The PET method: tracer principle and radiochemistry
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Stuttgart
Steinbeis-Edition
[2016]
|
| Ausgabe: | 1st edition |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Auf dem Umschlag: Steinbeis-Transferzentrum, Institute for Radiopharmacy |
| Beschreibung: | XII, 221 Seiten Illustrationen 22 cm |
| ISBN: | 9783956630811 3956630815 |
Internformat
MARC
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|---|---|---|---|
| 001 | BV044471520 | ||
| 003 | DE-604 | ||
| 005 | 20170914 | ||
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| 008 | 170904s2016 gw a||| |||| 00||| eng d | ||
| 015 | |a 16,N46 |2 dnb | ||
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| 020 | |a 3956630815 |9 3-95663-081-5 | ||
| 024 | 3 | |a 9783956630811 | |
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| 084 | |a 610 |2 sdnb | ||
| 100 | 1 | |a Machulla, Hans-Jürgen |d 1942- |e Verfasser |0 (DE-588)144006650 |4 aut | |
| 245 | 1 | 0 | |a The PET method |b tracer principle and radiochemistry |c Hans-Jürgen Machulla, Ehab al-Momani, Noeen Malik |
| 250 | |a 1st edition | ||
| 264 | 1 | |a Stuttgart |b Steinbeis-Edition |c [2016] | |
| 300 | |a XII, 221 Seiten |b Illustrationen |c 22 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Auf dem Umschlag: Steinbeis-Transferzentrum, Institute for Radiopharmacy | ||
| 653 | |a Wissenschaftler, Ärzte, Mediziner | ||
| 653 | |a Clinical Diagnostics | ||
| 653 | |a Molecular Imagine | ||
| 653 | |a PET-Method | ||
| 700 | 1 | |a Momani, Ehab al- |d 1981- |e Verfasser |0 (DE-588)1025507770 |4 aut | |
| 700 | 1 | |a Malik, Noeen |d 1982- |e Verfasser |0 (DE-588)101644429X |4 aut | |
| 710 | 2 | |a Steinbeis-Stiftung für Wirtschaftsförderung |0 (DE-588)103002-4 |4 pbl | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029871939&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-029871939 | ||
Datensatz im Suchindex
| _version_ | 1804177802148184064 |
|---|---|
| adam_text | TABLE OF CONTENT
PREFACE.....................................................................................................................VI
ACKNOWLEDGEMENT.............................................................................................VIII
AIM.............................................................................................................................
1
1
INTRODUCTION.......................................................................................................
2
1.1 THE TRACER
PRINCIPLE.......................................................................................5
1.2 APPLICATION IN VITRO AND IN VIVO
...................................................................
6
1.2.1 RADIOPHARMACEUTICAL CONCEPTS FOR APPLICATION IN VIVO
.........................
9
1.2.2 QUANTIFICATION OF GLUCOSE METABOLISM
.................................................
11
1.3 RADIONUCLIDES IN TRACERS FOR PET AND SPECT IMAGING
............................
14
1.4 MEASUREMENT BY PET AND
SPECT............................................................. 19
1.5 LOW AMOUNT OF TRACER NOT EFFECTING METABOLIC FUNCTIONS
...........................
22
1.6 SPECIFIC ACTIVITY
............................................................................................
24
2 PET
TRACERS......................................................................................................26
2.1 CARBON-11
...................................................................................................26
2.1.1 PRODUCTION OF
CARBON-11.......................................................................28
2.1.2 [UC]-SYNTHONS FOR
RADIOSYNTHESIS........................................................
29
2.1.2.1 FORMATION OF NC H 3I
.................................................................. 32
2.1.3 RADIOSYNTHESIS OF
[UC]-TRACERS.............................................................33
2.1.3.1 RADIOSYNTHESIS WITH SYNTHONS PRODUCED WITHIN THE TARGET
.....
33
2.1.3.2 RADIOSYNTHESIS WITH SYNTHONS PRODUCED SUBSEQUENTLY
............
