Textbook of nephro-endocrinology:
Gespeichert in:
| Weitere Verfasser: | , |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London ; San Diego, CA ; Cambridge, MA ; Oxford
Academic Press
[2018]
|
| Ausgabe: | Second edition |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | xv, 568 Seiten Illustrationen, Diagramme |
| ISBN: | 9780128032473 |
Internformat
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| 245 | 1 | 0 | |a Textbook of nephro-endocrinology |c edited by Ajay K. Singh, Gordon H. Williams |
| 250 | |a Second edition | ||
| 264 | 1 | |a London ; San Diego, CA ; Cambridge, MA ; Oxford |b Academic Press |c [2018] | |
| 300 | |a xv, 568 Seiten |b Illustrationen, Diagramme | ||
| 336 | |b txt |2 rdacontent | ||
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| 700 | 1 | |a Singh, Ajay K. |4 edt | |
| 700 | 1 | |a Williams, Gordon H. |4 edt | |
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Datensatz im Suchindex
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| adam_text | Contents
List of Contributors....
Preface................
..xiii
...XV
1. Physiology and Regulation of the Renin-Angiotensin-Aldosterone System
ROBERT M. CAREY AND SHETAL H. PADIA
1 The Classical Circulating Renin-Angiotensin System.................................................
2 Renin Biosynthesis and Secretion..................................................................................
3 The (Pro)Renin Receptor............................................................................................. ......................................................1
4 Angiotensin-Converting Enzyme.................................................................................. ......................................................3
5 The ACE-2/Angiotensin (l-7)/Mas Receptor Pathway............................................... ......................................................5
6 AT, RprfvntnrQ ...................... ......................................................7
7 ATj Receptors................................................................................................................
8 Newly Discovered Components and Actions of the Renin-Angiotensin System.......
9 Angiotensin Receptor Heterodimerization...................................................................
10 Tissue Renin-Angiotensin Systems..............................................................................
11 fntTCirpnäl Rpnin Antfinfpnsin Sv.QtPm ....................................................
12 Brain Renin-Angiotensin System.................................................................................
13 Vascular Tissue Renin-Angiotensin System................................................................. ....................................................14
14 Cardiac Renin-Angiotensin System.............................................................................
1 5 Rf^ntr։ Angintpnsin ............................................................
16 A at-։6 Mmpralniwi-irriirl Rprpntrirs................................................. 1 s
17 Clinical Effects of the Renin-Angiotensin-Aldosterone System................................
18 Summary........................................................................................................................
References.................................................................................................................................................... ..................................................................20
2. The Renin-Angiotensin-Aldosterone System and the Kidney
BENJAMIN KO AND GEORGE BAKR1S
1 Introduction...........................................................................................27
2 Historical Background..................................................................................28
3 Overview of the Renin-Angiotensin System Pathway.......................................................28
4 Physiologic Effects of Renin-Angiotensin System........................................................28
5 Renin-Angiotensin System in Human Disease..............................................................32
6 Conclusion ............................................................................................36
References..............................................................................................37
3. The Renin-Angiotensin System and the Heart
AARON J. TRASK AND CARLOS M. FERRARIO
1 Introduction...................................
2 Cardiac RAS...................................
3 Significance of the RAS on Cardiac Function...
4 Conclusions.....................................
References.....................................
