Controlled permeable polymersomes decorated with functional-antennae for biomedical applications:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Dresden
TUDpress
2014
|
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | VII, 157 Seiten Illustrationen, Diagramme |
| ISBN: | 9783944331874 |
Internformat
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Datensatz im Suchindex
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| adam_text |
TABLE OF CONTENTS
I.
INTRODUCTION AND BACKGROUND
1 PREFACE 2
2 THEORETICAL FUNDAMENTALS 12
2.1 MIMICKING THE NATURE: APPROACH TO POLYMERSOMES 12
2.2 SYNTHETIC ROUTES TO CREATE AMPHIPHILIC BLOCK COPOLYMERS 14
2.3 POLYMERSOMES FORMATION 16
2.4 RATIONAL DESIGN OF POLYMERSOMES AS DELIVERY VECTORS 21
2.4.1 STEALTH-LIKE PROPERTY 21
2.4.2 SIZE 23
2.4.3 FUNCTIONAL POLYMERSOMES MEMBRANE 24
2.4.4 TARGETED POLYMERSOMES CORONA 35
2.5 POLYMERSOMES THERAPEUTIC AND THERANOSTIC APPLICATIONS 39
2.6 REFERENCES 42
II. RESULTS AND DISCUSSION
3 CONTROLLED PERMEABLE POLYMERSOMES 56
3.1 INTRODUCTION 56
3.2 BLOCK COPOLYMER SYNTHESIS 57
3.3 SHAPE-PERSISTENT POLYMERSOMES 61
3.4 VESICULAR STRUCTURE AND MEMBRANE THICKNESS 66
3.5 POLYMERSOMES REVERSIBLE ON/OFF SWITCHES 69
3.6 DOXORUBICIN LOADING AND RELEASE 72
3.7 SUMMARY 75
3.8 REFERENCES 77
HTTP://D-NB.INFO/106298014X
4 POLYMERSOMES SURFACE FUNCTIONALIZATION 80
4.1 INTRODUCTION 80
4.2 SYNTHESIS OF FUNCTIONALIZED BLOCK COPOLYMERS 81
4.3 POLYMERSOMES BEARING FOLATE ANTENNAE 88
4.4 ESTIMATING THE NUMBER OF FOLATE ANTENNAE 92
4.5 MULTIFUNCTIONALIZED POLYMERSOMES AND POST-LABELING 93
4.6 DOXORUBICIN LOADING AND PH-DEPENDENT RELEASE 94
4.7 SUMMARY 96
4.8 REFERENCES 97
5 TUMOR TARGETING AND SELECTIVE TOXICITY 100
5.1 INTRODUCTION 100
5.2 CELL VIABILITY 101
5.3 TARGETING EFFICIENCY OF FA-ANTCNNAE POLYMERSOMES 102
5.4 ANTI-TUMOR ACTIVITY 105
5.5 DOX INTRACELLULAR DISTRIBUTION 109
5.6 SUMMARY 111
5.7 REFERENCES 112
6 CONCLUSIONS AND FUTURE PROSPECTIVE 116
7 EXPERIMENTAL PART 126
7.1 MATERIALS 126
7.2 TOOLS AND CHARACTERIZATION TECHNIQUES 128
7.3 SYNTHESIS PROCEDURES 131
7.3.1 SYNTHESES OF POLY(CTHYLCNE GLYCOL) MACROINITIATORS 131
7.3.2 SYNTHESIS OF BLOCK COPOLYMERS 132
7.4 POLYMERSOMES FORMATION 137
7.5 POLYMERSOMES PHOTO CROSSLINKING 139
7.6 ASYMMETRICAL FLOW FIELD-FLOW FRACTIONATION (AF4) 139
7.7 DOXORUBICIN-LOADED POLYMERSOMES 140
7.8 IN VITRO RELEASE STUDIES 141
7.9 BIOLOGICAL STUDIES 142
7.9.1 CELL CULTURE 142
7.9.2 CYTOTOXICITY ASSAY 142
7.9.3 FLOW CYTOMETRY ANALYSIS 142
7.9.4 CONFOCAL LASER-SCANNING MICROSCOPY 143
7.10 REFERENCES 144
ABBREVIATIONS 145
LIST OF FIGURES 147
LIST OF TABLES 154 |
| any_adam_object | 1 |
| author | Yassin, Mohamed A. 1983- |
| author_GND | (DE-588)1063653401 |
| author_facet | Yassin, Mohamed A. 1983- |
| author_role | aut |
| author_sort | Yassin, Mohamed A. 1983- |
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| dewey-full | 547.8404545 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 547 - Organic chemistry |
| dewey-raw | 547.8404545 |
| dewey-search | 547.8404545 |
| dewey-sort | 3547.8404545 |
| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie |
| format | Thesis Book |
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| isbn | 9783944331874 |
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| physical | VII, 157 Seiten Illustrationen, Diagramme |
| publishDate | 2014 |
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| publisher | TUDpress |
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| spelling | Yassin, Mohamed A. 1983- Verfasser (DE-588)1063653401 aut Controlled permeable polymersomes decorated with functional-antennae for biomedical applications vorgelegt von Mohamed A. Yassin Dresden TUDpress 2014 VII, 157 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Dissertation Technische Universität Dresden 2014 Vernetzung Chemie (DE-588)4139250-4 gnd rswk-swf Blockcopolymere (DE-588)4146026-1 gnd rswk-swf Nanopartikel (DE-588)4333369-2 gnd rswk-swf Polyethylenglykolderivate (DE-588)4325470-6 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Nanopartikel (DE-588)4333369-2 s Blockcopolymere (DE-588)4146026-1 s Vernetzung Chemie (DE-588)4139250-4 s Polyethylenglykolderivate (DE-588)4325470-6 s DE-604 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=4951806&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029664423&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Yassin, Mohamed A. 1983- Controlled permeable polymersomes decorated with functional-antennae for biomedical applications Vernetzung Chemie (DE-588)4139250-4 gnd Blockcopolymere (DE-588)4146026-1 gnd Nanopartikel (DE-588)4333369-2 gnd Polyethylenglykolderivate (DE-588)4325470-6 gnd |
| subject_GND | (DE-588)4139250-4 (DE-588)4146026-1 (DE-588)4333369-2 (DE-588)4325470-6 (DE-588)4113937-9 |
| title | Controlled permeable polymersomes decorated with functional-antennae for biomedical applications |
| title_auth | Controlled permeable polymersomes decorated with functional-antennae for biomedical applications |
| title_exact_search | Controlled permeable polymersomes decorated with functional-antennae for biomedical applications |
| title_full | Controlled permeable polymersomes decorated with functional-antennae for biomedical applications vorgelegt von Mohamed A. Yassin |
| title_fullStr | Controlled permeable polymersomes decorated with functional-antennae for biomedical applications vorgelegt von Mohamed A. Yassin |
| title_full_unstemmed | Controlled permeable polymersomes decorated with functional-antennae for biomedical applications vorgelegt von Mohamed A. Yassin |
| title_short | Controlled permeable polymersomes decorated with functional-antennae for biomedical applications |
| title_sort | controlled permeable polymersomes decorated with functional antennae for biomedical applications |
| topic | Vernetzung Chemie (DE-588)4139250-4 gnd Blockcopolymere (DE-588)4146026-1 gnd Nanopartikel (DE-588)4333369-2 gnd Polyethylenglykolderivate (DE-588)4325470-6 gnd |
| topic_facet | Vernetzung Chemie Blockcopolymere Nanopartikel Polyethylenglykolderivate Hochschulschrift |
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