Metal ions and neurodegenerative disorders:
Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Singapore
World Scientific Pub. Co.
c2003
|
| Schlagworte: | |
| Online-Zugang: | FHN01 Volltext |
| Zusammenfassung: | Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer's, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena. Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on "Metals and the Brain: From Neurochemistry to Neurodegeneration" (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa. This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy |
| Beschreibung: | xxiii, 511 p. ill |
| ISBN: | 9789812796691 |
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| 520 | |a Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer's, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena. Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on "Metals and the Brain: From Neurochemistry to Neurodegeneration" (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa. This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy | ||
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| spelling | Metal ions and neurodegenerative disorders editor, Paolo Zatta Singapore World Scientific Pub. Co. c2003 xxiii, 511 p. ill txt rdacontent c rdamedia cr rdacarrier Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer's, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena. Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on "Metals and the Brain: From Neurochemistry to Neurodegeneration" (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa. This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy Nervous system / Degeneration Metal ions / Physiological effect Molecular neurobiology Neurotoxicology Zatta, Paolo Sonstige oth Erscheint auch als Druck-Ausgabe 9789812383983 Erscheint auch als Druck-Ausgabe 9812383980 http://www.worldscientific.com/worldscibooks/10.1142/5298#t=toc Verlag URL des Erstveroeffentlichers Volltext |
| spellingShingle | Metal ions and neurodegenerative disorders Nervous system / Degeneration Metal ions / Physiological effect Molecular neurobiology Neurotoxicology |
| title | Metal ions and neurodegenerative disorders |
| title_auth | Metal ions and neurodegenerative disorders |
| title_exact_search | Metal ions and neurodegenerative disorders |
| title_full | Metal ions and neurodegenerative disorders editor, Paolo Zatta |
| title_fullStr | Metal ions and neurodegenerative disorders editor, Paolo Zatta |
| title_full_unstemmed | Metal ions and neurodegenerative disorders editor, Paolo Zatta |
| title_short | Metal ions and neurodegenerative disorders |
| title_sort | metal ions and neurodegenerative disorders |
| topic | Nervous system / Degeneration Metal ions / Physiological effect Molecular neurobiology Neurotoxicology |
| topic_facet | Nervous system / Degeneration Metal ions / Physiological effect Molecular neurobiology Neurotoxicology |
| url | http://www.worldscientific.com/worldscibooks/10.1142/5298#t=toc |
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