Non-neuronal cells in Alzheimer's disease:
Alzheimer's disease (AD) is a devastating pathology of the central nervous system (CNS) of unknown etiology which represents the most common neurodegenerative disorder. AD is the major cause of senile dementia, affecting approximately 5% of the population over 70. This syndrome is characterized...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Singapore
World Scientific Pub. Co.
c1995
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| Schlagworte: | |
| Online-Zugang: | FHN01 Volltext |
| Zusammenfassung: | Alzheimer's disease (AD) is a devastating pathology of the central nervous system (CNS) of unknown etiology which represents the most common neurodegenerative disorder. AD is the major cause of senile dementia, affecting approximately 5% of the population over 70. This syndrome is characterized by loss of short-term memory and progressive impairment of intellectual functions. No established therapeutic strategy has been found so far. Until recently, much of the literature on AD discussed the effects of this syndrome on the CNS. In the last few years, however, a large amount of information has appeared which underscored the importance of studying AD from other perspectives with the view of identifying reliable biological markers. The amyloid precursor proteins (APPs), for instance, constitute a complex family of membrane-bound and soluble glycoproteins that are derived by alternative splicing of a gene on chromosome 21. In the hemopoietic system, APPs have been detected in a number of cell types, such as leukocytes, megakaryocytes and platelets. In addition plasma contains picomolar concentrations of APP isoforms most likely derived from platelets. Abnormalities were also detected in the electrophoretic profile of erythrocytic membranes from AD patients. Numerous abnormalities have been proposed as peripheral markers for AD and several laboratories around the world are deeply involved in this challenging research. This book provides up-to-date information, as review chapters, on non-neuronal cells, with the aim of stimulating the formulation of potential diagnostic-therapeutic strategies |
| Beschreibung: | xix, 232 p. ill |
| ISBN: | 9789812831354 |
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| 520 | |a Alzheimer's disease (AD) is a devastating pathology of the central nervous system (CNS) of unknown etiology which represents the most common neurodegenerative disorder. AD is the major cause of senile dementia, affecting approximately 5% of the population over 70. This syndrome is characterized by loss of short-term memory and progressive impairment of intellectual functions. No established therapeutic strategy has been found so far. Until recently, much of the literature on AD discussed the effects of this syndrome on the CNS. In the last few years, however, a large amount of information has appeared which underscored the importance of studying AD from other perspectives with the view of identifying reliable biological markers. The amyloid precursor proteins (APPs), for instance, constitute a complex family of membrane-bound and soluble glycoproteins that are derived by alternative splicing of a gene on chromosome 21. In the hemopoietic system, APPs have been detected in a number of cell types, such as leukocytes, megakaryocytes and platelets. In addition plasma contains picomolar concentrations of APP isoforms most likely derived from platelets. Abnormalities were also detected in the electrophoretic profile of erythrocytic membranes from AD patients. Numerous abnormalities have been proposed as peripheral markers for AD and several laboratories around the world are deeply involved in this challenging research. This book provides up-to-date information, as review chapters, on non-neuronal cells, with the aim of stimulating the formulation of potential diagnostic-therapeutic strategies | ||
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| spelling | Non-neuronal cells in Alzheimer's disease editors, P. Zatta & M. Nicolini Singapore World Scientific Pub. Co. c1995 xix, 232 p. ill txt rdacontent c rdamedia cr rdacarrier Alzheimer's disease (AD) is a devastating pathology of the central nervous system (CNS) of unknown etiology which represents the most common neurodegenerative disorder. AD is the major cause of senile dementia, affecting approximately 5% of the population over 70. This syndrome is characterized by loss of short-term memory and progressive impairment of intellectual functions. No established therapeutic strategy has been found so far. Until recently, much of the literature on AD discussed the effects of this syndrome on the CNS. In the last few years, however, a large amount of information has appeared which underscored the importance of studying AD from other perspectives with the view of identifying reliable biological markers. The amyloid precursor proteins (APPs), for instance, constitute a complex family of membrane-bound and soluble glycoproteins that are derived by alternative splicing of a gene on chromosome 21. In the hemopoietic system, APPs have been detected in a number of cell types, such as leukocytes, megakaryocytes and platelets. In addition plasma contains picomolar concentrations of APP isoforms most likely derived from platelets. Abnormalities were also detected in the electrophoretic profile of erythrocytic membranes from AD patients. Numerous abnormalities have been proposed as peripheral markers for AD and several laboratories around the world are deeply involved in this challenging research. This book provides up-to-date information, as review chapters, on non-neuronal cells, with the aim of stimulating the formulation of potential diagnostic-therapeutic strategies Alzheimer's disease / Cytopathology Alzheimer's disease / Molecular aspects Alzheimer's disease / Pathophysiology Pathophysiologie (DE-588)4044898-8 gnd rswk-swf Cytopathologie (DE-588)4122103-5 gnd rswk-swf Alzheimerkrankheit (DE-588)4112510-1 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Alzheimerkrankheit (DE-588)4112510-1 s Pathophysiologie (DE-588)4044898-8 s 2\p DE-604 Cytopathologie (DE-588)4122103-5 s 3\p DE-604 Zatta, Paolo Sonstige oth Nicolini, Marino Sonstige oth Erscheint auch als Druck-Ausgabe 9789810220921 Erscheint auch als Druck-Ausgabe 9810220928 http://www.worldscientific.com/worldscibooks/10.1142/2596#t=toc Verlag URL des Erstveroeffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Non-neuronal cells in Alzheimer's disease Alzheimer's disease / Cytopathology Alzheimer's disease / Molecular aspects Alzheimer's disease / Pathophysiology Pathophysiologie (DE-588)4044898-8 gnd Cytopathologie (DE-588)4122103-5 gnd Alzheimerkrankheit (DE-588)4112510-1 gnd |
| subject_GND | (DE-588)4044898-8 (DE-588)4122103-5 (DE-588)4112510-1 (DE-588)4143413-4 |
| title | Non-neuronal cells in Alzheimer's disease |
| title_auth | Non-neuronal cells in Alzheimer's disease |
| title_exact_search | Non-neuronal cells in Alzheimer's disease |
| title_full | Non-neuronal cells in Alzheimer's disease editors, P. Zatta & M. Nicolini |
| title_fullStr | Non-neuronal cells in Alzheimer's disease editors, P. Zatta & M. Nicolini |
| title_full_unstemmed | Non-neuronal cells in Alzheimer's disease editors, P. Zatta & M. Nicolini |
| title_short | Non-neuronal cells in Alzheimer's disease |
| title_sort | non neuronal cells in alzheimer s disease |
| topic | Alzheimer's disease / Cytopathology Alzheimer's disease / Molecular aspects Alzheimer's disease / Pathophysiology Pathophysiologie (DE-588)4044898-8 gnd Cytopathologie (DE-588)4122103-5 gnd Alzheimerkrankheit (DE-588)4112510-1 gnd |
| topic_facet | Alzheimer's disease / Cytopathology Alzheimer's disease / Molecular aspects Alzheimer's disease / Pathophysiology Pathophysiologie Cytopathologie Alzheimerkrankheit Aufsatzsammlung |
| url | http://www.worldscientific.com/worldscibooks/10.1142/2596#t=toc |
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