Targeted biomarker quantitation by LC-MS:
Gespeichert in:
Weitere Verfasser: | , |
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Format: | Elektronisch E-Book |
Sprache: | English |
Veröffentlicht: |
Hoboken, NJ
Wiley
2017
|
Ausgabe: | First edition |
Schlagworte: | |
Online-Zugang: | FRO01 UBG01 URL des Erstveröffentlichers |
Beschreibung: | Includes bibliographical references and index Title Page ; Copyright Page; Contents; List of Contributors; Preface; Abbreviations; Part 1 Overview; Chapter 1 Overview of Targeted Quantitation of Biomarkers and Its Applications; 1.1 Introduction; 1.2 Biomarker Definition; 1.3 Current Challenges of a Biomarker; 1.4 Biomarker Validation Process; 1.5 Current Regulatory Requirement for Target Biomarker Quantitation; 1.6 Challenges of Biomarker Quantitation; 1.7 Current Technologies for Biomarker Quantitation; 1.7.1 LC-MS; 1.7.2 GC-MS; 1.7.3 Ligand-Binding Assay ; 1.7.4 Flow Cytometry; 1.7.5 Quantitative PCR (qPCR) 1.8 Current Biomarker Quantitation Applications1.8.1 Protein Biomarkers; 1.8.2 Peptide Biomarkers; 1.8.3 RNA Biomarkers; 1.8.4 Nucleotide Biomarkers; 1.8.5 Small Molecule Biomarkers; 1.9 Conclusion and Future Perspective; References; Chapter 2 Translational Application of Biomarkers; 2.1 Introduction; 2.2 Translational Medicine; 2.3 Biomarkers; 2.4 Biomarker Categories; 2.5 Neurobiological Disorders; 2.6 Cardiovascular Disorders; 2.7 Chronic Obstructive Pulmonary Disease; 2.8 Oncology; 2.9 Biomarker Measurements and Regulatory Considerations; 2.10 Conclusions; Acknowledgment; References Chapter 3 Current Regulatory Guidance Pertaining Biomarker Assay Establishment and Industrial Practice of Fit-for-Purpose and Tiered Approach 3.1 Introduction; 3.2 Current Regulatory Guidance and Interpretation; 3.3 Current Industrial Discussion and Recommendations; 3.4 Considerations for Assay Validation and Sample Analysis; 3.4.1 Sensitivity; 3.4.2 Specificity and Selectivity; 3.4.3 Matrix Effects and Sample Variables; 3.4.3.1 Authentic Analyte/Authentic Matrix Approach; 3.4.3.2 Surrogate Analyte/Authentic Matrix Approach; 3.4.3.3 Authentic Analyte/Surrogate Matrix Approach 4.2.1 Importance of Separation4.2.2 Basic Principle of LC; 4.2.3 Major Modes of LC Used for Targeted Biomarker Quantitation; 4.2.4 Modern LC Technologies; 4.2.4.1 HPLC and UHPLC; 4.2.4.2 Miniaturized Column LC; 4.2.4.3 2D-LC ; 4.3 Mass Spectrometry; 4.3.1 Major Types of MS Used for Targeted Biomarker Quantitation; 4.3.2 Ionization Techniques; 4.3.3 Ion Mobility; 4.3.4 Fragmentation Mode; 4.3.5 Emerging MS Techniques; 4.3.5.1 MS Imaging; 4.3.5.2 Other Surface Analysis MS Techniques; 4.4 Summary and Future Perspectives; References |
Beschreibung: | 1 Online-Ressource (xxx, 431 Seiten) |
ISBN: | 9781119413066 9781119413059 9781119413073 |
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250 | |a First edition | ||
264 | 1 | |a Hoboken, NJ |b Wiley |c 2017 | |
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500 | |a Includes bibliographical references and index | ||
500 | |a Title Page ; Copyright Page; Contents; List of Contributors; Preface; Abbreviations; Part 1 Overview; Chapter 1 Overview of Targeted Quantitation of Biomarkers and Its Applications; 1.1 Introduction; 1.2 Biomarker Definition; 1.3 Current Challenges of a Biomarker; 1.4 Biomarker Validation Process; 1.5 Current Regulatory Requirement for Target Biomarker Quantitation; 1.6 Challenges of Biomarker Quantitation; 1.7 Current Technologies for Biomarker Quantitation; 1.7.1 LC-MS; 1.7.2 GC-MS; 1.7.3 Ligand-Binding Assay ; 1.7.4 Flow Cytometry; 1.7.5 Quantitative PCR (qPCR) | ||
