Clinical biochemistry:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford
Oxford University Press
[2017]
|
| Ausgabe: | Second edition |
| Schriftenreihe: | Fundamentals of biomedical science
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index. - Description based on print version record |
| Beschreibung: | xxiv, 646 Seiten Illustrationen, Diagramme |
| ISBN: | 9780199674442 |
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| 250 | |a Second edition | ||
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Datensatz im Suchindex
| _version_ | 1804177356845219840 |
|---|---|
| adam_text | COlA/teiA/tS
An introduction to the Fundamentals of
Biomedical Science series xi
Online learning materials xiii
Preface xv
Contributors xvii
Abbreviations xix
Reference ranges xxiii
1 Biochemical investigations and
quality control 1
David Cameron
1.1 Nature of biochemical disorders 3
1.2 Historical background 4
1.3 Modern clinical biochemistry laboratories 5
1.4 Point-of-care testing 14
1.5 Evaluation of a clinical method 15
1.6 Quality control 22
1.7 Audit 27
Summary 29
Further reading 29
Questions 30
2 Automation 33
Tim James
2.1 Historical context 34
2.2 General automated chemistry systems 35
2.3 Automated immunochemistry analysers 44
2.4 Integration of processes and robotics 46
2.5 Automation in specialized areas of clinical
biochemistry 50
Summary 51
Further reading 51
Questions 52
3 Kidney disease 53
Edmund Lamb
3.1 Renal anatomy 54
3.2 Renal physiology 57
3.3 Kidney function tests 62
3.4 Kidney disease 74
3.5 Specific kidney disease 79
Summary 85
Further reading 86
Questions 86
4 Hyperuricaemia and gout 89
Joanne Marsden
4.1 Sources of purines 92
4.2 Purine catabolism and excretion 93
4.3 Hypouricaemia 95
4.4 Hyperuricaemia 96
4.5 Clinical features of gout 97
4.6 Diagnosis of gout 98
4.7 Treatment and management of gout 100
Summary 102
Further reading 102
Questions 102
5 Fluid and electrolyte disorders 104
Tim James
5.1 Water homeostasis 105
5.2 Assessing fluid and electrolyte status 108
5.3 Disturbances of plasma sodium 110
5.4 Disturbances of plasma potassium 114
5.5 Plasma and urine osmolality 120
5.6 Chloride and bicarbonate 121
Summary 123
Further reading 123
Questions J 124
6 Acid-base disorders 125
David Tierney r T
6.1 Hydrogen ion (H+) and pH 125
6.2 Acids, bases, and buffers 127
CONTENTS
6.3 Physiological role of H+ 130
6.4 Production of surplus H+ 130
6.5 Hydrogen ion homeostasis 131
6.6 Classification and investigation
of acid-base disorders 137
6.7 Metabolic acid-base disorders 139
6.8 Respiratory acid-base disorders 146
6.9 Mixed acid-base disorders 150
6.10 Interpretation of acid-base data 151
Summary 155
Further reading 155
Questions 156
7 Clinical enzymology and
biomarkers 157
Paul Collinson and Amy Lloyd
7.1 Enzymes and enzyme activities 158
7.2 Isoenzymes 159
7.3 Biomarkers 161
7.4 Cardiac disease 161
7.5 Cardiac disease, electrocardiogram, and
biomarkers 163
7.6 Development of heart disease 164
7.7 Cardiac biomarkers in clinical practice 165
7.8 Biomarkers of muscle damage for the
diagnosis of acute myocardial infarction 169
7.9 Natriuretic peptides 170
7.10 Possible future biomarkers in
cardiac disease 171
Summary 171
Further reading 172
Questions 172
8 Liver function tests 173
Roy Sherwood
8.1 Liver 173
8.2 Diseases of the liver 178
8.3 Liver function tests 181
8.4 The current liver function tests:
pros and cons 188
Summary 188
Further reading 188
Questions 189
9 Abnormalities of lipid
metabolism 190
Mike France
9.1 Types of lipids 191
9.2 Lipoproteins
9.3 Lipoprotein (a) 202
9.4 Classification of lipid disorders 204
9.5 Hypercholesterolaemia ?Q6
9.6 Hypocholesterolaemia 209
9.7 Hypertriglyceridaemia 212
9.8 Lipids, atheroma, and heart disease 213
9.9 Measurement of lipids in clinical samples 215
