Oral bioavailability assessment: basics and strategies for drug discovery and development
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Hoboken, NJ
Wiley
[2017]
|
| Schriftenreihe: | Wiley series on pharmaceutical science and biotechnology
|
| Schlagworte: | |
| Beschreibung: | Includes bibliographical references and index Drug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective |
| Beschreibung: | viii, 436 Seiten Illustrationen, Diagramme |
| ISBN: | 9781118916698 |
Internformat
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| 100 | 1 | |a El-Kattan, Ayman F. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Oral bioavailability assessment |b basics and strategies for drug discovery and development |c Ayman F. El-Kattan |
| 264 | 1 | |a Hoboken, NJ |b Wiley |c [2017] | |
| 300 | |a viii, 436 Seiten |b Illustrationen, Diagramme | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Wiley series on pharmaceutical science and biotechnology | |
| 500 | |a Includes bibliographical references and index | ||
| 500 | |a Drug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective | ||
| 650 | 4 | |a MEDICAL / Pharmacology / bisacsh | |
| 650 | 4 | |a Dental pharmacology / fast / (OCoLC)fst00890550 | |
| 650 | 4 | |a Medizin | |
| 650 | 4 | |a Dental pharmacology | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |z 978-1-118-91692-6 |
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| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, ePub |z 978-1-118-91693-3 |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-029954305 | ||
Datensatz im Suchindex
| _version_ | 1804177923016491008 |
|---|---|
| any_adam_object | |
| author | El-Kattan, Ayman F. |
| author_facet | El-Kattan, Ayman F. |
| author_role | aut |
| author_sort | El-Kattan, Ayman F. |
| author_variant | a f e k afe afek |
| building | Verbundindex |
| bvnumber | BV044555561 |
| classification_rvk | VX 8550 |
| ctrlnum | (OCoLC)1003273424 (DE-599)BVBBV044555561 |
| dewey-full | 615.1/9 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.1/9 |
| dewey-search | 615.1/9 |
| dewey-sort | 3615.1 19 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Book |
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| id | DE-604.BV044555561 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:55:47Z |
| institution | BVB |
| isbn | 9781118916698 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029954305 |
| oclc_num | 1003273424 |
| open_access_boolean | |
| owner | DE-473 DE-BY-UBG DE-19 DE-BY-UBM |
| owner_facet | DE-473 DE-BY-UBG DE-19 DE-BY-UBM |
| physical | viii, 436 Seiten Illustrationen, Diagramme |
| publishDate | 2017 |
| publishDateSearch | 2017 |
| publishDateSort | 2017 |
| publisher | Wiley |
| record_format | marc |
| series2 | Wiley series on pharmaceutical science and biotechnology |
| spelling | El-Kattan, Ayman F. Verfasser aut Oral bioavailability assessment basics and strategies for drug discovery and development Ayman F. El-Kattan Hoboken, NJ Wiley [2017] viii, 436 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Wiley series on pharmaceutical science and biotechnology Includes bibliographical references and index Drug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective MEDICAL / Pharmacology / bisacsh Dental pharmacology / fast / (OCoLC)fst00890550 Medizin Dental pharmacology Erscheint auch als Online-Ausgabe 978-1-118-91692-6 Erscheint auch als Online-Ausgabe, Adobe PDF 978-1-118-91694-0 Erscheint auch als Online-Ausgabe, ePub 978-1-118-91693-3 |
| spellingShingle | El-Kattan, Ayman F. Oral bioavailability assessment basics and strategies for drug discovery and development MEDICAL / Pharmacology / bisacsh Dental pharmacology / fast / (OCoLC)fst00890550 Medizin Dental pharmacology |
| title | Oral bioavailability assessment basics and strategies for drug discovery and development |
| title_auth | Oral bioavailability assessment basics and strategies for drug discovery and development |
| title_exact_search | Oral bioavailability assessment basics and strategies for drug discovery and development |
| title_full | Oral bioavailability assessment basics and strategies for drug discovery and development Ayman F. El-Kattan |
| title_fullStr | Oral bioavailability assessment basics and strategies for drug discovery and development Ayman F. El-Kattan |
| title_full_unstemmed | Oral bioavailability assessment basics and strategies for drug discovery and development Ayman F. El-Kattan |
| title_short | Oral bioavailability assessment |
| title_sort | oral bioavailability assessment basics and strategies for drug discovery and development |
| title_sub | basics and strategies for drug discovery and development |
| topic | MEDICAL / Pharmacology / bisacsh Dental pharmacology / fast / (OCoLC)fst00890550 Medizin Dental pharmacology |
| topic_facet | MEDICAL / Pharmacology / bisacsh Dental pharmacology / fast / (OCoLC)fst00890550 Medizin Dental pharmacology |
| work_keys_str_mv | AT elkattanaymanf oralbioavailabilityassessmentbasicsandstrategiesfordrugdiscoveryanddevelopment |