Poly(ADP-Ribose) Polymerase: methods and protocols
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| Format: | Book |
| Language: | English |
| Published: |
New York, NY
Humana Press
[2017]
|
| Edition: | Second edition |
| Series: | Methods in molecular biology
1608 |
| Subjects: | |
| Online Access: | Inhaltstext Inhaltsverzeichnis |
| Physical Description: | XV, 528 Seiten Illustrationen, Diagramme |
| ISBN: | 9781493969920 1493969927 |
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| 245 | 1 | 0 | |a Poly(ADP-Ribose) Polymerase |b methods and protocols |c edited by Alexei V. Tulin |
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Record in the Search Index
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Titel: Poly(ADP-Ribose) Polymerase
Autor: Tulin, Alexei V
Jahr: 2017
Contents
Preface. v
Contributors. xi
Part I Detection and Quantification of pADPr
1 Quantitation of Poly(ADP-Ribose) by Isotope Dilution
Mass Spectrometry. 3
Tabea Zubel, Rita Martello, Alexander Biirkle, and Aswin Mangerich
2 Quantification of PARP Activity in Human Tissues: Ex Vivo Assays
in Blood Cells and Immunohistochemistry in Human Biopsies. 19
Eszter M. Horvath, Zsuzsanna K. ZsengelUr, and Csaba Szabo
3 Detecting and Quantifying pADPr In Vivo. 27
Ti-Chen Lai, Rajesb K. Aneja, Margaret A, Satcbell,
and Robert S.B. Clark
4 Compartment-Specific Poly-ADP-Ribose Formation as a Biosensor
for Subcellular NAD Pools. 45
Magali R. VanLinden, Marc Niere, Andrey A. Nikiforov,
Matbias Ziegler, and Christian Dblle
5 Cell Cycle Resolved Measurements of Poly(ADP-Ribose) Formation
and DNA Damage Signaling by Quantitative Image-Based Cytometry. 57
Jone Michelena and Matthias Altmeyer
Part II Identification of Protein Targets
6 Detecting Protein ADP-Ribosylation Using a Clickable Aminooxy Probe . 71
Rory K. Morgan and Michael S. Cohen
7 ADP-Ribosylated Peptide Enrichment and Site Identification:
The Phosphodiesterase-Based Method. 79
Casey M. Daniels, Shao-En Ong, and Anthony K.L. Leung
8 Using Clickable NAD* Analogs to Label Substrate Proteins of PARPs. 95
Lu Zhang and Hening Lin
9 Identification of Protein Substrates of Specific PARP Enzymes Using Analog-
Sensitive PARP Mutants and a "Clickable" NAD* Analog. Ill
Bryan A. Gibson and W. Lee Kraus
10 Identification of ADP-Ribose Acceptor Sites on In Vitro Modified
Proteins by Liquid Chromatography-Tandem Mass Spectrometry. 137
Mario Leutert, Vera Bilan, Peter Gehrig, and Michael O. Hottiger
Vii
viii Contents
11 Proteome-Wide Identification of In Vivo ADP-Ribose Acceptor Sites
by Liquid Chromatography-Tandem Mass Spectrometry. 149
Sara C. Larsen, Mario Leutert, Vera Bilan, Rita Martello,
Stephanie Jungmichel, Clifford Young, Michael O. Hottiger,
and Michael L. Nielsen
Part III Functional Analysis
12 Poly(ADP-Ribose)-Dependent Chromatin Remodeling in DNA Repair. 165
ThSo Lebeaupin, Rebecca Smith, Sebastien Huet, and Gyula Timinszky
13 Methods to Assess the Role of Poly(ADP-Ribose) Polymerases
in Regulating Mitochondrial Oxidation. 185
Edit Mikd, Tiinde Kovdcs, Tamds Fodor, and Pdter Bai
14 Approaches for Investigating Translational Regulation Controlled
by PARP1: Biotin-Based UV Cross-Linking and Luciferase Reporter Assay . 201
Yingbiao Ji
15 Methodology to Identify Poly-ADP-Ribose Polymerase 1 (PARPl)-mRNA
Targets by PAR-CLiP. 211
Manana Mekishvili, Elena Matveeva, and Yvonne Fondufe-Mittendorf
Part IV Regulation of PARP-1 and Its Partners
16 Biochemical and Biophysical Methods for Analysis of Poly(ADP-Ribose)
Polymerase 1 and Its Interactions with Chromatin. 231
Maggie H. ChassS, Uma M. Muthurajan, Nicholas J. Clark,
Michael A. Kramer, Srinivas Chakravarthy, Thomas Irving,
and Karolin Luger
17 PARP-1 Interaction with and Activation by Histones and Nucleosomes. 255
Colin Thomas, Elena Kotova, and Alexei V. Tulin
Part V Designing and Testing PARP-1 Inhibitors
18 Strategies Employed for the Development of PARP Inhibitors. 271
Stacie Canan, Karen Maegley, and Nicola J. Curtin
