Affinity and efficacy: the components of drug-receptor interactions
The interaction of a drug with a receptor generates a code of information having components of affinity and efficacy. How this information is translated into a response depends on the unique cells, tissue, organ or system in which the receptor resides. This book describes how to analyze various resp...
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Singapore
World Scientific Pub. Co.
[2015]
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| Schlagworte: | |
| Online-Zugang: | FHN01 UBM01 URL des Erstveröffentlichers |
| Zusammenfassung: | The interaction of a drug with a receptor generates a code of information having components of affinity and efficacy. How this information is translated into a response depends on the unique cells, tissue, organ or system in which the receptor resides. This book describes how to analyze various responses to estimate the affinity and efficacy components of the initial drug–receptor interaction. More specifically, it describes how to measure the affinity and efficacy of drugs through the analysis of single receptor activity, the activation state of a population of receptors, and responses downstream from receptor activation. More light is thrown on ligand-gated ion channels and G protein-coupled receptors in this book. The topics discussed include radioligand binding, estimation of agonist affinity and efficacy, competitive antagonism, inverse agonism, allosteric agonists and modulators, agonist bias, modulation of pathway selectivity, and the estimation of ligand affinity for active and inactive receptor states. The natural history and structure of ligand-gated ion channels, G proteins, and G protein-coupled receptors are also discussed |
| Beschreibung: | 1 Online-Ressource (ix, 739 S.) Illustrationen |
| ISBN: | 9789814324229 |
Internformat
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| 520 | |a The interaction of a drug with a receptor generates a code of information having components of affinity and efficacy. How this information is translated into a response depends on the unique cells, tissue, organ or system in which the receptor resides. This book describes how to analyze various responses to estimate the affinity and efficacy components of the initial drug–receptor interaction. More specifically, it describes how to measure the affinity and efficacy of drugs through the analysis of single receptor activity, the activation state of a population of receptors, and responses downstream from receptor activation. More light is thrown on ligand-gated ion channels and G protein-coupled receptors in this book. The topics discussed include radioligand binding, estimation of agonist affinity and efficacy, competitive antagonism, inverse agonism, allosteric agonists and modulators, agonist bias, modulation of pathway selectivity, and the estimation of ligand affinity for active and inactive receptor states. The natural history and structure of ligand-gated ion channels, G proteins, and G protein-coupled receptors are also discussed | ||
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Datensatz im Suchindex
| _version_ | 1804178054687227904 |
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| author | Ehlert, Frederick J. |
| author_facet | Ehlert, Frederick J. |
| author_role | aut |
| author_sort | Ehlert, Frederick J. |
| author_variant | f j e fj fje |
| building | Verbundindex |
| bvnumber | BV044638238 |
| classification_rvk | VS 5900 |
| collection | ZDB-124-WOP |
| ctrlnum | (ZDB-124-WOP)00006285 (OCoLC)988733514 (DE-599)BVBBV044638238 |
| dewey-full | 615.7/0452 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
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| dewey-search | 615.7/0452 |
| dewey-sort | 3615.7 3452 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Electronic eBook |
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| id | DE-604.BV044638238 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:57:52Z |
| institution | BVB |
| isbn | 9789814324229 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-030036212 |
| oclc_num | 988733514 |
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| owner_facet | DE-92 DE-19 DE-BY-UBM |
| physical | 1 Online-Ressource (ix, 739 S.) Illustrationen |
| psigel | ZDB-124-WOP ZDB-124-WOP FHN_PDA_WOP ZDB-124-WOP UBM_PDA_WOP_Kauf |
| publishDate | 2015 |
| publishDateSearch | 2015 |
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| publisher | World Scientific Pub. Co. |
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| spelling | Ehlert, Frederick J. Verfasser aut Affinity and efficacy the components of drug-receptor interactions Frederick J. Ehlert Singapore World Scientific Pub. Co. [2015] 1 Online-Ressource (ix, 739 S.) Illustrationen txt rdacontent c rdamedia cr rdacarrier The interaction of a drug with a receptor generates a code of information having components of affinity and efficacy. How this information is translated into a response depends on the unique cells, tissue, organ or system in which the receptor resides. This book describes how to analyze various responses to estimate the affinity and efficacy components of the initial drug–receptor interaction. More specifically, it describes how to measure the affinity and efficacy of drugs through the analysis of single receptor activity, the activation state of a population of receptors, and responses downstream from receptor activation. More light is thrown on ligand-gated ion channels and G protein-coupled receptors in this book. The topics discussed include radioligand binding, estimation of agonist affinity and efficacy, competitive antagonism, inverse agonism, allosteric agonists and modulators, agonist bias, modulation of pathway selectivity, and the estimation of ligand affinity for active and inactive receptor states. The natural history and structure of ligand-gated ion channels, G proteins, and G protein-coupled receptors are also discussed Drug receptors Protein binding Radioligand assay Erscheint auch als Druck-Ausgabe 9789814322560 https://doi.orgs/10.1142/7888 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Ehlert, Frederick J. Affinity and efficacy the components of drug-receptor interactions Drug receptors Protein binding Radioligand assay |
| title | Affinity and efficacy the components of drug-receptor interactions |
| title_auth | Affinity and efficacy the components of drug-receptor interactions |
| title_exact_search | Affinity and efficacy the components of drug-receptor interactions |
| title_full | Affinity and efficacy the components of drug-receptor interactions Frederick J. Ehlert |
| title_fullStr | Affinity and efficacy the components of drug-receptor interactions Frederick J. Ehlert |
| title_full_unstemmed | Affinity and efficacy the components of drug-receptor interactions Frederick J. Ehlert |
| title_short | Affinity and efficacy |
| title_sort | affinity and efficacy the components of drug receptor interactions |
| title_sub | the components of drug-receptor interactions |
| topic | Drug receptors Protein binding Radioligand assay |
| topic_facet | Drug receptors Protein binding Radioligand assay |
| url | https://doi.orgs/10.1142/7888 |
| work_keys_str_mv | AT ehlertfrederickj affinityandefficacythecomponentsofdrugreceptorinteractions |