500 | |a 1.8 Current Biomarker Quantitation Applications1.8.1 Protein Biomarkers; 1.8.2 Peptide Biomarkers; 1.8.3 RNA Biomarkers; 1.8.4 Nucleotide Biomarkers; 1.8.5 Small Molecule Biomarkers; 1.9 Conclusion and Future Perspective; References; Chapter 2 Translational Application of Biomarkers; 2.1 Introduction; 2.2 Translational Medicine; 2.3 Biomarkers; 2.4 Biomarker Categories; 2.5 Neurobiological Disorders; 2.6 Cardiovascular Disorders; 2.7 Chronic Obstructive Pulmonary Disease; 2.8 Oncology; 2.9 Biomarker Measurements and Regulatory Considerations; 2.10 Conclusions; Acknowledgment; References | ||
500 | |a Chapter 3 Current Regulatory Guidance Pertaining Biomarker Assay Establishment and Industrial Practice of Fit-for-Purpose and Tiered Approach 3.1 Introduction; 3.2 Current Regulatory Guidance and Interpretation; 3.3 Current Industrial Discussion and Recommendations; 3.4 Considerations for Assay Validation and Sample Analysis; 3.4.1 Sensitivity; 3.4.2 Specificity and Selectivity; 3.4.3 Matrix Effects and Sample Variables; 3.4.3.1 Authentic Analyte/Authentic Matrix Approach; 3.4.3.2 Surrogate Analyte/Authentic Matrix Approach; 3.4.3.3 Authentic Analyte/Surrogate Matrix Approach | ||
500 | |a 4.2.1 Importance of Separation4.2.2 Basic Principle of LC; 4.2.3 Major Modes of LC Used for Targeted Biomarker Quantitation; 4.2.4 Modern LC Technologies; 4.2.4.1 HPLC and UHPLC; 4.2.4.2 Miniaturized Column LC; 4.2.4.3 2D-LC ; 4.3 Mass Spectrometry; 4.3.1 Major Types of MS Used for Targeted Biomarker Quantitation; 4.3.2 Ionization Techniques; 4.3.3 Ion Mobility; 4.3.4 Fragmentation Mode; 4.3.5 Emerging MS Techniques; 4.3.5.1 MS Imaging; 4.3.5.2 Other Surface Analysis MS Techniques; 4.4 Summary and Future Perspectives; References | ||
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650 | 4 | |a Mass spectrometry | |
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650 | 4 | |a Biochemical markers | |
700 | 1 | |a Weng, Naidong |4 edt | |
700 | 1 | |a Jian, Wenying |4 edt | |
776 | 0 | 8 | |i Erscheint auch als |n Druckausgabe |z 9781119103066 |
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Datensatz im Suchindex
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any_adam_object | |
author2 | Weng, Naidong Jian, Wenying |
author2_role | edt edt |
author2_variant | n w nw w j wj |
author_facet | Weng, Naidong Jian, Wenying |
building | Verbundindex |
bvnumber | BV044554405 |
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ctrlnum | (OCoLC)1011367372 (DE-599)BVBBV044554405 |
dewey-full | 572/.36 |
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dewey-ones | 572 - Biochemistry |
dewey-raw | 572/.36 |
dewey-search | 572/.36 |
dewey-sort | 3572 236 |
dewey-tens | 570 - Biology |
discipline | Biologie |
edition | First edition |
format | Electronic eBook |
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institution | BVB |
isbn | 9781119413066 9781119413059 9781119413073 |
language | English |
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spelling | Targeted biomarker quantitation by LC-MS edited by Naidong Weng and Wenying Jian, Janssen Research & Development, LLC. Targeted biomarker quantitation by liquid chromatography-mass spectrometry First edition Hoboken, NJ Wiley 2017 1 Online-Ressource (xxx, 431 Seiten) txt rdacontent c rdamedia cr rdacarrier Includes bibliographical references and index Title Page ; Copyright Page; Contents; List of Contributors; Preface; Abbreviations; Part 1 Overview; Chapter 1 Overview of Targeted Quantitation of Biomarkers and Its Applications; 1.1 Introduction; 1.2 Biomarker Definition; 1.3 Current Challenges