35
2.1.3.3 LABELING BY
[UC]-ALKYLATION.......................................................
41
2.2
FLUORINE-18...................................................................................................44
2.2.1 PRODUCTION OF
FLUORINE-18.....................................................................46
2.2.2 REACTIONS FOR
RADIOFLUORINATION............................................................47
2.2.2.1 LABELING BY ELECTROPHILIC REACTIONS
...........................................
47
2.2.2.2 NUCLEOPHILICITY OF [ 18F] FLUORIDE FOR NUCLEOPHILIC SUBSTITUTION
...49
2.2.23 NUCLEOPHILIC ALIPHATIC
SUBSTITUTION............................................51
2.Z.2.4 NUCLEOPHILIC AROMATIC [18F]FLUORINATION
...................................
54
2.2.2.5
[18F]-SYNTHONS..............................................................................57
2.3 GALLIUM-68 (68G A)
......................................................................................
67
2.3.1 AVAILABILITY OF
68GA...............................................................................67
2.3.2
RADIOCHEMISTRY......................................................................................68
2.3.3
RADIOSYNTHESIS........................................................................................69
3 SPECT TRACERS
...............................................................................................
76
3.1
TECHNETIUM-99M.........................................................................................
76
3.1.1 PROCEDURE FOR PROVIDING TECHNETIUM-99M
..........................................
76
3.1.2
RADIOLABELING.........................................................................................
79
3.1.3 99NTC-LABELED COMPOUNDS AS RADIOPHARMACEUTICALS
FOR SPECT
MEASUREMENT......................................................................
80
3.2
RADIOIODINE..................................................................................................84
3.2.1 ROLE OF RADIOIODINE IN RADIOPHARMACEUTICAL CONCEPTS
.......................
86
3.2.2 METHODS OF
PRODUCTION.........................................................................89
3.2.3 RADIOSYNTHESIS
.......................................................................................
90
3.2.3.1 NUCLEOPHILIC SUBSTITUTIONS OF HALOGENS
......................................
91
3.2.3.2 DIRECT ELECTROPHILIC RADIOIODINATION AND
ELECTROPHILIC DEMETALLATION
.........................................................
93
3.2.3.3 PROSTHETIC GROUPS IN LABELING WITH RADIOIODINE
.........................
97
4 APPLICATIONS IN LIFE
SCIENCES...........................................................................99
4.1 FDG FOR THE ASSAY OF GLUCOSE METABOLISM
................................................
102
4.2 ASSAY OF OXYGEN METABOLISM AND ROLE OF
MOVEMENT.................................105
4.3 PET IMAGING OF BRAIN TUM ORS
...................................................................
106
4.4 IMAGING OF TUMOR GROWTH BY
FLT.............................................................I L L
4.5 HYPOXIA IMAGING
........................................................................................
114
4.6
CARDIOLOGY..................................................................................................120
4.7 PROSTATE
CANCER...........................................................................................
123
4.8 IMAGING OF PATIENTS WITH ALZHEIMER S DISEASE (A D
)..................................129
4.9 DETERMINATION OF APOPTOSIS IN CONSEQUENCE OF CHEMOTHERAPY
................
134
4.10 ASSAY OF NEUROTRANSMITTER FUNCTION IN BRAIN
............................................
137
4.11 DRUG EVALUATION IN PHARMACEUTICAL RESEARCH
............................................
142
5 CURRENT SITUATION AND PERSPECTIVES O F THE PET METHOD
...........................
146
5.1 CURRENT
SITUATION.......................................................................................
146
5.2 FIELDS OF
APPLICATION...................................................................................147
5.2.1
ONCOLOGY..............................................................................................147
5.2.2 NEUROLOGY AND
PSYCHIATRY..................................................................
148
5.2.3 DRUG
DEVELOPMENT..............................................................................
148
5.3 TECHNOLOGICAL AND SCIENTIFIC IMPROVEMENTS
.............................................
