Advances in molecular and cell biology, Volume 22A, Protein structural biology in biomedical research:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Greenwich, CT
JAI Press
1997
|
| Schriftenreihe: | Advances in molecular and cell biology
22A. |
| Schlagworte: | |
| Online-Zugang: | FAW01 URL des Erstveröffentlichers |
| Beschreibung: | Includes bibliographical references and index Recent advances in protein structural biology, coupled with new developments in human genetics, have opened the door to understanding the molecular basis of many metabolic, physiological, and developmental processes in human biology. Medical pathologies, and their chemical therapies, are increasingly being described at the molecular level. For single-gene diseases, and some multi-gene conditions, identification of highly correlated genes immediately leads to identification of covalent structures of the actual chemical agents of the disease, namely the protein gene products. Once the primary sequence of a protein is ascertained, structural biologists work to determine its three-dimensional, biologically active structure, or to predict its probable fold and/or function by comparison to the data base of known protein structures. Similarly, three-dimensional structures of proteins produced by microbiological pathogens are the subject of intense study, for example, the proteins necessary for maturation of the human HIV virus. Once the three-dimensional structure of a protein is known or predicted, its function, as well as potential binding sites for drugs that inhibit its function, become tractable questions. The medical ramifications of the burgeoning results of protein structural biology, from gene replacement therapy to "rational" drug design, are well recognized by researchers in biomedical areas, and by a significant proportion of the general population. The purpose of this book is to introduce biomedical scientists to important areas of protein structural biology, and to provide an insightful orientation to the primary literature that shapes the field in each subject. The chapters in this volume cover aspects of protein structural biology which have led to the recognition of fundamental relationships between protein structure and function |
| Beschreibung: | xvii, 337 pages |
| ISBN: | 0762302836 9780762302833 |
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| discipline | Biologie |
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| id | DE-604.BV044380821 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:51:20Z |
| institution | BVB |
| isbn | 0762302836 9780762302833 |
| language | English |
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| physical | xvii, 337 pages |
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| publishDate | 1997 |
| publishDateSearch | 1997 |
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| publisher | JAI Press |
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| series2 | Advances in molecular and cell biology |
| spelling | Advances in molecular and cell biology, Volume 22A, Protein structural biology in biomedical research guest editors, Norma M. Allewell, Clare Woodward Protein structural biology in biomedical research Greenwich, CT JAI Press 1997 xvii, 337 pages txt rdacontent c rdamedia cr rdacarrier Advances in molecular and cell biology 22A. Includes bibliographical references and index Recent advances in protein structural biology, coupled with new developments in human genetics, have opened the door to understanding the molecular basis of many metabolic, physiological, and developmental processes in human biology. Medical pathologies, and their chemical therapies, are increasingly being described at the molecular level. For single-gene diseases, and some multi-gene conditions, identification of highly correlated genes immediately leads to identification of covalent structures of the actual chemical agents of the disease, namely the protein gene products. Once the primary sequence of a protein is ascertained, structural biologists work to determine its three-dimensional, biologically active structure, or to predict its probable fold and/or function by comparison to the data base of known protein structures. Similarly, three-dimensional structures of proteins produced by microbiological pathogens are the subject of intense study, for example, the proteins necessary for maturation of the human HIV virus. Once the three-dimensional structure of a protein is known or predicted, its function, as well as potential binding sites for drugs that inhibit its function, become tractable questions. The medical ramifications of the burgeoning results of protein structural biology, from gene replacement therapy to "rational" drug design, are well recognized by researchers in biomedical areas, and by a significant proportion of the general population. The purpose of this book is to introduce biomedical scientists to important areas of protein structural biology, and to provide an insightful orientation to the primary literature that shapes the field in each subject. The chapters in this volume cover aspects of protein structural biology which have led to the recognition of fundamental relationships between protein structure and function Proteins / Research fast Proteins / Structure fast Proteins Structure Proteins Research Allewell, Norma M. Sonstige oth Woodward, Clare Sonstige oth http://www.sciencedirect.com/science/bookseries/15692558/22 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Advances in molecular and cell biology, Volume 22A, Protein structural biology in biomedical research Proteins / Research fast Proteins / Structure fast Proteins Structure Proteins Research |
| title | Advances in molecular and cell biology, Volume 22A, Protein structural biology in biomedical research |
| title_alt | Protein structural biology in biomedical research |
| title_auth | Advances in molecular and cell biology, Volume 22A, Protein structural biology in biomedical research |
| title_exact_search | Advances in molecular and cell biology, Volume 22A, Protein structural biology in biomedical research |
| title_full | Advances in molecular and cell biology, Volume 22A, Protein structural biology in biomedical research guest editors, Norma M. Allewell, Clare Woodward |
| title_fullStr | Advances in molecular and cell biology, Volume 22A, Protein structural biology in biomedical research guest editors, Norma M. Allewell, Clare Woodward |
| title_full_unstemmed | Advances in molecular and cell biology, Volume 22A, Protein structural biology in biomedical research guest editors, Norma M. Allewell, Clare Woodward |
| title_short | Advances in molecular and cell biology, Volume 22A, Protein structural biology in biomedical research |
| title_sort | advances in molecular and cell biology volume 22a protein structural biology in biomedical research |
| topic | Proteins / Research fast Proteins / Structure fast Proteins Structure Proteins Research |
| topic_facet | Proteins / Research Proteins / Structure Proteins Structure Proteins Research |
| url | http://www.sciencedirect.com/science/bookseries/15692558/22 |
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