of a Biomarker; 1.4 Biomarker Validation Process; 1.5 Current Regulatory Requirement for Target Biomarker Quantitation; 1.6 Challenges of Biomarker Quantitation; 1.7 Current Technologies for Biomarker Quantitation; 1.7.1 LC-MS; 1.7.2 GC-MS; 1.7.3 Ligand-Binding Assay ; 1.7.4 Flow Cytometry; 1.7.5 Quantitative PCR (qPCR) 1.8 Current Biomarker Quantitation Applications1.8.1 Protein Biomarkers; 1.8.2 Peptide Biomarkers; 1.8.3 RNA Biomarkers; 1.8.4 Nucleotide Biomarkers; 1.8.5 Small Molecule Biomarkers; 1.9 Conclusion and Future Perspective; References; Chapter 2 Translational Application of Biomarkers; 2.1 Introduction; 2.2 Translational Medicine; 2.3 Biomarkers; 2.4 Biomarker Categories; 2.5 Neurobiological Disorders; 2.6 Cardiovascular Disorders; 2.7 Chronic Obstructive Pulmonary Disease; 2.8 Oncology; 2.9 Biomarker Measurements and Regulatory Considerations; 2.10 Conclusions; Acknowledgment; References Chapter 3 Current Regulatory Guidance Pertaining Biomarker Assay Establishment and Industrial Practice of Fit-for-Purpose and Tiered Approach 3.1 Introduction; 3.2 Current Regulatory Guidance and Interpretation; 3.3 Current Industrial Discussion and Recommendations; 3.4 Considerations for Assay Validation and Sample Analysis; 3.4.1 Sensitivity; 3.4.2 Specificity and Selectivity; 3.4.3 Matrix Effects and Sample Variables; 3.4.3.1 Authentic Analyte/Authentic Matrix Approach; 3.4.3.2 Surrogate Analyte/Authentic Matrix Approach; 3.4.3.3 Authentic Analyte/Surrogate Matrix Approach 4.2.1 Importance of Separation4.2.2 Basic Principle of LC; 4.2.3 Major Modes of LC Used for Targeted Biomarker Quantitation; 4.2.4 Modern LC Technologies; 4.2.4.1 HPLC and UHPLC; 4.2.4.2 Miniaturized Column LC; 4.2.4.3 2D-LC ; 4.3 Mass Spectrometry; 4.3.1 Major Types of MS Used for Targeted Biomarker Quantitation; 4.3.2 Ionization Techniques; 4.3.3 Ion Mobility; 4.3.4 Fragmentation Mode; 4.3.5 Emerging MS Techniques; 4.3.5.1 MS Imaging; 4.3.5.2 Other Surface Analysis MS Techniques; 4.4 Summary and Future Perspectives; References Biochemical markers Liquid chromatography Mass spectrometry SCIENCE / Life Sciences / Biochemistry Weng, Naidong edt Jian, Wenying edt Erscheint auch als Druckausgabe 9781119103066 https://onlinelibrary.wiley.com/doi/book/10.1002/9781119413073 Verlag URL des Erstveröffentlichers Volltext |
spellingShingle | Targeted biomarker quantitation by LC-MS Biochemical markers Liquid chromatography Mass spectrometry SCIENCE / Life Sciences / Biochemistry |
title | Targeted biomarker quantitation by LC-MS |
title_alt | Targeted biomarker quantitation by liquid chromatography-mass spectrometry |
title_auth | Targeted biomarker quantitation by LC-MS |
title_exact_search | Targeted biomarker quantitation by LC-MS |
title_full | Targeted biomarker quantitation by LC-MS edited by Naidong Weng and Wenying Jian, Janssen Research & Development, LLC. |
title_fullStr | Targeted biomarker quantitation by LC-MS edited by Naidong Weng and Wenying Jian, Janssen Research & Development, LLC. |
title_full_unstemmed | Targeted biomarker quantitation by LC-MS edited by Naidong Weng and Wenying Jian, Janssen Research & Development, LLC. |
title_short | Targeted biomarker quantitation by LC-MS |
title_sort | targeted biomarker quantitation by lc ms |
topic | Biochemical markers Liquid chromatography Mass spectrometry SCIENCE / Life Sciences / Biochemistry |
topic_facet | Biochemical markers Liquid chromatography Mass spectrometry SCIENCE / Life Sciences / Biochemistry |
url | https://onlinelibrary.wiley.com/doi/book/10.1002/9781119413073 |
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