The quantal theory of immunity: the molecular basis of autoimmunity and leukemia
This book explains how the immune system functions, namely, how individual cells of the immune system make the decision to respond or not to respond to foreign microbes and molecules, and how the critical molecules function to trigger the cellular reactions in an all-or-none (quantal) manner. To dat...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Singapore
World Scientific Pub. Co.
c2010
|
| Schlagworte: | |
| Online-Zugang: | FHN01 Volltext |
| Zusammenfassung: | This book explains how the immune system functions, namely, how individual cells of the immune system make the decision to respond or not to respond to foreign microbes and molecules, and how the critical molecules function to trigger the cellular reactions in an all-or-none (quantal) manner. To date, there has not been a complete description of the immune system and its cells and molecules, primarily because most of the information has accumulated only in the last 40 years and our understanding has been expanding rapidly only in the last 20 years. It is now clear that the cells have evolved a way to "count" the number of foreign antigenic molecular "hits", and they only react when a critical number of events have accumulated. Subsequently, control over the reaction is transferred to a systemic lymphocytotrophic hormone system that determines the tempo, magnitude and duration of the immune reaction. This book explains in detail how the immune system, cells and molecules work for the first time. With this understanding as a basis, the pathogenesis of autoimmunity can now be understood as a mutational usurpation of the genes encoding molecules that participate in a sensitive feedback regulatory control of the immune reaction. By comparison, malignant transformation is understood as a mutational usurpation of the genes encoding the molecules that control the quantal decision to proliferate, so that normal ligand/receptor cell growth control is circumvented |
| Beschreibung: | xi, 235 p. ill. (some col.) |
| ISBN: | 9789814271769 |
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| 520 | |a This book explains how the immune system functions, namely, how individual cells of the immune system make the decision to respond or not to respond to foreign microbes and molecules, and how the critical molecules function to trigger the cellular reactions in an all-or-none (quantal) manner. To date, there has not been a complete description of the immune system and its cells and molecules, primarily because most of the information has accumulated only in the last 40 years and our understanding has been expanding rapidly only in the last 20 years. It is now clear that the cells have evolved a way to "count" the number of foreign antigenic molecular "hits", and they only react when a critical number of events have accumulated. Subsequently, control over the reaction is transferred to a systemic lymphocytotrophic hormone system that determines the tempo, magnitude and duration of the immune reaction. This book explains in detail how the immune system, cells and molecules work for the first time. With this understanding as a basis, the pathogenesis of autoimmunity can now be understood as a mutational usurpation of the genes encoding molecules that participate in a sensitive feedback regulatory control of the immune reaction. By comparison, malignant transformation is understood as a mutational usurpation of the genes encoding the molecules that control the quantal decision to proliferate, so that normal ligand/receptor cell growth control is circumvented | ||
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Datensatz im Suchindex
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| author | Smith, Kendall A. |
| author_facet | Smith, Kendall A. |
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| author_sort | Smith, Kendall A. |
| author_variant | k a s ka kas |
| building | Verbundindex |
| bvnumber | BV044637696 |
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| ctrlnum | (ZDB-124-WOP)00001125 (OCoLC)802339227 (DE-599)BVBBV044637696 |
| dewey-full | 616.97/8 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.97/8 |
| dewey-search | 616.97/8 |
| dewey-sort | 3616.97 18 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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| id | DE-604.BV044637696 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:57:51Z |
| institution | BVB |
| isbn | 9789814271769 |
| language | English |
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| physical | xi, 235 p. ill. (some col.) |
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| spelling | Smith, Kendall A. Verfasser aut The quantal theory of immunity the molecular basis of autoimmunity and leukemia Kendall A. Smith Singapore World Scientific Pub. Co. c2010 xi, 235 p. ill. (some col.) txt rdacontent c rdamedia cr rdacarrier This book explains how the immune system functions, namely, how individual cells of the immune system make the decision to respond or not to respond to foreign microbes and molecules, and how the critical molecules function to trigger the cellular reactions in an all-or-none (quantal) manner. To date, there has not been a complete description of the immune system and its cells and molecules, primarily because most of the information has accumulated only in the last 40 years and our understanding has been expanding rapidly only in the last 20 years. It is now clear that the cells have evolved a way to "count" the number of foreign antigenic molecular "hits", and they only react when a critical number of events have accumulated. Subsequently, control over the reaction is transferred to a systemic lymphocytotrophic hormone system that determines the tempo, magnitude and duration of the immune reaction. This book explains in detail how the immune system, cells and molecules work for the first time. With this understanding as a basis, the pathogenesis of autoimmunity can now be understood as a mutational usurpation of the genes encoding molecules that participate in a sensitive feedback regulatory control of the immune reaction. By comparison, malignant transformation is understood as a mutational usurpation of the genes encoding the molecules that control the quantal decision to proliferate, so that normal ligand/receptor cell growth control is circumvented Immune response Interleukin-2 T cells Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Immunsystem (DE-588)4026643-6 gnd rswk-swf Leukämie (DE-588)4035487-8 gnd rswk-swf Autoaggressionskrankheit (DE-588)4003935-3 gnd rswk-swf Immunsystem (DE-588)4026643-6 s Molekularbiologie (DE-588)4039983-7 s Autoaggressionskrankheit (DE-588)4003935-3 s Leukämie (DE-588)4035487-8 s 1\p DE-604 Erscheint auch als Druck-Ausgabe 9789814271752 (hbk.) Erscheint auch als Druck-Ausgabe 9814271756 (hbk.) http://www.worldscientific.com/worldscibooks/10.1142/7269#t=toc Verlag URL des Erstveroeffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Smith, Kendall A. The quantal theory of immunity the molecular basis of autoimmunity and leukemia Immune response Interleukin-2 T cells Molekularbiologie (DE-588)4039983-7 gnd Immunsystem (DE-588)4026643-6 gnd Leukämie (DE-588)4035487-8 gnd Autoaggressionskrankheit (DE-588)4003935-3 gnd |
| subject_GND | (DE-588)4039983-7 (DE-588)4026643-6 (DE-588)4035487-8 (DE-588)4003935-3 |
| title | The quantal theory of immunity the molecular basis of autoimmunity and leukemia |
| title_auth | The quantal theory of immunity the molecular basis of autoimmunity and leukemia |
| title_exact_search | The quantal theory of immunity the molecular basis of autoimmunity and leukemia |
| title_full | The quantal theory of immunity the molecular basis of autoimmunity and leukemia Kendall A. Smith |
| title_fullStr | The quantal theory of immunity the molecular basis of autoimmunity and leukemia Kendall A. Smith |
| title_full_unstemmed | The quantal theory of immunity the molecular basis of autoimmunity and leukemia Kendall A. Smith |
| title_short | The quantal theory of immunity |
| title_sort | the quantal theory of immunity the molecular basis of autoimmunity and leukemia |
| title_sub | the molecular basis of autoimmunity and leukemia |
| topic | Immune response Interleukin-2 T cells Molekularbiologie (DE-588)4039983-7 gnd Immunsystem (DE-588)4026643-6 gnd Leukämie (DE-588)4035487-8 gnd Autoaggressionskrankheit (DE-588)4003935-3 gnd |
| topic_facet | Immune response Interleukin-2 T cells Molekularbiologie Immunsystem Leukämie Autoaggressionskrankheit |
| url | http://www.worldscientific.com/worldscibooks/10.1142/7269#t=toc |
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