellen |
| title_sub | = Einfluss der Glutaminylzyklasen auf die Bildung von Pyroglutamat-Beta-Amyloid in transgenen Mausmodellen |
| topic | Pyroglutaminsäure (DE-588)4386088-6 gnd Amyloid beta- (DE-588)4385528-3 gnd Glutaminyl-Peptid-Cyclotransferase (DE-588)4796106-5 gnd |
| topic_facet | Pyroglutaminsäure Amyloid beta- Glutaminyl-Peptid-Cyclotransferase Hochschulschrift |
| url | http://d-nb.info/1152044524/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030257064&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT beckerandreas influenceofglutaminylcyclasesonpyroglutamateamyloidbetaformationintransgenicmousemodelseinflussderglutaminylzyklasenaufdiebildungvonpyroglutamatbetaamyloidintransgenenmausmodellen AT beckerandreas einflussderglutaminylzyklasenaufdiebildungvonpyroglutamatbetaamyloidintransgenenmausmodellen |
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