Antimicrobial peptides: discovery, design and novel therapeutic strategies
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Wallingford ; Boston
CABI
[2017]
|
| Ausgabe: | 2nd edition |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | xvii, 268 Seiten Illustrationen, Diagramme |
| ISBN: | 9781786390394 |
Internformat
MARC
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| 250 | |a 2nd edition | ||
| 264 | 1 | |a Wallingford ; Boston |b CABI |c [2017] | |
| 264 | 4 | |c © 2017 | |
| 300 | |a xvii, 268 Seiten |b Illustrationen, Diagramme | ||
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Datensatz im Suchindex
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|---|---|
| adam_text | Contents
;
-V
■ • ■,
K:
Contributors xi
Preface xiii
Introduction to the Second Edition xvii
Michael Zasloff
Part i: overview of antimicrobial peptides
1 Discovery, Classification and Functional Diversity of Antimicrobial Peptides 1
Guangshun Wang
11A Brief Timeline of Discovery 2
1 2 Nomenclature of Antimicrobial Peptides 5
1 3 Classification of Antimicrobial Peptides 6
131 Source kingdoms 6
132 Peptide synthesis machinery 8
133 Chemical modifications 8
134 Peptide charge, length and hydrophobic content 9
135 Three-dimensional structures 10
136 Unified peptide classification based on polypeptide chain
bonding patterns 10
137 Peptide binding targets and mechanisms of action 11
1 4 Functional Diversity and Terminology of Antimicrobial Peptides 11
141 Antimicrobial peptides 11
142 Host defence peptides 13
143 Innate immune peptides 13
1 5 Concluding Remarks -14
Part n: natural templates for peptide engineering
2 Structural and Functional Diversity of Cathelicidins 20
Alessandro Tossi, Barbara Skerlavaj, Francesca D’Este and Renato Gennaro
v
VI
Contents
2 1 Introduction 20
2 2 Discovery of Cathelicidins 21
2 3 Evolution, Structural Diversity and Features of the Proregion 26
231 Evolution 26
232 Structural diversity 26
233 Features of the proregion 29
2 4 Expression and Processing 30
2 5 Structure-dependent Mode of Action 31
2 6 Pleiotropic Roles of Cathelicidins in Host Defence and Potential
Applications 35
2 7 Conclusions 37
3 Disulfide-linked Defensins 49
Monique L van Hoek
3 1 Overview 49
311 Introduction to disulfide-linked defensins 49
312 Mechanisms of action 50
313 Structural features of defensins 50
3 2 Vertebrate Defensins 51
321 ß-defensins 51
322 cc-defensins 57
323 0-defensins 59
3 3 Arthropod Defensins 59
331 Insect defensins 59
332 Therapeutic potential of insect defensins 61
333 Antiparasitic activity of arthropod defensin peptides 61
334 Horseshoe crab and oyster big-defensins 61
3 4 Plant Defensins 62
3 5 When is a Disulfide-linked Antimicrobial Peptide not a Defensin? 62
3 6 Therapeutic Potential of Synthetic Disulfide-linked Defensin Peptides 63
3 7 Summary 63
371 Phylogenetic diversity of defensin gene expression 63
372 Defensin activity 63
4 Lantibiotics: Bioengineering and Applications 72
Brian Healy and Paul D Cotter
4 1 Lantibiotics: Background, Structure, Mode of Action and
Classification 72
4 2 Lantibiotics as Clinical and Chemotherapeutic Agents 75
4 3 Lantibiotics as Biopreservatives 76
4 4 Lantibiotic Bioengineering and Synthetic Engineering 77
441 In vivo engineering 77
442 (Semi)Synthetic engineering 79
4 5 Future Outlook and Conclusion 80
Part hi: expanding peptide space: combinatorial library, genome-based prediction
AND DE NOVO DESIGN
5 Discovery of Novel Antimicrobial Peptides Using Combinatorial Chemistry and
High-throughput Screening 86
Charles G Starr and William C Wimley
5 1 The Interfacial Activity Model of AMP Activity 86
5 2 Combinatorial Chemistry Methods 87
Contents
VII
r
J:
,
■
■
?- ■
■I V
■
5:
-
521 Overview of library synthesis
522 Non-indexed methods
523 Indexed methods
5 3 High-throughput Screening
531 Biological assays
532 Non-biological assays
533 Parallel screening for selection of discrete characteristics
5 4 Accomplishments
541 Beyond high-throughput screening
5 5 Future Directions
6 Prediction and Design of Antimicrobial Peptides: Methods and Applications to
Genomes and Proteomes
Guangshun Wang
6 1 Antimicrobial Peptide Prediction
611 Prediction based on mature peptides
612 Prediction based on highly conserved propeptide sequences