......43
......44
......47
......50
......50
v
vi
CONTENTS
4* Renin-Angiotensin Blockade: Therapeutic Agents
DOMENICA. SICA
1 Introduction.............................................................................................
2 Therapeutic Classes....................................*.................................................58
3 Pharmacology..............................................................................................59
4 Chronotherapeutics With Renin-Angiotensin System Inhibitors...............................................64
5 Direct Renin Inhibitors...................................................................................65
6 Hemodynamic Effects of RAS Inhibitors.....................................................................66
7 Additional Pathway Considerations and Mechanism of Action for RAS Inhibitors..............................67
8 Blood Pressure Lowering Effect............................................................................67
9 Renin-Angiotensin System Inhibitors With Other Agents.....................................................68
10 Side Effects Particular to Angiotensin-Receptor Blockers.................................................69
11 Side Effects Unique to Direct Renin Inhibitors.*..................................................... 70
12 Side Effects Unique to ACE Inhibitors....*..............................................................70
13 Select Side Effect Common to All Renin-Angiotensin System Inhibitors.....................................70
References.................................................................................................71
Further Reading............................................................................................75
5. Vasopressin in the Kidney-Historical Aspects
LYNN E. SCHLANGER AND JEFF M. SANDS
1 Introduction..................................................*.....*...................................77
2 Hypothalamus...........................................................................................78
3 Vasopressin Receptors..................................................................................79
4 Aquaporins.............................................................................................82
5 Vasopressin-Regulated Urea Transport...................................................................84
6 Nephrogenic Diabetes Insipidus....................................................................... 87
7 Vaptans.............................................................................................. 88
8 Summary................................................................................................89
References..............................................................................................89
6. Molecular Biology and Gene Regulation
SWASTITIWARI AND CAROLYN M. ECELBARGER
1 Introduction.............................................................................................. ’95
2 AVP Synthesis, Storage, and Release..........................................................................96
3 Vasopressin Receptors........................................................................................98
4 Cellular Regulation of Water, Electrolyte, and Mineral Reabsorption.........................................105
5 Vasopressin, Renal Hemodynamics, and Blood Pressure.........................................................Ill
References...................................................................................................113
7* Vasopressin Antagonists in Physiology and Disease
TOMAS BERL AND ROBERT W. SCHR1ER
1 Introduction.............................................................................................117
2 Physiologic Antagonists..............................*....................................................117
3 Vasopressin Antagonists and Their Role in the Treatment of Water-Retaining Disorders.....................121
4 Are Vasopressin Antagonists Safe?........................................................................127
5 Summary and Unanswered Questions.........................................................................127
References................................................................................................128
8. Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone
MICHAEL L. MORITZ AND JUAN C. AYUS
1 Introduction...............................................................................................134
2 Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone......................................134
3 Hyponatrémie Encephalopathy................................................................................152
References..................................................................................................156
CONTENTS
9. The Cardiac Natriuretic Peptide System: Linking the Heart and Kidney in Cardiorenal
Homeostasis and Therapeutics
LAURA MEEMS, YANG CHEN, AND JOHN C. BURNETT JR.
1 Natriuretic Peptides...................................................................................164
2 Natriuretic Peptide Therapeutics.......................................................................165
3 Designer Natriuretic Peptides for Cardiorenal Disease..................................................166
4 Neprilysin and Neprilysin Inhibition...................................................................168
5 Neprilysin Inhibition as a Therapeutic Strategy for Targeting the Cardiorenal Axis.....................168
6 Future Directions......................................................................................169
Acknowledgments....................................................................................... 169
References..............................................................................................170
10. Aldosterone s Mechanism of Action: Genomic and Nongenomic Signaling
RENE BAUDRAND, LUMINiTA POJOGA, AND JOSE R. ROMERO
1 Introduction...........................................................................................173
2 The Mineralocorticoid Receptor.........................................................................174
3 Genomic Actions of Aldosterone.........................................................................177
4 Nongenomic Actions of Aldosterone......................................................................179
5 Epigenetic Effects.....................................................................................181
6 Mineralocorticoid Receptor Modulators..................................................................181
7 Novel Mineralocorticoid Receptor Antagonists...........................................................183
