Piezo channels:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cambridge, MA, United States
Elsevier, Academic Press
2017
|
| Schriftenreihe: | Current topics in membranes
volume 79 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Enthält Literaturangaben |
| Beschreibung: | xiv, 334 Seiten Illustrationen, Diagramme |
| ISBN: | 9780128093894 |
Internformat
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| 245 | 1 | 0 | |a Piezo channels |c edited by Philip A. Gottlieb, State University of New York at Buffalo, Buffalo, NY, United States |
| 264 | 1 | |a Cambridge, MA, United States |b Elsevier, Academic Press |c 2017 | |
| 300 | |a xiv, 334 Seiten |b Illustrationen, Diagramme | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| 490 | 1 | |a Current topics in membranes |v volume 79 | |
| 500 | |a Enthält Literaturangaben | ||
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Datensatz im Suchindex
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| adam_text | CONTENTS
Contributors xi
Preface xiii
1. A Tour de Force: The Discovery, Properties, and Function of Piezo
Channels 1
PA Gottlieb
1. Background 2
2. Discovery of Piezo Channels 5
3. Conclusion 28
Acknowledgment 29
References 29
2. Piezo! Channels in Vascular Development and the Sensing
of Shear Stress 37
AJ. Hyman, S. Tumova, D.J. Beech
1. Introduction 38
2. Shear Stress in Vascular Development 39
3. Ion Channels in Shear Stress Sensing 40
4. Piezol Channels 42
5. Conclusions and Future Directions 52
Acknowledgments 52
References 53
3. Origin of the Force: The Force-From-Lipids Principle Applied
to Piezo Channels 59
CD. Cox, N. Bavi, B. Martinac
1. Introduction 60
2. Origin of the Force-From-Lipids Principle 62
3. Applicability of Force-From-Lipids to Eukaryotic Channels 66
4. Which Force is the Right Force? 71
5. Architectural Blueprint of Piezo Channels 83
6. Conclusions and Future Perspectives 87
References 88
v
vi
Contents
4. Genetic Diseases of PIEZ01 and PIEZ02 Dysfunction 97
S.L Al per
1. Introduction 98
2. PIEZOI Loss-of-Function: Congenital Lymphatic Dysplasia 100
3. PIEZOI Gain-of-Function: Hereditary Xerocytosis/Dehydrated
Stomatocytosis 104
4. PIEZOI Lo$s-of-Function Phenotypes in Animal Models 109
5. Additional Pathological Associations of Human PIEZ01 113
6. PIEZ02 Loss-of֊Function Disease: Recessive Syndrome of Distal
Arthrogryposis, Scoliosis, Muscle Atrophy, Proprioception Deficits, and
Transient Neonatal Respiratory Insufficiency 115
7. PIEZ02 Gain-of֊Function Disease: Dominant Distal Arthrogryposis
Types 3 (Gordon Syndrome) and 5, and Marden-Walker Syndrome 117
8. PIEZ02 Loss-of-Function Phenotypes in Mouse Models 119
9. Additional Human Genetic Associations With PIEZQ2 122
10. Conclusions and Future Prospects 124
References 126
5. The Structural Basis for Sensing by the Piezol Protein 135
W. Li, N. Gao, M. Yang
1. Introduction 136
2. Structure of Mouse Piezol 139
3. Possible Gating Mechanisms of Mouse Piezol 148
4. Conciusions and Future Prospects 150
References 153
6. In Touch With the Mechanosensitive Piezo Channels:
Structure, Ion Permeation, and Mechanotransduction 159
J. Geng, Q. Zhao, T. Zhang, B. Xiao
1. Introduction 161
2. The Piezo Family of Proteins Represents a Physiologically and
Pathophysiologically Important Gass of MS Cation Channels 163
3. Piezo Proteins Form a Distinct Class of MS Cation Channels 167
4. The Three-Dimensional Cryo-EM Structure of mPiezol 172
5. Piezol Topology 175
6. The Central Ion-Conducting Pore 178
7. Molecular Basis for Piezo Ion Permeation, Ion Selectivity, and
Pore Blockade * 182
Contents
vii
8. The Molecular Basis for Piezo Mechanotransduction 185
9. A Proposed Working Model for Mechanosensitive Piezo Channels 188
10. Conclusion and Perspective 188
Acknowledgments 190
References 190
7. Piezo2 in Cutaneous and Proprioceptive Mechanotransduction
invertebrates 197
E.O. Anderson, E.R. Schneider, S.N. Bagriantsev
1. Introduction 198
2. Somatosensory Neurons 200
3. Light Touch 204
4. Proprioception 207
5. Merkel Cells 208
6. Nociception 210
7. Conclusions and Perspectives 212
References 212
8. Mechanosensitive Piezo Channels in the Gastrointestinal
Tract 219
C. Alcaino, G. Farrugia, A. Beyder
