Gene regulation, epigenetics and hormone signaling: Volume 2
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
2017
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | xii, 329-663 Seiten Illustrationen, Diagramme |
| ISBN: | 9783527322817 |
Internformat
MARC
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| adam_text | Contents
Preface XIII
Volume I
1 Eukaryotic Gene Expression by RNA Polymerase II 1
Geetha Durairaj, Shivani Malik, and Sukesh R. Bhaumik
2 Epigenetic Code: Histone Modification, Gene Regulation, and Chromatin
Dynamics 29
Arunoday Bhan, Paromita Deb, and Subhrangsu S. MandaI
3 Histone Lysine Methylation, Demethylation, and Hormonal Gene
Regulation 59
Yaling Huang, Briana Dennehey, and Xiaobincj Shi
4 The Role of HATs and HDACs in Cell Physiology and Disease 101
Irene Santos-Barriopedro, Helena Raurefl-Vila, and Alejandro Vaquero
5 The Short and Medium Stories of Noncoding RNAs: microRNA and
SÍRNA 137
Arunoday Bhan, Paromita Deb, Miiad Soieimani, and Subhrangsu S. MandaI
6 Long Noncoding RNA (IncRNA): Functions in Health and Disease 169
Arunoday Bhan, Milad Soieimani, and Subhrangsu S. MandaI
7 Histone Variants: Structure, Function, and implication in Diseases 209
Francisca Alvarez and Alejandra Loyola
8 Genomic Imprinting in Mammals: Origin and Complexity of an
Epigenetically Regulated Phenomenon 227
Elena de la Casa-Esperón
VI Contents
9 Centromere and Kinetochore: Essential Components for Chromosome
Segregation 259
Shreyas Sridhar, Arti DumbrepatH, Lakshmi Sreekumar, Sundar Ram
Sankaranarayanan, Krishnendu Guin, and Kaustuv Sanya 1
10 Nuclear Receptors and NR-coregulators: Mechanism of Action and
Cell Signaling 289
Arunoday Bhan and Subhrangsu S. Mandal
Volume II
11 Estrogen and Progesterone Receptor Signaling and Action 329
Linda l. Perrotti
11.1 Introduction 329
11.2 Nuclear Hormone Receptor Superfamily 330
11.3 Estrogen and Progesterone Receptor Isoforms 332
11.4 Mechanisms of Estrogen and Progesterone Signaling 334
11.4.1 Direct Genomic Signaling (Ligand Dependent) 335
11.4.2 Indirect Genomic Signaling --- Ligand Independent 336
11 A3 Nongenomic Signaling - Membrane Steroid Receptors 336
11A3.1 Nongenomic Estrogen Signaling 337
11.4.3.2 Nongenomic Progesterone Signaling 338
11.5 Integration of Membrane and Nuclear Signaling 338
11.6 Coregulators of Estrogen and Progesterone Signaling 338
11.6.1 The pl60 Steroid Receptor Coactivator Family 339
11.6.2 Corepressors of Steroid Hormone Receptors 342
11.7 Convergence of ER and PR Signaling Mechanisms: Focus on the
Brain 342
11.7.1 Expression and Distribution of Corepressors in the Brain 345
11.8 Conclusion 345
References 345
12 Gonadal Steroid Hormones and Brain Protection 355
Meharvan Singh, Courtney Brock,, Rebecca Cunningham, and Chang Su
12.1 Introduction 355
12.2 The Protective Effects of Estrogens on the Brain 355
12.3 The Protective Effects of Progesterone on the Brain 356
12.4 The Protective Effects of Androgens in the Brain 359
12.5 Clinical Studies of Estrogens in Alzheimer s Disease 361
12.6 Clinical Studies Addressing the Protective Effects of Progesterone and
Related Progestins 362
12.7 Clinical Studies Addressing the Potential Beneficial Effects of
Androgens 364
12.8 Conclusions 365
References 366
13
Glucocorticoid Receptor-Mediated Signaling and Stress
Metabolism 377
Rosalie M. Uht and Shreyas Bhave
13.1 Introduction 377
13.2 Gene Regulation 378
13.2.1 History of the GR 378
13.2.2 Overall Structure 378
13.2.3 Glucocorticoid Response Elements (GREs) 379
13.2.3.1 Activating GREs, Palindromes 379
13.2.3.2 Negative GREs (nGREs) 380
13.2.3.3 Bioinformatic Contributions 381
13.2.4 Co regulators 381
13.2.4.1 Coactivators 381