8 Conclusions........................................................................................ 183
References..............................................................................................184
11. Erythropoietin: An Historical Overview of Physiology, Molecular Biology, and
Gene Regulation
DAVID R. MOLE AND PETER J. RATCLIFFE
1 Introduction...........................................................................................189
2 Hormonal Regulation of Erythropoiesis..................................................*..............191
3 Identification of the Site of Erythropoietin Production................................................191
4 Assays of Erythropoietin...............................................................................192
5 Isolation and Characterization of Erythropoietin.......................................................192
6 Erythropoietin Effector Mechanisms.....................................................................193
7 Regulation of Erythropoiesis by Hypoxia................................................................193
8 Regulatory Elements of Erythropoietin Gene.............................................................194
9 Erythropoietin—The Paradigm for Gene Regulation by Hypoxia.............................................195
10 Hypoxia-Inducible Factor..............................................................................197
11 The Elusive Nature of the Oxygen Sensor...............................................................198
12 Degradation of Hypoxia-Inducible Factor by the Ubiquitin-Proteosomal Pathway..........................199
13 Targeting of Hypoxia-Inducible Factor by the von Hippel-Lindau E3 Ubiquitin Ligase....................199
14 Regulation of the Hypoxia-Inducible Factor-von Hippel-Lindau Interaction..............................200
15 The Hypoxia-Inducible Factor Hydroxylases as Oxygen Sensors...........................................200
16 Disruption of the Oxygen-Sensing Pathway in Cancer....................................................201
17 Disruption of the Oxygen-Sensing Pathway in Hereditary Polycythemia...................................203
18 Pharmacological Manipulation of Hypoxia-Inducible Factor..............................................203
19 Summary...՛...........................................................................................204
References..............................................................................................204
12. Erythropoiesis: The Roles of Erythropoietin and Iron
AJAYK. SINGH
1 Erythropoiesis: An Overview............................................................................207
2 Role of Erythropoietin in Erythropoiesis...............................................................209
3 Role of Iron in Erythropoiesis.........................................................................211
Acknowledgments.........................................................................................213
References..............................................................................................214
viii
CONTENTS
13. Development of Recombinant Erythropoietin and Erythropoietin Analogs
IAIN C. MACDOUGALL
1 Introduction........................................................................................ 217
2 History of Recombinant Human Erythropoietin...........................................................218
3 Biosimilar Erythropoietins............................................................................219
4 Potential Strategies for Modifying Erythropoietin to Create New Erythropoietin Analogs................220
5 Darbepoetin Alfa.................................................................................... 221
6 Continuous Erythropoietin Receptor Activator..........................................................224
7 Small Molecule Erythropoiesis-Stimulating Agents.................................................... 226
8 Other Strategies for Stimulating Erythropoiesis.......................................................228
9 Conclusions...........................................................................................228
References.............................................................................................228
Further Reading...................................................................................... 232
14. Insulin Resistance and the Metabolic Syndrome in Chronic Renal Disease
DONALD C. SIMONSON
1 Introduction..........................................................................................233
2 Historical Perspective................................................................................234
3 Cellular Mechanisms of Insulin Secretion and Action................................................. 234
4 Clinical Physiology of Insulin Resistance.............................................................236
5 Measurement of Insulin Resistance.....................................................................237
6 Metabolic Syndrome....................................................................................239
7 Pathogenesis of Insulin Resistance in Chronic Kidney Disease..........................................247
8 Regulation of Renal Glucose Production................................................................248
9 Syndromes of Severe Insulin Resistance................................................................248
10 Treatment............................................................................................249
11 Management of Diabetes in Chronic Kidney Disease.....................................................251
12 Hyperglycemia Associated With Renal Transplantation..................................................252
13 Conclusions..........................................................................................253
References.............................................................................................253
15. Growth Hormone
JOHN D. MAHAN AND ROSE AYOOB
1 Growth Hormone and Insulin-Like Growth Factor-1 in Renal Failure......................................259
2 Pediatric Implications: Growth Failure and the GH/IGF-1 Axis in CKD...................................264
3 Adult Implications: Myriad Effects of Disturbed GH/IGF-1 Axis in CKD..................................267
4 Effects of Recombinant Growth Hormone Treatment in Renal Failure......................................267
5 The Horizon for Improving Growth and Anabolism in Renal Failure.......................................272
6 Summary............................................................................................. 272
References.............................................................................................273
