The role of DNA damage and repair in cell aging:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam
Elsevier
2001
|
| Ausgabe: | 1st ed |
| Schriftenreihe: | Advances in cell aging and gerontology
v. 4 |
| Schlagworte: | |
| Online-Zugang: | FAW01 URL des Erstveröffentlichers |
| Beschreibung: | Includes bibliographical references Aging occurs at the level of individual cells, a complex interplay between intrinsic "programming" and exogenous "wear and tear", with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of aging and its specific manifestations. In 12 chapters, "The Role of DNA Damage and Repair in Cell Aging" provides an intellectual framework for aging of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of aging. As part of a series entitled "Advances in Cell Aging and Gerontology," this volume also summarizes seminal recent discoveries such as the molecular basis for Werner syndrome (a mutant DNA helicase), the complementary roles of telomere shortening and telomerase activity in cell senescence versus immortalization, the role of apoptosis in the homeostasis of aging tissue, and the existence of an inducible SOS-like response in mammalian cells that minimizes DNA damage from repeatedly encountered injurious environmental agents. Insights into the relationship between cellular aging and age-associated diseases, particularly malignancies, are also provided in several chapters. This book is an excellent single source of information for anyone interested in DNA repair, mechanisms of aging, or certainly their intersection. Students will gain a general appreciation of these fields, but even the most senior investigators will benefit from the detailed coverage of rapidly advancing areas |
| Beschreibung: | vii, 257 pages |
| ISBN: | 044450494X 9780444504944 |
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Datensatz im Suchindex
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| dewey-full | 571.8/7836 |
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| dewey-ones | 571 - Physiology & related subjects |
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| indexdate | 2024-07-10T07:51:19Z |
| institution | BVB |
| isbn | 044450494X 9780444504944 |
| language | English |
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| spelling | The role of DNA damage and repair in cell aging volume editors, Barbara A. Gilchrest, Vilhelm A. Bohr 1st ed Amsterdam Elsevier 2001 vii, 257 pages txt rdacontent c rdamedia cr rdacarrier Advances in cell aging and gerontology v. 4 Includes bibliographical references Aging occurs at the level of individual cells, a complex interplay between intrinsic "programming" and exogenous "wear and tear", with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of aging and its specific manifestations. In 12 chapters, "The Role of DNA Damage and Repair in Cell Aging" provides an intellectual framework for aging of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of aging. As part of a series entitled "Advances in Cell Aging and Gerontology," this volume also summarizes seminal recent discoveries such as the molecular basis for Werner syndrome (a mutant DNA helicase), the complementary roles of telomere shortening and telomerase activity in cell senescence versus immortalization, the role of apoptosis in the homeostasis of aging tissue, and the existence of an inducible SOS-like response in mammalian cells that minimizes DNA damage from repeatedly encountered injurious environmental agents. Insights into the relationship between cellular aging and age-associated diseases, particularly malignancies, are also provided in several chapters. This book is an excellent single source of information for anyone interested in DNA repair, mechanisms of aging, or certainly their intersection. Students will gain a general appreciation of these fields, but even the most senior investigators will benefit from the detailed coverage of rapidly advancing areas Cell Aging / genetics DNA Damage DNA Repair Apoptosis fast Cells / Aging fast DNA damage fast DNA repair fast DNA damage DNA repair Cells Aging Apoptosis DNS-Reparatur (DE-588)4150347-8 gnd rswk-swf DNS-Schädigung (DE-588)4150350-8 gnd rswk-swf Altern (DE-588)4068596-2 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Altern (DE-588)4068596-2 s DNS-Reparatur (DE-588)4150347-8 s 2\p DE-604 DNS-Schädigung (DE-588)4150350-8 s 3\p DE-604 Gilchrest, Barbara A. Sonstige oth Bohr, Vilhelm A. Sonstige oth http://www.sciencedirect.com/science/bookseries/15663124/4 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | The role of DNA damage and repair in cell aging Cell Aging / genetics DNA Damage DNA Repair Apoptosis fast Cells / Aging fast DNA damage fast DNA repair fast DNA damage DNA repair Cells Aging Apoptosis DNS-Reparatur (DE-588)4150347-8 gnd DNS-Schädigung (DE-588)4150350-8 gnd Altern (DE-588)4068596-2 gnd |
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| title | The role of DNA damage and repair in cell aging |
| title_auth | The role of DNA damage and repair in cell aging |
| title_exact_search | The role of DNA damage and repair in cell aging |
| title_full | The role of DNA damage and repair in cell aging volume editors, Barbara A. Gilchrest, Vilhelm A. Bohr |
| title_fullStr | The role of DNA damage and repair in cell aging volume editors, Barbara A. Gilchrest, Vilhelm A. Bohr |
| title_full_unstemmed | The role of DNA damage and repair in cell aging volume editors, Barbara A. Gilchrest, Vilhelm A. Bohr |
| title_short | The role of DNA damage and repair in cell aging |
| title_sort | the role of dna damage and repair in cell aging |
| topic | Cell Aging / genetics DNA Damage DNA Repair Apoptosis fast Cells / Aging fast DNA damage fast DNA repair fast DNA damage DNA repair Cells Aging Apoptosis DNS-Reparatur (DE-588)4150347-8 gnd DNS-Schädigung (DE-588)4150350-8 gnd Altern (DE-588)4068596-2 gnd |
| topic_facet | Cell Aging / genetics DNA Damage DNA Repair Apoptosis Cells / Aging DNA damage DNA repair Cells Aging DNS-Reparatur DNS-Schädigung Altern Aufsatzsammlung |
| url | http://www.sciencedirect.com/science/bookseries/15663124/4 |
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