13.2.4.2 Corepressors 382
13.2.4.3 Coregulators with Activating and Repressing Activities 383
13.2.5 Chromatin Remodeling 383
13.2.6 Structural Analysis of GR 384
13.2.6.1 Crystal Structures 384
13.2.7 Summary 385
13.3 Metabolism 385
13.3.1 PEPCK Promoter Mapping 386
13.3.1.1 GR Binding Sites 387
13.3.1.2 Other TF Binding Sites 387
13.3.2 Role of Coactivators 387
13.3.2.1 Mechanisms of PEPCK Repression 388
13.3.2.2 PEPCK Chromatin 388
13.3.2.3 Metabolic Network 388
13.3.3 Summary 388
13.4 The HPA Axis 389
13.4.1 The CRH Promoter 389
13.4.2 Methylated CpG Binding Protein 2 (MeCP2) 391
13.4.3 Specificity 392
13.4.4 Summary 393
13.5 Conclusion 393
References 394
14 Targeting Androgen Signaling in Prostate Cancer 399
Paul H. Chung, Preethi Ravindranathan, Bishoy A. Gayed, and
Ganesh V. Raj
14.1 Introduction 399
14.2 Disease States of Metastatic Prostate Cancer 400
14.3 Androgens and Androgen Receptor 401
14.4 Castrate-Sensitive Prostate Cancer 404
14.5 Prostate Cancer Progression 405
14.6 Prostate Cancer Drugs 407
VIII Contents
14.6.1 Blocking Androgen Production 407
14.6.2 Blocking the Androgen Receptor 409
14.6.3 Destabilizing the Androgen Receptor 410
14.6.4 Modifying Androgen Receptor DNA 410
14.7 Future of Prostate Cancer Therapy 411
14.8 Conclusion 412
References 412
15 Role of Peroxisome Proliferator-Activated Receptors In Inflammation
and Angiogenesis 417
Suchismito Acharya
15.1 Introduction 417
15.2 PPARa (NR1C1) 432
15.2.1 Inflammation 432
15.2.1.1 Hepatic Inflammation 433
15.2.1.2 Inflammation in Vascular Wall 433
15.2.1.3 Inflammation in Spinal Cord 434
15.2.2 Angiogenesis 434
15.2.2.1 Anticancer/Antiangiogenic Activity 434
15.2.2.2 Proangiogenic Activity 436
15.3 PPARß/5 (NR1C2) 436
15.3.1 Inflammation 437
15.3.2 Wound Healing 437
15.3.3 Angiogenesis 438
15.3.3.1 Proangiogenic Activity 438
15.3.4 Antiangiogenic Activity 438
15.4 PPARy (NR1C3) 439
15.4.1 Inflammation 440
15.4.1.1 Allergic Inflammation 440
15.4.1.2 Viral Inflammation 440
15.4.1.3 Neuroprotection/Inflammation-AZ/PD 441
15.4.1.4 Atherosclerosis 441
15.4.2 Angiogenesis 441
15.4.2.1 Cornea and Retina 441
15.4.2.2 Lung/Bone/Fat Tissue/Placenta 443
15.5 Concluding Remarks 443
References 444
16 RAR/RXR-Mediated Signaling 457
Jörg Mey
16.1 Introduction 457
16.2 Vitamin A Receptors and Their Response Elements 457
16.2.1 RAR and RXR Ligands 459
16.2.2 The Structure of Retinoid Receptors 461
16.2.3 Retinoic Acid Response Elements 463
Contents IX
16.3
16.3.1
16.3.2
16.3.3
16.3.4
16.3.5
16.4
16.4.1
16.4.2
16.4.3
16.4.4
16.4.5
16.5
16.5.1
16.5.2
16.5.3
16.5.4
16.5.5
16.6
16.6.1
16.6.2
16.6.3
16.7
16.7.1
16.7.2
16.7.3
16.8
16.8.1
16.8.2
16.8.3
16.8.4
16.9
16.9.1
16.9.2
16.10
16.10.1
16.10.2
16.10.3
16.10.4
16.11
Transcriptional RAR/RXR Signaling: The Standard Model and Recent
Discoveries 463
Ligand Binding and Exchange of Co factors 465
Histone Modification and Recruitment of the Transcription
Machinery 465
Termination of RAR-Dependent Signaling 467
New RAR Binding Sites 467
Variations of the Classical Model of Activation 467
Regulation of RAR Signaling: Ligand Synthesis and Metabolism 468
Cleavage of Provitamin A and Retinyl Esters 468
Uptake of Dietary Retinol 470
Synthesis of Retinal 470
Synthesis of Retinoic Acid 471
Retinoic Acid Degradation 471
Regulation of RAR Signaling: The Role of Binding Proteins 474
Intestinal Uptake and Hepatic Storage 475
Transport in the Circulation 476
Cellular Uptake in Target Tissues 477
Retinoic Acid Synthesis and Degradation 477
Nuclear Receptor Activation 478
Regulation of RAR Signaling: Receptor Expression, Modification,
and Degradation 479
Specific Expression of RARs in the Body 479
Nuclear Translocation 479