16. Sexual Dysfunction in Men and Women With Chronic Kidney Disease
BIFFE PALMER
1 Introduction..........................................................................................277
2 Sexual Dysfunction in Uremic Men.....................................................................277
3 Evaluation of Sexual Dysfunction in the Uremic Man...................................................281
4 Treatment of Sexual Dysfunction in the Uremic Man.................................................. 282
5 Outcomes Associated With Hypogonadism and Treatment..................................................284
6 Sexual Dysfunction in Uremic Women................................................................. 285
7 Treatment..............................................................................................
References.......................................................................................... 288
CONTENTS lx
17. Metabolic Acidosis of Chronic Kidney Disease
JEFFREY A. KRAUT AND GLENN T. NAGAMI
1 Introduction..........................................................................................292
2 Regulation of Acid-Base Balance With Normal Renal Function and Chronic Kidney Disease.................292
3 Acid-Base Production..................................................................................293
4 Renal Bicarbonate Generation..........................................................................294
5 Cellular Buffering....................................................................................295
6 Renal Tubular Bicarbonate Reabsorption................................................................296
7 Hormonal Regulation of Acid-Base Balance With Normal Renal Function and CKD...........................297
8 Aldosterone...........................................................................................297
9 Angiotensin II........................................................................................298
10 Parathyroid Hormone..................................................................................298
11 Glucocorticoids......................................................................................298
12 Antidiuretic Hormone.................................................................................299
13 Glucagon.............................................................................................299
14 Endothelin...........................................................................................299
15 Insulin..............................................................................................299
16 Growth Hormone and IGF-1.............................................................................300
17 Clinical Characteristics of the Metabolic Acidosis of Chronic Kidney Disease.........................300
18 Serum Electrolyte Pattern............................................................................302
19 Renal Tubular Bicarbonate Generation and Urinary Acidification.......................................303
20 Clinical Characteristics of Acid-Base Parameters in Dialysis Patients................................305
21 Effects of Metabolic Acidosis of CKD on Cellular Function............................................306
22 Exacerbation or Production of Bone Disease...........................................................306
23 Muscle Wasting.......................................................................................307
24 Reduced Albumin Synthesis.......................................................................... 308
25 Acceleration of Progression of CKD...................................................................308
26 Exacerbation or Development of Cardiac Disease.......................................................309
27 Impaired Glucose Homeostasis and Lipid Metabolism....................................................310
28 Lepttn...............................................................................................310
29 Accumulation of P2 Microglobulin.....................................................................310
30 Growth Hormone and Thyroid Function.................................................................310
31 Inflammatory Response...............................................................................311
32 Treatment of the Metabolic Acidosis of CKD..........................................................311
References............................................................................................313
18. Pregnancy and the Kidney
S. ANANTH KARUMANCHI
1 Normal Pregnancy......................................................................................320
2 Preeclampsia and HELLP Syndrome.......................................................................321
3 Other Hypertensive Disorders of Pregnancy.............................................................332
4 Renal Failure in Pregnancy.......................................................................... 334
References..................*.........................................................................339
19. Vitamin D: Molecular Biology and Gene Regulation
ADRIANA S. DUSSO AND ALEX J. BROWN
1 Vitamin D.............................................................................................347
2 The l,25 Dihydroxyvitamin D/Vitamin D Receptor Complex................................................349
3 Relevance of 1,25-Dihydroxyvitamin D/Vitamin D Receptor Actions in Health and in Kidney Disease.......358
4 Concluding Remarks....................................................................................364
Acknowledgments.......................................................................................364
References............................................................................................364
X
CONTENTS
20. Clinical Syndromes of Vitamin D and Phosphate Dysrégulation
KARAN SUD, AKHIL PARASHAR, AND VEERAISH CHAUHAN
1 Introduction......................................................................................374
2 Metabolism........................................................................................374
3 Transport.........................................................................................375
4 Mechanism of Action...............................................................................375
5 Functions of Vitamin D............................................................................375
6 Recommended Dietary Allowance Guidelines for Vitamin D............................................376
7 Vitamin D Dysrégulation: Epidemiology of Insufficiency and Toxicity States........................377
8 Skeletal Manifestations of Vitamin D Dysrégulation................................................378
9 Looking Beyond the Bones: Extraskeletal Manifestations of Vitamin D Dysrégulation.................380
10 Vitamin D Toxicity...............................................................................384
11 Conclusion.......................................................................................385
References.........................................................................................385