613 Prediction based on both propeptides and mature peptides
614 Prediction based on the processing enzymes or transporters
615 Genomic context-based prediction
616 Applications to genomes and proteomes
6 2 Database-aided Peptide Design and Improvement
621 Anti-HIV and anti-MRSA peptide screening
622 Sequence shuffling and the combinatorial library approach
623 The hybrid approach and grammar-based peptide design
624 De novo and database-aided peptide design
6 3 Computational Design of Novel AMPs
6 4 Prediction Based on Biophysical Approaches
6 5 Concluding Remarks
Part iv: mechanisms of action: biophysics and structural biology
7 Antimicrobial Peptides: Multiple Mechanisms against a Variety of Targets
Li-av Segev-Zarko, Maria Luisa Mangoni and Yechiel Shai
7 1 Target Selectivity of Antimicrobial Peptides
7 2 Membrane-lytic Antimicrobial Peptides
7 3 Intracellular Targets of Antimicrobial Peptides
7 4 LPS and LTA Neutralization by Antimicrobial Peptides
7 5 Antibiofilm Antimicrobial Peptides
7 6 Antifungal Antimicrobial Peptides
7 7 Anticancer Antimicrobial Peptides
7 8 Antiviral Antimicrobial Peptides
7 9 Antimicrobial Peptide Modification and How It Affects the Mode of
Action
791 Lipopeptides
792 Modification of amino acids content
7 10 Conclusion
8 Microbial Membranes and the Action of Antimicrobial Peptides
Jose Carlos Bozelli, Jr , Shirley Schreier and Richard M Epand
8 1 Introduction
8 2 Physicochemical Properties of AMPs and the Molecular Organization of
The Cell Envelope of Different Microorganisms
87
88
90
91
91
94
94
96
97
98
101
102
103
105
106
106
107
107
108
108
110
110
111
112
113
113
119
120
121
122
122
123
124
124
125
126
126
126
127
135
135
136
Contents
viii
8 3 The Role of Cell Wall Components on AMP Toxicity 139
8 4 Membrane Lipid Composition and AMP Sensitivity 141
8 5 Antimicrobial Agents that Promote Clustering of Anionic Lipids 142
8 6 Synergistic Action of AMPs and Other Antimicrobial Agents 143
8 7 Summary and Future Perspective 143
9 Non-membranolytic Mechanisms of Action of Antimicrobial Peptides -
Novel Therapeutic Opportunities? 149
Marco Scocchi, Mario Mardirossian, Giulia Runti and Monica Benincasa
9 1 Introduction 149
9 2 Intracellular Mode of Action 151
921 Inhibition of molecular chaperones and of protein synthesis 151
922 Binding to DNA and inhibition of transcription/replication 155
9 3 Cell Surface Modes of Action 156
931 Cell wall inhibition 156
932 Inhibition of cytokinesis 157
9 4 Other Membrane-independent Mechanisms of Bacterial Killing 158
9 5 Immune Modulatory Effects 158
9 6 Towards Novel Therapeutic Opportunities 159
9 7 Concluding Remarks 160
10 Structural Insight into the Mechanisms of Action of Antimicrobial Peptides
and Structure-based Design 169
Guangshun Wang
10 1 Introduction to Structural Methods and Membrane Models 170
10 2 Three-dimensional Structures of Antimicrobial Peptides 171
10 2 1 a-helical AMPs 171
10 2 2 ß-sheet AMPs 174
10 2 3 aß-AMPs 176
10 2 4 Non-aß AMPs 177
10 3 Structure-based Peptide Design 179
10 3 1 Structural basis for the improvement of peptide druggability 179
10 3 2 Stable scaffold-based grafting 180
10 4 Concluding Remarks 180
Part v: novel therapeutic strategies: synergy, immune modulation, surface coating
AND DELIVERY
11 Synergy of Antimicrobial Peptides 188
Mobaswar H Chowdhury, Gill Diamond and Lisa Kathleen Ryan
11 1 Introduction 188
11 2 Principles of Synergy of Antimicrobial Peptides 189
11 3 How Antimicrobial Peptides Synergize to Kill Microorganisms 190
11 4 Synergism of Antimicrobial Peptides with Conventional Antibiotics 192
11 5 Synergy with AMP Analogues 196
11 6 Conclusion 196
12 Surface Immobilization of Antimicrobial Peptides to Prevent Biofilm
Formation 202
Biswajit Mishra, Scott Reiling and Guangshun Wang
12 1 Introduction 202
12 2 Surface Coating Methods 203
Contents
ix
12 2 1 Non-peptide microbicidal materials 203
12 2 2 Antibiotic immobilized surfaces 204
12 2 3 Antimicrobial peptide immobilization 204
12 3 Chemical and Physical Characterization of Peptide Coated Surfaces 208
12 4 Antimicrobial and Antibiofilm Activities of Peptide Coated Surfaces 209
12 5 Mechanism of Action of Immobilized Peptides 212
12 6 Biocompatibility 213
12 7 Conclusions and Future Outlook 213