9.10 Assessment of cardiovascular risk T 7
9.11 Management of hyperlipidaemias 21B
Summary 2.22
Further reading 222
Questions 223
10 Disorders of calcium, phosphate,
and magnesium homeostasis ¿.tJ-
Nessar Ahmed
10.1 Distribution, function, and regulation
of calcium 226
10.2 Disorders of calcium homeostasis 232
10.3 Distribution, function, and regulation of
phosphate 240
10.4 Disorders of phosphate homeostasis 242
10.5 Distribution, function, and regulation of 247
magnesium
10.6 Disorders of magnesium homeostasis 249
10.7 Bone metabolism 254
10.8 Markers of bone disease 255
10.9 Metabolic bone disease 256
Summary 260
Further reading 260
Questions 261
11 Abnormal pituitary function 263
Garry McDowell
11.1 Endocrine system 263
11.2 Structure of the hypothalamus and
pituitary gland 265
CONTENTS
ì 1.3 Anterior pituitary hormones 268 13.13 Hypoglycaemia 329
1 !.4 Posterior pituitary hormones 271 Summary 331
1 *: / Disorders of pituitary function 271 Further reading 332
Anterior pituitary hyperfunction 272 Questions 333
1 ? Anterior pituitary hypofunction 277 14 Adrenal disease 334
? : ։·! Posterior pituitary dysfunction 280 John Honour
■rr.mary 282
‘■ ■nrther reading 282 14.1 Adrenal glands 335
Questions 283 14.2 Disorders of adrenal glands 345
14.3 Investigation of adrenal disorders 355
:֊; Thyroid disease 284 14.4 Management of adrenal disorders 364
Garry McDowell Summary 365
• i Structure of the thyroid gland 284 Further reading 365
J 2 2 Thyroid hormones 286 Questions 366
i 23 Function of thyroid hormones 288 15 Reproductive endocrinology 367
¿2.4 Control of thyroid hormone secretion 289 Ian Laing and Julie Thornton
’2.5 Disorders of thyroid function 289
: . .O Hyperthyroidism 289 15.1 Reproductive endocrinology in the female 368
7 Hypothyroidism 292 15.2 Hormonal changes in the menstrual cycle 372
■՝ Laboratory tests to determine 15.3 Menopause 375
the cause of thyroid dysfunction 295 15.4 Causes of anovulatory infertility 376
. _ 9 Interpretation of thyroid function tests 295 15.5 Polycystic ovary syndrome 378
Summary 297 15.6 Investigations in female reproductive
Further reading 297 endocrinology 384
Questions 298 15.7 Management of anovulatory infertility 387
15.8 Reproductive endocrinology in the male 389
13 Diabetes mellitus and 15.9 Limitations in assays for steroid and
hypoglycaemia 300 polypeptide hormones 393
Allen Yates and Ian Laing Summary 394
13.1 The islets of Langerhans 302 Further reading 395
302 Questions 396
13.2 Glucose-induced insulin secretion
13.3 Glucagon secretion 306 16 Biochemical nutrition 397
13.4 Insulin, glucagon, and the Patrick Twomey and William Simpson
counter-regulatory hormones 306
13.5 Incretin hormones 309 16.1 Types of nutrients 397
13.6 impaired glucose and lipid handling 309 16.2 Specific nutrients: macronutrients 399
13.7 Diagnosis, classification, and aetiology 16.3 Specific nutrients: organic micronutrients 400
of diabetes 316 16.4 Specific nutrients: inorganic micronutrients 408
13.8 Acute complications of diabetes 320 16.5 Assessment of nutritional status 410
13.9 Long-term complications of diabetes 322 16.6 Disordered eating patterns 414
13.10 Evidence-based medicine and 16.7 Nutritional intervention 416
diabetes treatment 324 Summary 417
13.11 Treatments for diabetes 324 Further reading 418
13.12 Monitoring and management of diabetes 327 Questions 418
CONTENTS
17 Gastrointestinal disorders 20.2 Effects of a metabolic block 505
and malabsorption 420 20.3 Approaches to treatment 506
Garry McDowell and Gordon Brydon 20.4 Laboratory testing for inherited
metabolic disorders 506
17.1 Gastrointestinal biochemistry and physiology 421 TA C ôf A lì a li/“ /4 1 f A KnOKC
17.2 Biochemical investigation of zu.j jroups OT meiaDoiic uisoruers j jy
gastrointestinal tract diseases 431 20.6 Antenatal diagnosis 52.9