1. The Gastrointestinal Tract Mecha nosensitivity 220
2. Mechanosensitive Cells in the Gastrointestinal Tract 220
3. Mechanosensitive Ion Channels 221
4. Summary and Conclusions 234
Acknowledgments 235
References 235
9. Regulation of Piezo Channels by Cellular Signaling Pathways 245
I. Borbiro, T Rohacs
Abbreviations 245
1. Introduction 246
2. Phospholipase C and Cyclic Adenosine Monophosphate Signaling 247
3. Sensitization of Sensory Ion Channels by Inflammatory Pathways 249
4. Calcium-Induced Inhibition of Piezo Channels—the Role of
Phosphoinositides 253
5. Conclusions 256
Acknowledgments 256
References 257
viii
Contents
10. Role of Piezo Channels in Joint Health and Injury 263
W. Lee, F. Guilak, W. Liedtke
1. Introduction 264
2. Mechanotransduction in Chondrocytes 265
3. Piezo 1 and Piezo2 in Articular Chondrocytes 266
4. Continuum of Mechanical Loads 267
5. Key Contributors of Piezo-media ted High-strain Mechanotransduction in
Chondrocytes 269
6. Follow-Up Questions 270
7. Summary 270
References 271
11. The Kinetics and the Permeation Properties of Piezo Channels 275
R. Gnanasambandam, PA Gottlieb, F. Sachs
1. Introduction 276
2. Structure Defines Function: The Force-Sensing and the Pore Modules
of Piezo Channels 278
3. Comparison of the Kinetics of Piezo Currents Against Those
of Endogenous Mechanosensitive Channel Currents 279
4. Domains Influence the Kinetics of Piezo Channels 281
5. Modeling and Its Thermodynamic Underpinnings 283
6. Mechanosensitive Channel Gating Energy; What Is the Predicted
Value of AG? 287
7. Mutations in Piezo Channels That Affect Channel Kinetics 288
8. Removing PIEZ01 Inactivation 290
9. Kinetic Properties of Piezol Channels Are Altered by Yodal 293
10. Permeation and Selectivity of Piezo Channels 293
11. Mutations That Alter Pore Module Residues and Their Effects on
Permeation and Conductance 296
12. Conclusions 297
Acknowledgment 298
References 298
12. A Microfluidic Approach for Studying Piezo Channels 309
M.M. Maneshi, PA Gottlieb, S.Z. Hua
1. Fundamentals of Stress in Solids and Fluids 310
2. The Shear Stress Response 317
Contents
ix
3. Mechanical Couplings of Cytoskeleton to Mechanosensitive Ion Channels 323
4. Shear Stress as a High-Throughput Assay for Mechanosensitive Ion
Channel Specific Drugs 324
5. Microfluidic Shear Stress Chamber Versus Other Mechanical Assays 327
6. Microfluidic Devices to Measure Other Properties of Piezo Channels 328
7. Perspective and Future Development 329
References 329
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| indexdate | 2024-07-10T07:53:21Z |
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| isbn | 9780128093894 |
| language | English |
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| spelling | Piezo channels edited by Philip A. Gottlieb, State University of New York at Buffalo, Buffalo, NY, United States Cambridge, MA, United States Elsevier, Academic Press 2017 xiv, 334 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Current topics in membranes volume 79 Enthält Literaturangaben Ionenaustausch (DE-588)4162300-9 gnd rswk-swf Biomembran (DE-588)4006884-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Biomembran (DE-588)4006884-5 s Ionenaustausch (DE-588)4162300-9 s DE-604 Gottlieb, Philip A. edt Current topics in membranes volume 79 (DE-604)BV036839511 79 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029853447&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Piezo channels Current topics in membranes Ionenaustausch (DE-588)4162300-9 gnd Biomembran (DE-588)4006884-5 gnd |
| subject_GND | (DE-588)4162300-9 (DE-588)4006884-5 (DE-588)4143413-4 |
| title | Piezo channels |
| title_auth | Piezo channels |
| title_exact_search | Piezo channels |
| title_full | Piezo channels edited by Philip A. Gottlieb, State University of New York at Buffalo, Buffalo, NY, United States |
| title_fullStr | Piezo channels edited by Philip A. Gottlieb, State University of New York at Buffalo, Buffalo, NY, United States |
| title_full_unstemmed | Piezo channels edited by Philip A. Gottlieb, State University of New York at Buffalo, Buffalo, NY, United States |
| title_short | Piezo channels |
| title_sort | piezo channels |
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