13 Sustained Delivery of Cathelicidin Antimicrobial Peptide-inducing Compounds
to Minimize Infection and Enhance Wound Healing 219
Jingwei Xie, Gitali Ganguli-Indra, Arup K Indra and Adrian F Gombart
13 1 Introduction 219
13 2 The Role of the CAMP Gene in Protection against Infection 220
13 3 LL-37 Modulates the Host Immune Response 221
13 3 1 Formyl peptide receptor 2 (FPR2) 221
13 3 2 Purinergic receptor P2X7 222
13 3 3 Toll-like receptors (TLRs) 222
13 3 4 Other transmembrane receptors 222
13 4 Function of Vitamin D Signalling in Normal Skin Homeostasis 223
13 5 The Role of Vitamin D and CAMP/LL-37 in Cutaneous Wound Healing 225
13 6 Induction of CAMP Gene Expression by Other Natural Compounds 226
13 7 Preventing Infections and Improving Wound Healing with Vitamin D3
and Other Immune Boosting Compounds 226
13 8 Summary 229
14 Immunomodulatory Activities of Cationic Host Defence Peptides and Novel
Therapeutic Strategies 238
Kelli C Wuerth and Robert E W Hancock
14 1 Classical AMPs and HDPs 239
14 1 1 Defensins 239
14 1 2 Cathelicidins 239
14 1 3 Histatins and liver-expressed antimicrobial peptides (LEAPs) 241
14 1 4 Modified and synthetic HDPs 241
14 2 Hormones and Neuropeptides: The New HDPs 241
14 2 1 Natriuretic peptides 241
14 2 2 Secretin family 244
14 2 3 Calcitonin family 244
14 2 4 Somatostatin family 244
14 2 5 Pro-opiomelanocortin derivatives 245
14 3 Activities of HDPs 245
14 3 1 Anti-infective/immunomodulatory 245
14 3 2 Antibiofilm 247
14 3 3 Anticancer 247
14 3 4 Wound healing and angiogenesis 248
14 3 5 Cardiovascular disease and metabolism 248
14 3 6 Adjuvants 248
14 4 HDPs as Therapeutics: Peptides in Clinical Trials 249
14 4 1 Challenges 251
14 5 Conclusions 252
Index
|
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| edition | 2nd edition |
| format | Book |
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| spelling | Antimicrobial peptides discovery, design and novel therapeutic strategies edited by Guangshun Wang, University of Nebraska Medical Center, Omaha, Nebraska, USA 2nd edition Wallingford ; Boston CABI [2017] © 2017 xvii, 268 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Antimikrobieller Wirkstoff (DE-588)4142688-5 gnd rswk-swf Peptide (DE-588)4045125-2 gnd rswk-swf Peptidantibiotikum (DE-588)4173714-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Antimikrobieller Wirkstoff (DE-588)4142688-5 s Peptide (DE-588)4045125-2 s DE-604 Peptidantibiotikum (DE-588)4173714-3 s b DE-604 Wang, Guangshun Sonstige oth Erscheint auch als Online Ressource, e-book 978-1-78639-040-0 Erscheint auch als Online Ressource, e-pub 978-1-78639-041-7 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029839525&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Antimicrobial peptides discovery, design and novel therapeutic strategies Antimikrobieller Wirkstoff (DE-588)4142688-5 gnd Peptide (DE-588)4045125-2 gnd Peptidantibiotikum (DE-588)4173714-3 gnd |
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| title | Antimicrobial peptides discovery, design and novel therapeutic strategies |
| title_auth | Antimicrobial peptides discovery, design and novel therapeutic strategies |
| title_exact_search | Antimicrobial peptides discovery, design and novel therapeutic strategies |
| title_full | Antimicrobial peptides discovery, design and novel therapeutic strategies edited by Guangshun Wang, University of Nebraska Medical Center, Omaha, Nebraska, USA |
| title_fullStr | Antimicrobial peptides discovery, design and novel therapeutic strategies edited by Guangshun Wang, University of Nebraska Medical Center, Omaha, Nebraska, USA |
| title_full_unstemmed | Antimicrobial peptides discovery, design and novel therapeutic strategies edited by Guangshun Wang, University of Nebraska Medical Center, Omaha, Nebraska, USA |
| title_short | Antimicrobial peptides |
| title_sort | antimicrobial peptides discovery design and novel therapeutic strategies |
| title_sub | discovery, design and novel therapeutic strategies |
| topic | Antimikrobieller Wirkstoff (DE-588)4142688-5 gnd Peptide (DE-588)4045125-2 gnd Peptidantibiotikum (DE-588)4173714-3 gnd |
| topic_facet | Antimikrobieller Wirkstoff Peptide Peptidantibiotikum Aufsatzsammlung |
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