17.3 Management of gastrointestinal disease 441 20.7 Newborn screening BO
Summary 442 Summary 532
Further reading 443 Further reading 532
Questions 443 Questions 533
18 Specific protein markers 445 21 Therapeutic drug monitoring K A
Gerald Maguire Robin Whelpton, Nigel Brown,
18.1 Plasma proteins 445 and Robert Flanagan
18.2 Albumin 448 21.1 Drug administration, distribution,
18.3 Alpha 1 -antitrypsin 450 and elimination 535
18.4 Haptoglobin 452 21.2 Pharmacokinetics 541
18.5 Caeruloplasmin 453
21.3 Analytical methods * :V O
18.6 Transferrin 453
18.7 C-reactive protein 454 21.4 Therapeutic drug monitoring: practicalities JJ li
18.8 Immunoglobulins 455 21.5 Therapeutic monitoring of specific drugs
18.9 Measuring concentrations of Summary 558
specific proteins 461 Further reading 558
Summary 474 Questions 559
Further reading 474
Questions 475 22 Chemical toxicology 569
Gwendolen Ayers
19 Cancer biochemistry and
tumour markers 477 22.1 Types of poisons and poisoning 560
Joanne Adaway and Gilbert Wieringa 22.2 Clinical features of poisoning 563
22.3 Biochemical features of poisoning 563
19.1 Causes of cancer 478
19,2 Types of cancers 479 22.4 Management of the poisoned patient 564
19.3 The effects of cancer 480 22.5 Laboratory investigation of poisoning 566
19.4 Cancer treatments 485 22.6 Toxicology of specific compounds 572
19.5 Tumour markers 487 Summary 582
19.6 The future of clinical biochemistry in Further reading 582
cancer diagnostics 497 Questions 582
Summary 499
Further reading 500 Answers to self-check questions 584
Questions 500 Answers to case studies 590
Answers to end-of-chapter questions 599
20 Inherited metabolic disorders Glossary 605
and newborn screening 502 Index 629
Mary Anne Preece
20.1 Modes of inheritance 503
|
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| discipline | Biologie Medizin |
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| spelling | Clinical biochemistry edited by Dr Nessar Ahmed (PhD, CSci, FIBMS, Reader in Clinical Biochemistry, School of Healthcare Science, Manchester Metropolian University) Second edition Oxford Oxford University Press [2017] xxiv, 646 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Fundamentals of biomedical science Includes bibliographical references and index. - Description based on print version record Biochemistry Klinische Chemie (DE-588)4135255-5 gnd rswk-swf Biomedizin (DE-588)4647152-2 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf Chemistry, Clinical / methods (DE-588)4143413-4 Aufsatzsammlung gnd-content Biomedizin (DE-588)4647152-2 s Biochemie (DE-588)4006777-4 s Klinische Chemie (DE-588)4135255-5 s b DE-604 Ahmed, Nessar edt Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029619686&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | Clinical biochemistry |
| title_auth | Clinical biochemistry |
| title_exact_search | Clinical biochemistry |
| title_full | Clinical biochemistry edited by Dr Nessar Ahmed (PhD, CSci, FIBMS, Reader in Clinical Biochemistry, School of Healthcare Science, Manchester Metropolian University) |
| title_fullStr | Clinical biochemistry edited by Dr Nessar Ahmed (PhD, CSci, FIBMS, Reader in Clinical Biochemistry, School of Healthcare Science, Manchester Metropolian University) |
| title_full_unstemmed | Clinical biochemistry edited by Dr Nessar Ahmed (PhD, CSci, FIBMS, Reader in Clinical Biochemistry, School of Healthcare Science, Manchester Metropolian University) |
| title_short | Clinical biochemistry |
| title_sort | clinical biochemistry |
| topic | Biochemistry Klinische Chemie (DE-588)4135255-5 gnd Biomedizin (DE-588)4647152-2 gnd Biochemie (DE-588)4006777-4 gnd |
| topic_facet | Biochemistry Klinische Chemie Biomedizin Biochemie Aufsatzsammlung |
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