Posttranslational Modification of RAR/RXR 481
Transrepression and Crosstalk with Other Transcription Factors 482
Transrepression of Other Regulatory Sequences 483
Interactions between RAR and Other Transcription Factors 483
Transcriptional Control by Other Retinoids 484
Nongenomic Mechanisms of RA/RAR Signaling 485
Rapid Physiological Effects of RA 486
Cytosolic Localization of RAR 486
Direct Interactions with Protein Kinases 487
Suppression of Protein Translation 487
The Role of Retinoid Binding Proteins in Phototransduction 488
The Retinoid Cycle of Phototransduction 488
Phototransduction and the Evolution of RA Nuclear Signaling 490
Retinoic acid-Regulated Genes 490
Direct Gene Targets of RA 490
Indirect Targets of RA 492
Discrepancies between DNA Binding and Active Signaling 492
“Systems Biology” of RA Signaling 493
Conclusion 493
List of Abbreviations and Symbols 495
References 496
X Contents
17 On the Trail of Thyroid Hormone Receptor Epigenetics 511
Prodip K. Sarkar
17.1 Introduction 511
17.1.1 Brief Historical Background 511
17.1.2 Functional Background 512
17.1.2.1 Biosynthesis of Thyroid Hormones and Their Metabolites 512
17.1.2.2 Thyroid Hormone Transportation 514
17.1.2.3 Physiologic Pathway of Thyroid Hormone Secretion 515
17.2 Overview of Thyroid Hormone Action 517
17.2.1 Molecular Mechanism of Thyroid Hormone Action 518
17.2.1.1 Concepts of Cellular Thyroid Hormone Receptors 518
17.2.1.2 Classification of the Nuclear Receptors for Thyroid Hormones and
Their Isoforms 518
17.2.1.3 Thyroid Hormone Receptor Functional Domains 522
17.2.1.4 Thyroid Response Elements (TREs) 524
17.3 Molecular Mechanisms of Regulation of Gene Expression by Thyroid
Hormone-Specific Nuclear Receptors 526
17.4 Nongenomic Mechanism of Action of Thyroid Hormones 530
17.5 Conclusion 533
References 534
18
18.1
18.2
18.2.1
18.2.2
18.2.3
18.3
18.4
18.4.1
18.4.2
18.4.3
18.5
18.6
18.6.1
18.6.1.1
18.6.1.2
18.6.1.3
18.7
18.7.1
18.8
18.8.1
18.8.2
18.8.3
Insulin Signaling, Epigenetics, and Human Diseases 541
Ragitha Chruvattil, Muskaan BêlantTushar P. Patel, and Sarita Gupta
Introduction to Epigenetics 541
Types of Epigenetic Modifications 542
Histone Acetylation/Deacetylation 542
DNA-Histone Methylation/Demethylation 543
Histone Phosporylation and O-Linked N-Acetylglucosamination 54S
Epigenetic Links to Endocrine System 545
Insulin 546
Epigenetic Pattern of Ins Gene 547
Glucose-Induced Chromatin Modification in Ins Gene Promoter 549
Epigenetics Related to Insulin Biosynthesis 549
Insulin Signaling 552
Insulin Receptor 553
Regulation of Insulin Receptor 553
Genetic Regulation 554
Epigenetic Regulation 554
Hormonal Regulation 555
Insulin Receptor Substrate (1RS) 555
Epigenetics Involved with 1RS 555
The PI(3)K Pathway 556
Epigenetics Involved with PI(3)K/AKT 557
Epigenetics Involved with GSK3 (Glycogen Synthase Kinase 3) 557
Epigenetics Involved with Glucose Transporters 558
18.9 The Ras Pathway 559
18.9.1 Epigenetics Involved in Ras Pathway 560
18.10 Insulin Resistance and Metabolic Derangements 560
18.10.1 Insulin Resistance and Epigenetics 561
18.10.2 Insulin Resistance, Metabolic Derangements, and Chromatin
Remodeling 563
18.11 Conclusion 564
Acknowledgment 565
Abbreviations 565
Function of the Genes Discussed in this Chapter 566
References 567
19 Endocrine Disruptors and Epigenetics 577
John D. Bowman, Shaikh Mizanoor Rahman, and Mahua Choudhury
19.1 Introduction 577
19.2 Endocrine Disruptors 582
19.2.1 Bisphenol-A 582
19.2.2 Diethylstilbestrol 583
19.2.3 Phthalates 584
19.2.3.1 Di(2-Ethylhexyl) Phthalate (DEHP) 584
19.2.3.2 Di-n-Butyl Phthalate (DBP) 584
19.2.3.3 Benzyl Butyl Phthalate (BBzP or BBP) 584
19.2.4 Vinclozolin 585