21. Molecular Biology of Renin and Regulation of Its Gene
DANIEL F CATANZARO
1 Introduction......................................................................................389
2 Production and Activation of Renin................................................................390
3 Renin Gene Structure and Regulation...............................................................393
4 Renin Gene Mutation and Disease...................................................................395
5 Future Perspectives...............................................................................397
Acknowledgments....................................................................................398
References.........................................................................................398
Further Reading....................................................................................400
22. Vitamin D and the Kidney: Introduction and Historical Perspective
SAGAR U. NIGWEKAR AND AjAY K. SINGH
1 Introduction......................................................................................401
2 Vitamin D....................................................................................... 401
3 Role of Vitamin D in Kidney Disease...............................................................405
4 Role of Vitamin D in Other Disease States.........................................................406
References.........................................................................................408
23. Extrahematopoietic Actions of Erythropoietin
MICHAEL BRINES
1 The Biology of Erythropoietin.....................................................................412
2 Examples of Nonerythropoietic Activities of EPO in Different Tissues..............................420
References.........................................................................................426
24. Regulation of Aldosterone Production
SILVIA MONTICONE, WILLIAM E. RAINEY, WENDY B. BOLLAG, AND CARLOS M. ISALES
1 Introduction.........................................................................................429
2 Aldosterone Biosynthesis.............................................................................430
3 Factors Regulating Aldosterone Production.......................................................... 431
4 Adrenocorticotropic Hormone..........................................................................436
5 Diseases of Aldosterone Production...................................................................439
6 Conclusions..........................................................................................444
References...........................................................................................444
LUNTEN: S XI
25. Aldosterone and Its Cardiovascular Effects
RAJESH GARG AND GAIL K. ADLER
1 Introduction..........................................................................................452
2 Aldosterone and the Heart............................................................................452
3 Aldosterone and Brain................................................................................455
4 Aldosterone and Renal Disease........................................................................456
5 Potential Molecular Pathways Mediating the Adverse Vascular Ettects of Aldosterone...................457
6 Therapeutic Considerations...........................................................................459
7 Conclusions........................................................................................ 460
References............................................................................................460
26. Aldosterone: History and Introduction
KORO GOTOH AND HIROTAKA SHIBATA
1 Early History of Aldosterone..........................................................................465
2 Aldosterone and Mineralocorticoid Receptor in Clinical Medicine.................................... 470
3 Mineralocorticoid Receptor Antagonists...............................................................471
References............................................................................................474
27. Thyroid Status in Chronic Renal Failure Patients
CONNIE M. RHEE AND SAHIR KAUM
1 Epidemiology of Thyroid Dysfunction in Kidney Disease.................................................478
2 Thyroid Physiology...................................................................................479
3 Thyroid Functional Test Derangements in Kidney Disease...............................................480
4 Potential Mechanisms Linking Thyroid and Kidney Disease..............................................482
5 Thyroid Dysfunction and Outcomes.....................................................................484
6 Treatment of Thyroid Dysfunction.....................................................................487
7 Future Directions....................................................................................488
References............................................................................................489
28. Aldosterone/Mineralocorticoid Receptors and Their Renal Effects: Molecular Biology
and Gene Regulation
CELSO E. GOMEZ-SANCHEZ, ELISE P. GOMEZ-SANCHEZ, AND ANASTASIA S. M1HAIL1DOU
1 Introduction.........................................................................................494
2 Aldosterone-Binding Sites and the Mineralocorticoid Receptor....................................... 494
3 Molecular Biology of the Mineralocorticoid Receptor..................................................494
4 Genomic Structure and Organization............................................................... 496
5 Posttranslational Modifications of the Mineralocorticoid Receptor....................................497
6 Oligomeric Structure of Steroid Receptors.......................................................... 499
7 Cytoplasmic-Nuclear Shuttling of Steroid Receptors...................................................499
8 Mineralocorticoid Receptor Selectivity............................................................. 501
9 Distribution of the Mineralocorticoid Receptor in the Nephron........................................502
10 Proteins Induced by Aldosterone in Transport Epithelia............................................. 505
11 Nongenomic Effects of Aldosterone in the Kidney......................................................506
12 Cross Talk of the Mineralocorticoid Receptor With Membrane Receptors.................................506
13 Aldosterone Effects Mediated by CPER (GPR30).........................................................507
14 Renal Nongenomic Effects of Aldosterone..............................................................508
15 Physiological and Pharmacological Role of Antagonists of the Mineralocorticoid Receptor in
Human Physiology and Pathology........................................................................509
16 Conclusions........................................................................................ 509
References............................................................................................510
