Solid state properties of pharmaceutical materials:
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Hoboken, NJ
Wiley
2017
|
| Schlagworte: | |
| Online-Zugang: | FRO01 UBG01 Volltext |
| Beschreibung: | Includes index Solid-State Properties of Pharmaceutical Materials; Contents; Preface; Acknowledgments; 1 Solid-State Properties and Pharmaceutical Development; 1.1 Introduction; 1.2 Solid-State Forms; 1.3 ICH Q6A Decision Trees; 1.4 "Big Questions" for Drug Development; 1.5 Accelerating Drug Development; 1.6 Solid-State Chemistry in Preformulation and Formulation; 1.7 Learning Before Doing and Quality by Design; 1.8 Performance and Stability in Pharmaceutical Development; 1.9 Moisture Uptake; 1.10 Solid-State Reactions; 1.11 Noninteracting Formulations: Physical Characterizations; References; 2 Polymorphs 2.1 Introduction2.2 How Are Polymorphs Formed?; 2.3 Structural Aspect of Polymorphs; 2.3.1 Configurational Polymorphs; 2.3.2 Conformational Polymorphs; 2.4 Physical, Chemical, and Mechanical Properties; 2.4.1 Solubility; 2.4.2 Chemical Stability; 2.4.3 Mechanical Properties; 2.5 Thermodynamic Stability of Polymorphs; 2.5.1 Monotropy and Enantiotropy; 2.5.2 Burger and Rambergers Rules; 2.5.3 vant Hoff Plot; 2.5.4 DG/Temperature Diagram; 2.6 Polymorph Conversion; 2.6.1 Solution-Mediated Transformation; 2.6.2 Solid-State Conversion; 2.7 Control of Polymorphs; 2.8 Polymorph Screening 2.9 Polymorph PredictionReferences; 3 Solvates and Hydrates; 3.1 Introduction; 3.2 Pharmaceutical Importance of Hydrates; 3.3 Classification of Pharmaceutical Hydrates; 3.4 Water Activity; 3.5 Stoichiometric Hydrates; 3.6 Nonstoichiometric Hydrates; 3.7 Hydration/Dehydration; 3.8 Preparation and Characterization of Hydrates and Solvates; References; 4 Pharmaceutical Salts; 4.1 Introduction; 4.2 Importance of Pharmaceutical Salts; 4.3 Weak Acid, Weak Base, and Salt; 4.4 pH-Solubility Profiles of Ionizable Compounds; 4.5 Solubility, Dissolution, and Bioavailability of Pharmaceutical Salts 4.6 Physical Stability of Pharmaceutical Salts4.7 Strategies for Salt Selection; References; 5 Pharmaceutical Cocrystals; 5.1 Introduction; 5.2 Cocrystals and Crystal Engineering; 5.3 Solubility Phase Diagrams For Cocrystals; 5.4 Preparation of Cocrystals; 5.5 Dissolution and Bioavailability of Cocrystals; 5.6 Comparison of Pharmaceutical Salts and Cocrystals; References; 6 Amorphous Solids; 6.1 Introduction; 6.2 The Formation of Amorphous Solids; 6.3 Methods of Preparing Amorphous Solids; 6.4 The Glass Transition Temperature; 6.5 Structural Features of Amorphous Solids 6.6 Molecular Mobility6.6.1 Overview of Molecular Mobility; 6.6.2 Viscosity and Molecular Mobility; 6.6.3 Relaxation Time; 6.6.4 Fragility in Supercooled Liquids; 6.6.5 Diffusive Relaxation Time in the Glassy State; 6.6.6 Secondary Relaxations in Amorphous Solids; 6.7 Mixtures of Amorphous Solids; 6.7.1 Overview; 6.7.2 Thermodynamics of Molecular Mixing in Amorphous Solids; 6.7.3 The Glass Transition Temperature and Molecular Mobility of Miscible Amorphous Mixtures; References; 7 Crystal Mesophases and Nanocrystals; 7.1 Introduction; 7.2 Overview of Crystal Mesophases; 7.3 Liquid Crystals |
| Beschreibung: | 1 Online-Resssource (xiii, 406 Seiten) |
| ISBN: | 9781119264453 9781119264446 9781119264408 |
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| 264 | 1 | |a Hoboken, NJ |b Wiley |c 2017 | |
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| 500 | |a Solid-State Properties of Pharmaceutical Materials; Contents; Preface; Acknowledgments; 1 Solid-State Properties and Pharmaceutical Development; 1.1 Introduction; 1.2 Solid-State Forms; 1.3 ICH Q6A Decision Trees; 1.4 "Big Questions" for Drug Development; 1.5 Accelerating Drug Development; 1.6 Solid-State Chemistry in Preformulation and Formulation; 1.7 Learning Before Doing and Quality by Design; 1.8 Performance and Stability in Pharmaceutical Development; 1.9 Moisture Uptake; 1.10 Solid-State Reactions; 1.11 Noninteracting Formulations: Physical Characterizations; References; 2 Polymorphs | ||
