Epigenetic mechanisms in the pathogenesis and therapy of anxiety disorders: = Epigenetische Mechanismen in der Pathogenese und Therapie von Angsterkrankungen
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Würzburg
2016
|
| Schlagworte: | |
| Online-Zugang: | Volltext Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | VIII, 92, viii Blätter Diagramme 30 cm |
Internformat
MARC
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Datensatz im Suchindex
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| adam_text | EPIGENETIC MECHANISMS IN THE PATHOGENESIS AND
THERAPY OF ANXIETY DISORDERS
EPIGENETISCHE MECHANISMEN IN DER PATHOGENESE
UND THERAPIE VON ANGSTERKRANKUNGEN
DOCTORAL THESIS FOR A DOCTORAL DEGREE
AT THE GRADUATE SCHOOL OF LIFE SCIENCES,
JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG,
SECTION NEUROSCIENCE
SUBMITTED BY
CHRISTIANE ZIEGLER
FROM
SUHL, GERMANY
WUERZBURG, 2016
T
ABLE
OF
C
ONTENTS
TABLE OF
CONTENTS............................................................................................................................
I
AFFIDAVIT..............................................................................................................................................ILL
EIDESSTATTLICHE
ERKLAERUNG..............................................................................................................
ILL
ABBREVIATIONS...................................................................................................................................IV
SUMMARY........................................................................................................................................
VII
ZUSAMMENFASSUNG.....................................................................................................................
VIII
I. I
N T R O D U C T IO N
......................................................................................................................
1
1.1. ANXIETY
DISORDERS.............................................................................................................1
1.1.1. SOCIAL ANXIETY DISORDER (S A D
)..............................................................................2
1.1.2. PANIC
DISORDER..........................................................................................................
3
1.2. EPIGENETIC
MECHANISMS..................................................................................................
4
1.2.1. DNA
METHYLATION.....................................................................................................
5
1.2.2. HISTONE MODIFICATIONS
..............................................................................................
7
1.2.3. NON-CODING
RNAS...................................................................................................9
1.3. EPIGENETIC MECHANISMS IN NEUROPSYCHIATRIC DISORDERS
...........................................
10
1.3.1. GENERAL IMPORTANCE OF EPIGENETIC
MECHANISMS............................................10
1.3.2. IMPORTANCE IN SPECIFIC NEUROPSYCHIATRIC
DISORDERS..........................................11
1.4. AIM OF THE
THESIS.............................................................................................................16
II. M
A T E R IA L S
A N D
M
E T H O D S
...........................................................................................
17
2.1.
MATERIALS..........................................................................................................................17
2.1.1. USED
KITS.................................................................................................................
17
2.1.2. MEDIA, BUFFERS AND STOCK SOLUTIONS
...................................................................
17
2.1.3.
CHEMICALS...............................................................................................................18
2.1.4. SPECIAL CONSUMABLE
SUPPLIES..............................................................................18
2.1.5. EQUIPMENT AND
DEVICES...................................................................
19
2.1.6.
SOFTWARE.................................................................................................................20
2.2.
METHODS..........................................................................................................................
21
2.2.1. STUDY I
.................................................................................................................21
2.2.2. STUDY I I
................................................................................................................23
2.3. BLOOD
COLLECTION............................................................................................................
27
2.3.1. STUDY I
.................................................................................................................27
2.3.2. STUDY I I
............
........................................................... 27
2.4. DNA EXTRACTION FROM FROZEN WHOLE BLOOD SAMPLES
...............................................
27
2.5. DNA METHYLATION ANALYSIS.............................
............................................................
29
2.5.1. BISULFITE CONVERSION OF HUMAN GENOMIC D N A
.................................................
29
2.5.2. DESIGN OF DNA METHYLATION
ASSAYS..................................................................32
2.5.3. POLYMERASE CHAIN REACTION (P C R
).....................................................................35
2.5.4. GEL
ELECTROPHORESIS..............................................................................................
36
2.5.5. DIRECT
SEQUENCING.................................................................................................37
2.5.6. EPIGENETIC SEQUENCING METHYLATION ANALYSIS TOOL - ESM
E.........................37
2.6. GENOTYPING OF
OXTR
RS53576....................................................................................37
2.7. GENOTYPING OF
MAOA
V N T R
......................................................................................38
2.8. STATISTICS.................................................... 39
2.8.1. STUDY I
.................................................................................................................39
2.8.2. STUDY I I
................................................................................................................40
III. R
E S U L T S
............................................................................................................41
3.1. STUDY I
.........................................................................................................................
41
3.1.1. OXYTOCIN RECEPTOR GENE HYPOMETHYLATION IS ASSOCIATED WITH THE
CATEGORICAL PHENOTYPE OF
SAD............................................................................................41
3.1.2. OXYTOCIN RECEPTOR GENE HYPOMETHYLATION IS ASSOCIATED WITH
DIMENSIONAL
TRAITS OF SOCIAL
ANXIETY...........................................................................................................
47
3.1.3. OXYTOCIN RECEPTOR GENE HYPOMETHYLATION IS ASSOCIATED WITH
INCREASED
CORTISOL RESPONSE TO SOCIAL STRESS (T S S T
)........................................................................48
3.1.4. OXYTOCIN RECEPTOR GENE HYPOMETHYLATION IS ASSOCIATED WITH
INCREASED
AMYGDALA ACTIVITY TO SOCIAL PHOBIA RELATED
WORDS............................................................ 48
3.2. STUDY I I
..............................
49
3.2.1. MONOAMINE OXIDASE A
(MAOA)
GENE HYPOMETHYLATION IN FEMALE PD
PATIENTS
.................................................................................................................................
49
3.2.2.