xii
CONTENTS
29. The History of the Renin-Angiotensin System
JOEL MENARD
1 Introduction.................................
2 The 20th Century.............................
3 The 21st Century.............................
4 The Dream to Be Normotensive and Drug Free...
5 Conclusion...................................
References....................................
Further Reading...............................
..................517
..................517
..................520
..................521
..................521
..................521
..................522
30. Molecular Biology of Parathyroid Hormone
JEAN-PIERRE VILARDAGA AND PETER A. FRIEDMAN
1 Biosynthesis and Metabolism...............................................................................523
2 Parathyroid Hormone Receptors....................................................................... 527
3 Mechanisms of Parathyroid Hormone Binding and Parathyroid Hormone Receptor Signaling......................528
4 Physiological Actions of Parathyroid Hormone..............................................................531
5 Disordered Parathyroid Hormone Regulation in Chronic Kidney Disease.......................................533
Acknowledgments.......................................................................................... 534
References................................................... ............................................534
31. Endocrine Regulation of Phosphate Homeostasis
RONALD B. BROWN AND MOHAMMED S. RAZZAQUE
1 Introduction...................................
2 Phosphate Homeostasis..........................
3 Endocrine Regulatory Factors...................
4 Dysrégulation of Phosphate Homeostasis........
5 Conclusion....................................
References.....................................
Index
549
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| edition | Second edition |
| format | Book |
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| genre | (DE-588)4123623-3 Lehrbuch gnd-content |
| genre_facet | Lehrbuch |
| id | DE-604.BV044694266 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:59:32Z |
| institution | BVB |
| isbn | 9780128032473 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-030091150 |
| oclc_num | 1019993866 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | xv, 568 Seiten Illustrationen, Diagramme |
| publishDate | 2018 |
| publishDateSearch | 2018 |
| publishDateSort | 2018 |
| publisher | Academic Press |
| record_format | marc |
| spelling | Textbook of nephro-endocrinology edited by Ajay K. Singh, Gordon H. Williams Second edition London ; San Diego, CA ; Cambridge, MA ; Oxford Academic Press [2018] xv, 568 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Endokrine Regulation (DE-588)4113434-5 gnd rswk-swf Niere (DE-588)4042270-7 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Niere (DE-588)4042270-7 s Endokrine Regulation (DE-588)4113434-5 s DE-604 Singh, Ajay K. edt Williams, Gordon H. edt Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030091150&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Textbook of nephro-endocrinology Endokrine Regulation (DE-588)4113434-5 gnd Niere (DE-588)4042270-7 gnd |
| subject_GND | (DE-588)4113434-5 (DE-588)4042270-7 (DE-588)4123623-3 |
| title | Textbook of nephro-endocrinology |
| title_auth | Textbook of nephro-endocrinology |
| title_exact_search | Textbook of nephro-endocrinology |
| title_full | Textbook of nephro-endocrinology edited by Ajay K. Singh, Gordon H. Williams |
| title_fullStr | Textbook of nephro-endocrinology edited by Ajay K. Singh, Gordon H. Williams |
| title_full_unstemmed | Textbook of nephro-endocrinology edited by Ajay K. Singh, Gordon H. Williams |
| title_short | Textbook of nephro-endocrinology |
| title_sort | textbook of nephro endocrinology |
| topic | Endokrine Regulation (DE-588)4113434-5 gnd Niere (DE-588)4042270-7 gnd |
| topic_facet | Endokrine Regulation Niere Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030091150&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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