19 High-Throughput Colorimetric Assay for Identifying PARP-1 Inhibitors
Using a Large Small-Molecule Collection. 299
Elena Kotova and Alexei V. Tulin
20 Testing PARP Inhibitors Using a Murine Xenograft Model. 313
Peter Makhov, Sei Naito, and Vladimir M. Kolenko
21 In Vitro Long-Term Proliferation Assays to Study Antiproliferative Effects
of PARP Inhibitors on Cancer Cells. 321
Heike Keilhack and Paul Chang
22 Use of Inosine Monophosphate Dehydrogenase Activity Assay to Determine
the Specificity of PARJP-1 Inhibitors. 337
Sajitha Anthony, Jeffrey R. Peterson, and Yingbiao Ji
Contents ix
23 The Use of PARP Inhibitors in Cancer Therapy: Use as Adjuvant
with Chemotherapy or Radiotherapy, Use as a Single Agent in Susceptible
Patients, and Techniques Used to Identify Susceptible Patients. 343
Sydney Shall, Terry Gaymes, Farzin Farzaneh, Nicola J. Curtin,
and Ghulam J. Mufti
Part VI Targeting the Understudied Components of pADPr Pathway
24 Purification of Recombinant Human PARP-3. 373
Jean-Christophe Ami, Barbara Camuzeaux, Franfoise Dantzer,
and Valerie Schreiber
25 Purification of Recombinant Human PARG and Activity Assays. 395
Jean-Christophe Ami, £lia Hiberli, Barbara Camuzeaux,
Franfoise Dantzer, and Valirie Schreiber
26 Studying Catabolism of Protein ADP-Ribosylation. 415
Luca Palazzo, Dominic I. James, Ian D. Waddell, and Ivan Ahel
27 Purification of DNA Damage-Dependent PARPs from E. coli for Structural
and Biochemical Analysis. 431
Marie-France Langelier, Jamin D. Steffen, Amanda A. Riccio,
Michael McCauley, and John M. Pascal
28 Identifying and Validating Tankyrase Binders and Substrates:
A Candidate Approach. 445
Katie Pollock, Michael Ranes, Ian Collins, and Sebastian Guettler
29 Computational and Experimental Studies of ADP-Ribosylation. 475
Robert G. Hammond, Xuan Tan, Matthew Chan, Anupam Goel,
and Margaret A. Johnson
Index
515 |
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| dewey-search | 570 |
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| discipline | Biologie |
| edition | Second edition |
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| spelling | Poly(ADP-Ribose) Polymerase methods and protocols edited by Alexei V. Tulin Second edition New York, NY Humana Press [2017] XV, 528 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Methods in molecular biology 1608 Springer protocols Methode (DE-588)4038971-6 gnd rswk-swf NAD-ADP-Ribosyltransferase (DE-588)4313462-2 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content NAD-ADP-Ribosyltransferase (DE-588)4313462-2 s Methode (DE-588)4038971-6 s 2\p DE-604 Tulin, Alexei V. edt Erscheint auch als eBook 978-1-4939-6993-7 Methods in molecular biology 1608 (DE-604)BV035362695 1608 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=317e26e1c34045b0abdccac8c5cbb3f8&prov=M&dok_var=1&dok_ext=htm Inhaltstext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029752328&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Poly(ADP-Ribose) Polymerase methods and protocols Methods in molecular biology Methode (DE-588)4038971-6 gnd NAD-ADP-Ribosyltransferase (DE-588)4313462-2 gnd |
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| title | Poly(ADP-Ribose) Polymerase methods and protocols |
| title_auth | Poly(ADP-Ribose) Polymerase methods and protocols |
| title_exact_search | Poly(ADP-Ribose) Polymerase methods and protocols |
| title_full | Poly(ADP-Ribose) Polymerase methods and protocols edited by Alexei V. Tulin |
| title_fullStr | Poly(ADP-Ribose) Polymerase methods and protocols edited by Alexei V. Tulin |
| title_full_unstemmed | Poly(ADP-Ribose) Polymerase methods and protocols edited by Alexei V. Tulin |
| title_short | Poly(ADP-Ribose) Polymerase |
| title_sort | poly adp ribose polymerase methods and protocols |
| title_sub | methods and protocols |
| topic | Methode (DE-588)4038971-6 gnd NAD-ADP-Ribosyltransferase (DE-588)4313462-2 gnd |
| topic_facet | Methode NAD-ADP-Ribosyltransferase Aufsatzsammlung |
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