Computational methods for processing and analysis of biological pathways:
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cham
Springer
[2017]
|
| Schriftenreihe: | SpringerBriefs in computer science
|
| Schlagworte: | |
| Online-Zugang: | BTU01 FHA01 FHI01 FHM01 FHN01 FHR01 FKE01 FLA01 FRO01 FWS01 FWS02 HTW01 UBG01 UBM01 UBR01 UBT01 UBW01 UBY01 UER01 UPA01 Volltext Inhaltsverzeichnis |
| Beschreibung: | 1 Online-Ressource (VIII, 87 Seiten, 11 illus. in color) |
| ISBN: | 9783319538686 |
| ISSN: | 2191-5768 |
| DOI: | 10.1007/978-3-319-53868-6 |
Internformat
MARC
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| 100 | 1 | |a Bezerianos, Anastasios |e Verfasser |4 aut | |
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Datensatz im Suchindex
| DE-BY-FWS_katkey | 644077 |
|---|---|
| _version_ | 1806181074889342976 |
| adam_text | Contents
1 Introduction 1
1 1 Biological Networks 2
111 Properties 2
112 Categories of Biological Networks 3
1 2 Pathway Analysis 4
121 Methodology 5
122 Evolution of Pathway Analysis Methods 6
1 3 Systems Pharmacology 8
References 9
2 Networks and Pathways in Systems Pharmacology 11
2 1 Introduction 11
2 2 Network- and Pathway/Sub-pathway-Based Characterization
of Drugs Mechanism of Action 15
2 3 Identification of New Drug Targets and Polypharmacology
Applications 24
231 Target Characterization and Identification Using Network
Properties of Drug Targets 24
232 Identification of Drug Targets Based on Integrative
Network Approaches 26
233 Network-Based Polypharmacology 28
2 4 Network-Based Drug Repositioning 29
241 Drug Repositioning Based on Molecular Profiles 30
242 Drug Repositioning Based on Phenotypic Profiles 33
2 5 Network-Based Side Effect Modeling and Prediction 35
251 Approaches Based on Chemical Structure 36
252 Approaches Based on Pathways/Sub-pathways 38
2 6 Current Challenges and Future Considerations 39
References 41
vii
Contents
viii
3 Time-Varying Methods for Pathway and Sub-pathway Analysis 47
3 1 Introduction 47
3 2 Conversion of Pathway Databases to Graphs 50
3 3 Time-Varying Pathway and Sub-pathway Extraction 54
331 Linear Sub-pathway Extraction 54
332 Nonlinear Sub-pathway Extraction 56
3 4 Temporal Dynamics Scoring Schemes 57
341 Approach Followed in CHRONOS 57
342 Other Approaches 61
3 5 Synthetic and Biological Data Analysis Results 65
References 67
4 Identification of Differentially Expressed Pathways
and Sub-pathways 69
4 1 Introduction 70
4 2 Approaches Based on Gene Sets 70
4 3 Approaches Based on Pathway Topology 72
4 4 Conversion of Pathway Databases Information to Graphs 79
4 5 Gene and Pathway-Level Statistics of Differential Expression 80
451 Methods Using Experimental Data for Sub-pathway
Identification 80
452 Methods Using Experimental Data for Evaluating
the Statistical Significance of Sub-pathways 81
4 6 DEsubs: A Flexible Tool for Identification of Differentially
Expressed Sub-pathways 82
|
| any_adam_object | 1 |
| author | Bezerianos, Anastasios Dragomir, Andrei Balomenos, Panos |
| author_facet | Bezerianos, Anastasios Dragomir, Andrei Balomenos, Panos |
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| discipline | Biologie Informatik |
| doi_str_mv | 10.1007/978-3-319-53868-6 |
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| illustrated | Not Illustrated |
| indexdate | 2024-08-01T12:35:01Z |
| institution | BVB |
| isbn | 9783319538686 |
| issn | 2191-5768 |
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| publishDate | 2017 |
| publishDateSearch | 2017 |
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| publisher | Springer |
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| spellingShingle | Bezerianos, Anastasios Dragomir, Andrei Balomenos, Panos Computational methods for processing and analysis of biological pathways Computer science Bioinformatics Systems biology Computer Science Computational Biology/Bioinformatics Systems Biology Informatik |
| title | Computational methods for processing and analysis of biological pathways |
| title_auth | Computational methods for processing and analysis of biological pathways |
| title_exact_search | Computational methods for processing and analysis of biological pathways |
| title_full | Computational methods for processing and analysis of biological pathways Anastasios Bezerianos, Andrei Dragomir, Panos Balomenos |
| title_fullStr | Computational methods for processing and analysis of biological pathways Anastasios Bezerianos, Andrei Dragomir, Panos Balomenos |
| title_full_unstemmed | Computational methods for processing and analysis of biological pathways Anastasios Bezerianos, Andrei Dragomir, Panos Balomenos |
| title_short | Computational methods for processing and analysis of biological pathways |
| title_sort | computational methods for processing and analysis of biological pathways |
| topic | Computer science Bioinformatics Systems biology Computer Science Computational Biology/Bioinformatics Systems Biology Informatik |
| topic_facet | Computer science Bioinformatics Systems biology Computer Science Computational Biology/Bioinformatics Systems Biology Informatik |
| url | https://doi.org/10.1007/978-3-319-53868-6 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029662351&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT bezerianosanastasios computationalmethodsforprocessingandanalysisofbiologicalpathways AT dragomirandrei computationalmethodsforprocessingandanalysisofbiologicalpathways AT balomenospanos computationalmethodsforprocessingandanalysisofbiologicalpathways |