MAOA
HYPOMETHYLATION IS ASSOCIATED WITH PANIC DISORDER SEVERITY IN
FEMALES
..................................................................................................................................53
3.2.3.
MAOA
METHYLATION CHANGE DURING CBT TREATM ENT
........................................
54
IV. D
IS C U S S IO N
.......................................................................................................
58
V. R
E F E R E N C E S
.....................................................................................................
70
V I. A
P P E N D I X
.................................................................................................................................I
6.1. LIST OF
FIGURES...................................................................................................................
I
6.2. LIST OF
TABLES.....................................................................................................................I
6.3. CURRICULUM V ITAE
...........................................................................
III
6.4.
PUBLICATIONS....................................................................................................................VII
6.5.
ACKNOWLEDGEMENTS......................................................................................................VIII
|
| any_adam_object | 1 |
| author | Ziegler, Christiane 1989- |
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| author_role | aut |
| author_sort | Ziegler, Christiane 1989- |
| author_variant | c z cz |
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| bvnumber | BV044344786 |
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| dewey-full | 610 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610 |
| dewey-search | 610 |
| dewey-sort | 3610 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Thesis Book |
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| spelling | Ziegler, Christiane 1989- Verfasser (DE-588)1134988311 aut Epigenetic mechanisms in the pathogenesis and therapy of anxiety disorders = Epigenetische Mechanismen in der Pathogenese und Therapie von Angsterkrankungen submitted by Christiane Ziegler from Suhl, Germany Epigenetische Mechanismen in der Pathogenese und Therapie von Angsterkrankungen Würzburg 2016 VIII, 92, viii Blätter Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Julius-Maximilians-Universität Würzburg 2017 Zusammenfassung in deutscher und englischer Sprache Psychische Störung (DE-588)4047686-8 gnd rswk-swf Angst (DE-588)4002053-8 gnd rswk-swf DNS (DE-588)4070512-2 gnd rswk-swf Epigenetik (DE-588)7566079-9 gnd rswk-swf Methylierung (DE-588)4123751-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Angst (DE-588)4002053-8 s Psychische Störung (DE-588)4047686-8 s Epigenetik (DE-588)7566079-9 s Methylierung (DE-588)4123751-1 s DNS (DE-588)4070512-2 s DE-604 Erscheint auch als Online-Ausgabe, PDF urn:nbn:de:bvb:20-opus-146815 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-146815 Resolving-System kostenfrei Volltext B:DE-101 application/pdf http://d-nb.info/1132730791/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029747754&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ziegler, Christiane 1989- Epigenetic mechanisms in the pathogenesis and therapy of anxiety disorders = Epigenetische Mechanismen in der Pathogenese und Therapie von Angsterkrankungen Psychische Störung (DE-588)4047686-8 gnd Angst (DE-588)4002053-8 gnd DNS (DE-588)4070512-2 gnd Epigenetik (DE-588)7566079-9 gnd Methylierung (DE-588)4123751-1 gnd |
| subject_GND | (DE-588)4047686-8 (DE-588)4002053-8 (DE-588)4070512-2 (DE-588)7566079-9 (DE-588)4123751-1 (DE-588)4113937-9 |
| title | Epigenetic mechanisms in the pathogenesis and therapy of anxiety disorders = Epigenetische Mechanismen in der Pathogenese und Therapie von Angsterkrankungen |
| title_alt | Epigenetische Mechanismen in der Pathogenese und Therapie von Angsterkrankungen |
| title_auth | Epigenetic mechanisms in the pathogenesis and therapy of anxiety disorders = Epigenetische Mechanismen in der Pathogenese und Therapie von Angsterkrankungen |
| title_exact_search | Epigenetic mechanisms in the pathogenesis and therapy of anxiety disorders = Epigenetische Mechanismen in der Pathogenese und Therapie von Angsterkrankungen |
| title_full | Epigenetic mechanisms in the pathogenesis and therapy of anxiety disorders = Epigenetische Mechanismen in der Pathogenese und Therapie von Angsterkrankungen submitted by Christiane Ziegler from Suhl, Germany |
| title_fullStr | Epigenetic mechanisms in the pathogenesis and therapy of anxiety disorders = Epigenetische Mechanismen in der Pathogenese und Therapie von Angsterkrankungen submitted by Christiane Ziegler from Suhl, Germany |
| title_full_unstemmed | Epigenetic mechanisms in the pathogenesis and therapy of anxiety disorders = Epigenetische Mechanismen in der Pathogenese und Therapie von Angsterkrankungen submitted by Christiane Ziegler from Suhl, Germany |
| title_short | Epigenetic mechanisms in the pathogenesis and therapy of anxiety disorders |
| title_sort | epigenetic mechanisms in the pathogenesis and therapy of anxiety disorders epigenetische mechanismen in der pathogenese und therapie von angsterkrankungen |
| title_sub | = Epigenetische Mechanismen in der Pathogenese und Therapie von Angsterkrankungen |
| topic | Psychische Störung (DE-588)4047686-8 gnd Angst (DE-588)4002053-8 gnd DNS (DE-588)4070512-2 gnd Epigenetik (DE-588)7566079-9 gnd Methylierung (DE-588)4123751-1 gnd |
| topic_facet | Psychische Störung Angst DNS Epigenetik Methylierung Hochschulschrift |
| url | https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-146815 http://d-nb.info/1132730791/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029747754&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT zieglerchristiane epigeneticmechanismsinthepathogenesisandtherapyofanxietydisordersepigenetischemechanismeninderpathogeneseundtherapievonangsterkrankungen AT zieglerchristiane epigenetischemechanismeninderpathogeneseundtherapievonangsterkrankungen |