| 500 | |a 2.1 Introduction2.2 How Are Polymorphs Formed?; 2.3 Structural Aspect of Polymorphs; 2.3.1 Configurational Polymorphs; 2.3.2 Conformational Polymorphs; 2.4 Physical, Chemical, and Mechanical Properties; 2.4.1 Solubility; 2.4.2 Chemical Stability; 2.4.3 Mechanical Properties; 2.5 Thermodynamic Stability of Polymorphs; 2.5.1 Monotropy and Enantiotropy; 2.5.2 Burger and Rambergers Rules; 2.5.3 vant Hoff Plot; 2.5.4 DG/Temperature Diagram; 2.6 Polymorph Conversion; 2.6.1 Solution-Mediated Transformation; 2.6.2 Solid-State Conversion; 2.7 Control of Polymorphs; 2.8 Polymorph Screening | ||
| 500 | |a 2.9 Polymorph PredictionReferences; 3 Solvates and Hydrates; 3.1 Introduction; 3.2 Pharmaceutical Importance of Hydrates; 3.3 Classification of Pharmaceutical Hydrates; 3.4 Water Activity; 3.5 Stoichiometric Hydrates; 3.6 Nonstoichiometric Hydrates; 3.7 Hydration/Dehydration; 3.8 Preparation and Characterization of Hydrates and Solvates; References; 4 Pharmaceutical Salts; 4.1 Introduction; 4.2 Importance of Pharmaceutical Salts; 4.3 Weak Acid, Weak Base, and Salt; 4.4 pH-Solubility Profiles of Ionizable Compounds; 4.5 Solubility, Dissolution, and Bioavailability of Pharmaceutical Salts | ||
| 500 | |a 4.6 Physical Stability of Pharmaceutical Salts4.7 Strategies for Salt Selection; References; 5 Pharmaceutical Cocrystals; 5.1 Introduction; 5.2 Cocrystals and Crystal Engineering; 5.3 Solubility Phase Diagrams For Cocrystals; 5.4 Preparation of Cocrystals; 5.5 Dissolution and Bioavailability of Cocrystals; 5.6 Comparison of Pharmaceutical Salts and Cocrystals; References; 6 Amorphous Solids; 6.1 Introduction; 6.2 The Formation of Amorphous Solids; 6.3 Methods of Preparing Amorphous Solids; 6.4 The Glass Transition Temperature; 6.5 Structural Features of Amorphous Solids | ||
| 500 | |a 6.6 Molecular Mobility6.6.1 Overview of Molecular Mobility; 6.6.2 Viscosity and Molecular Mobility; 6.6.3 Relaxation Time; 6.6.4 Fragility in Supercooled Liquids; 6.6.5 Diffusive Relaxation Time in the Glassy State; 6.6.6 Secondary Relaxations in Amorphous Solids; 6.7 Mixtures of Amorphous Solids; 6.7.1 Overview; 6.7.2 Thermodynamics of Molecular Mixing in Amorphous Solids; 6.7.3 The Glass Transition Temperature and Molecular Mobility of Miscible Amorphous Mixtures; References; 7 Crystal Mesophases and Nanocrystals; 7.1 Introduction; 7.2 Overview of Crystal Mesophases; 7.3 Liquid Crystals | ||
| 650 | 4 | |a MEDICAL / Pharmacology | |
| 650 | 4 | |a Solid state chemistry | |
| 650 | 4 | |a Solid dosage forms / Properties | |
| 700 | 1 | |a Zografi, George |e Verfasser |4 aut | |
| 700 | 1 | |a Chen, Xiaoming |e Verfasser |4 aut | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9781118145302 |
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Datensatz im Suchindex
| _version_ | 1804178023190102016 |
|---|---|
| any_adam_object | |
| author | Byrn, Stephen R. Zografi, George Chen, Xiaoming |
| author_facet | Byrn, Stephen R. Zografi, George Chen, Xiaoming |
| author_role | aut aut aut |
| author_sort | Byrn, Stephen R. |
| author_variant | s r b sr srb g z gz x c xc |
| building | Verbundindex |
| bvnumber | BV044621503 |
| collection | ZDB-35-WIC |
| ctrlnum | (OCoLC)1011400423 (DE-599)BVBBV044621503 |
| dewey-full | 615.1028/4 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.1028/4 |
| dewey-search | 615.1028/4 |
| dewey-sort | 3615.1028 14 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:57:22Z |
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| isbn | 9781119264453 9781119264446 9781119264408 |
| language | English |
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| spelling | Byrn, Stephen R. Verfasser aut Solid state properties of pharmaceutical materials Stephen R. Byrn, George Zografi, Xiaoming (Sean) Chen Hoboken, NJ Wiley 2017 1 Online-Resssource (xiii, 406 Seiten) txt rdacontent c rdamedia cr rdacarrier Includes index Solid-State Properties of Pharmaceutical Materials; Contents; Preface; Acknowledgments; 1 Solid-State Properties and Pharmaceutical Development; 1.1 Introduction; 1.2 Solid-State Forms; 1.3 ICH Q6A Decision Trees; 1.4 "Big Questions" for Drug Development; 1.5 Accelerating Drug Development; 1.6 Solid-State Chemistry in