Human genome editing: science, ethics, and governance
Gespeichert in:
| Körperschaft: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Washington, DC
National Academies Press
2017
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | "Committee on Human Gene Editing : Scientific, Medical, and Ethical Considerations." Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions |
| Beschreibung: | xviii, 310 Seiten Illustrationen 23 cm |
| ISBN: | 9780309452885 0309452880 |
Internformat
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Datensatz im Suchindex
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| adam_text | Titel: Human genome editing
Autor:
Jahr: 2017
Human Genome Editing SCIENCE, ETHICS, AND GOVERNANCE Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations A Report of The National Academies of SCIENCES • ENGINEERING • MEDICINE THE NATIONAL ACADEMIES PRESS Washington, DC www.nap.edu
Contents SUMMARY 1 1 INTRODUCTION 15 Study Context, 16 Background, 18 Study Approach, 25 Organization of the Report, 26 2 OVERSIGHT OF HUMAN GENOME EDITING AND OVERARCHING PRINCIPLES FOR GOVERNANCE 29 Principles for Governance of Human Genome Editing, 30 Regulation of Gene Therapy in the United States, 34 Governance in Other Nations, 57 Conclusions and Recommendation, 59 3 BASIC RESEARCH USING GENOME EDITING 61 The Basic Tools of Genome Editing, 61 Rapid Advances in Genome-Editing Technology, 68 Basic Laboratory Research to Advance Understanding of Human Cells and Tissues, 69 Basic Laboratory Research to Advance Understanding of Mammalian Reproduction and Development, 71 Ethical and Regulatory Issues in Basic Research, 80 Conclusions and Recommendation, 81 xm
XIV CONTENTS 4 SOMATIC GENOME EDITING 83 Background, 84 Advantages of Genome Editing Over Traditional Gene Therapy and Earlier Approaches, 86 Homologous and Nonhomologous Repair Methods Used for Nuclease-Based Genome Editing, 90 Potential Human Applications of Somatic Cell Genome Editing, 91 Scientific and Technical Considerations Associated with the Design and Application of Genome-Editing Strategies, 94 Ethical and Regulatory Issues Posed by Somatic Cell Genome Editing, 103 Conclusions and Recommendations, 109 5 HERITABLE GENOME EDITING 111 Potential Applications and Alternatives, 113 Scientific and Technical Issues, 116 Ethics and Regulation of Editing the Germline to Correct Disease-Causing Traits, 119 Regulation, 130 Conclusions and Recommendation, 133 6 ENHANCEMENT 137 Human Genetic Variation and Defining “Normal” and “Natural,” 138 Understanding Public Attitudes Toward Enhancement, 139 Drawing Lines: Therapy Versus Enhancement, 145 Heritable Genome Editing and Enhancement, 153 Conclusions and Recommendations, 159 7 PUBLIC ENGAGEMENT 163 Public Engagement: Broad Concepts, 165 U.S. Practices, 168 International Practices, 173 Lessons Learned from Public Engagement Activities, 175 Moving Forward, 176 Conclusions and Recommendations, 177 8 SUMMARY OF PRINCIPLES AND RECOMMENDATIONS 181 Overarching Principles for Governance of Human Genome Editing, 182 Existing U.S. Oversight Mechanisms for Human Genome Editing, 183
CONTENTS XV REFERENCES 195 APPENDIXES A The Basic Science of Genome Editing 217 B International Research Oversight and Regulations 261 C Data Sources and Methods 273 D Committee Member Biographies 279 E Glossary 293
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| spelling | National Academies of Sciences, Engineering, and Medicine Verfasser (DE-588)1114889792 aut Human genome editing science, ethics, and governance a report of the National Academies of Science, Engineering, Medicine Washington, DC National Academies Press 2017 xviii, 310 Seiten Illustrationen 23 cm txt rdacontent n rdamedia nc rdacarrier "Committee on Human Gene Editing : Scientific, Medical, and Ethical Considerations." Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions Oversight of human genome editing and overarching principles for governance -- Basic research using genome editing -- Somatic genome editing -- Heritable genome editing -- Enhancement -- Public engagement -- Summary of principles and recommendations Humangenetik (DE-588)4072653-8 gnd rswk-swf Bioethik (DE-588)4006791-9 gnd rswk-swf Gentechnologie (DE-588)4071722-7 gnd rswk-swf Human genetics Genetic engineering Ethics Humangenetik (DE-588)4072653-8 s Gentechnologie (DE-588)4071722-7 s Bioethik (DE-588)4006791-9 s DE-604 Online version National Academies of Sciences, Engineering, and Medicine (U.S.) Human genome editing Washington, D.C. : National Academies Press, 1969 9780309452885 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029886069&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Human genome editing science, ethics, and governance Oversight of human genome editing and overarching principles for governance -- Basic research using genome editing -- Somatic genome editing -- Heritable genome editing -- Enhancement -- Public engagement -- Summary of principles and recommendations Humangenetik (DE-588)4072653-8 gnd Bioethik (DE-588)4006791-9 gnd Gentechnologie (DE-588)4071722-7 gnd |
| subject_GND | (DE-588)4072653-8 (DE-588)4006791-9 (DE-588)4071722-7 |
| title | Human genome editing science, ethics, and governance |
| title_auth | Human genome editing science, ethics, and governance |
| title_exact_search | Human genome editing science, ethics, and governance |
| title_full | Human genome editing science, ethics, and governance a report of the National Academies of Science, Engineering, Medicine |
| title_fullStr | Human genome editing science, ethics, and governance a report of the National Academies of Science, Engineering, Medicine |
| title_full_unstemmed | Human genome editing science, ethics, and governance a report of the National Academies of Science, Engineering, Medicine |
| title_short | Human genome editing |
| title_sort | human genome editing science ethics and governance |
| title_sub | science, ethics, and governance |
| topic | Humangenetik (DE-588)4072653-8 gnd Bioethik (DE-588)4006791-9 gnd Gentechnologie (DE-588)4071722-7 gnd |
| topic_facet | Humangenetik Bioethik Gentechnologie |
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