Computational modeling of drugs against Alzheimer's disease:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Schriftenreihe: | Neuromethods
132 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | xvii, 645 Seiten Illustrationen |
| ISBN: | 9781493974030 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804177915681701888 |
|---|---|
| adam_text | Contents
Preface to the series..................................................... V
Preface................................................................... vii
Contributors. . . ........................................................ xv
Part I An Introduction to the Disease
1 Alzheimer’s Disease Therapy: Present and Future Molecules............. 3
Awanish Kumar and Ashwini Kumar
Part II Computational Modeling Methods
for Anti-Alzheimer Agents
2 Recent Advances in Computational Approaches
for Designing Potential Anti-Alzheimer’s Agents....................... 25
Sergi Gomez-Ganau, Jesus Vicente de Julidn-Ortiz, and Rafael Gozalbes
3 Computer-Aided Drug Design Approaches to Study Key
Therapeutic Targets in Alzheimer’s Disease ........................... 61
Agostinho LemoSy Rita Melo, Irina S. Moreira,
and M. Natalia D.S. Cordeiro
4 Virtual Screening in the Search of New and Potent
Anti-Alzheimer Agents................................................. 107
Livia Basile
5 Molecular Field Topology Analysis (MFTA) in the Design
of Neuroprotective Compounds........... —....................... 139
Eugene V Radchenko, Vladimir A. Palyulin, and Nikolay S. Zefirov
Part III Modeling of Ligands Acting Against
Specific Anti-Alzheimer Drug Targets
6 Galantamine Derivatives as Acetylcholinesterase Inhibitors:
Docking, Design, Synthesis, and Inhibitory Activity................... 163
Irini Doytchinova, Mariyana Atanasovay Georgi Stavrakov՝f
Irena Philipova, and Dimitvina Zheleva-JDimitvova
7 Modeling of BACE-1 Inhibitors as Anti-Alzheimer’s Agents.............. 177
Odailson Santos Paz Thamires Quadros Froesy
Franco Henrique Leite, and Marcelo Santos Castilho
8 Design of Anti-Alzheimer’s Disease Agents Focusing
on a Specific Interaction with Target Biomolecules.................... 207
Yoshio Hama da and Kenji Usui
xi
xii Contents
9 Molecular Docking and Molecular Dynamics Simulation
to Evaluate Compounds That Avoid the Amyloid
Beta 1-42 Aggregation................................................. 229
Mavicarmen Hernández Rodríguez, Leticia Guadalupe Fragoso Morales,
José correa Basurto, and Martha Cecilia Rosales Hernandez
10 In Silico Strategies to Design Small Molecules to Study
Beta-Amyloid Aggregation............................................... 249
Braveen P.N. Rao and Deguo Du
11 Computational Approaches to Understand Cleavage Mechanism
of Amyloid Beta (Ap) Peptide........................................... 263
Kailas Dashrath Sonawane and Maruti Jayaram Dhanavade
12 Computational Modeling of Gamma-Secretase Inhibitors
as Anti-Alzheimer Agents .............................................. 283
Prabu Manohamn and Nanda Ghoshal
13 Molecular Modeling of Tau Proline- D irected Protein
Kinase (PDPK) Inhibitors............................................. 305
Carlos Navarro-Retamal and Julio Caballero
14 Computational Modelling of Kinase Inhibitors
as Anti-Alzheimer Agents............................................... 347
Mange Ram Yadav, Mahesh A. Barmade, Rnpesh V Chikhale,
and Prashant R. Murumkar
15 Computational Modeling of Drugs for Alzheimer’s Disease:
Design of Serotonin 5 -HT6 Antagonists................................ 419
Adám A Kelemen, Stefan Mordalski, Andrzej ƒ. Bojarski,
and György M. Keserű
16 Computational Modeling of Diagnostic Imaging Agents
for Alzheimer’s Disease: Molecular Imaging Agents
for the In Vivo Detection of Amyloid Plaques in Alzheimer’s Disease... 463