Preformulation and Formulation; 1.7 Learning Before Doing and Quality by Design; 1.8 Performance and Stability in Pharmaceutical Development; 1.9 Moisture Uptake; 1.10 Solid-State Reactions; 1.11 Noninteracting Formulations: Physical Characterizations; References; 2 Polymorphs 2.1 Introduction2.2 How Are Polymorphs Formed?; 2.3 Structural Aspect of Polymorphs; 2.3.1 Configurational Polymorphs; 2.3.2 Conformational Polymorphs; 2.4 Physical, Chemical, and Mechanical Properties; 2.4.1 Solubility; 2.4.2 Chemical Stability; 2.4.3 Mechanical Properties; 2.5 Thermodynamic Stability of Polymorphs; 2.5.1 Monotropy and Enantiotropy; 2.5.2 Burger and Rambergers Rules; 2.5.3 vant Hoff Plot; 2.5.4 DG/Temperature Diagram; 2.6 Polymorph Conversion; 2.6.1 Solution-Mediated Transformation; 2.6.2 Solid-State Conversion; 2.7 Control of Polymorphs; 2.8 Polymorph Screening 2.9 Polymorph PredictionReferences; 3 Solvates and Hydrates; 3.1 Introduction; 3.2 Pharmaceutical Importance of Hydrates; 3.3 Classification of Pharmaceutical Hydrates; 3.4 Water Activity; 3.5 Stoichiometric Hydrates; 3.6 Nonstoichiometric Hydrates; 3.7 Hydration/Dehydration; 3.8 Preparation and Characterization of Hydrates and Solvates; References; 4 Pharmaceutical Salts; 4.1 Introduction; 4.2 Importance of Pharmaceutical Salts; 4.3 Weak Acid, Weak Base, and Salt; 4.4 pH-Solubility Profiles of Ionizable Compounds; 4.5 Solubility, Dissolution, and Bioavailability of Pharmaceutical Salts 4.6 Physical Stability of Pharmaceutical Salts4.7 Strategies for Salt Selection; References; 5 Pharmaceutical Cocrystals; 5.1 Introduction; 5.2 Cocrystals and Crystal Engineering; 5.3 Solubility Phase Diagrams For Cocrystals; 5.4 Preparation of Cocrystals; 5.5 Dissolution and Bioavailability of Cocrystals; 5.6 Comparison of Pharmaceutical Salts and Cocrystals; References; 6 Amorphous Solids; 6.1 Introduction; 6.2 The Formation of Amorphous Solids; 6.3 Methods of Preparing Amorphous Solids; 6.4 The Glass Transition Temperature; 6.5 Structural Features of Amorphous Solids 6.6 Molecular Mobility6.6.1 Overview of Molecular Mobility; 6.6.2 Viscosity and Molecular Mobility; 6.6.3 Relaxation Time; 6.6.4 Fragility in Supercooled Liquids; 6.6.5 Diffusive Relaxation Time in the Glassy State; 6.6.6 Secondary Relaxations in Amorphous Solids; 6.7 Mixtures of Amorphous Solids; 6.7.1 Overview; 6.7.2 Thermodynamics of Molecular Mixing in Amorphous Solids; 6.7.3 The Glass Transition Temperature and Molecular Mobility of Miscible Amorphous Mixtures; References; 7 Crystal Mesophases and Nanocrystals; 7.1 Introduction; 7.2 Overview of Crystal Mesophases; 7.3 Liquid Crystals MEDICAL / Pharmacology Solid state chemistry Solid dosage forms / Properties Zografi, George Verfasser aut Chen, Xiaoming Verfasser aut Erscheint auch als Druck-Ausgabe 9781118145302 https://onlinelibrary.wiley.com/doi/book/10.1002/9781119264408 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Byrn, Stephen R. Zografi, George Chen, Xiaoming Solid state properties of pharmaceutical materials MEDICAL / Pharmacology Solid state chemistry Solid dosage forms / Properties |
| title | Solid state properties of pharmaceutical materials |
| title_auth | Solid state properties of pharmaceutical materials |
| title_exact_search | Solid state properties of pharmaceutical materials |
| title_full | Solid state properties of pharmaceutical materials Stephen R. Byrn, George Zografi, Xiaoming (Sean) Chen |
| title_fullStr | Solid state properties of pharmaceutical materials Stephen R. Byrn, George Zografi, Xiaoming (Sean) Chen |
| title_full_unstemmed | Solid state properties of pharmaceutical materials Stephen R. Byrn, George Zografi, Xiaoming (Sean) Chen |
| title_short | Solid state properties of pharmaceutical materials |
| title_sort | solid state properties of pharmaceutical materials |
| topic | MEDICAL / Pharmacology Solid state chemistry Solid dosage forms / Properties |
| topic_facet | MEDICAL / Pharmacology Solid state chemistry Solid dosage forms / Properties |
| url | https://onlinelibrary.wiley.com/doi/book/10.1002/9781119264408 |
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