150
5.3.1 TECHNICAL
PROGRESS............................................................................
150
5.3.2 ROUTINE PRODUCTION OF
TRACERS.............................................................151
5.3.3 BIOTECHNOLOGY AND COORDINATION CHEMISTRY
......................................
152
5.3.4
INTERDISCIPLINARITY................................................................................153
5.4
PERSPECTIVES................................................................................................
155
FURTHER
READINGS..................................................................................................158
NOTES O F
REFERENCES.............................................................................................
160
REFERENCES.............................................................................................................
164
LIST O F
ABBREVIATIONS...........................................................................................192
LIST O F COPYRIGHT
PERMISSIONS...........................................................................196
TABLE O F
FIGURES....................................................................................................
198
LIST O F
TABLES........................................................................................................
206
INDEX......................................................................................................................207
AUTHORS.................................................................................................................
220
|
| any_adam_object | 1 |
| author | Machulla, Hans-Jürgen 1942- Momani, Ehab al- 1981- Malik, Noeen 1982- |
| author_GND | (DE-588)144006650 (DE-588)1025507770 (DE-588)101644429X |
| author_facet | Machulla, Hans-Jürgen 1942- Momani, Ehab al- 1981- Malik, Noeen 1982- |
| author_role | aut aut aut |
| author_sort | Machulla, Hans-Jürgen 1942- |
| author_variant | h j m hjm e a m ea eam n m nm |
| building | Verbundindex |
| bvnumber | BV044471520 |
| ctrlnum | (OCoLC)963868651 (DE-599)DNB1118388607 |
| dewey-full | 610 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610 |
| dewey-search | 610 |
| dewey-sort | 3610 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 1st edition |
| format | Book |
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| id | DE-604.BV044471520 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:53:52Z |
| institution | BVB |
| institution_GND | (DE-588)103002-4 |
| isbn | 9783956630811 3956630815 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029871939 |
| oclc_num | 963868651 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM |
| owner_facet | DE-19 DE-BY-UBM |
| physical | XII, 221 Seiten Illustrationen 22 cm |
| publishDate | 2016 |
| publishDateSearch | 2016 |
| publishDateSort | 2016 |
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| spelling | Machulla, Hans-Jürgen 1942- Verfasser (DE-588)144006650 aut The PET method tracer principle and radiochemistry Hans-Jürgen Machulla, Ehab al-Momani, Noeen Malik 1st edition Stuttgart Steinbeis-Edition [2016] XII, 221 Seiten Illustrationen 22 cm txt rdacontent n rdamedia nc rdacarrier Auf dem Umschlag: Steinbeis-Transferzentrum, Institute for Radiopharmacy Wissenschaftler, Ärzte, Mediziner Clinical Diagnostics Molecular Imagine PET-Method Momani, Ehab al- 1981- Verfasser (DE-588)1025507770 aut Malik, Noeen 1982- Verfasser (DE-588)101644429X aut Steinbeis-Stiftung für Wirtschaftsförderung (DE-588)103002-4 pbl DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029871939&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Machulla, Hans-Jürgen 1942- Momani, Ehab al- 1981- Malik, Noeen 1982- The PET method tracer principle and radiochemistry |
| title | The PET method tracer principle and radiochemistry |
| title_auth | The PET method tracer principle and radiochemistry |
| title_exact_search | The PET method tracer principle and radiochemistry |
| title_full | The PET method tracer principle and radiochemistry Hans-Jürgen Machulla, Ehab al-Momani, Noeen Malik |
| title_fullStr | The PET method tracer principle and radiochemistry Hans-Jürgen Machulla, Ehab al-Momani, Noeen Malik |
| title_full_unstemmed | The PET method tracer principle and radiochemistry Hans-Jürgen Machulla, Ehab al-Momani, Noeen Malik |
| title_short | The PET method |
| title_sort | the pet method tracer principle and radiochemistry |
| title_sub | tracer principle and radiochemistry |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029871939&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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