Dionysia Papagiannopoulou and Dimitra Hadjipavlou-Litina
Part IV Special Topics
17 Computational Approaches for Therapeutic Application
of Natural Products in Alzheimer’s Disease............................ 483
Manika Awasthi, Swati Singh, Sameeksha Tiwari,
Veda P. Pandey, and Upendra N. Dwivedi
18 In Silico Studies Applied to Natural Products with Potential
Activity Against Alzheimer’s Disease.................................. 513
Luciana Scotti and Marcus T. Scotti
19 Computational Modeling of Multi-Target-Directed Inhibitors
Against Alzheimer’s Disease........................................... 533
Akhil Kumar and Ashok Sharma
Contents
xiii
20 Neuropharmacology in Flux: Molecular Modeling Tools
for Understanding Protein Conformational Shifts
in Alzheimer’s Disease and Related Disorders......................... 573
Gerald H. Lushington, Frances E.S. Parker, Thomas H. W. Lushington
and Nora M. Wallace
21 Computational Nanotechnology: A Tool for Screening
Therapeutic Nanomaterials Against Alzheimer’s Disease.................. 613
R. Navanietha Krishnaraj Dipayan Samanta, and Rajesh IC Sam
Index..................................................................... 637
|
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| illustrated | Illustrated |
| indexdate | 2024-07-10T07:55:40Z |
| institution | BVB |
| isbn | 9781493974030 |
| language | English |
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| physical | xvii, 645 Seiten Illustrationen |
| publishDateSearch | 2018 |
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| series | Neuromethods |
| series2 | Neuromethods Springer Protocols |
| spelling | Computational modeling of drugs against Alzheimer's disease edited by Kunal Roy New York, NY Humana Press [2018] xvii, 645 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Neuromethods 132 Springer Protocols Medizin Computational chemistry (DE-588)4290091-8 gnd rswk-swf Alzheimerkrankheit (DE-588)4112510-1 gnd rswk-swf Arzneimitteldesign (DE-588)4278218-1 gnd rswk-swf Medicine Neurosciences Biomedicine (DE-588)4143413-4 Aufsatzsammlung gnd-content Alzheimerkrankheit (DE-588)4112510-1 s Arzneimitteldesign (DE-588)4278218-1 s Computational chemistry (DE-588)4290091-8 s DE-604 Roy, Kunal edt Erscheint auch als Online-Ausgabe 978-1-4939-7404-7 Neuromethods 132 (DE-604)BV008920602 132 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029950136&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Computational modeling of drugs against Alzheimer's disease Neuromethods Medizin Computational chemistry (DE-588)4290091-8 gnd Alzheimerkrankheit (DE-588)4112510-1 gnd Arzneimitteldesign (DE-588)4278218-1 gnd |
| subject_GND | (DE-588)4290091-8 (DE-588)4112510-1 (DE-588)4278218-1 (DE-588)4143413-4 |
| title | Computational modeling of drugs against Alzheimer's disease |
| title_auth | Computational modeling of drugs against Alzheimer's disease |
| title_exact_search | Computational modeling of drugs against Alzheimer's disease |
| title_full | Computational modeling of drugs against Alzheimer's disease edited by Kunal Roy |
| title_fullStr | Computational modeling of drugs against Alzheimer's disease edited by Kunal Roy |
| title_full_unstemmed | Computational modeling of drugs against Alzheimer's disease edited by Kunal Roy |
| title_short | Computational modeling of drugs against Alzheimer's disease |
| title_sort | computational modeling of drugs against alzheimer s disease |
| topic | Medizin Computational chemistry (DE-588)4290091-8 gnd Alzheimerkrankheit (DE-588)4112510-1 gnd Arzneimitteldesign (DE-588)4278218-1 gnd |
| topic_facet | Medizin Computational chemistry Alzheimerkrankheit Arzneimitteldesign Aufsatzsammlung |
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