19.2.5 Perfluorooctanoic Acid (PFOA) 585
19.3 Associated Diseases 586
19.3.1 Systemic Lupus Erythematosus (SLE) 586
.1 9.3.2 Diabetes and Obesity 587
19.3.3 Neuroendocrine-Associated Pathophysiology 590
19.3.4 Cancer 592
19.3.5 Effects on Reproduction 594
19.4 Endocrine Disruptors and Development of Transgenerational
Disease 596
19.5 Discussion 597
References 597
20 Endocrine Disruptors: Mechanism of Action and Impacts on Health
and Environment 607
Paromita Deb and Subhrangsu S. Mandai
20.1 Introduction 607
20.2 Mechanism of Action of EDC 611
20.2.1 Interference in Nuclear Receptor-Mediated Cell Signaling 611
20.2.2 Alternation in Epigenetics by EDCs 613
20.3 Bisphenol A (BPA) and its Health Impacts 613
20.3.1 Molecular Mechanism of Action of BPA 614
20.3.2 Health Impacts of BPA 615
XIII Contents
20.4 Diethylstilbestrol (DES) 616
20.4.1 Mechanism of Action of DES 617
20.4.2 Health Impacts of DES 618
20.5 Atrazine 619
20.5.1 Mechanism of Action and Health Impacts of Atrazine 619
20.6 Polychlorinated Biphenyls (PCBs) 620
20.6.1 Health Defects Caused by PCBs and Potential Mechanism 620
20.7 Phthalates 621
20.7.1 Health Defects Caused by Phthalates 622
20.8 Phytoestrogens 622
20.9 Methoxychlor 624
20.9.1 Health Impacts by Methoxychlor 625
20.10 Dioxins: An Environmental Contaminant 625
20.11 Conclusion 626
Acknowledgments 627
Abbreviations 627
References 628
Index 639
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| id | DE-604.BV044439130 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:52:59Z |
| institution | BVB |
| isbn | 9783527322817 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029840342 |
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| owner_facet | DE-11 DE-355 DE-BY-UBR DE-703 DE-29 |
| physical | xii, 329-663 Seiten Illustrationen, Diagramme |
| publishDate | 2017 |
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| spelling | Gene regulation, epigenetics and hormone signaling Volume 2 edited by Subhrangsu S. Mandal Weinheim Wiley-VCH 2017 xii, 329-663 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Endokrine Regulation (DE-588)4113434-5 gnd rswk-swf Epigenetik (DE-588)7566079-9 gnd rswk-swf Genregulation (DE-588)4122166-7 gnd rswk-swf Genregulation (DE-588)4122166-7 s Epigenetik (DE-588)7566079-9 s Endokrine Regulation (DE-588)4113434-5 s DE-604 Mandal, Subhrangsu S. Sonstige (DE-588)1137339268 oth (DE-604)BV044342350 2 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029840342&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gene regulation, epigenetics and hormone signaling Endokrine Regulation (DE-588)4113434-5 gnd Epigenetik (DE-588)7566079-9 gnd Genregulation (DE-588)4122166-7 gnd |
| subject_GND | (DE-588)4113434-5 (DE-588)7566079-9 (DE-588)4122166-7 |
| title | Gene regulation, epigenetics and hormone signaling |
| title_auth | Gene regulation, epigenetics and hormone signaling |
| title_exact_search | Gene regulation, epigenetics and hormone signaling |
| title_full | Gene regulation, epigenetics and hormone signaling Volume 2 edited by Subhrangsu S. Mandal |
| title_fullStr | Gene regulation, epigenetics and hormone signaling Volume 2 edited by Subhrangsu S. Mandal |
| title_full_unstemmed | Gene regulation, epigenetics and hormone signaling Volume 2 edited by Subhrangsu S. Mandal |
| title_short | Gene regulation, epigenetics and hormone signaling |
| title_sort | gene regulation epigenetics and hormone signaling |
| topic | Endokrine Regulation (DE-588)4113434-5 gnd Epigenetik (DE-588)7566079-9 gnd Genregulation (DE-588)4122166-7 gnd |
| topic_facet | Endokrine Regulation Epigenetik Genregulation |
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